SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5v57'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_A_RBFA301_1
(PROTEIN (FLAVODOXIN))		 5v57 SMOOTHENED
HOMOLOG,FLAVODOXIN,S
MOOTHENED HOMOLOG
(Desulfovibrio
vulgaris;
Homo
sapiens) 		6 / 7 THR A1012
ASN A1014
THR A1059
TRP A1060
GLY A1094
ASP A1095
 FMN  A1202 (-3.5A)
FMN  A1202 (-3.8A)
FMN  A1202 (-3.9A)
FMN  A1202 (-4.2A)
FMN  A1202 (-3.3A)
None
 0.45A 1bu5A-5v57A:
30.9		 1bu5A-5v57A:
27.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_B_RBFB302_1
(PROTEIN (FLAVODOXIN))		 5v57 SMOOTHENED
HOMOLOG,FLAVODOXIN,S
MOOTHENED HOMOLOG
(Desulfovibrio
vulgaris;
Homo
sapiens) 		6 / 8 THR A1012
ASN A1014
THR A1059
TRP A1060
GLY A1094
ASP A1095
 FMN  A1202 (-3.5A)
FMN  A1202 (-3.8A)
FMN  A1202 (-3.9A)
FMN  A1202 (-4.2A)
FMN  A1202 (-3.3A)
None
 0.42A 1bu5B-5v57A:
31.0		 1bu5B-5v57A:
27.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_B_RBFB302_1
(PROTEIN (FLAVODOXIN))		 5v57 SMOOTHENED
HOMOLOG,FLAVODOXIN,S
MOOTHENED HOMOLOG
(Desulfovibrio
vulgaris;
Homo
sapiens) 		4 / 8 THR A1012
THR A1059
TRP A1060
ASP A1062
 FMN  A1202 (-3.5A)
FMN  A1202 (-3.9A)
FMN  A1202 (-4.2A)
None
 0.67A 1bu5B-5v57A:
31.0		 1bu5B-5v57A:
27.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD6_0
(GRAMICIDIN A)		 5v57 SMOOTHENED
HOMOLOG,FLAVODOXIN,S
MOOTHENED HOMOLOG
(Desulfovibrio
vulgaris;
Homo
sapiens) 		3 / 3 TRP A 537
ALA A 540
VAL A 536
 None
 0.93A 1c4dC-5v57A:
undetectable
1c4dD-5v57A:
undetectable		 1c4dC-5v57A:
3.00
1c4dD-5v57A:
3.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 5v57 SMOOTHENED
HOMOLOG,FLAVODOXIN,S
MOOTHENED HOMOLOG
(Desulfovibrio
vulgaris;
Homo
sapiens) 		4 / 4 LEU A 267
VAL A 270
CYH A 273
ALA A 327
 None
 1.25A 1mz9E-5v57A:
undetectable		 1mz9E-5v57A:
7.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)		 5v57 SMOOTHENED
HOMOLOG,FLAVODOXIN,S
MOOTHENED HOMOLOG
(Desulfovibrio
vulgaris;
Homo
sapiens) 		4 / 8 VAL A 411
VAL A 329
LEU A 412
HIS A 470
 None
None
None
836  A1201 ( 4.9A)
 0.96A 2ddwA-5v57A:
3.5		 2ddwA-5v57A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_A_BEZA143_0
(PUTATIVE REDOX
PROTEIN)		 5v57 SMOOTHENED
HOMOLOG,FLAVODOXIN,S
MOOTHENED HOMOLOG
(Desulfovibrio
vulgaris;
Homo
sapiens) 		4 / 7 ALA A 250
THR A 251
ALA A 254
ARG A 547
 None
 0.97A 2ql8A-5v57A:
undetectable
2ql8B-5v57A:
undetectable		 2ql8A-5v57A:
12.38
2ql8B-5v57A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA424_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5v57 SMOOTHENED
HOMOLOG,FLAVODOXIN,S
MOOTHENED HOMOLOG
(Desulfovibrio
vulgaris;
Homo
sapiens) 		4 / 8 LEU A 125
ARG A 168
ARG A 173
GLY A  94
 None
 0.79A 3hcrA-5v57A:
3.7		 3hcrA-5v57A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5v57 SMOOTHENED
HOMOLOG,FLAVODOXIN,S
MOOTHENED HOMOLOG
(Desulfovibrio
vulgaris;
Homo
sapiens) 		4 / 7 LEU A 125
ARG A 168
ARG A 173
GLY A  94
 None
 0.81A 3hcrB-5v57A:
5.1		 3hcrB-5v57A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 5v57 SMOOTHENED
HOMOLOG,FLAVODOXIN,S
MOOTHENED HOMOLOG
(Desulfovibrio
vulgaris;
Homo
sapiens) 		5 / 12 ARG A1125
GLY A1103
GLY A1056
GLY A1092
GLU A1109
 None
 0.85A 3kkzB-5v57A:
undetectable		 3kkzB-5v57A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_B_KANB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5v57 SMOOTHENED
HOMOLOG,FLAVODOXIN,S
MOOTHENED HOMOLOG
