SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5v8f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E73_M_ASCM995_0
(MYROSINASE MA1)		 5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 5
(Saccharomyces
cerevisiae) 		4 / 6 ILE E 333
TYR E 473
PHE E 474
PHE E 350
 None
 1.29A 1e73M-5v8fE:
undetectable		 1e73M-5v8fE:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 5v8f DNA REPLICATION
LICENSING FACTOR
MCM7
(Saccharomyces
cerevisiae) 		5 / 12 VAL 7 410
VAL 7 437
ALA 7 645
ILE 7 642
ILE 7 476
 None
 1.00A 1epbA-5v8f7:
undetectable		 1epbA-5v8f7:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 5v8f DNA REPLICATION
LICENSING FACTOR
MCM7
(Saccharomyces
cerevisiae) 		5 / 12 VAL 7 410
VAL 7 437
ALA 7 645
ILE 7 642
ILE 7 476
 None
 0.96A 1epbB-5v8f7:
undetectable		 1epbB-5v8f7:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX9_A_REAA1163_1
(BETA-LACTOGLOBULIN)		 5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 564
VAL A 598
ILE A 459
ILE A 475
VAL A 492
 None
 1.38A 1gx9A-5v8fA:
undetectable		 1gx9A-5v8fA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KB9_A_PCFA514_0
(CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 3
(Saccharomyces
cerevisiae) 		4 / 8 ILE C 280
PHE C 281
VAL C 299
SER C 324
 None
 1.14A 1kb9A-5v8fC:
undetectable
1kb9C-5v8fC:
undetectable
1kb9D-5v8fC:
undetectable
1kb9E-5v8fC:
undetectable		 1kb9A-5v8fC:
22.01
1kb9C-5v8fC:
21.06
1kb9D-5v8fC:
17.52
1kb9E-5v8fC:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KB9_A_PCFA514_0
(CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 3
ORIGIN RECOGNITION
COMPLEX SUBUNIT 5
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 8 SER E 137
VAL C 139
MET C 142
SER C 146
 None
 0.93A 1kb9A-5v8fE:
undetectable
1kb9C-5v8fE:
undetectable
1kb9D-5v8fE:
undetectable
1kb9E-5v8fE:
undetectable		 1kb9A-5v8fE:
22.10
1kb9C-5v8fE:
21.96
1kb9D-5v8fE:
19.33
1kb9E-5v8fE:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 5v8f DNA REPLICATION
LICENSING FACTOR
MCM7
(Saccharomyces
cerevisiae) 		5 / 12 VAL 7 456
LEU 7 434
LEU 7 432
LEU 7 426
GLU 7 715
 None
 1.32A 1kw0A-5v8f7:
undetectable		 1kw0A-5v8f7:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 5v8f DNA REPLICATION
LICENSING FACTOR
MCM7
(Saccharomyces
cerevisiae) 		5 / 12 VAL 7 456
LEU 7 434
LEU 7 432
LEU 7 426
GLU 7 715
 None
 1.28A 1mmkA-5v8f7:
undetectable		 1mmkA-5v8f7:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 5v8f DNA REPLICATION
LICENSING FACTOR
MCM7
(Saccharomyces
cerevisiae) 		5 / 11 VAL 7 456
LEU 7 434
LEU 7 432
LEU 7 426
GLU 7 715
 None
 1.29A 1mmtA-5v8f7:
undetectable		 1mmtA-5v8f7:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA733_1
(ALPHA AMYLASE)		 5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 1
ORIGIN RECOGNITION
COMPLEX SUBUNIT 5
(Saccharomyces
cerevisiae) 		4 / 6 SER E 180
ASN A 871
LEU A 874
ASP A 875
 None
 1.10A 1mxdA-5v8fE:
undetectable		 1mxdA-5v8fE:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)		 5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 1
ORIGIN RECOGNITION
COMPLEX SUBUNIT 5
(Saccharomyces
cerevisiae) 		4 / 8 SER E 180
ASN A 871
LEU A 874
ASP A 875
 None
