SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5v6t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 5v6t PLEXIN-D1
(Mus
musculus) 		5 / 12 ILE A1888
LEU A1423
PHE A1426
ILE A1877
LEU A1444
 None
 1.10A 1ddrB-5v6tA:
undetectable		 1ddrB-5v6tA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 5v6t PLEXIN-D1
(Mus
musculus) 		5 / 10 LEU A1620
VAL A1583
TYR A1642
TRP A1610
LEU A1650
 None
 1.17A 1fkoA-5v6tA:
undetectable		 1fkoA-5v6tA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3003_1
(SERUM ALBUMIN)		 5v6t PLEXIN-D1
(Mus
musculus) 		4 / 6 PHE A1413
LYS A1879
LYS A1882
ALA A1881
 None
 1.15A 1hk2A-5v6tA:
undetectable		 1hk2A-5v6tA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 5v6t PLEXIN-D1
(Mus
musculus) 		5 / 12 ILE A1888
LEU A1423
PHE A1426
ILE A1877
LEU A1444
 None
 1.09A 1jolA-5v6tA:
undetectable		 1jolA-5v6tA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_B_FFOB361_0
(DIHYDROFOLATE
REDUCTASE)		 5v6t PLEXIN-D1
(Mus
musculus) 		5 / 12 ILE A1888
LEU A1423
PHE A1426
ILE A1877
LEU A1444
 None
 1.09A 1jolB-5v6tA:
undetectable		 1jolB-5v6tA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_A_MTXA170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 5v6t PLEXIN-D1
(Mus
musculus) 		5 / 12 ILE A1888
LEU A1423
PHE A1426
ILE A1877
LEU A1444
 None
 1.08A 1tdrA-5v6tA:
undetectable		 1tdrA-5v6tA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2003_1
(SERUM ALBUMIN)		 5v6t PLEXIN-D1
(Mus
musculus) 		5 / 9 LEU A1417
PHE A1413
LEU A1448
LEU A1444
ALA A1873
 None
 1.34A 2bxeA-5v6tA:
undetectable		 2bxeA-5v6tA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 5v6t PLEXIN-D1
(Mus
musculus) 		5 / 11 LEU A1795
LEU A1776
ILE A1785
PRO A1347
LEU A1714
 None
 1.32A 2ft9A-5v6tA:
undetectable		 2ft9A-5v6tA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		 5v6t PLEXIN-D1
(Mus
musculus) 		4 / 8 LEU A1580
MET A1652
ALA A1651
LEU A1650
 None
 0.78A 3cldB-5v6tA:
undetectable		 3cldB-5v6tA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_1
(DIHYDROFOLATE
REDUCTASE)		 5v6t PLEXIN-D1
(Mus
musculus) 		5 / 12 ILE A1888
LEU A1423
PHE A1426
ILE A1877
LEU A1444
 None
 1.04A 3ia4D-5v6tA:
undetectable		 3ia4D-5v6tA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF202_1
(PROTEIN S100-A4)		 5v6t PLEXIN-D1
(Mus
musculus) 		5 / 11 ASP A1440
LEU A1448
SER A1446
ILE A1877
PHE A1360
 None
 1.10A 3ko0E-5v6tA:
undetectable
3ko0F-5v6tA:
1.0
3ko0G-5v6tA:
1.0
3ko0H-5v6tA:
0.9		 3ko0E-5v6tA:
11.44
3ko0F-5v6tA:
11.44
3ko0G-5v6tA:
11.44
3ko0H-5v6tA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL202_1
(PROTEIN S100-A4)		 5v6t PLEXIN-D1
(Mus
musculus) 		5 / 12 ASP A1440
LEU A1448
SER A1446
ILE A1877
PHE A1360
 None
 1.21A 3ko0K-5v6tA:
1.0
3ko0L-5v6tA:
1.0
3ko0M-5v6tA:
undetectable
3ko0N-5v6tA:
1.0		 3ko0K-5v6tA:
11.44
3ko0L-5v6tA:
11.44
3ko0M-5v6tA:
11.44
3ko0N-5v6tA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA207_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 5v6t PLEXIN-D1
