SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5v8c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_B_MTXB733_1
(THYMIDYLATE SYNTHASE)		 5v8c TRANSCRIPTIONAL
REGULATOR
(Actinomyces
oris) 		5 / 11 TRP A 254
ASP A 217
LEU A 222
GLY A 221
VAL A 215
 None
 1.36A 1axwB-5v8cA:
undetectable		 1axwB-5v8cA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 5v8c TRANSCRIPTIONAL
REGULATOR
(Actinomyces
oris) 		5 / 12 GLY A 282
SER A 286
LEU A 291
LEU A 204
LEU A 294
 None
 0.95A 1mx1C-5v8cA:
undetectable		 1mx1C-5v8cA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_F_THAF6_1
(LIVER
CARBOXYLESTERASE I)		 5v8c TRANSCRIPTIONAL
REGULATOR
(Actinomyces
oris) 		5 / 12 GLY A 282
SER A 286
LEU A 291
LEU A 204
LEU A 294
 None
 0.93A 1mx1F-5v8cA:
undetectable		 1mx1F-5v8cA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		 5v8c TRANSCRIPTIONAL
REGULATOR
(Actinomyces
oris) 		5 / 12 LEU A 134
LEU A 101
LEU A 189
MET A  88
TYR A 360
 None
 1.43A 1sqnA-5v8cA:
undetectable		 1sqnA-5v8cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_B_EDTB1511_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 5v8c TRANSCRIPTIONAL
REGULATOR
(Actinomyces
oris) 		4 / 8 MET A  88
ARG A  83
TRP A 100
THR A 186
 None
 1.43A 1zlqB-5v8cA:
undetectable		 1zlqB-5v8cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1003_0
(ALDEHYDE
DEHYDROGENASE A)		 5v8c TRANSCRIPTIONAL
REGULATOR
(Actinomyces
oris) 		4 / 5 ILE A 207
LEU A 232
ASP A 210
ALA A 276
 None
 1.03A 2opxA-5v8cA:
undetectable		 2opxA-5v8cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		 5v8c TRANSCRIPTIONAL
REGULATOR
(Actinomyces
oris) 		4 / 6 LEU A 355
LEU A 354
ILE A 184
ARG A 136
 None
 0.86A 2rlfC-5v8cA:
undetectable
2rlfD-5v8cA:
undetectable		 2rlfC-5v8cA:
15.19
2rlfD-5v8cA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		 5v8c TRANSCRIPTIONAL
REGULATOR
(Actinomyces
oris) 		5 / 12 LEU A 134
LEU A 101
LEU A 189
MET A  88
TYR A 360
 None
 1.44A 2w8yB-5v8cA:
undetectable		 2w8yB-5v8cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_A_NOGA1001_1
(PROGESTERONE
RECEPTOR)		 5v8c TRANSCRIPTIONAL
REGULATOR
(Actinomyces
oris) 		5 / 12 LEU A 134
LEU A 101
LEU A 189
MET A  88
TYR A 360
 None
 1.44A 3d90A-5v8cA:
undetectable		 3d90A-5v8cA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5v8c TRANSCRIPTIONAL
REGULATOR
(Actinomyces
oris) 		5 / 12 LEU A 147
LEU A 355
SER A 361
ILE A 153
THR A  99
 None
 1.05A 3hj3A-5v8cA:
undetectable		 3hj3A-5v8cA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 5v8c TRANSCRIPTIONAL
REGULATOR
(Actinomyces
oris) 		3 / 3 GLY A 317
TRP A 100
VAL A 135
 PE4  A 403 ( 3.9A)
None
None
 0.71A 3n62B-5v8cA:
undetectable		 3n62B-5v8cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N65_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 5v8c TRANSCRIPTIONAL
REGULATOR
