SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5v6m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EIL_A_FOLA703_0 (BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE)	5v6m	HEAVY CHAIN OF FAB FRAGMENT OF RABBIT ANTI-HIV1 GP120 V3 MAB 10A3 (Oryctolagus cuniculus)	5 / 11	VAL H 107 ALA H 85 PHE H 67 LEU H 20 VAL H 105	None	1.43A	4eilA-5v6mH: undetectable	4eilA-5v6mH: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EIL_C_FOLC703_0 (BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE)	5v6m	HEAVY CHAIN OF FAB FRAGMENT OF RABBIT ANTI-HIV1 GP120 V3 MAB 10A3 (Oryctolagus cuniculus)	5 / 11	VAL H 107 ALA H 85 PHE H 67 LEU H 20 VAL H 105	None	1.42A	4eilC-5v6mH: undetectable	4eilC-5v6mH: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5MTH_A_ACTA302_0 (ANTIBODY FAB HEAVY CHAIN)	5v6m	HEAVY CHAIN OF FAB FRAGMENT OF RABBIT ANTI-HIV1 GP120 V3 MAB 10A3 (Oryctolagus cuniculus)	4 / 5	SER H 108 ALA H 110 PHE H 142 LEU H 166	None	0.39A	5mthA-5v6mH: 26.3	5mthA-5v6mH: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6A94_B_ZOTB3001_0 (5-HYDROXYTRYPTAMINE RECEPTOR 2A,SOLUBLE CYTOCHROME B562)	5v6m	HEAVY CHAIN OF FAB FRAGMENT OF RABBIT ANTI-HIV1 GP120 V3 MAB 10A3 (Oryctolagus cuniculus)	6 / 12	VAL H 180 THR H 131 LEU H 155 VAL H 159 GLY H 158 VAL H 207	None	1.49A	6a94B-5v6mH: undetectable	6a94B-5v6mH: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6B58_A_ACTA606_0 (FUMARATE REDUCTASE FLAVOPROTEIN SUBUNIT)	5v6m	HEAVY CHAIN OF FAB FRAGMENT OF RABBIT ANTI-HIV1 GP120 V3 MAB 10A3 (Oryctolagus cuniculus)	4 / 5	GLU H 144 PHE H 142 HIS H 196 THR H 106	None	1.11A	6b58A-5v6mH: undetectable	6b58A-5v6mH: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BPY_A_ACTA408_0 (THIOREDOXIN REDUCTASE)	5v6m	HEAVY CHAIN OF FAB FRAGMENT OF RABBIT ANTI-HIV1 GP120 V3 MAB 10A3 (Oryctolagus cuniculus)	3 / 3	PRO H 181 SER H 183 SER H 184	None	0.50A	6bpyA-5v6mH: undetectable	6bpyA-5v6mH: undetectable

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4EIL_A_FOLA703_0","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","5v6m","HEAVY CHAIN OF FAB FRAGMENT OF RABBIT ANTI-HIV1 GP120 V3 MAB 10A3","Oryctolagus cuniculus",5,"VAL H 107;ALA H  85;PHE H  67;LEU H  20;VAL H 105","None","1.43A","4eilA-5v6mH:undetectable","4eilA-5v6mH:undetectable"],["4EIL_C_FOLC703_0","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","5v6m","HEAVY CHAIN OF FAB FRAGMENT OF RABBIT ANTI-HIV1 GP120 V3 MAB 10A3","Oryctolagus cuniculus",5,"VAL H 107;ALA H  85;PHE H  67;LEU H  20;VAL H 105","None","1.42A","4eilC-5v6mH:undetectable","4eilC-5v6mH:undetectable"],["5MTH_A_ACTA302_0","ANTIBODY FAB HEAVY CHAIN","5v6m","HEAVY CHAIN OF FAB FRAGMENT OF RABBIT ANTI-HIV1 GP120 V3 MAB 10A3","Oryctolagus cuniculus",4,"SER H 108;ALA H 110;PHE H 142;LEU H 166","None","0.39A","5mthA-5v6mH:26.3","5mthA-5v6mH:undetectable"],["6A94_B_ZOTB3001_0","5-HYDROXYTRYPTAMINE RECEPTOR 2A,SOLUBLE CYTOCHROME B562","5v6m","HEAVY CHAIN OF FAB FRAGMENT OF RABBIT ANTI-HIV1 GP120 V3 MAB 10A3","Oryctolagus cuniculus",6,"VAL H 180;THR H 131;LEU H 155;VAL H 159;GLY H 158;VAL H 207","None","1.49A","6a94B-5v6mH:undetectable","6a94B-5v6mH:undetectable"],["6B58_A_ACTA606_0","FUMARATE REDUCTASE FLAVOPROTEIN SUBUNIT","5v6m","HEAVY CHAIN OF FAB FRAGMENT OF RABBIT ANTI-HIV1 GP120 V3 MAB 10A3","Oryctolagus cuniculus",4,"GLU H 144;PHE H 142;HIS H 196;THR H 106","None","1.11A","6b58A-5v6mH:undetectable","6b58A-5v6mH:undetectable"],["6BPY_A_ACTA408_0","THIOREDOXIN REDUCTASE","5v6m","HEAVY CHAIN OF FAB FRAGMENT OF RABBIT ANTI-HIV1 GP120 V3 MAB 10A3","Oryctolagus cuniculus",3,"PRO H 181;SER H 183;SER H 184","None","0.50A","6bpyA-5v6mH:undetectable","6bpyA-5v6mH:undetectable"]]