(Mus
musculus) 		4 / 7 LEU A1452
LYS A1455
THR A1870
ALA A1451
 None
 1.15A 3mbgA-5v6tA:
undetectable
3mbgB-5v6tA:
undetectable		 3mbgA-5v6tA:
11.36
3mbgB-5v6tA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 5v6t PLEXIN-D1
(Mus
musculus) 		5 / 12 ILE A1424
LEU A1423
LEU A1448
LEU A1444
ILE A1877
 None
 0.90A 3uvvA-5v6tA:
undetectable		 3uvvA-5v6tA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLF_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5v6t PLEXIN-D1
(Mus
musculus) 		5 / 11 ILE A1888
LEU A1423
PHE A1426
ILE A1877
LEU A1444
 None
 1.10A 4qlfA-5v6tA:
undetectable		 4qlfA-5v6tA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5v6t PLEXIN-D1
(Mus
musculus) 		4 / 7 CYH A1806
ILE A1803
PRO A1768
ILE A1725
 None
 1.03A 4w5oA-5v6tA:
undetectable		 4w5oA-5v6tA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5v6t PLEXIN-D1
(Mus
musculus) 		4 / 7 CYH A1806
ILE A1803
PRO A1768
ILE A1725
 None
 1.06A 4z4eA-5v6tA:
undetectable		 4z4eA-5v6tA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5v6t PLEXIN-D1
(Mus
musculus) 		4 / 7 CYH A1806
ILE A1803
PRO A1768
ILE A1725
 None
 1.04A 4z4gA-5v6tA:
undetectable		 4z4gA-5v6tA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 5v6t PLEXIN-D1
(Mus
musculus) 		5 / 12 ILE A1888
LEU A1423
PHE A1426
ILE A1877
LEU A1444
 None
 1.14A 5e8qB-5v6tA:
undetectable		 5e8qB-5v6tA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5v6t PLEXIN-D1
(Mus
musculus) 		5 / 12 ALA A1825
THR A1540
GLN A1524
SER A1709
THR A1713
 None
 1.09A 5hfjB-5v6tA:
undetectable		 5hfjB-5v6tA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 5v6t PLEXIN-D1
(Mus
musculus) 		5 / 12 VAL A1835
ASP A1757
HIS A1760
PHE A1741
ARG A1484
 None
 1.24A 5hnzB-5v6tA:
undetectable		 5hnzB-5v6tA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 5v6t PLEXIN-D1
(Mus
musculus) 		4 / 5 LEU A1541
LYS A1711
LEU A1823
TYR A1824
 None
 1.41A 5ki6A-5v6tA:
undetectable		 5ki6A-5v6tA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIO_B_LOCB502_1
(TUBULIN BETA CHAIN)		 5v6t PLEXIN-D1
(Mus
musculus) 		5 / 12 LEU A1714
ALA A1520
LEU A1518
THR A1788
ILE A1798
 None
 1.10A 5mioB-5v6tA:
undetectable		 5mioB-5v6tA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_B_ACTB405_0
(THIOREDOXIN
REDUCTASE)		 5v6t PLEXIN-D1
(Mus
musculus) 		3 / 3 GLY A1454
LEU A1456
HIS A1453
 None
 0.66A 5u63B-5v6tA:
undetectable		 5u63B-5v6tA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 5v6t PLEXIN-D1
(Mus
musculus) 		5 / 12 ILE A1888
LEU A1423
PHE A1426
ILE A1877
LEU A1444
 None
 1.14A 5ujxB-5v6tA:
undetectable		 5ujxB-5v6tA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 5v6t PLEXIN-D1
(Mus
musculus) 		5 / 12 THR A1449
ILE A1450
PHE A1868
PHE A1354
LEU A1506
 None
 1.27A 6a93A-5v6tA:
undetectable		 6a93A-5v6tA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		 5v6t PLEXIN-D1
(Mus
musculus) 		3 / 3 TRP A1762
ILE A1471
GLU A1746
 None
 0.83A 6hcxA-5v6tA:
undetectable		 6hcxA-5v6tA:
8.27