(Actinomyces
oris) 		3 / 3 GLY A 317
TRP A 100
VAL A 135
 PE4  A 403 ( 3.9A)
None
None
 0.70A 3n65B-5v8cA:
undetectable		 3n65B-5v8cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 5v8c TRANSCRIPTIONAL
REGULATOR
(Actinomyces
oris) 		3 / 3 GLY A 317
TRP A 100
VAL A 135
 PE4  A 403 ( 3.9A)
None
None
 0.69A 3n66B-5v8cA:
undetectable		 3n66B-5v8cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_2
(CYTOCHROME P450 3A4)		 5v8c TRANSCRIPTIONAL
REGULATOR
(Actinomyces
oris) 		5 / 9 ILE A 332
LEU A 134
THR A  95
ARG A 352
GLY A 183
 None
 1.42A 3nxuB-5v8cA:
undetectable		 3nxuB-5v8cA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5v8c TRANSCRIPTIONAL
REGULATOR
(Actinomyces
oris) 		4 / 5 ASP A 333
ASN A 146
ILE A 132
VAL A 241
 None
 1.43A 4hytA-5v8cA:
undetectable		 4hytA-5v8cA:
6.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 5v8c TRANSCRIPTIONAL
REGULATOR
(Actinomyces
oris) 		5 / 12 LEU A 240
GLY A 221
PHE A 197
THR A 199
VAL A 273
 None
 1.42A 5d0yA-5v8cA:
undetectable		 5d0yA-5v8cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		 5v8c TRANSCRIPTIONAL
REGULATOR
(Actinomyces
oris) 		3 / 3 THR A 166
ALA A 177
ASN A 173
 None
 0.60A 5ersA-5v8cA:
undetectable		 5ersA-5v8cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_B_SAMB304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 5v8c TRANSCRIPTIONAL
REGULATOR
(Actinomyces
oris) 		5 / 10 THR A 174
LEU A 189
GLY A 170
ILE A 132
ALA A 129
 None
 1.01A 5l0zB-5v8cA:
undetectable		 5l0zB-5v8cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA602_0
(THIOCYANATE
DEHYDROGENASE)		 5v8c TRANSCRIPTIONAL
REGULATOR
(Actinomyces
oris) 		3 / 3 LYS A  78
HIS A 296
HIS A  79
 CO  A 401 (-2.8A)
CO  A 401 (-3.5A)
CO  A 401 (-3.3A)
 1.34A 5oexA-5v8cA:
undetectable		 5oexA-5v8cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC603_0
(THIOCYANATE
DEHYDROGENASE)		 5v8c TRANSCRIPTIONAL
REGULATOR
(Actinomyces
oris) 		3 / 3 LYS A  78
HIS A 296
HIS A  79
 CO  A 401 (-2.8A)
CO  A 401 (-3.5A)
CO  A 401 (-3.3A)
 1.35A 5oexC-5v8cA:
undetectable		 5oexC-5v8cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD603_0
(THIOCYANATE
DEHYDROGENASE)		 5v8c TRANSCRIPTIONAL
REGULATOR
(Actinomyces
oris) 		3 / 3 LYS A  78
HIS A 296
HIS A  79
 CO  A 401 (-2.8A)
CO  A 401 (-3.5A)
CO  A 401 (-3.3A)
 1.33A 5oexD-5v8cA:
undetectable		 5oexD-5v8cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5v8c TRANSCRIPTIONAL
REGULATOR
(Actinomyces
oris) 		3 / 3 GLY A 317
TRP A 100
VAL A 135
 PE4  A 403 ( 3.9A)
None
None
 0.70A 5vuoB-5v8cA:
undetectable		 5vuoB-5v8cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_C_RFPC502_1
(RIFAMPIN
MONOOXYGENASE)		 5v8c TRANSCRIPTIONAL
REGULATOR
(Actinomyces
oris) 		5 / 12 VAL A 135
MET A  88
VAL A  84
THR A 105
GLY A 104
 None
 1.15A 6brdC-5v8cA:
undetectable		 6brdC-5v8cA:
26.51