SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5v6y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AO8_A_MTXA170_2
(DIHYDROFOLATE
REDUCTASE)		 5v6y MALTOSE-BINDING
PERIPLASMIC
PROTEIN,RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 1,CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		4 / 4 TRP A1074
LEU A1036
ARG A2067
THR A2068
 None
 1.30A 1ao8A-5v6yA:
0.0		 1ao8A-5v6yA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB8_0
(GRAMICIDIN A)		 5v6y MALTOSE-BINDING
PERIPLASMIC
PROTEIN,RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 1,CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		3 / 3 TRP A 160
VAL A 261
TRP A 342
 None
None
MAL  A2201 (-3.7A)
 1.28A 1c4dA-5v6yA:
undetectable
1c4dB-5v6yA:
undetectable		 1c4dA-5v6yA:
undetectable
1c4dB-5v6yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_A_IPBA600_0
(ODORANT-BINDING
PROTEIN)		 5v6y MALTOSE-BINDING
PERIPLASMIC
PROTEIN,RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 1,CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		4 / 6 VAL A  10
VAL A  52
ILE A  62
ASN A 269
 None
 0.96A 1e06A-5v6yA:
undetectable		 1e06A-5v6yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_D_H4BD1290_1
(PTERIDINE REDUCTASE
1)		 5v6y MALTOSE-BINDING
PERIPLASMIC
PROTEIN,RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 1,CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		4 / 8 PHE A  87
LEU A  91
LEU A 292
LEU A 286
 None
 1.03A 2bfpD-5v6yA:
undetectable		 2bfpD-5v6yA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2002_1
(SERUM ALBUMIN)		 5v6y MALTOSE-BINDING
PERIPLASMIC
PROTEIN,RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 1,CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		4 / 8 ALA A 340
ALA A 372
GLU A 373
VAL A 183
 None
 0.83A 2bxgA-5v6yA:
3.3		 2bxgA-5v6yA:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5v6y MALTOSE-BINDING
PERIPLASMIC
PROTEIN,RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 1,CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		5 / 11 ALA A 305
ILE A 110
VAL A  99
LEU A  78
ILE A  81
 None
 1.25A 2h42A-5v6yA:
undetectable		 2h42A-5v6yA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		 5v6y MALTOSE-BINDING
PERIPLASMIC
PROTEIN,RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 1,CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		4 / 6 ASP A 199
THR A 195
LYS A 202
ASP A 360
 None
 1.16A 2j2pE-5v6yA:
undetectable
2j2pF-5v6yA:
undetectable		 2j2pE-5v6yA:
17.92
2j2pF-5v6yA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 5v6y MALTOSE-BINDING
PERIPLASMIC
PROTEIN,RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 1,CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		4 / 8 THR A  95
LEU A 287
ASP A 289
GLU A 113
 None
None
None
MAL  A2201 (-3.2A)
 1.00A 2zw9A-5v6yA:
undetectable		 2zw9A-5v6yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_A_RBFA191_1
(LUMAZINE PROTEIN)		 5v6y MALTOSE-BINDING
PERIPLASMIC
PROTEIN,RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 1,CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		5 / 12 LEU A 194
THR A 195
ALA A 348
THR A 347
ILE A 350
 None
 1.19A 3a35A-5v6yA:
undetectable		 3a35A-5v6yA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_B_RBFB191_1
(LUMAZINE PROTEIN)		 5v6y MALTOSE-BINDING
PERIPLASMIC
PROTEIN,RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 1,CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		5 / 12 LEU A 194
THR A 195
ALA A 348
THR A 347
ILE A 350
 None
 1.21A 3a35B-5v6yA:
undetectable		 3a35B-5v6yA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3B_A_RBFA191_1
(LUMAZINE PROTEIN)		 5v6y MALTOSE-BINDING
PERIPLASMIC
PROTEIN,RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 1,CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		5 / 12 LEU A 194
THR A 195
ALA A 348
THR A 347
ILE A 350
 None
 1.22A 3a3bA-5v6yA:
undetectable		 3a3bA-5v6yA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 5v6y MALTOSE-BINDING
PERIPLASMIC
PROTEIN,RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 1,CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		4 / 6 PHE A 260
ALA A 164
LEU A 249
PRO A 161
 None
 0.98A 3bgdA-5v6yA:
undetectable		 3bgdA-5v6yA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_1
(PHOSPHOLIPASE A2)		 5v6y MALTOSE-BINDING
PERIPLASMIC
PROTEIN,RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 1,CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		4 / 7 VAL A 112
GLY A 302
PRO A 231
LYS A 307
 None
 0.74A 3bjwC-5v6yA:
undetectable		 3bjwC-5v6yA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_1
(PHOSPHOLIPASE A2)		 5v6y MALTOSE-BINDING
PERIPLASMIC
PROTEIN,RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 1,CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		4 / 8 VAL A 112
GLY A 302
PRO A 231
LYS A 307
 None
 0.94A 3bjwA-5v6yA:
undetectable		 3bjwA-5v6yA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_A_EPAA1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5v6y MALTOSE-BINDING
PERIPLASMIC