 1.09A 1mxgA-5v8fE:
undetectable		 1mxgA-5v8fE:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5v8f DNA REPLICATION
LICENSING FACTOR
MCM7
(Saccharomyces
cerevisiae) 		4 / 6 LEU 7 469
VAL 7 540
ILE 7 523
ARG 7 560
 None
 1.01A 1opjB-5v8f7:
undetectable		 1opjB-5v8f7:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_A_MTXA351_1
(PTERIDINE REDUCTASE
1)		 5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 3
(Saccharomyces
cerevisiae) 		5 / 12 SER C 235
PHE C 203
LEU C 150
LEU C 185
LEU C 222
 None
 1.37A 1p33A-5v8fC:
undetectable		 1p33A-5v8fC:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		 5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 3
ORIGIN RECOGNITION
COMPLEX SUBUNIT 5
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 ASP C 207
GLU E 426
TYR E 443
 None
 0.74A 1wsvA-5v8fC:
undetectable		 1wsvA-5v8fC:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 5v8f DNA REPLICATION
LICENSING FACTOR
MCM7
(Saccharomyces
cerevisiae) 		4 / 7 ALA 7 567
ASP 7 527
ILE 7 523
ASP 7 524
 None
 0.99A 1yc5A-5v8f7:
undetectable		 1yc5A-5v8f7:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)		 5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 5
(Saccharomyces
cerevisiae) 		5 / 12 SER E 412
ALA E 334
ILE E 337
ILE E 389
ALA E 392
 None
 1.07A 2bxcA-5v8fE:
undetectable		 2bxcA-5v8fE:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		 5v8f DNA REPLICATION
LICENSING FACTOR
MCM7
(Saccharomyces
cerevisiae) 		4 / 6 ASP 7 453
SER 7 562
LEU 7 434
GLY 7 438
 None
 1.02A 2j2pA-5v8f7:
undetectable
2j2pC-5v8f7:
undetectable		 2j2pA-5v8f7:
12.82
2j2pC-5v8f7:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2MJI_A_KTRA201_1
(FATTY ACID-BINDING
PROTEIN, INTESTINAL)		 5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 3
(Saccharomyces
cerevisiae) 		5 / 12 ILE C 597
TYR C 528
LEU C 527
PHE C 540
TYR C 541
 None
 1.35A 2mjiA-5v8fC:
undetectable		 2mjiA-5v8fC:
11.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_C_SNLC3001_1
(MINERALOCORTICOID
RECEPTOR)		 5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 3
(Saccharomyces
cerevisiae) 		5 / 12 LEU C 128
ASN C 126
ALA C 200
LEU C 223
LEU C 150
 None
 1.47A 2oaxC-5v8fC:
undetectable		 2oaxC-5v8fC:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OK6_D_BEZD2002_0
(AROMATIC AMINE
DEHYDROGENASE, LARGE
SUBUNIT
AROMATIC AMINE
DEHYDROGENASE, SMALL
SUBUNIT)		 5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 3
(Saccharomyces
cerevisiae) 		5 / 9 LEU C 432
ASN C 278
GLN C 282
GLY C 277
LEU C 317
 None
 1.48A 2ok6B-5v8fC:
undetectable
2ok6D-5v8fC:
undetectable		 2ok6B-5v8fC:
19.75
2ok6D-5v8fC:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OK6_H_BEZH2001_0
(AROMATIC AMINE
DEHYDROGENASE, LARGE
SUBUNIT
AROMATIC AMINE
DEHYDROGENASE, SMALL
SUBUNIT)		 5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 3
(Saccharomyces
cerevisiae) 		5 / 10 LEU C 432
ASN C 278
GLN C 282
GLY C 277
LEU C 317
 None
 1.48A 2ok6A-5v8fC:
undetectable
2ok6H-5v8fC:
undetectable		 2ok6A-5v8fC:
19.75
2ok6H-5v8fC:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		 5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 3
ORIGIN RECOGNITION
