SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5v5s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5v5s OUTER MEMBRANE
PROTEIN TOLC
(Escherichia
coli) 		4 / 7 ILE A 400
LEU A 415
ASP A 411
LEU A 407
 None
 1.04A 2qqcB-5v5sA:
undetectable
2qqcC-5v5sA:
undetectable		 2qqcB-5v5sA:
14.71
2qqcC-5v5sA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5v5s OUTER MEMBRANE
PROTEIN TOLC
(Escherichia
coli) 		4 / 7 LEU A 415
ASP A 411
LEU A 407
ILE A 400
 None
 1.06A 2qqcA-5v5sA:
undetectable
2qqcF-5v5sA:
undetectable		 2qqcA-5v5sA:
10.91
2qqcF-5v5sA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5v5s OUTER MEMBRANE
PROTEIN TOLC
(Escherichia
coli) 		4 / 7 LEU A 415
ASP A 411
LEU A 407
ILE A 400
 None
 1.02A 2qqcI-5v5sA:
undetectable
2qqcL-5v5sA:
undetectable		 2qqcI-5v5sA:
10.91
2qqcL-5v5sA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3007_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5v5s OUTER MEMBRANE
PROTEIN TOLC
(Escherichia
coli) 		5 / 9 THR A 111
ALA A 110
LEU A 107
SER A 402
ASN A 399
 None
 1.19A 3kp6B-5v5sA:
0.6		 3kp6B-5v5sA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB504_1
(HEMOLYTIC LECTIN
CEL-III)		 5v5s OUTER MEMBRANE
PROTEIN TOLC
(Escherichia
coli) 		4 / 5 ASP A 101
GLU A  16
TYR A  98
GLN A  94
 None
 1.25A 3w9tB-5v5sA:
undetectable		 3w9tB-5v5sA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD506_1
(HEMOLYTIC LECTIN
CEL-III)		 5v5s OUTER MEMBRANE
PROTEIN TOLC
(Escherichia
coli) 		4 / 5 ASP A 101
GLU A  16
TYR A  98
GLN A  94
 None
 1.30A 3w9tD-5v5sA:
undetectable		 3w9tD-5v5sA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE505_1
(HEMOLYTIC LECTIN
CEL-III)		 5v5s OUTER MEMBRANE
PROTEIN TOLC
(Escherichia
coli) 		4 / 5 ASP A 101
GLU A  16
TYR A  98
GLN A  94
 None
 1.26A 3w9tE-5v5sA:
undetectable		 3w9tE-5v5sA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG505_1
(HEMOLYTIC LECTIN
CEL-III)		 5v5s OUTER MEMBRANE
PROTEIN TOLC
(Escherichia
coli) 		4 / 5 ASP A 101
GLU A  16
TYR A  98
GLN A  94
 None
 1.24A 3w9tG-5v5sA:
undetectable		 3w9tG-5v5sA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5v5s OUTER MEMBRANE
PROTEIN TOLC
(Escherichia
coli) 		4 / 4 SER A  13
ALA A  10
GLN A 184
THR A 109
 None
 1.42A 5n0rA-5v5sA:
undetectable		 5n0rA-5v5sA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5v5s OUTER MEMBRANE
PROTEIN TOLC
(Escherichia
coli) 		4 / 4 SER A  13
ALA A  10
GLN A 184
THR A 109
 None
 1.40A 5n0xA-5v5sA:
undetectable		 5n0xA-5v5sA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_G_ACTG702_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 5v5s OUTER MEMBRANE
PROTEIN TOLC
(Escherichia
coli) 		3 / 3 GLY A  59
THR A 266
ASN A  61
 None
 0.60A 5odiG-5v5sA:
undetectable		 5odiG-5v5sA:
20.85