SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5v6p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)		 5v6p ERAD-ASSOCIATED E3
UBIQUITIN-PROTEIN
LIGASE HRD1
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 125
HIS A 122
ASP A 161
LEU A 157
 None
 1.04A 1e7cA-5v6pA:
1.7		 1e7cA-5v6pA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 5v6p ERAD-ASSOCIATED E3
UBIQUITIN-PROTEIN
LIGASE HRD1
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 185
SER A 182
ASP A 179
PHE A 111
 None
 1.27A 1ismB-5v6pA:
undetectable		 1ismB-5v6pA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5v6p ERAD-ASSOCIATED E3
UBIQUITIN-PROTEIN
LIGASE HRD1
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 112
THR A  93
GLN A 189
PHE A 193
 None
 1.09A 2qx4A-5v6pA:
undetectable
2qx4B-5v6pA:
undetectable		 2qx4A-5v6pA:
19.66
2qx4B-5v6pA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 5v6p ERAD-ASSOCIATED E3
UBIQUITIN-PROTEIN
LIGASE HRD1
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 156
ASN A 153
LEU A  66
ILE A 124
 None
 1.14A 4okxA-5v6pA:
undetectable		 4okxA-5v6pA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I0Y_A_TRPA3001_0
(23S RIBOSOMAL RNA
TRYPTOPHANASE OPERON
LEADER PEPTIDE)		 5v6p ERAD-ASSOCIATED E3
UBIQUITIN-PROTEIN
LIGASE HRD1
(Saccharomyces
cerevisiae) 		3 / 3 TRP A 305
ILE A 307
ASP A 306
 None
 0.88A 6i0y7-5v6pA:
undetectable		 6i0y7-5v6pA:
6.85