COMPLEX SUBUNIT 5
(Saccharomyces
cerevisiae) 		4 / 7 SER C 254
ARG C 257
PHE E 256
ILE E 255
 None
None
AGS  E2001 (-4.8A)
None
 1.22A 2qb4A-5v8fC:
undetectable		 2qb4A-5v8fC:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA803_0
(FERROCHELATASE)		 5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 5
(Saccharomyces
cerevisiae) 		4 / 5 LEU E 108
PRO E 105
LEU E  74
ILE E  77
 None
 0.75A 2qd4A-5v8fE:
undetectable		 2qd4A-5v8fE:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		 5v8f DNA REPLICATION
LICENSING FACTOR
MCM7
(Saccharomyces
cerevisiae) 		4 / 6 ARG 7 687
PHE 7 594
ILE 7 563
PHE 7 526
 AGS  72001 (-2.3A)
None
None
None
 0.99A 2qeiA-5v8f7:
undetectable		 2qeiA-5v8f7:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		 5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 3
ORIGIN RECOGNITION
COMPLEX SUBUNIT 5
(Saccharomyces
cerevisiae) 		4 / 6 SER C 254
ARG C 257
PHE E 256
ILE E 255
 None
None
AGS  E2001 (-4.8A)
None
 1.22A 2qeiA-5v8fC:
undetectable		 2qeiA-5v8fC:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)		 5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 2
ORIGIN RECOGNITION
COMPLEX SUBUNIT 3
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 10 VAL B 319
GLY B 320
ASP B 457
GLY C 595
LEU C 596
 None
 0.96A 2v3kA-5v8fB:
undetectable		 2v3kA-5v8fB:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB7_A_NCAA901_0
(PROSTAGLANDIN
REDUCTASE 2)		 5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 5
(Saccharomyces
cerevisiae) 		4 / 5 TYR E 322
ILE E 458
LEU E 332
LEU E 432
 None
 1.14A 2zb7A-5v8fE:
undetectable		 2zb7A-5v8fE:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZSE_A_PAUA600_0
(PANTOTHENATE KINASE)		 5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 5
(Saccharomyces
cerevisiae) 		4 / 7 TYR E 168
PHE E 175
ILE E  34
ASN E  32
 None
 1.12A 2zseA-5v8fE:
undetectable		 2zseA-5v8fE:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB6_0
(FERROCHELATASE)		 5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 2
(Saccharomyces
cerevisiae) 		5 / 12 LEU B 441
PHE B 437
LEU B 427
ILE B 379
SER B 455
 None
 1.27A 3aqiB-5v8fB:
undetectable		 3aqiB-5v8fB:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		 5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 3
ORIGIN RECOGNITION
COMPLEX SUBUNIT 5
(Saccharomyces
cerevisiae) 		5 / 12 GLY E 252
SER E  39
VAL E 197
ALA E 257
SER C 254
 None
 1.11A 3d91B-5v8fE:
undetectable		 3d91B-5v8fE:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_1
(PCZA361.24)		 5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 3
(Saccharomyces
cerevisiae) 		3 / 3 ARG C 124
GLU C 121
ASP C  77
 None
 0.93A 3g2oA-5v8fC:
undetectable		 3g2oA-5v8fC:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_1
(PCZA361.24)		 5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 3
(Saccharomyces
cerevisiae) 		3 / 3 ARG C 124
GLU C 121
ASP C  82
 None
 0.87A 3g2oA-5v8fC:
undetectable		 3g2oA-5v8fC:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_E_NIOE5660_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 3
(Saccharomyces
cerevisiae) 		3 / 3 GLU C 416
GLU C 415
TRP C 443
 None
 1.18A 3hrdA-5v8fC:
