SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5v4p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H60_A_STRA500_1
(PENTAERYTHRITOL
TETRANITRATE
REDUCTASE)		 5v4p NADPH DEHYDROGENASE
3
(Saccharomyces
cerevisiae) 		5 / 9 THR A  37
TYR A  82
HIS A 191
TYR A 196
TYR A 375
 HBA  A 402 ( 3.9A)
None
FMN  A 401 ( 3.5A)
HBA  A 402 (-4.2A)
HBA  A 402 ( 4.4A)
 0.80A 1h60A-5v4pA:
49.1		 1h60A-5v4pA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ABA_A_STRA1500_1
(PENTAERYTHRITOL
TETRANITRATE
REDUCTASE)		 5v4p NADPH DEHYDROGENASE
3
(Saccharomyces
cerevisiae) 		5 / 9 THR A  37
TYR A  82
HIS A 191
TYR A 196
TYR A 375
 HBA  A 402 ( 3.9A)
None
FMN  A 401 ( 3.5A)
HBA  A 402 (-4.2A)
HBA  A 402 ( 4.4A)
 0.77A 2abaA-5v4pA:
49.2		 2abaA-5v4pA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 5v4p NADPH DEHYDROGENASE
3
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  27
ILE A  22
VAL A 357
PHE A 284
HIS A 286
 None
 1.30A 2qo4A-5v4pA:
undetectable		 2qo4A-5v4pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 5v4p NADPH DEHYDROGENASE
3
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 125
LEU A 127
PHE A  74
ASN A  84
ASP A  83
 None
 1.46A 2x2iA-5v4pA:
5.4		 2x2iA-5v4pA:
5.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)		 5v4p NADPH DEHYDROGENASE
3
(Saccharomyces
cerevisiae) 		5 / 12 THR A  73
ALA A 183
ALA A 176
THR A  25
ILE A 104
 None
 1.22A 3dl9B-5v4pA:
undetectable		 3dl9B-5v4pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_0
(REPRESSOR PROTEIN
MPHR(A))		 5v4p NADPH DEHYDROGENASE
3
(Saccharomyces
cerevisiae) 		5 / 12 THR A  70
VAL A 240
LEU A 272
SER A 117
VAL A 228
 None
 1.10A 3frqA-5v4pA:
1.2		 3frqA-5v4pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UPW_A_NCAA412_0
(OLD YELLOW ENZYME
2.6 (OYE2.6), NADPH
DEHYDROGENASE)		 5v4p NADPH DEHYDROGENASE
3
(Saccharomyces
cerevisiae) 		5 / 9 THR A  37
HIS A 191
TYR A 196
PHE A 250
TYR A 375
 HBA  A 402 ( 3.9A)
FMN  A 401 ( 3.5A)
HBA  A 402 (-4.2A)
HBA  A 402 ( 4.8A)
HBA  A 402 ( 4.4A)
 0.36A 3upwA-5v4pA:
58.7		 3upwA-5v4pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WFA_B_EDTB802_0
(ALPHA-GLUCOSIDASE)		 5v4p NADPH DEHYDROGENASE
3
(Saccharomyces
cerevisiae) 		4 / 6 TYR A 375
ARG A  40
ASP A 370
TYR A 382
 HBA  A 402 ( 4.4A)
None
None
None
 1.17A 3wfaA-5v4pA:
7.9
3wfaB-5v4pA:
2.6		 3wfaA-5v4pA:
undetectable
3wfaB-5v4pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_A_NCAA1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 5v4p NADPH DEHYDROGENASE
3
(Saccharomyces
cerevisiae) 		6 / 7 THR A  37
TRP A 116
HIS A 191
ASN A 194
TYR A 196
TYR A 375
 HBA  A 402 ( 3.9A)
HBA  A 402 ( 4.8A)
FMN  A 401 ( 3.5A)
HBA  A 402 ( 3.7A)
HBA  A 402 (-4.2A)
HBA  A 402 ( 4.4A)
 0.37A 4a3uA-5v4pA:
48.6		 4a3uA-5v4pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_NCAB1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 5v4p NADPH DEHYDROGENASE
3
(Saccharomyces
cerevisiae) 		6 / 7 THR A  37
TRP A 116
HIS A 191
ASN A 194
TYR A 196
TYR A 375
 HBA  A 402 ( 3.9A)
HBA  A 402 ( 4.8A)
FMN  A 401 ( 3.5A)
HBA  A 402 ( 3.7A)
HBA  A 402 (-4.2A)
HBA  A 402 ( 4.4A)
 0.35A 4a3uB-5v4pA:
48.7		 4a3uB-5v4pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA502_0
(OXIDOREDUCTASE,
FMN-BINDING)		 5v4p NADPH DEHYDROGENASE
3
(Saccharomyces
cerevisiae) 		5 / 7 THR A  37
TRP A 116
HIS A 191
ASN A 194
