SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5v4r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_1
(VITAMIN D3 RECEPTOR)		 5v4r LA-RELATED PROTEIN 1
(Homo
sapiens) 		4 / 5 TYR A 883
SER A 843
ARG A 847
HIS A 797
 MGT  A1001 (-3.9A)
None
None
None
 1.39A 1s19A-5v4rA:
undetectable		 1s19A-5v4rA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1
(INWARD RECTIFIER
POTASSIUM CHANNEL)		 5v4r LA-RELATED PROTEIN 1
(Homo
sapiens) 		4 / 5 ALA A 862
TYR A 872
ALA A 866
GLN A 833
 None
 1.07A 1xl6A-5v4rA:
undetectable
1xl6B-5v4rA:
undetectable		 1xl6A-5v4rA:
17.86
1xl6B-5v4rA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I45_A_NIOA500_1
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN)		 5v4r LA-RELATED PROTEIN 1
(Homo
sapiens) 		4 / 8 GLU A 857
LEU A 821
PHE A 839
LEU A 838
 None
 0.91A 3i45A-5v4rA:
undetectable		 3i45A-5v4rA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA811_0
(GEPHYRIN)		 5v4r LA-RELATED PROTEIN 1
(Homo
sapiens) 		3 / 3 LEU A 838
LEU A 821
ARG A 817
 None
 0.69A 6fgcA-5v4rA:
undetectable		 6fgcA-5v4rA:
16.26