SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5v4f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKF_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 5v4f PUTATIVE
TRANSLATIONAL
INHIBITOR PROTEIN
(Yersinia
pestis) 		5 / 11 TYR A 102
ARG A   3
ILE A 127
ILE A  33
PHE A 101
 None
 1.36A 1fkfA-5v4fA:
undetectable		 1fkfA-5v4fA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKJ_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 5v4f PUTATIVE
TRANSLATIONAL
INHIBITOR PROTEIN
(Yersinia
pestis) 		5 / 11 TYR A 102
ARG A   3
ILE A 127
ILE A  33
PHE A 101
 None
 1.38A 1fkjA-5v4fA:
undetectable		 1fkjA-5v4fA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TCO_C_FK5C509_2
(FK506-BINDING
PROTEIN)		 5v4f PUTATIVE
TRANSLATIONAL
INHIBITOR PROTEIN
(Yersinia
pestis) 		5 / 11 TYR A 102
ARG A   3
ILE A 127
ILE A  33
PHE A 101
 None
 1.39A 1tcoC-5v4fA:
undetectable		 1tcoC-5v4fA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)		 5v4f PUTATIVE
TRANSLATIONAL
INHIBITOR PROTEIN
(Yersinia
pestis) 		5 / 12 VAL A  77
ALA A 109
GLU A  24
THR A  30
THR A 130
 None
 1.30A 3dl9B-5v4fA:
undetectable		 3dl9B-5v4fA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHZ_A_FK5A501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)		 5v4f PUTATIVE
TRANSLATIONAL
INHIBITOR PROTEIN
(Yersinia
pestis) 		5 / 10 TYR A 102
ARG A   3
ILE A 127
ILE A  33
PHE A 101
 None
 1.40A 3ihzA-5v4fA:
undetectable		 3ihzA-5v4fA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O5R_A_FK5A1001_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 5v4f PUTATIVE
TRANSLATIONAL
INHIBITOR PROTEIN
(Yersinia
pestis) 		5 / 11 TYR A 102
ARG A   3
ILE A 127
ILE A  33
PHE A 101
 None
 1.39A 3o5rA-5v4fA:
undetectable		 3o5rA-5v4fA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQB_A_FOLA2001_0
(DIHYDROFOLATE
REDUCTASE)		 5v4f PUTATIVE
TRANSLATIONAL
INHIBITOR PROTEIN
(Yersinia
pestis) 		5 / 11 LEU A  59
THR A  81
ILE A 125
LEU A  51
ILE A  94
 None
None
None
GOL  A 205 (-4.2A)
None
 1.12A 3tqbA-5v4fA:
undetectable		 3tqbA-5v4fA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UF8_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 5v4f PUTATIVE
TRANSLATIONAL
INHIBITOR PROTEIN
(Yersinia
pestis) 		5 / 10 TYR A 102
ARG A   3
ILE A 127
ILE A  33
PHE A 101
 None
 1.36A 3uf8A-5v4fA:
undetectable		 3uf8A-5v4fA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQA_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 5v4f PUTATIVE
TRANSLATIONAL
INHIBITOR PROTEIN
(Yersinia
pestis) 		5 / 10 TYR A 102
ARG A   3
ILE A 127
ILE A  33
PHE A 101
 None
 1.36A 3uqaA-5v4fA:
undetectable		 3uqaA-5v4fA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5v4f PUTATIVE
TRANSLATIONAL
INHIBITOR PROTEIN
(Yersinia
pestis) 		5 / 12 ALA A 100
THR A  81
ILE A 125
LEU A  51
ILE A  94
 None
None
None
GOL  A 205 (-4.2A)
None
 0.95A 4kjkA-5v4fA:
undetectable		 4kjkA-5v4fA:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJL_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5v4f PUTATIVE
TRANSLATIONAL
INHIBITOR PROTEIN
(Yersinia
pestis) 		5 / 12 ALA A 100
THR A  81
ILE A 125
LEU A  51
ILE A  94
 None
None
None
GOL  A 205 (-4.2A)
None
 1.03A 4kjlA-5v4fA:
undetectable		 4kjlA-5v4fA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5v4f PUTATIVE
TRANSLATIONAL
INHIBITOR PROTEIN
(Yersinia
pestis) 		5 / 12 ALA A 100
THR A  81
ILE A 125
LEU A  51
ILE A  94
 None
None
None
GOL  A 205 (-4.2A)
None
 1.02A 4p3qA-5v4fA:
undetectable		 4p3qA-5v4fA:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 5v4f PUTATIVE
TRANSLATIONAL
INHIBITOR PROTEIN
(Yersinia
pestis) 		5 / 12 VAL A  23
LEU A  66
ASP A  75
ALA A 108
SER A  20
 None
 1.40A 5hnzB-5v4fA:
undetectable		 5hnzB-5v4fA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5v4f PUTATIVE
TRANSLATIONAL
INHIBITOR PROTEIN
(Yersinia
pestis) 		5 / 12 ILE A  98
GLY A  18
TYR A 102
GLU A 126
ARG A  78
 None
None
None
GOL  A 206 (-3.6A)
None
 1.43A 5igwA-5v4fA:
undetectable		 5igwA-5v4fA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NU7_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 4)		 5v4f PUTATIVE
TRANSLATIONAL
INHIBITOR PROTEIN
(Yersinia
pestis) 		4 / 8 LEU A 118
ALA A  34
VAL A  84
GLN A  54
 None
GOL  A 206 ( 4.8A)
None
None
 0.97A 5nu7A-5v4fA:
undetectable		 5nu7A-5v4fA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5v4f PUTATIVE
TRANSLATIONAL
INHIBITOR PROTEIN
(Yersinia
pestis) 		5 / 10 ILE A  94
ILE A  33
ALA A 129
LEU A  79
ALA A 108
 None
 1.25A 5zjiB-5v4fA:
undetectable		 5zjiB-5v4fA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5v4f PUTATIVE
TRANSLATIONAL
INHIBITOR PROTEIN
(Yersinia
pestis) 		5 / 12 ALA A 100
THR A  81
ILE A 125
LEU A  51
ILE A  94
 None
None
None
GOL  A 205 (-4.2A)
None
 1.00A 7dfrA-5v4fA:
undetectable		 7dfrA-5v4fA:
25.31