TYR A 196
 HBA  A 402 ( 3.9A)
HBA  A 402 ( 4.8A)
FMN  A 401 ( 3.5A)
HBA  A 402 ( 3.7A)
HBA  A 402 (-4.2A)
 0.34A 4awuA-5v4pA:
49.2		 4awuA-5v4pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF2_A_4CHA506_0
(NADPH DEHYDROGENASE)		 5v4p NADPH DEHYDROGENASE
3
(Saccharomyces
cerevisiae) 		4 / 6 THR A  37
HIS A 191
TYR A 196
TYR A 375
 HBA  A 402 ( 3.9A)
FMN  A 401 ( 3.5A)
HBA  A 402 (-4.2A)
HBA  A 402 ( 4.4A)
 0.34A 4df2A-5v4pA:
58.8		 4df2A-5v4pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_1
(MDR769 HIV-1
PROTEASE)		 5v4p NADPH DEHYDROGENASE
3
(Saccharomyces
cerevisiae) 		5 / 11 GLY A 184
ALA A 185
ASP A 186
THR A  73
VAL A 113
 None
 1.12A 4l1aA-5v4pA:
undetectable		 4l1aA-5v4pA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA207_0
(OXIDOREDUCTASE)		 5v4p NADPH DEHYDROGENASE
3
(Saccharomyces
cerevisiae) 		4 / 4 GLU A 303
GLY A 300
HIS A 329
ARG A 291
 None
 1.35A 4r82A-5v4pA:
undetectable
4r82B-5v4pA:
undetectable		 4r82A-5v4pA:
undetectable
4r82B-5v4pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5v4p NADPH DEHYDROGENASE
3
(Saccharomyces
cerevisiae) 		4 / 5 VAL A 113
TYR A 265
ILE A 262
THR A 293
 None
 1.25A 4ze1A-5v4pA:
undetectable		 4ze1A-5v4pA:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 5v4p NADPH DEHYDROGENASE
3
(Saccharomyces
cerevisiae) 		8 / 8 THR A  37
TRP A 116
HIS A 191
ASN A 194
TYR A 196
PHE A 250
PRO A 295
TYR A 375
 HBA  A 402 ( 3.9A)
HBA  A 402 ( 4.8A)
FMN  A 401 ( 3.5A)
HBA  A 402 ( 3.7A)
HBA  A 402 (-4.2A)
HBA  A 402 ( 4.8A)
None
HBA  A 402 ( 4.4A)
 0.16A 5v4vA-5v4pA:
75.5		 5v4vA-5v4pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 5v4p NADPH DEHYDROGENASE
3
(Saccharomyces
cerevisiae) 		8 / 8 THR A  37
TRP A 116
HIS A 191
ASN A 194
TYR A 196
PHE A 250
PRO A 295
TYR A 375
 HBA  A 402 ( 3.9A)
HBA  A 402 ( 4.8A)
FMN  A 401 ( 3.5A)
HBA  A 402 ( 3.7A)
HBA  A 402 (-4.2A)
HBA  A 402 ( 4.8A)
None
HBA  A 402 ( 4.4A)
 0.17A 5v4vB-5v4pA:
75.4		 5v4vB-5v4pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_C_CHDC401_0
(BILE SALT HYDROLASE)		 5v4p NADPH DEHYDROGENASE
3
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 244
ILE A 315
ALA A 221
LEU A 225
 None
 0.78A 5y7pC-5v4pA:
undetectable		 5y7pC-5v4pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5v4p NADPH DEHYDROGENASE
3
(Saccharomyces
cerevisiae) 		4 / 7 ALA A 183
GLN A  93
VAL A  94
TRP A  97
 None
 0.87A 6cduA-5v4pA:
undetectable
6cduE-5v4pA:
undetectable		 6cduA-5v4pA:
undetectable
6cduE-5v4pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_H_EY4H500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5v4p NADPH DEHYDROGENASE
3
(Saccharomyces
cerevisiae) 		4 / 7 GLN A  93
VAL A  94
TRP A  97
ALA A 183
 None
 0.89A 6cduH-5v4pA:
undetectable
6cduI-5v4pA:
undetectable		 6cduH-5v4pA:
undetectable
6cduI-5v4pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		 5v4p NADPH DEHYDROGENASE
3
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 310
ASN A 309
PHE A 311
PRO A 290
GLY A 324
 None
None
None
None
FMN  A 401 (-3.6A)
 1.31A 6gnfA-5v4pA:
undetectable		 6gnfA-5v4pA:
8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		 5v4p NADPH DEHYDROGENASE
3
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 332
ASN A 309
PHE A 311
PRO A 290
GLY A 324
 None
None
None
None
FMN  A 401 (-3.6A)
 1.40A 6gnfA-5v4pA:
undetectable		 6gnfA-5v4pA:
8.81