SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5v7i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_A_FFOA1002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		7 / 12 LEU A 166
GLY A 169
HIS A 171
LEU A 172
SER A 226
ALA A 227
ARG A 425
 8Z1  A 601 (-4.7A)
8Z1  A 601 ( 3.8A)
LLP  A 280 (-3.3A)
8Z1  A 601 (-4.1A)
LLP  A 280 (-3.4A)
8Z1  A 601 ( 4.3A)
8Z1  A 601 ( 3.8A)
 0.52A 1dfoA-5v7iA:
51.5		 1dfoA-5v7iA:
44.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_A_FFOA1002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		5 / 5 GLU A  98
TYR A 105
TYR A 106
PHE A 320
PRO A 321
 None
 0.72A 1dfoB-5v7iA:
51.9		 1dfoB-5v7iA:
44.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_B_FFOB2002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		5 / 5 GLU A  98
TYR A 105
TYR A 106
PHE A 320
PRO A 321
 None
 0.73A 1dfoA-5v7iA:
51.5		 1dfoA-5v7iA:
44.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_B_FFOB2002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		7 / 12 LEU A 166
GLY A 169
HIS A 171
LEU A 172
SER A 226
ALA A 227
ARG A 425
 8Z1  A 601 (-4.7A)
8Z1  A 601 ( 3.8A)
LLP  A 280 (-3.3A)
8Z1  A 601 (-4.1A)
LLP  A 280 (-3.4A)
8Z1  A 601 ( 4.3A)
8Z1  A 601 ( 3.8A)
 0.53A 1dfoB-5v7iA:
51.9		 1dfoB-5v7iA:
44.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_C_FFOC3002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		7 / 12 LEU A 166
GLY A 169
HIS A 171
LEU A 172
SER A 226
ALA A 227
ARG A 425
 8Z1  A 601 (-4.7A)
8Z1  A 601 ( 3.8A)
LLP  A 280 (-3.3A)
8Z1  A 601 (-4.1A)
LLP  A 280 (-3.4A)
8Z1  A 601 ( 4.3A)
8Z1  A 601 ( 3.8A)
 0.52A 1dfoC-5v7iA:
51.9		 1dfoC-5v7iA:
44.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_C_FFOC3002_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		5 / 5 GLU A  98
TYR A 105
TYR A 106
PHE A 320
PRO A 321
 None
 0.73A 1dfoD-5v7iA:
51.6		 1dfoD-5v7iA:
44.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_D_FFOD4002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		5 / 5 GLU A  98
TYR A 105
TYR A 106
PHE A 320
PRO A 321
 None
 0.73A 1dfoC-5v7iA:
51.9		 1dfoC-5v7iA:
44.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_D_FFOD4002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		7 / 12 LEU A 166
GLY A 169
HIS A 171
LEU A 172
SER A 226
ALA A 227
ARG A 425
 8Z1  A 601 (-4.7A)
8Z1  A 601 ( 3.8A)
LLP  A 280 (-3.3A)
8Z1  A 601 (-4.1A)
LLP  A 280 (-3.4A)
8Z1  A 601 ( 4.3A)
8Z1  A 601 ( 3.8A)
 0.53A 1dfoD-5v7iA:
51.6		 1dfoD-5v7iA:
44.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_A_FFOA1293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		7 / 12 LEU A 166
GLY A 169
HIS A 171
LEU A 172
SER A 226
ALA A 227
ARG A 425
 8Z1  A 601 (-4.7A)
8Z1  A 601 ( 3.8A)
LLP  A 280 (-3.3A)
8Z1  A 601 (-4.1A)
LLP  A 280 (-3.4A)
8Z1  A 601 ( 4.3A)
8Z1  A 601 ( 3.8A)
 0.50A 1eqbA-5v7iA:
51.3		 1eqbA-5v7iA:
44.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_A_FFOA1293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 GLU A  98
TYR A 105
PHE A 320
 None
 0.47A 1eqbB-5v7iA:
51.8		 1eqbB-5v7iA:
44.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		5 / 8 SER A  76
HIS A 171
SER A 226
HIS A 254
ARG A 425
 None
LLP  A 280 (-3.3A)
LLP  A 280 (-3.4A)
LLP  A 280 ( 4.0A)
8Z1  A 601 ( 3.8A)
 0.25A 1eqbA-5v7iA:
51.3
1eqbB-5v7iA:
51.8		 1eqbA-5v7iA:
44.38
1eqbB-5v7iA:
