SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5v4b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4002_1
(SERUM ALBUMIN)		 5v4b F-BOX/WD
REPEAT-CONTAINING
PROTEIN 7
(Homo
sapiens) 		4 / 6 LEU B2403
VAL B2424
SER B2427
GLN B2428
 None
None
None
SO4  B2804 (-3.7A)
 1.11A 1e7aB-5v4bB:
undetectable		 1e7aB-5v4bB:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5v4b F-BOX/WD
REPEAT-CONTAINING
PROTEIN 7
(Homo
sapiens) 		4 / 7 VAL B2555
GLY B2557
THR B2584
ILE B2563
 None
 0.62A 1gtnC-5v4bB:
undetectable
1gtnD-5v4bB:
undetectable		 1gtnC-5v4bB:
10.96
1gtnD-5v4bB:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5v4b F-BOX/WD
REPEAT-CONTAINING
PROTEIN 7
(Homo
sapiens) 		4 / 5 GLY B2477
TRP B2486
VAL B2474
SER B2426
 None
 1.29A 1p6kB-5v4bB:
undetectable		 1p6kB-5v4bB:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QW6_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5v4b F-BOX/WD
REPEAT-CONTAINING
PROTEIN 7
(Homo
sapiens) 		3 / 3 ARG B2674
VAL B2424
TRP B2425
 SO4  B2803 (-4.9A)
None
None
 1.23A 1qw6A-5v4bB:
undetectable		 1qw6A-5v4bB:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5v4b F-BOX/WD
REPEAT-CONTAINING
PROTEIN 7
(Homo
sapiens) 		4 / 5 GLY B2477
TRP B2486
VAL B2474
SER B2426
 None
 1.26A 1rs6B-5v4bB:
undetectable		 1rs6B-5v4bB:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_A_9CRA131_1
(TRANSTHYRETIN)		 5v4b F-BOX/WD
REPEAT-CONTAINING
PROTEIN 7
(Homo
sapiens) 		4 / 6 ALA B2626
LEU B2583
SER B2585
THR B2628
 None
 1.28A 1tyrA-5v4bB:
undetectable		 1tyrA-5v4bB:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAG_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5v4b F-BOX/WD
REPEAT-CONTAINING
PROTEIN 7
(Homo
sapiens) 		3 / 3 ARG B2674
VAL B2424
TRP B2425
 SO4  B2803 (-4.9A)
None
None
 1.26A 1vagA-5v4bB:
undetectable		 1vagA-5v4bB:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZVI_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5v4b F-BOX/WD
REPEAT-CONTAINING
PROTEIN 7
(Homo
sapiens) 		3 / 3 ARG B2674
VAL B2424
TRP B2425
 SO4  B2803 (-4.9A)
None
None
 1.23A 1zviA-5v4bB:
undetectable		 1zviA-5v4bB:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5v4b F-BOX/WD
REPEAT-CONTAINING
PROTEIN 7
(Homo
sapiens) 		4 / 5 GLY B2477
TRP B2486
VAL B2474
SER B2426
 None
 1.26A 1zzuB-5v4bB:
undetectable		 1zzuB-5v4bB:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 5v4b F-BOX/WD
REPEAT-CONTAINING
PROTEIN 7
(Homo
sapiens) 		3 / 3 ASP B2550
PHE B2549
LEU B2547
 None
 0.60A 2zi9A-5v4bB:
undetectable		 2zi9A-5v4bB:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P)		 5v4b F-BOX/WD
REPEAT-CONTAINING
PROTEIN 7
(Homo
sapiens) 		4 / 8 VAL B2627
VAL B2637
ASN B2598
GLY B2597
 None
 0.80A 3hjoB-5v4bB:
undetectable		 3hjoB-5v4bB:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		 5v4b F-BOX/WD
REPEAT-CONTAINING
PROTEIN 7
(Homo
sapiens) 		5 / 11 THR B2692
GLY B2691
THR B2695
GLY B2687
ASP B2381
 None
 1.06A 3t8nD-5v4bB:
undetectable
3t8nF-5v4bB:
undetectable		 3t8nD-5v4bB:
13.30
3t8nF-5v4bB:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5v4b F-BOX/WD
REPEAT-CONTAINING
PROTEIN 7
(Homo
sapiens) 		3 / 3 HIS B2359
GLU B2328
ASN B2635
 None
 1.01A 4bupB-5v4bB:
undetectable		 4bupB-5v4bB:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1Y_A_RBFA1176_1
(PUTATIVE PROTEASE I)		 5v4b F-BOX/WD
REPEAT-CONTAINING
PROTEIN 7
(Homo
sapiens) 		4 / 8 ASN B2635
GLN B2358
THR B2680
TRP B2365
 None
None
SO4  B2802 (-4.0A)
IMD  B2810 ( 4.2A)
 1.13A 4d1yA-5v4bB:
undetectable
4d1yB-5v4bB:
undetectable		 4d1yA-5v4bB:
18.59
4d1yB-5v4bB:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L78_A_ACTA1327_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 5v4b F-BOX/WD
REPEAT-CONTAINING
PROTEIN 7
(Homo
sapiens) 		4 / 4 VAL B2686