undetectable
3hrdE-5v8fC:
undetectable
3hrdF-5v8fC:
undetectable		 3hrdA-5v8fC:
20.73
3hrdE-5v8fC:
20.73
3hrdF-5v8fC:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_A_4CHA191_0
(DEHALOPEROXIDASE A)		 5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 2
(Saccharomyces
cerevisiae) 		4 / 6 PHE B 316
PHE B 325
HIS B 425
VAL B 453
 None
 1.27A 3lb3A-5v8fB:
undetectable		 3lb3A-5v8fB:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_B_4CHB192_0
(DEHALOPEROXIDASE A)		 5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 2
(Saccharomyces
cerevisiae) 		4 / 6 PHE B 316
PHE B 325
HIS B 425
VAL B 453
 None
 1.27A 3lb3B-5v8fB:
undetectable		 3lb3B-5v8fB:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		 5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 3
(Saccharomyces
cerevisiae) 		3 / 3 ASP C 217
ASN C 214
SER C 254
 None
 0.99A 3lslA-5v8fC:
undetectable
3lslD-5v8fC:
undetectable		 3lslA-5v8fC:
18.79
3lslD-5v8fC:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		 5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 3
(Saccharomyces
cerevisiae) 		3 / 3 SER C 254
ASP C 217
ASN C 214
 None
 0.97A 3lslA-5v8fC:
undetectable
3lslD-5v8fC:
undetectable		 3lslA-5v8fC:
18.79
3lslD-5v8fC:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_A_PFLA319_1
(GLR4197 PROTEIN)		 5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 2
ORIGIN RECOGNITION
COMPLEX SUBUNIT 3
(Saccharomyces
cerevisiae) 		4 / 7 ILE B 401
LEU B 402
THR C 113
ILE C 116
 None
 0.99A 3p50A-5v8fB:
undetectable		 3p50A-5v8fB:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		 5v8f DNA REPLICATION
LICENSING FACTOR
MCM7
(Saccharomyces
cerevisiae) 		5 / 11 LEU 7 590
SER 7 592
THR 7 685
THR 7 688
GLY 7 691
 None
AGS  72001 ( 4.9A)
None
None
None
 1.45A 3sfuC-5v8f7:
undetectable		 3sfuC-5v8f7:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_2
(SECRETED ASPARTIC
PROTEASE)		 5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 5
(Saccharomyces
cerevisiae) 		4 / 6 TYR E  13
VAL E 187
THR E   5
THR E   4
 None
 1.15A 3tneA-5v8fE:
undetectable		 3tneA-5v8fE:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U88_A_CHDA611_0
(MENIN)		 5v8f DNA REPLICATION
LICENSING FACTOR
MCM7
(Saccharomyces
cerevisiae) 		3 / 3 SER 7 249
PHE 7 310
LYS 7 252
 None
 0.98A 3u88A-5v8f7:
undetectable		 3u88A-5v8f7:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 5 SER A 700
GLY A 701
THR A 625
VAL A 483
 None
None
None
AGS  A2001 (-4.9A)
 1.08A 4eohA-5v8fA:
undetectable		 4eohA-5v8fA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 5
(Saccharomyces
cerevisiae) 		4 / 4 LEU E 108
PRO E 105
LEU E  74
ILE E  77
 None
 0.79A 4f4dB-5v8fE:
undetectable		 4f4dB-5v8fE:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 5
(Saccharomyces
cerevisiae) 		4 / 5 LEU E 108
PRO E 105
LEU E  74
ILE E  77
 None
 0.78A 4klrA-5v8fE:
undetectable		 4klrA-5v8fE:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 5v8f DNA REPLICATION
LICENSING FACTOR
MCM7
(Saccharomyces
cerevisiae) 		4 / 8 ASP 7 101
SER 7 104
ALA 7 219
SER 7 221
 None
 1.12A 4lv9A-5v8f7:
undetectable
4lv9B-5v8f7:
undetectable		 4lv9A-5v8f7:
21.34