44.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_B_FFOB2293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 GLU A  98
TYR A 105
PHE A 320
 None
 0.45A 1eqbA-5v7iA:
51.3		 1eqbA-5v7iA:
44.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_B_FFOB2293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		7 / 12 LEU A 166
GLY A 169
HIS A 171
LEU A 172
SER A 226
ALA A 227
ARG A 425
 8Z1  A 601 (-4.7A)
8Z1  A 601 ( 3.8A)
LLP  A 280 (-3.3A)
8Z1  A 601 (-4.1A)
LLP  A 280 (-3.4A)
8Z1  A 601 ( 4.3A)
8Z1  A 601 ( 3.8A)
 0.51A 1eqbB-5v7iA:
51.7		 1eqbB-5v7iA:
44.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_B_FFOB2293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 166
GLY A 169
SER A 226
ALA A 227
ASN A 410
 8Z1  A 601 (-4.7A)
8Z1  A 601 ( 3.8A)
LLP  A 280 (-3.4A)
8Z1  A 601 ( 4.3A)
8Z1  A 601 ( 4.6A)
 0.99A 1eqbB-5v7iA:
51.7		 1eqbB-5v7iA:
44.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		5 / 8 SER A  76
HIS A 171
SER A 226
HIS A 254
ARG A 425
 None
LLP  A 280 (-3.3A)
LLP  A 280 (-3.4A)
LLP  A 280 ( 4.0A)
8Z1  A 601 ( 3.8A)
 0.25A 1eqbA-5v7iA:
51.3
1eqbB-5v7iA:
51.8		 1eqbA-5v7iA:
44.38
1eqbB-5v7iA:
44.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_C_FFOC3293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		7 / 12 LEU A 166
GLY A 169
HIS A 171
LEU A 172
SER A 226
ALA A 227
ARG A 425
 8Z1  A 601 (-4.7A)
8Z1  A 601 ( 3.8A)
LLP  A 280 (-3.3A)
8Z1  A 601 (-4.1A)
LLP  A 280 (-3.4A)
8Z1  A 601 ( 4.3A)
8Z1  A 601 ( 3.8A)
 0.50A 1eqbC-5v7iA:
51.7		 1eqbC-5v7iA:
44.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_C_FFOC3293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 GLU A  98
TYR A 105
PHE A 320
 None
 0.46A 1eqbD-5v7iA:
51.3		 1eqbD-5v7iA:
44.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		5 / 8 SER A  76
HIS A 171
SER A 226
HIS A 254
ARG A 425
 None
LLP  A 280 (-3.3A)
LLP  A 280 (-3.4A)
LLP  A 280 ( 4.0A)
8Z1  A 601 ( 3.8A)
 0.24A 1eqbC-5v7iA:
51.7
1eqbD-5v7iA:
51.3		 1eqbC-5v7iA:
44.38
1eqbD-5v7iA:
44.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_D_FFOD4293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 GLU A  98
TYR A 105
PHE A 320
 None
 0.46A 1eqbC-5v7iA:
51.7		 1eqbC-5v7iA:
44.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_D_FFOD4293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		7 / 12 LEU A 166
GLY A 169
HIS A 171
LEU A 172
SER A 226
ALA A 227
ARG A 425
 8Z1  A 601 (-4.7A)
8Z1  A 601 ( 3.8A)
LLP  A 280 (-3.3A)
8Z1  A 601 (-4.1A)
LLP  A 280 (-3.4A)
8Z1  A 601 ( 4.3A)
8Z1  A 601 ( 3.8A)
 0.51A 1eqbD-5v7iA:
51.3		 1eqbD-5v7iA:
44.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		5 / 8 SER A  76
HIS A 171
SER A 226
HIS A 254
ARG A 425
 None
LLP  A 280 (-3.3A)
LLP  A 280 (-3.4A)
LLP  A 280 ( 4.0A)
8Z1  A 601 ( 3.8A)
 0.25A 1eqbC-5v7iA:
51.7
1eqbD-5v7iA:
51.3		 1eqbC-5v7iA:
44.38
1eqbD-5v7iA:
44.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 SER A  97
ARG A 104
GLN A 324
PHE A 320
 None
 1.22A 1rs6A-5v7iA:
undetectable		 1rs6A-5v7iA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 SER A  97
ARG A 104
GLN A 324
PHE A 320
 None
 1.28A 1rs6B-5v7iA:
1.3		 1rs6B-5v7iA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 SER A  97
ARG A 104
GLN A 324
PHE A 320
 None
 1.23A 1rs7B-5v7iA:
undetectable		 1rs7B-5v7iA:
23.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VMY_A_FFOA505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		5 / 6 GLU A  98
