SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5v7v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRH_A_NIOA200_1
(PROTEIN HP0721)		 5v7v ERAD-ASSOCIATED E3
UBIQUITIN-PROTEIN
LIGASE COMPONENT
HRD3
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 603
ILE A 584
THR A 588
LEU A 618
 None
 0.85A 2xrhA-5v7vA:
undetectable		 2xrhA-5v7vA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)		 5v7v ERAD-ASSOCIATED E3
UBIQUITIN-PROTEIN
LIGASE COMPONENT
HRD3
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 198
GLU A 552
ASP A 597
 None
 0.64A 3bxoA-5v7vA:
undetectable		 3bxoA-5v7vA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)		 5v7v ERAD-ASSOCIATED E3
UBIQUITIN-PROTEIN
LIGASE COMPONENT
HRD3
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 507
GLU A 552
ASP A 597
 None
 0.75A 3bxoA-5v7vA:
undetectable		 3bxoA-5v7vA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_1
(N,N-DIMETHYLTRANSFER
ASE)		 5v7v ERAD-ASSOCIATED E3
UBIQUITIN-PROTEIN
LIGASE COMPONENT
HRD3
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 198
GLU A 552
ASP A 597
 None
 0.71A 3bxoB-5v7vA:
undetectable		 3bxoB-5v7vA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_1
(N,N-DIMETHYLTRANSFER
ASE)		 5v7v ERAD-ASSOCIATED E3
UBIQUITIN-PROTEIN
LIGASE COMPONENT
HRD3
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 507
GLU A 552
ASP A 597
 None
 0.85A 3bxoB-5v7vA:
undetectable		 3bxoB-5v7vA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		 5v7v ERAD-ASSOCIATED E3
UBIQUITIN-PROTEIN
LIGASE COMPONENT
HRD3
(Saccharomyces
cerevisiae) 		3 / 3 MET A 473
MET A 438
PHE A 481
 None
 1.17A 3gn8A-5v7vA:
undetectable		 3gn8A-5v7vA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		 5v7v ERAD-ASSOCIATED E3
UBIQUITIN-PROTEIN
LIGASE COMPONENT
HRD3
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 176
TYR A 178
ALA A 182
ARG A 180
 None
 1.09A 3rd0A-5v7vA:
2.8		 3rd0A-5v7vA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 5v7v ERAD-ASSOCIATED E3
UBIQUITIN-PROTEIN
LIGASE COMPONENT
HRD3
(Saccharomyces
cerevisiae) 		4 / 8 SER A 210
THR A 511
ASP A 514
TYR A 195
 None
 1.05A 4drjB-5v7vA:
3.0		 4drjB-5v7vA:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_A_1LDA501_0
(CYTOSINE DEAMINASE)		 5v7v ERAD-ASSOCIATED E3
UBIQUITIN-PROTEIN
LIGASE COMPONENT
HRD3
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  93
PHE A 120
ILE A 112
GLU A  91
LEU A  92
 None
 1.35A 4r88A-5v7vA:
undetectable		 4r88A-5v7vA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_B_1LDB501_0
(CYTOSINE DEAMINASE)		 5v7v ERAD-ASSOCIATED E3
UBIQUITIN-PROTEIN
LIGASE COMPONENT
HRD3
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  93
PHE A 120
ILE A 112
GLU A  91
LEU A  92
 None
 1.33A 4r88B-5v7vA:
undetectable		 4r88B-5v7vA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_C_1LDC501_0
(CYTOSINE DEAMINASE)		 5v7v ERAD-ASSOCIATED E3
UBIQUITIN-PROTEIN
LIGASE COMPONENT
HRD3
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  93
PHE A 120
ILE A 112
GLU A  91
LEU A  92
 None
 1.33A 4r88C-5v7vA:
undetectable		 4r88C-5v7vA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_D_1LDD501_0
(CYTOSINE DEAMINASE)		 5v7v ERAD-ASSOCIATED E3
UBIQUITIN-PROTEIN
LIGASE COMPONENT
HRD3
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  93
PHE A 120
ILE A 112
GLU A  91
LEU A  92
 None
 1.34A 4r88D-5v7vA:
undetectable		 4r88D-5v7vA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_E_1LDE501_0
(CYTOSINE DEAMINASE)		 5v7v ERAD-ASSOCIATED E3
UBIQUITIN-PROTEIN
LIGASE COMPONENT
HRD3
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  93
PHE A 120
ILE A 112
GLU A  91
LEU A  92
 None
 1.36A 4r88E-5v7vA:
undetectable		 4r88E-5v7vA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_F_1LDF502_0
(CYTOSINE DEAMINASE)		 5v7v ERAD-ASSOCIATED E3
UBIQUITIN-PROTEIN
LIGASE COMPONENT
HRD3
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  93
PHE A 120
ILE A 112
GLU A  91
LEU A  92
 None
 1.35A 4r88F-5v7vA:
undetectable		 4r88F-5v7vA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 5v7v ERAD-ASSOCIATED E3
UBIQUITIN-PROTEIN
LIGASE COMPONENT
HRD3
(Saccharomyces
cerevisiae) 		4 / 6 TYR A 507
GLY A 594
GLU A 552
ASP A 597
 None
 0.73A 5emlA-5v7vA:
undetectable		 5emlA-5v7vA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5v7v ERAD-ASSOCIATED E3
UBIQUITIN-PROTEIN
LIGASE COMPONENT
HRD3
(Saccharomyces
cerevisiae) 		4 / 6 TYR A 551
ILE A 217
TYR A 214
TYR A 507
 None
 1.00A 5ih0A-5v7vA:
undetectable		 5ih0A-5v7vA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5v7v ERAD-ASSOCIATED E3
UBIQUITIN-PROTEIN
LIGASE COMPONENT
HRD3
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 586
SER A 557
ALA A 554
GLN A 545
 None
 1.42A 5n0tA-5v7vA:
undetectable		 5n0tA-5v7vA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA205_0
(N-ACETYLTRANSFERASE)		 5v7v ERAD-ASSOCIATED E3
UBIQUITIN-PROTEIN
LIGASE COMPONENT
HRD3
(Saccharomyces
cerevisiae) 		4 / 4 ALA A 527
ALA A 530
ALA A 539
ALA A 542
 None
 0.75A 6gtqA-5v7vA:
undetectable
6gtqB-5v7vA:
undetectable		 6gtqA-5v7vA:
13.54
6gtqB-5v7vA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA205_0
(N-ACETYLTRANSFERASE)		 5v7v ERAD-ASSOCIATED E3
UBIQUITIN-PROTEIN
LIGASE COMPONENT
HRD3
(Saccharomyces
cerevisiae) 		4 / 4 ALA A 539
ALA A 542
ALA A 527
ALA A 530
 None
 0.75A 6gtqA-5v7vA:
undetectable
6gtqB-5v7vA:
undetectable		 6gtqA-5v7vA:
13.54
6gtqB-5v7vA:
13.54