SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5v4l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX9_A_REAA1163_1
(BETA-LACTOGLOBULIN)		 5v4l ADENYLOSUCCINATE
LYASE
(Cryptococcus
neoformans) 		5 / 11 LEU A 167
ILE A 271
LYS A 257
VAL A 161
PHE A 138
 None
 1.36A 1gx9A-5v4lA:
undetectable		 1gx9A-5v4lA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5v4l ADENYLOSUCCINATE
LYASE
(Cryptococcus
neoformans) 		4 / 7 LEU A 248
PHE A  21
MET A  17
SER A  14
 None
 1.00A 1wrlA-5v4lA:
undetectable
1wrlB-5v4lA:
undetectable		 1wrlA-5v4lA:
11.23
1wrlB-5v4lA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5v4l ADENYLOSUCCINATE
LYASE
(Cryptococcus
neoformans) 		4 / 7 LEU A 304
PHE A  21
MET A  17
SER A  14
 None
 0.81A 1wrlA-5v4lA:
undetectable
1wrlB-5v4lA:
undetectable		 1wrlA-5v4lA:
11.23
1wrlB-5v4lA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5v4l ADENYLOSUCCINATE
LYASE
(Cryptococcus
neoformans) 		4 / 6 LEU A 304
PHE A  21
MET A  17
SER A  14
 None
 0.84A 1wrlB-5v4lA:
undetectable		 1wrlB-5v4lA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_C_TFPC208_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5v4l ADENYLOSUCCINATE
LYASE
(Cryptococcus
neoformans) 		4 / 5 LEU A 248
PHE A  21
MET A  17
SER A  14
 None
 1.22A 1wrlC-5v4lA:
undetectable		 1wrlC-5v4lA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_C_TFPC208_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5v4l ADENYLOSUCCINATE
LYASE
(Cryptococcus
neoformans) 		4 / 5 LEU A 304
PHE A  21
MET A  17
SER A  14
 None
 0.97A 1wrlC-5v4lA:
undetectable		 1wrlC-5v4lA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_E_TFPE212_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5v4l ADENYLOSUCCINATE
LYASE
(Cryptococcus
neoformans) 		4 / 7 LEU A 248
PHE A  21
MET A  17
SER A  14
 None
 1.11A 1wrlE-5v4lA:
undetectable		 1wrlE-5v4lA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_E_TFPE212_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5v4l ADENYLOSUCCINATE
LYASE
(Cryptococcus
neoformans) 		4 / 7 LEU A 304
PHE A  21
MET A  17
SER A  14
 None
 0.75A 1wrlE-5v4lA:
undetectable		 1wrlE-5v4lA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_G_ASDG1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 5v4l ADENYLOSUCCINATE
LYASE
(Cryptococcus
neoformans) 		4 / 7 LEU A 245
PRO A 247
ALA A 182
LEU A 179
 None
 0.94A 2vcvG-5v4lA:
3.2		 2vcvG-5v4lA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5v4l ADENYLOSUCCINATE
LYASE
(Cryptococcus
neoformans) 		4 / 4 LEU A 245
GLN A 309
THR A 311
THR A 340
 None
 1.47A 2zj0D-5v4lA:
undetectable		 2zj0D-5v4lA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_1
(PROTEASE)		 5v4l ADENYLOSUCCINATE
LYASE
(Cryptococcus
neoformans) 		5 / 9 ILE A 271
VAL A 161
ILE A 169
ILE A 351
ILE A 262
 None
 1.00A 3s43A-5v4lA:
undetectable		 3s43A-5v4lA:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5v4l ADENYLOSUCCINATE
LYASE
(Cryptococcus
neoformans) 		5 / 11 THR A  29
LEU A  20
PHE A  21
PHE A 225
TYR A 236
 None
 1.48A 4claA-5v4lA:
1.7		 4claA-5v4lA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_B_NCTB501_1
(CYTOCHROME P450 2A13)		 5v4l ADENYLOSUCCINATE
LYASE
(Cryptococcus
neoformans) 		4 / 8 PHE A 338
ALA A 182
LEU A 125
LEU A 124
 None
 0.83A 4ejgB-5v4lA:
undetectable		 4ejgB-5v4lA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)		 5v4l ADENYLOSUCCINATE
LYASE
(Cryptococcus
neoformans) 		4 / 8 ASN A  36
PHE A 223
LEU A  60
TYR A 107
 None
 0.95A 4f5zA-5v4lA:
undetectable		 4f5zA-5v4lA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_1
(CYP51 VARIANT1)		 5v4l ADENYLOSUCCINATE
LYASE
(Cryptococcus
neoformans) 		5 / 12 ALA A 259
PHE A  21
ILE A 334
GLY A 120
LEU A 179
 None
 1.12A 5fsaA-5v4lA:
undetectable		 5fsaA-5v4lA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA603_1
(CHITINASE)		 5v4l ADENYLOSUCCINATE
LYASE
(Cryptococcus
neoformans) 		4 / 8 PHE A 225
GLY A 187
ASP A 241
ARG A 330
 None
 0.97A 5gqbA-5v4lA:
undetectable		 5gqbA-5v4lA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_A_MMZA503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 5v4l ADENYLOSUCCINATE
LYASE
(Cryptococcus
neoformans) 		3 / 3 ASN A 178
SER A 250
SER A 249
 None
 0.63A 5gsnA-5v4lA:
undetectable		 5gsnA-5v4lA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_0
(OXAC)		 5v4l ADENYLOSUCCINATE
LYASE
(Cryptococcus
neoformans) 		5 / 12 ALA A 165
GLY A 162
LEU A 355
LEU A 348
ASP A 261
 None
 1.20A 5w7pA-5v4lA:
undetectable		 5w7pA-5v4lA:
25.05