TYR A 105
TYR A 106
PHE A 320
PRO A 321
 None
 0.65A 2vmyA-5v7iA:
52.1		 2vmyA-5v7iA:
43.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VMY_A_FFOA505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		7 / 12 LEU A 166
GLY A 169
HIS A 171
LEU A 172
SER A 226
ALA A 227
ARG A 425
 8Z1  A 601 (-4.7A)
8Z1  A 601 ( 3.8A)
LLP  A 280 (-3.3A)
8Z1  A 601 (-4.1A)
LLP  A 280 (-3.4A)
8Z1  A 601 ( 4.3A)
8Z1  A 601 ( 3.8A)
 0.56A 2vmyB-5v7iA:
52.1		 2vmyB-5v7iA:
43.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VMY_A_GLYA502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 SER A  76
HIS A 171
HIS A 254
ARG A 425
 None
LLP  A 280 (-3.3A)
LLP  A 280 ( 4.0A)
8Z1  A 601 ( 3.8A)
 0.27A 2vmyA-5v7iA:
52.1
2vmyB-5v7iA:
52.1		 2vmyA-5v7iA:
43.79
2vmyB-5v7iA:
43.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VMY_B_FFOB505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 GLU A  98
TYR A 105
TYR A 106
PHE A 320
 None
 0.75A 2vmyB-5v7iA:
52.1		 2vmyB-5v7iA:
43.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		5 / 8 SER A  76
HIS A 171
SER A 226
HIS A 254
ARG A 425
 None
LLP  A 280 (-3.3A)
LLP  A 280 (-3.4A)
LLP  A 280 ( 4.0A)
8Z1  A 601 ( 3.8A)
 0.33A 2vmyA-5v7iA:
52.1
2vmyB-5v7iA:
52.1		 2vmyA-5v7iA:
43.79
2vmyB-5v7iA:
43.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC800_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ASP A 363
ARG A 359
ALA A 362
 None
 0.75A 3mbgC-5v7iA:
undetectable		 3mbgC-5v7iA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 SER A  97
ARG A 104
GLN A 324
PHE A 320
 None
 1.25A 3n62A-5v7iA:
undetectable		 3n62A-5v7iA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 SER A  97
ARG A 104
GLN A 324
PHE A 320
 None
 1.25A 3n66B-5v7iA:
undetectable		 3n66B-5v7iA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N6D_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 TRP A 134
PHE A 268
VAL A 136
PRO A 267
 PEG  A 603 (-4.5A)
None
None
None
 1.44A 3n6dA-5v7iA:
undetectable
3n6dB-5v7iA:
undetectable		 3n6dA-5v7iA:
23.16
3n6dB-5v7iA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_2
(PROTEASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG A 425
LEU A 381
THR A 281
 8Z1  A 601 ( 3.8A)
None
LLP  A 280 ( 3.9A)
 0.73A 3oxcA-5v7iA:
undetectable		 3oxcA-5v7iA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_1
(HIV-1 PROTEASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 ARG A 425
LEU A 381
ASN A 379
VAL A 354
GLY A 257
 8Z1  A 601 ( 3.8A)
None
None
None
None
 1.14A 3spkA-5v7iA:
undetectable		 3spkA-5v7iA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		3 / 4 SER A 417
GLY A 175
GLU A 191
 None
 0.62A 4juoA-5v7iA:
2.0
4juoC-5v7iA:
undetectable		 4juoA-5v7iA:
23.36
4juoC-5v7iA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_2
(ADENOSINE KINASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 LEU A 164
SER A 226
LEU A 166
LEU A 197
 None
LLP  A 280 (-3.4A)
8Z1  A 601 (-4.7A)
None
 1.15A 4n09B-5v7iA:
4.6		 4n09B-5v7iA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_2
(ADENOSINE KINASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 LEU A 164
SER A 226
LEU A 166
LEU A 197
 None
LLP  A 280 (-3.4A)
8Z1  A 601 (-4.7A)
None
 1.14A 4n09D-5v7iA:
4.7		 4n09D-5v7iA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ARG A 283