PROTEIN,RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 1,CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		5 / 12 VAL A 345
GLY A 189
ALA A 190
LEU A 194
LEU A 162
 None
 1.03A 3hs6A-5v6yA:
undetectable		 3hs6A-5v6yA:
9.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_1
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 5v6y MALTOSE-BINDING
PERIPLASMIC
PROTEIN,RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 1,CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		10 / 12 ASP A  16
LYS A  17
LYS A  44
GLU A  46
GLU A  47
ALA A  65
ASP A  67
ARG A  68
GLU A 113
TRP A 232
 MAL  A2201 (-3.2A)
MAL  A2201 (-2.7A)
None
None
None
MAL  A2201 (-3.3A)
MAL  A2201 (-2.5A)
MAL  A2201 (-3.9A)
MAL  A2201 (-3.2A)
MAL  A2201 ( 4.8A)
 0.63A 3jyrA-5v6yA:
61.8		 3jyrA-5v6yA:
75.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_1
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 5v6y MALTOSE-BINDING
PERIPLASMIC
PROTEIN,RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 1,CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		10 / 12 ASP A  16
LYS A  17
LYS A  44
GLU A  46
GLU A  47
ALA A  65
ASP A  67
GLU A 113
PRO A 156
TRP A 232
 MAL  A2201 (-3.2A)
MAL  A2201 (-2.7A)
None
None
None
MAL  A2201 (-3.3A)
MAL  A2201 (-2.5A)
MAL  A2201 (-3.2A)
MAL  A2201 (-3.7A)
MAL  A2201 ( 4.8A)
 0.43A 3jyrA-5v6yA:
61.8		 3jyrA-5v6yA:
75.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_2
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 5v6y MALTOSE-BINDING
PERIPLASMIC
PROTEIN,RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 1,CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		6 / 7 ASN A  14
TRP A  64
GLU A 155
TYR A 157
MET A 332
TRP A 342
 MAL  A2201 (-4.1A)
MAL  A2201 (-4.5A)
MAL  A2201 (-3.7A)
MAL  A2201 (-3.9A)
MAL  A2201 ( 4.2A)
MAL  A2201 (-3.7A)
 0.28A 3jyrA-5v6yA:
61.8		 3jyrA-5v6yA:
75.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)		 5v6y MALTOSE-BINDING
PERIPLASMIC
PROTEIN,RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 1,CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		5 / 12 PHE A 158
GLY A 302
LEU A 301
GLU A 113
ALA A 233
 MAL  A2201 (-4.8A)
None
None
MAL  A2201 (-3.2A)
None
 0.81A 3tbgB-5v6yA:
undetectable		 3tbgB-5v6yA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)		 5v6y MALTOSE-BINDING
PERIPLASMIC
PROTEIN,RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 1,CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		5 / 12 PHE A 158
GLY A 302
LEU A 301
GLU A 113
ALA A 233
 MAL  A2201 (-4.8A)
None
None
MAL  A2201 (-3.2A)
None
 0.80A 3tbgD-5v6yA:
undetectable		 3tbgD-5v6yA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UPW_A_NCAA412_0
(OLD YELLOW ENZYME
2.6 (OYE2.6), NADPH
DEHYDROGENASE)		 5v6y MALTOSE-BINDING
PERIPLASMIC
PROTEIN,RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 1,CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		5 / 9 THR A1073
ALA A1070
TYR A2049
ASN A1086
TYR A1032
 None
 1.27A 3upwA-5v6yA:
undetectable		 3upwA-5v6yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M5M_A_DX4A401_0
(2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE)		 5v6y MALTOSE-BINDING
PERIPLASMIC
PROTEIN,RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 1,CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		4 / 8 GLY A1033
THR A1073
LEU A1041
PHE A1092
 None
 1.21A 4m5mA-5v6yA:
undetectable		 4m5mA-5v6yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB602_1
(SERUM ALBUMIN)		 5v6y MALTOSE-BINDING
PERIPLASMIC
PROTEIN,RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 1,CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		5 / 9 ALA A 266
ALA A 107
LEU A 105
LEU A 264
VAL A 263
 None
 1.10A 4or0B-5v6yA:
undetectable		 4or0B-5v6yA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCU_A_SAMA603_0
(CYSTATHIONINE
BETA-SYNTHASE)		 5v6y MALTOSE-BINDING
PERIPLASMIC
PROTEIN,RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 1,CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		4 / 7 PHE A2095
ASP A2090
THR A2037
ILE A2041
 None
 1.06A 4pcuA-5v6yA:
undetectable		 4pcuA-5v6yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB203_0
(HYDROXYNITRILE LYASE)		 5v6y MALTOSE-BINDING
PERIPLASMIC
PROTEIN,RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 1,CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		4 / 4 VAL A 112
ALA A 114
ILE A 319
THR A 322
 None
 1.20A 5e4dB-5v6yA:
undetectable		 5e4dB-5v6yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5v6y MALTOSE-BINDING
PERIPLASMIC
PROTEIN,RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 1,CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		4 / 5 TYR A 343
SER A 339
ALA A2116
GLN A  51
 None
 1.34A 5n0tA-5v6yA:
undetectable		 5n0tA-5v6yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA603_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5v6y MALTOSE-BINDING
PERIPLASMIC
PROTEIN,RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 1,CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		3 / 3 TYR A 157
ASN A 229
LEU A 115
 MAL  A2201 (-3.9A)
None
None
 0.83A 6b58A-5v6yA:
undetectable		 6b58A-5v6yA:
undetectable