(Desulfovibrio
vulgaris;
Homo
sapiens) 		3 / 3 ALA A 478
ARG A 482
LYS A 510
 None
 1.12A 3kp5B-5v57A:
1.2		 3kp5B-5v57A:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RFM_A_CFFA330_1
(ADENOSINE RECEPTOR
A2A)		 5v57 SMOOTHENED
HOMOLOG,FLAVODOXIN,S
MOOTHENED HOMOLOG
(Desulfovibrio
vulgaris;
Homo
sapiens) 		4 / 7 VAL A 321
LEU A 522
MET A 230
ILE A 234
 None
836  A1201 (-4.6A)
836  A1201 (-3.5A)
None
 0.87A 3rfmA-5v57A:
18.6		 3rfmA-5v57A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5v57 SMOOTHENED
HOMOLOG,FLAVODOXIN,S
MOOTHENED HOMOLOG
(Desulfovibrio
vulgaris;
Homo
sapiens) 		5 / 12 GLY A 328
ILE A 389
GLY A 277
PHE A 526
SER A 387
 None
None
None
None
836  A1201 (-4.5A)
 1.00A 3sudB-5v57A:
undetectable		 3sudB-5v57A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT0_A_ACTA1490_0
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)		 5v57 SMOOTHENED
HOMOLOG,FLAVODOXIN,S
MOOTHENED HOMOLOG
(Desulfovibrio
vulgaris;
Homo
sapiens) 		3 / 3 GLU A1099
TYR A1100
SER A1064
 None
 0.79A 4at0A-5v57A:
undetectable		 4at0A-5v57A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5v57 SMOOTHENED
HOMOLOG,FLAVODOXIN,S
MOOTHENED HOMOLOG
(Desulfovibrio
vulgaris;
Homo
sapiens) 		5 / 12 GLY A1045
GLY A1044
LEU A1078
SER A1077
ALA A1083
 None
 0.97A 4htfA-5v57A:
undetectable		 4htfA-5v57A:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5v57 SMOOTHENED
HOMOLOG,FLAVODOXIN,S
MOOTHENED HOMOLOG
(Desulfovibrio
vulgaris;
Homo
sapiens) 		5 / 12 GLY A1045
GLY A1044
LEU A1078
SER A1077
ALA A1083
 None
 0.99A 4htfB-5v57A:
undetectable		 4htfB-5v57A:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)		 5v57 SMOOTHENED
HOMOLOG,FLAVODOXIN,S
MOOTHENED HOMOLOG
(Desulfovibrio
vulgaris;
Homo
sapiens) 		5 / 9 TYR A 394
ASP A 473
VAL A 404
PHE A 391
GLY A 393
 836  A1201 (-4.6A)
836  A1201 ( 4.9A)
None
836  A1201 (-3.5A)
None
 1.24A 4mmeB-5v57A:
undetectable		 4mmeB-5v57A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAE_A_NIZA804_1
(CATALASE-PEROXIDASE)		 5v57 SMOOTHENED
HOMOLOG,FLAVODOXIN,S
MOOTHENED HOMOLOG
(Desulfovibrio
vulgaris;
Homo
sapiens) 		4 / 6 TYR A 322
LEU A 325
HIS A 470
THR A 466
 None
None
836  A1201 ( 4.9A)
None
 1.15A 4paeA-5v57A:
undetectable		 4paeA-5v57A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)		 5v57 SMOOTHENED
HOMOLOG,FLAVODOXIN,S
MOOTHENED HOMOLOG
(Desulfovibrio
vulgaris;
Homo
sapiens) 		5 / 12 ALA A 236
ALA A 524
MET A 525
GLY A 527
PHE A 526
 None
 1.28A 4r29B-5v57A:
1.4		 4r29B-5v57A:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_B_0HKB1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 5v57 SMOOTHENED
HOMOLOG,FLAVODOXIN,S
MOOTHENED HOMOLOG
(Desulfovibrio
vulgaris;
Homo
sapiens) 		5 / 12 THR A 248
THR A 251
ALA A 250
ALA A 254
TYR A 269
 None
 1.28A 4u15B-5v57A:
18.3		 4u15B-5v57A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 5v57 SMOOTHENED
HOMOLOG,FLAVODOXIN,S
MOOTHENED HOMOLOG
(Desulfovibrio
vulgaris;
Homo
sapiens) 		5 / 12 SER A  96
ASP A  95
ASP A 172
SER A  89
ARG A 173
 None
 1.16A 4uroB-5v57A:
undetectable		 4uroB-5v57A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5v57 SMOOTHENED
HOMOLOG,FLAVODOXIN,S
MOOTHENED HOMOLOG
(Desulfovibrio
vulgaris;
Homo
sapiens) 		4 / 5 ARG A 302
GLY A 383
THR A 307
GLU A 305
 None
 1.12A 5btiC-5v57A:
undetectable
5btiD-5v57A:
undetectable		 5btiC-5v57A:
22.40
