SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5v4s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_1
(HEMK PROTEIN)		 5v4s TRANSPORTER, CATION
CHANNEL FAMILY /
CYCLIC
NUCLEOTIDE-BINDING
DOMAIN MULTI-DOMAIN
PROTEIN
(Leptospira
licerasiae) 		4 / 4 THR A 213
GLY A 200
ASP A 201
ALA A 192
 None
 1.19A 1sg9A-5v4sA:
2.0		 1sg9A-5v4sA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_2
(TRANSTHYRETIN)		 5v4s TRANSPORTER, CATION
CHANNEL FAMILY /
CYCLIC
NUCLEOTIDE-BINDING
DOMAIN MULTI-DOMAIN
PROTEIN
(Leptospira
licerasiae) 		4 / 8 THR A 190
ALA A 160
LEU A 158
VAL A 191
 None
 0.99A 1sn5C-5v4sA:
undetectable		 1sn5C-5v4sA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5v4s TRANSPORTER, CATION
CHANNEL FAMILY /
CYCLIC
NUCLEOTIDE-BINDING
DOMAIN MULTI-DOMAIN
PROTEIN
(Leptospira
licerasiae) 		4 / 7 ARG A  30
ASP A  49
ILE A  48
TYR A  45
 None
 1.32A 5a06B-5v4sA:
undetectable		 5a06B-5v4sA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZSF_A_6T0A910_0
(TOLL-LIKE RECEPTOR 7)		 5v4s TRANSPORTER, CATION
CHANNEL FAMILY /
CYCLIC
NUCLEOTIDE-BINDING
DOMAIN MULTI-DOMAIN
PROTEIN
(Leptospira
licerasiae) 		4 / 7 THR A 193
ILE A 202
THR A 203
TYR A 212
 None
 0.96A 5zsfA-5v4sA:
undetectable
5zsfB-5v4sA:
undetectable		 5zsfA-5v4sA:
10.00
5zsfB-5v4sA:
10.00