SER A 351
GLY A 257
ALA A  84
GLY A 284
 None
 1.30A 4r29B-5v7iA:
1.5		 4r29B-5v7iA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 ALA A 333
ALA A  87
ALA A  83
SER A  81
ALA A 336
 None
 1.30A 4twdA-5v7iA:
undetectable
4twdB-5v7iA:
undetectable
4twdC-5v7iA:
undetectable
4twdD-5v7iA:
undetectable
4twdE-5v7iA:
undetectable		 4twdA-5v7iA:
19.71
4twdB-5v7iA:
19.71
4twdC-5v7iA:
19.71
4twdD-5v7iA:
19.71
4twdE-5v7iA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_D_AZMD303_1
(ALPHA-CARBONIC
ANHYDRASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 GLU A  72
VAL A 444
LEU A 400
THR A 406
ALA A 407
 None
 1.27A 4ygfD-5v7iA:
undetectable		 4ygfD-5v7iA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_D_AZMD303_1
(ALPHA-CARBONIC
ANHYDRASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 GLU A  72
VAL A 489
LEU A 400
THR A 406
ALA A 407
 None
 1.36A 4ygfD-5v7iA:
undetectable		 4ygfD-5v7iA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ASP A 392
ARG A 395
GLY A 455
THR A 462
 None
 0.94A 5bs8A-5v7iA:
undetectable
5bs8B-5v7iA:
undetectable
5bs8C-5v7iA:
undetectable		 5bs8A-5v7iA:
22.87
5bs8B-5v7iA:
22.17
5bs8C-5v7iA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ASP A 392
ARG A 395
GLY A 455
THR A 462
 None
 0.97A 5btaA-5v7iA:
1.8
5btaC-5v7iA:
1.3
5btaD-5v7iA:
undetectable		 5btaA-5v7iA:
22.62
5btaC-5v7iA:
22.62
5btaD-5v7iA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_E_GFNE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ASP A 392
ARG A 395
GLY A 455
THR A 462
 None
 0.95A 5btdA-5v7iA:
undetectable
5btdB-5v7iA:
undetectable
5btdC-5v7iA:
undetectable		 5btdA-5v7iA:
22.87
5btdB-5v7iA:
22.17
5btdC-5v7iA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ASP A 392
ARG A 395
GLY A 455
THR A 462
 None
 0.94A 5btdA-5v7iA:
1.3
5btdC-5v7iA:
undetectable
5btdD-5v7iA:
undetectable		 5btdA-5v7iA:
22.87
5btdC-5v7iA:
22.87
5btdD-5v7iA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_F_GFNF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ASP A 392
ARG A 395
GLY A 455
THR A 462
 None
 0.92A 5btfA-5v7iA:
undetectable
5btfB-5v7iA:
undetectable
5btfC-5v7iA:
undetectable		 5btfA-5v7iA:
22.62
5btfB-5v7iA:
22.17
5btfC-5v7iA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ASP A 392
ARG A 395
GLY A 455
THR A 462
 None
 0.90A 5btfA-5v7iA:
undetectable
5btfC-5v7iA:
undetectable
5btfD-5v7iA:
undetectable		 5btfA-5v7iA:
22.62
5btfC-5v7iA:
22.62
5btfD-5v7iA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_2
(PROTEASE E35D-SQV)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 ARG A 425
LEU A 381
ASN A 379
VAL A 354
GLY A 257
 8Z1  A 601 ( 3.8A)
None
None
None
None
 1.09A 5kqxB-5v7iA:
undetectable		 5kqxB-5v7iA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 SER A  97
ARG A 104
GLN A 324
PHE A 320
 None
 1.31A 5vunB-5v7iA:
undetectable		 5vunB-5v7iA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 GLY A 163
VAL A 240
MET A 237
 None
 0.46A 5ycpA-5v7iA:
undetectable		 5ycpA-5v7iA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW2_A_ACTA511_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG A 182
ILE A 188
SER A 187
 None
 0.83A 5zw2A-5v7iA:
undetectable		 5zw2A-5v7iA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 SER A  97
ARG A 104
GLN A 324
PHE A 320
 None
 1.30A 6auuB-5v7iA:
undetectable		 6auuB-5v7iA:
22.78