5btiD-5v57A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5v57 SMOOTHENED
HOMOLOG,FLAVODOXIN,S
MOOTHENED HOMOLOG
(Desulfovibrio
vulgaris;
Homo
sapiens) 		4 / 5 TYR A 394
LEU A 515
PRO A 513
LEU A 522
 836  A1201 (-4.6A)
None
836  A1201 (-4.1A)
836  A1201 (-4.6A)
 1.47A 5eshA-5v57A:
1.0		 5eshA-5v57A:
23.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L7I_A_VISA1202_1
(SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG)		 5v57 SMOOTHENED
HOMOLOG,FLAVODOXIN,S
MOOTHENED HOMOLOG
(Desulfovibrio
vulgaris;
Homo
sapiens) 		11 / 12 ASN A 219
TRP A 281
ASP A 384
SER A 387
TYR A 394
ARG A 400
GLN A 477
PHE A 484
GLU A 518
ASN A 521
LEU A 522
 836  A1201 (-3.1A)
None
836  A1201 (-3.1A)
836  A1201 (-4.5A)
836  A1201 (-4.6A)
836  A1201 (-3.0A)
836  A1201 (-3.6A)
836  A1201 (-3.9A)
836  A1201 (-3.5A)
836  A1201 (-3.4A)
836  A1201 (-4.6A)
 0.56A 5l7iA-5v57A:
45.8		 5l7iA-5v57A:
79.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L7I_A_VISA1202_1
(SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG)		 5v57 SMOOTHENED
HOMOLOG,FLAVODOXIN,S
MOOTHENED HOMOLOG
(Desulfovibrio
vulgaris;
Homo
sapiens) 		5 / 12 TRP A 281
ASP A 384
SER A 387
LEU A 522
MET A 525
 None
836  A1201 (-3.1A)
836  A1201 (-4.5A)
836  A1201 (-4.6A)
None
 1.10A 5l7iA-5v57A:
45.8		 5l7iA-5v57A:
79.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L7I_B_VISB1202_1
(SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG)		 5v57 SMOOTHENED
HOMOLOG,FLAVODOXIN,S
MOOTHENED HOMOLOG
(Desulfovibrio
vulgaris;
Homo
sapiens) 		5 / 12 TRP A 281
ASP A 384
SER A 387
LEU A 522
MET A 525
 None
836  A1201 (-3.1A)
836  A1201 (-4.5A)
836  A1201 (-4.6A)
None
 1.10A 5l7iB-5v57A:
39.4		 5l7iB-5v57A:
79.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L7I_B_VISB1202_1
(SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG)		 5v57 SMOOTHENED
HOMOLOG,FLAVODOXIN,S
MOOTHENED HOMOLOG
(Desulfovibrio
vulgaris;
Homo
sapiens) 		11 / 12 TRP A 281
ASP A 384
SER A 387
TYR A 394
ARG A 400
ASP A 473
GLN A 477
PRO A 513
GLU A 518
ASN A 521
LEU A 522
 None
836  A1201 (-3.1A)
836  A1201 (-4.5A)
836  A1201 (-4.6A)
836  A1201 (-3.0A)
836  A1201 ( 4.9A)
836  A1201 (-3.6A)
836  A1201 (-4.1A)
836  A1201 (-3.5A)
836  A1201 (-3.4A)
836  A1201 (-4.6A)
 0.54A 5l7iB-5v57A:
39.4		 5l7iB-5v57A:
79.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)		 5v57 SMOOTHENED
HOMOLOG,FLAVODOXIN,S
MOOTHENED HOMOLOG
(Desulfovibrio
vulgaris;
Homo
sapiens) 		4 / 7 LEU A 221
PHE A 222
SER A 385
GLU A 226
 836  A1201 (-4.8A)
None
None
None
 1.06A 5n5dA-5v57A:
undetectable		 5n5dA-5v57A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND4_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 5v57 SMOOTHENED
HOMOLOG,FLAVODOXIN,S
MOOTHENED HOMOLOG
(Desulfovibrio
vulgaris;
Homo
sapiens) 		5 / 12 VAL A 210
ASP A 209
GLU A 211
ALA A 115
PRO A 153
 None
 1.30A 5nd4B-5v57A:
4.4		 5nd4B-5v57A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 5v57 SMOOTHENED
HOMOLOG,FLAVODOXIN,S
MOOTHENED HOMOLOG
(Desulfovibrio
vulgaris;
Homo
sapiens) 		3 / 3 ARG A 161
LYS A 105
TYR A 130
 None
 1.04A 6gnaA-5v57A:
undetectable		 6gnaA-5v57A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 5v57 SMOOTHENED
HOMOLOG,FLAVODOXIN,S
MOOTHENED HOMOLOG
(Desulfovibrio
vulgaris;
Homo
sapiens) 		3 / 3 ARG A 161
LYS A 105
TYR A 130
 None
 1.04A 6gnbA-5v57A:
undetectable		 6gnbA-5v57A:
19.29