SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5v7q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5v7q 50S RIBOSOMAL
PROTEIN L19
(Mycobacterium
tuberculosis) 		3 / 3 GLN P  40
ILE P  16
HIS P  76
 None
 0.72A 1fm9A-5v7qP:
undetectable		 1fm9A-5v7qP:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5v7q 50S RIBOSOMAL
PROTEIN L19
(Mycobacterium
tuberculosis) 		3 / 3 GLN P  40
ILE P  16
HIS P  76
 None
 0.73A 1k74A-5v7qP:
undetectable		 1k74A-5v7qP:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 5v7q 50S RIBOSOMAL
PROTEIN L14
50S RIBOSOMAL
PROTEIN L19
(Mycobacterium
tuberculosis;
Mycobacterium
tuberculosis) 		3 / 3 TYR P  65
ARG K 104
GLN P  40
 None
 0.97A 1tw4A-5v7qP:
undetectable		 1tw4A-5v7qP:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG4_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 5v7q 50S RIBOSOMAL
PROTEIN L19
(Mycobacterium
tuberculosis) 		5 / 11 VAL P  29
ILE P  80
PHE P  73
HIS P  82
PHE P  58
 None
 1.25A 2dg4A-5v7qP:
undetectable		 2dg4A-5v7qP:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)		 5v7q 50S RIBOSOMAL
PROTEIN L19
(Mycobacterium
tuberculosis) 		4 / 6 PRO P  10
HIS P  76
ASP P  15
ASP P  14
 None
 1.44A 2lh8A-5v7qP:
undetectable		 2lh8A-5v7qP:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2O_B_DHIB24_0
(INSULIN B CHAIN)		 5v7q 50S RIBOSOMAL
PROTEIN L4
(Mycobacterium
tuberculosis) 		4 / 6 ARG E  52
GLY E  54
PRO E  99
LYS E 100
 C  A 533 ( 3.6A)
None
G  A1379 ( 4.0A)
G  A 798 ( 2.6A)
 1.31A 2m2oB-5v7qE:
undetectable		 2m2oB-5v7qE:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 5v7q 50S RIBOSOMAL
PROTEIN L14
(Mycobacterium
tuberculosis) 		5 / 12 ILE K  19
ARG K  64
ALA K  83
ALA K  84
VAL K  85
 None
 0.99A 2oc8A-5v7qK:
undetectable		 2oc8A-5v7qK:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)		 5v7q 50S RIBOSOMAL
PROTEIN L4
(Mycobacterium
tuberculosis) 		4 / 8 ALA E 152
THR E 155
VAL E 181
VAL E 162
 None
 0.83A 3me6B-5v7qE:
undetectable		 3me6B-5v7qE:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 5v7q LSU RIBOSOMAL
PROTEIN L21P
(Mycobacterium
tuberculosis) 		4 / 8 LEU R  38
VAL R  17
TYR R  15
LEU R  98
 None
 1.00A 3v81C-5v7qR:
undetectable		 3v81C-5v7qR:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5v7q 50S RIBOSOMAL
PROTEIN L4
(Mycobacterium
tuberculosis) 		4 / 4 LEU E  26
PRO E  27
LEU E  30
ILE E 130
 None
 0.95A 4f4dB-5v7qE:
undetectable		 4f4dB-5v7qE:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5v7q 50S RIBOSOMAL
PROTEIN L31
(Mycobacterium
tuberculosis) 		3 / 3 GLN 6  23
THR 6  24
THR 6  13
 None
 0.77A 4fu9A-5v7q6:
undetectable		 4fu9A-5v7q6:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUF_A_ACTA310_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5v7q 50S RIBOSOMAL
PROTEIN L31
(Mycobacterium
tuberculosis) 		3 / 3 GLN 6  23
THR 6  24
THR 6  13
 None
 0.77A 4fufA-5v7q6:
undetectable		 4fufA-5v7q6:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 5v7q LSU RIBOSOMAL
PROTEIN L21P
(Mycobacterium
tuberculosis) 		4 / 8 LEU R  38
VAL R  17
TYR R  15
LEU R  98
 None
 0.88A 4pwdC-5v7qR:
undetectable		 4pwdC-5v7qR:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5v7q 50S RIBOSOMAL
PROTEIN L19
(Mycobacterium
tuberculosis) 		3 / 3 GLN P  40
ILE P  16
HIS P  76
 None
 0.60A 5z12B-5v7qP:
undetectable		 5z12B-5v7qP:
19.17