SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5v4n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		 5v4n ALPHA3(135-145)-HLA-
DRB1*01:01
(Homo
sapiens) 		3 / 3 GLN C 319
TYR C 296
ARG C 288
 None
 0.95A 1gtbA-5v4nC:
undetectable		 1gtbA-5v4nC:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 5v4n ALPHA3(135-145)-HLA-
DRB1*01:01
(Homo
sapiens) 		3 / 3 SER C 286
GLU C 277
ASP C 306
 None
 0.74A 2zthA-5v4nC:
undetectable		 2zthA-5v4nC:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 5v4n ALPHA3(135-145)-HLA-
DRB1*01:01
(Homo
sapiens) 		3 / 3 SER C 286
GLU C 277
ASP C 306
 None
 0.86A 3bwyA-5v4nC:
undetectable		 3bwyA-5v4nC:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5v4n ALPHA3(135-145)-HLA-
DRB1*01:01
(Homo
sapiens) 		4 / 6 GLU C 277
TYR C 296
LEU C 317
PHE C 289
 None
 1.14A 4twdB-5v4nC:
3.8
4twdC-5v4nC:
3.5		 4twdB-5v4nC:
19.46
4twdC-5v4nC:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5v4n ALPHA3(135-145)-HLA-
DRB1*01:01
(Homo
sapiens) 		4 / 6 GLU C 277
TYR C 296
LEU C 317
PHE C 289
 None
 1.15A 4twdD-5v4nC:
3.5
4twdE-5v4nC:
3.5		 4twdD-5v4nC:
19.46
4twdE-5v4nC:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5v4n ALPHA3(135-145)-HLA-
DRB1*01:01
(Homo
sapiens) 		4 / 7 GLU C 277
TYR C 296
LEU C 317
PHE C 289
 None
 1.10A 4twdF-5v4nC:
undetectable
4twdJ-5v4nC:
undetectable		 4twdF-5v4nC:
19.46
4twdJ-5v4nC:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5v4n ALPHA3(135-145)-HLA-
DRB1*01:01
(Homo
sapiens) 		4 / 6 GLU C 277
TYR C 296
LEU C 317
PHE C 289
 None
 1.08A 4twdF-5v4nC:
2.5
4twdG-5v4nC:
2.3		 4twdF-5v4nC:
19.46
4twdG-5v4nC:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5v4n ALPHA3(135-145)-HLA-
DRB1*01:01
(Homo
sapiens) 		4 / 6 GLU C 277
TYR C 296
LEU C 317
PHE C 289
 None
 1.14A 4twdI-5v4nC:
undetectable
4twdJ-5v4nC:
2.4		 4twdI-5v4nC:
19.46
4twdJ-5v4nC:
19.46