THR B2695
GLU B2693
GLU B2694
 None
 0.98A 4l78A-5v4bB:
undetectable		 4l78A-5v4bB:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 5v4b F-BOX/WD
REPEAT-CONTAINING
PROTEIN 7
(Homo
sapiens) 		5 / 12 GLY B2597
LEU B2594
THR B2584
GLY B2557
ILE B2563
 None
 0.90A 5d4uC-5v4bB:
undetectable		 5d4uC-5v4bB:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 5v4b F-BOX/WD
REPEAT-CONTAINING
PROTEIN 7
(Homo
sapiens) 		5 / 12 GLY B2597
LEU B2594
THR B2584
GLY B2557
ILE B2563
 None
 0.87A 5d4uD-5v4bB:
undetectable		 5d4uD-5v4bB:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_G_ADNG501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5v4b F-BOX/WD
REPEAT-CONTAINING
PROTEIN 7
(Homo
sapiens) 		4 / 5 GLU B2471
GLU B2489
THR B2490
LEU B2494
 None
 1.23A 5hm8G-5v4bB:
undetectable		 5hm8G-5v4bB:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5v4b F-BOX/WD
REPEAT-CONTAINING
PROTEIN 7
(Homo
sapiens) 		3 / 3 THR B2639
THR B2584
LEU B2594
 None
 0.58A 5m66D-5v4bB:
undetectable		 5m66D-5v4bB:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5v4b F-BOX/WD
REPEAT-CONTAINING
PROTEIN 7
(Homo
sapiens) 		5 / 12 GLU B2569
GLY B2571
LEU B2589
GLY B2551
ILE B2552
 None
 0.94A 5vooA-5v4bB:
undetectable		 5vooA-5v4bB:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5v4b F-BOX/WD
REPEAT-CONTAINING
PROTEIN 7
(Homo
sapiens) 		5 / 12 GLU B2569
GLY B2571
LEU B2589
GLY B2551
ILE B2552
 None
 0.89A 5vooB-5v4bB:
undetectable		 5vooB-5v4bB:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5v4b F-BOX/WD
REPEAT-CONTAINING
PROTEIN 7
(Homo
sapiens) 		5 / 12 GLU B2569
GLY B2571
LEU B2589
GLY B2551
ILE B2552
 None
 0.94A 5vooC-5v4bB:
undetectable		 5vooC-5v4bB:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5v4b F-BOX/WD
REPEAT-CONTAINING
PROTEIN 7
(Homo
sapiens) 		5 / 12 GLU B2569
GLY B2571
LEU B2589
GLY B2551
ILE B2552
 None
 0.97A 5vooD-5v4bB:
undetectable		 5vooD-5v4bB:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5v4b F-BOX/WD
REPEAT-CONTAINING
PROTEIN 7
(Homo
sapiens) 		5 / 12 GLU B2569
GLY B2571
LEU B2589
GLY B2551
ILE B2552
 None
 1.01A 5vooE-5v4bB:
undetectable		 5vooE-5v4bB:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5v4b F-BOX/WD
REPEAT-CONTAINING
PROTEIN 7
(Homo
sapiens) 		5 / 12 GLU B2569
GLY B2571
LEU B2589
GLY B2551
ILE B2552
 None
 1.01A 5vooF-5v4bB:
undetectable		 5vooF-5v4bB:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5v4b F-BOX/WD
REPEAT-CONTAINING
PROTEIN 7
(Homo
sapiens) 		5 / 12 GLU B2569
GLY B2571
LEU B2589
GLY B2551
ILE B2552
 None
 0.92A 5vopA-5v4bB:
undetectable		 5vopA-5v4bB:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5v4b F-BOX/WD
REPEAT-CONTAINING
PROTEIN 7
(Homo
sapiens) 		5 / 12 GLU B2569
GLY B2571
LEU B2589
GLY B2551
ILE B2552
 None
 1.04A 5vopB-5v4bB:
undetectable		 5vopB-5v4bB:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 5v4b F-BOX/WD
REPEAT-CONTAINING
PROTEIN 7
(Homo
sapiens) 		3 / 3 HIS B2359
GLU B2328
ASN B2635
 None
 0.95A 5wbvA-5v4bB:
undetectable		 5wbvA-5v4bB:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 5v4b F-BOX/WD
REPEAT-CONTAINING
PROTEIN 7
(Homo
sapiens) 		3 / 3 HIS B2359
GLU B2328
ASN B2635
 None
 0.95A 5wbvB-5v4bB:
undetectable		 5wbvB-5v4bB:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 5v4b F-BOX/WD
REPEAT-CONTAINING
PROTEIN 7
(Homo
sapiens) 		4 / 6 GLY B2597
SER B2641
THR B2639
VAL B2603
 None
 0.99A 5ysiA-5v4bB:
undetectable		 5ysiA-5v4bB:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 5v4b F-BOX/WD
REPEAT-CONTAINING
PROTEIN 7
(Homo
sapiens) 		4 / 8 SER B2585
GLY B2669
SER B2665
VAL B2672
 None
 1.06A 6giqL-5v4bB:
undetectable
6giqP-5v4bB:
undetectable
6giqT-5v4bB:
undetectable		 6giqL-5v4bB:
22.52
6giqP-5v4bB:
19.14
6giqT-5v4bB:
10.02