SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5v5g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 5v5g UBIQUITIN VARIANT
CC.4
(synthetic
construct) 		5 / 12 ILE B   3
THR B   7
PHE B  45
LEU B  43
ILE B  30
 None
 0.86A 2cd2A-5v5gB:
undetectable		 2cd2A-5v5gB:
19.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FCN_B_DVAB35_0
(UBIQUITIN)		 5v5g UBIQUITIN VARIANT
CC.4
(synthetic
construct) 		4 / 6 GLN B  31
GLU B  34
ILE B  36
PRO B  37
 None
 0.48A 2fcnA-5v5gB:
15.4
2fcnB-5v5gB:
15.3		 2fcnA-5v5gB:
73.91
2fcnB-5v5gB:
73.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_D_ECND403_1
(FLAVOHEMOGLOBIN)		 5v5g UBIQUITIN VARIANT
CC.4
(synthetic
construct) 		5 / 12 PHE B  45
GLN B  62
LEU B  56
VAL B  17
LEU B  67
 None
EDO  B 102 (-3.7A)
None
None
None
 1.14A 4g1bD-5v5gB:
undetectable		 4g1bD-5v5gB:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MGH_A_ACTA1320_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 5v5g UBIQUITIN VARIANT
CC.4
(synthetic
construct) 		4 / 5 VAL B  70
ILE B  44
LEU B  43
ARG B  42
 None
 0.81A 4mghA-5v5gB:
undetectable		 4mghA-5v5gB:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5v5g UBIQUITIN VARIANT
CC.4
(synthetic
construct) 		4 / 7 ILE B  44
GLN B  49
ILE B  23
ASP B  52
 None
EDO  B 101 ( 4.1A)
None
EDO  B 101 (-2.5A)
 0.71A 4w5oA-5v5gB:
undetectable		 4w5oA-5v5gB:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5v5g UBIQUITIN VARIANT
CC.4
(synthetic
construct) 		4 / 6 ILE B  44
GLN B  49
ILE B  23
ASP B  52
 None
EDO  B 101 ( 4.1A)
None
EDO  B 101 (-2.5A)
 0.65A 4w5qA-5v5gB:
undetectable		 4w5qA-5v5gB:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5v5g UBIQUITIN VARIANT
CC.4
(synthetic
construct) 		4 / 6 ILE B  44
GLN B  49
ILE B  23
ASP B  52
 None
EDO  B 101 ( 4.1A)
None
EDO  B 101 (-2.5A)
 0.76A 4w5tA-5v5gB:
undetectable		 4w5tA-5v5gB:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5v5g UBIQUITIN VARIANT
CC.4
(synthetic
construct) 		4 / 6 ILE B  44
GLN B  49
ILE B  23
ASP B  52
 None
EDO  B 101 ( 4.1A)
None
EDO  B 101 (-2.5A)
 0.66A 4z4cA-5v5gB:
undetectable		 4z4cA-5v5gB:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5v5g UBIQUITIN VARIANT
CC.4
(synthetic
construct) 		4 / 6 ILE B  44
GLN B  49
ILE B  23
ASP B  52
 None
EDO  B 101 ( 4.1A)
None
EDO  B 101 (-2.5A)
 0.70A 4z4dA-5v5gB:
undetectable		 4z4dA-5v5gB:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5v5g UBIQUITIN VARIANT
CC.4
(synthetic
construct) 		4 / 7 ILE B  44
GLN B  49
ILE B  23
ASP B  52
 None
EDO  B 101 ( 4.1A)
None
EDO  B 101 (-2.5A)
 0.67A 4z4eA-5v5gB:
undetectable		 4z4eA-5v5gB:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5v5g UBIQUITIN VARIANT
CC.4
(synthetic
construct) 		4 / 7 ILE B  44
GLN B  49
ILE B  23
ASP B  52
 None
EDO  B 101 ( 4.1A)
None
EDO  B 101 (-2.5A)
 0.68A 4z4gA-5v5gB:
undetectable		 4z4gA-5v5gB:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA903_0
(PROTEIN ARGONAUTE-2)		 5v5g UBIQUITIN VARIANT
CC.4
(synthetic
construct) 		4 / 6 ILE B  44
GLN B  49
ILE B  23
ASP B  52
 None
EDO  B 101 ( 4.1A)
None
EDO  B 101 (-2.5A)
 0.73A 6cbdA-5v5gB:
undetectable		 6cbdA-5v5gB:
8.56