SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5v72'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MIC_A_DVAA6_0
(GRAMICIDIN A)		 5v72 NADPH-DEPENDENT
GLYOXYLATE/HYDROXYPY
RUVATE REDUCTASE
(Sinorhizobium
meliloti) 		3 / 3 ALA A  82
VAL A  88
TRP A 300
 None
 0.91A 1micA-5v72A:
undetectable
1micB-5v72A:
undetectable		 1micA-5v72A:
4.76
1micB-5v72A:
4.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)		 5v72 NADPH-DEPENDENT
GLYOXYLATE/HYDROXYPY
RUVATE REDUCTASE
(Sinorhizobium
meliloti) 		4 / 5 LEU A 161
LEU A 109
LEU A 107
LEU A 140
 None
 1.03A 1yajD-5v72A:
2.3		 1yajD-5v72A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2002_1
(SERUM ALBUMIN)		 5v72 NADPH-DEPENDENT
GLYOXYLATE/HYDROXYPY
RUVATE REDUCTASE
(Sinorhizobium
meliloti) 		5 / 10 ALA A 251
LEU A 243
LEU A 239
SER A 232
VAL A 234
 None
 1.15A 2bxeA-5v72A:
undetectable		 2bxeA-5v72A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 5v72 NADPH-DEPENDENT
GLYOXYLATE/HYDROXYPY
RUVATE REDUCTASE
(Sinorhizobium
meliloti) 		5 / 11 LEU A 219
LEU A 216
ILE A 226
THR A 111
ARG A 143
 None
 1.32A 2ft9A-5v72A:
undetectable		 2ft9A-5v72A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 5v72 NADPH-DEPENDENT
GLYOXYLATE/HYDROXYPY
RUVATE REDUCTASE
(Sinorhizobium
meliloti) 		3 / 3 VAL A 255
ASP A 254
GLU A 259
 None
 0.72A 2qeuA-5v72A:
undetectable		 2qeuA-5v72A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 5v72 NADPH-DEPENDENT
GLYOXYLATE/HYDROXYPY
RUVATE REDUCTASE
(Sinorhizobium
meliloti) 		3 / 3 VAL A 255
ASP A 254
GLU A 259
 None
 0.72A 2qeuC-5v72A:
undetectable		 2qeuC-5v72A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 5v72 NADPH-DEPENDENT
GLYOXYLATE/HYDROXYPY
RUVATE REDUCTASE
(Sinorhizobium
meliloti) 		5 / 12 ILE A 157
GLY A 149
GLY A 151
ALA A 156
VAL A 201
 None
 1.14A 2yvlB-5v72A:
5.3		 2yvlB-5v72A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_2
(HIV-1 PROTEASE)		 5v72 NADPH-DEPENDENT
GLYOXYLATE/HYDROXYPY
RUVATE REDUCTASE
(Sinorhizobium
meliloti) 		5 / 10 VAL A 201
GLY A 146
VAL A 145
VAL A 228
ILE A 200
 None
 0.86A 3oxwD-5v72A:
undetectable		 3oxwD-5v72A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)		 5v72 NADPH-DEPENDENT
GLYOXYLATE/HYDROXYPY
RUVATE REDUCTASE
(Sinorhizobium
meliloti) 		5 / 11 ALA A 104
GLY A 149
GLY A 154
ILE A 198
PRO A 202
 None
 1.15A 4dcmA-5v72A:
7.1		 4dcmA-5v72A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5v72 NADPH-DEPENDENT
GLYOXYLATE/HYDROXYPY
RUVATE REDUCTASE
(Sinorhizobium
meliloti) 		4 / 8 LEU A 112
ILE A 198
VAL A 228
GLY A 106
 None
 0.81A 4eq4B-5v72A:
2.6		 4eq4B-5v72A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5v72 NADPH-DEPENDENT
GLYOXYLATE/HYDROXYPY
RUVATE REDUCTASE
(Sinorhizobium
meliloti) 		3 / 3 SER A  63
LEU A  53
MET A  58
 None
 0.88A 5ikrB-5v72A:
undetectable		 5ikrB-5v72A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 5v72 NADPH-DEPENDENT
GLYOXYLATE/HYDROXYPY
RUVATE REDUCTASE
(Sinorhizobium
meliloti) 		5 / 12 LEU A 225
ILE A 248
GLY A 223
LEU A 253
LEU A 274
 None
 0.99A 5nfjB-5v72A:
2.1		 5nfjB-5v72A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 5v72 NADPH-DEPENDENT
GLYOXYLATE/HYDROXYPY
RUVATE REDUCTASE
(Sinorhizobium
meliloti) 		5 / 12 LEU A 225
ILE A 248
GLY A 223
LEU A 253
LEU A 274
 None
 0.98A 5nfjC-5v72A:
2.1		 5nfjC-5v72A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_0
(NS3 PROTEASE)		 5v72 NADPH-DEPENDENT
GLYOXYLATE/HYDROXYPY
RUVATE REDUCTASE
(Sinorhizobium
meliloti) 		5 / 12 GLY A  73
ILE A  12
GLY A  51
ALA A  68
ALA A  48
 None
 0.85A 6c2mD-5v72A:
undetectable		 6c2mD-5v72A:
15.38