4lv9B-5v8f7:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 5v8f DNA REPLICATION
LICENSING FACTOR
MCM7
(Saccharomyces
cerevisiae) 		4 / 7 ASP 7 101
SER 7 104
ALA 7 219
SER 7 221
 None
 1.17A 4lv9A-5v8f7:
undetectable
4lv9B-5v8f7:
undetectable		 4lv9A-5v8f7:
21.34
4lv9B-5v8f7:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 5v8f DNA REPLICATION
LICENSING FACTOR
MCM7
(Saccharomyces
cerevisiae) 		4 / 7 TYR 7 574
GLN 7 683
THR 7 685
THR 7 688
 None
 1.05A 4mbsA-5v8f7:
undetectable		 4mbsA-5v8f7:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_3
(PROTEASE)		 5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 2
ORIGIN RECOGNITION
COMPLEX SUBUNIT 3
ORIGIN RECOGNITION
COMPLEX SUBUNIT 5
(Saccharomyces
cerevisiae) 		3 / 3 ASP C 111
ASP B 466
ASN E 423
 None
 0.65A 4q5mA-5v8fC:
undetectable		 4q5mA-5v8fC:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_1
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 5
(Saccharomyces
cerevisiae) 		3 / 3 SER E 294
TYR E 250
ASP E 297
 None
 0.89A 4rp8C-5v8fE:
undetectable		 4rp8C-5v8fE:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 5v8f DNA REPLICATION
LICENSING FACTOR
MCM7
(Saccharomyces
cerevisiae) 		5 / 12 ILE 7 121
ALA 7  65
ARG 7 199
VAL 7  78
ILE 7  80
 None
 1.10A 4rvdA-5v8f7:
undetectable		 4rvdA-5v8f7:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 5v8f DNA REPLICATION
LICENSING FACTOR
MCM7
(Saccharomyces
cerevisiae) 		5 / 12 ILE 7 121
ALA 7  65
ARG 7 199
VAL 7  78
ILE 7  80
 None
 1.14A 4rvgA-5v8f7:
undetectable		 4rvgA-5v8f7:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2Q_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 5v8f DNA REPLICATION
LICENSING FACTOR
MCM7
(Saccharomyces
cerevisiae) 		3 / 3 ASN 7 210
SER 7 395
ARG 7 400
 None
 0.83A 5b2qA-5v8f7:
undetectable		 5b2qA-5v8f7:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2S_A_ACTA107_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 5v8f DNA REPLICATION
LICENSING FACTOR
MCM7
(Saccharomyces
cerevisiae) 		3 / 3 VAL 7 633
THR 7 631
ARG 7 413
 None
 0.75A 5b2sB-5v8f7:
undetectable		 5b2sB-5v8f7:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 5
(Saccharomyces
cerevisiae) 		4 / 8 PHE E 390
SER E 335
ALA E 334
LEU E 387
 None
 0.94A 5dzkd-5v8fE:
undetectable
5dzkr-5v8fE:
undetectable		 5dzkd-5v8fE:
18.94
5dzkr-5v8fE:
2.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 5
(Saccharomyces
cerevisiae) 		4 / 8 PHE E 390
SER E 335
ALA E 334
LEU E 387
 None
 0.96A 5dzkF-5v8fE:
undetectable
5dzkT-5v8fE:
undetectable		 5dzkF-5v8fE:
18.94
5dzkT-5v8fE:
2.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_2
(FK506-BINDING
PROTEIN 1)		 5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 2
(Saccharomyces
cerevisiae) 		5 / 11 PHE B 437
VAL B 375
ILE B 379
ILE B 450
ILE B 447
 None
 1.19A 5hw8G-5v8fB:
undetectable		 5hw8G-5v8fB:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_A_GBMA801_1
(PROLINE--TRNA LIGASE)		 5v8f DNA REPLICATION
LICENSING FACTOR
MCM7
(Saccharomyces
cerevisiae) 		5 / 12 LEU 7 343
ARG 7 242
ILE 7 315
GLY 7 243
ILE 7 244
 None
 1.22A 5ifuA-5v8f7:
undetectable		 5ifuA-5v8f7:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 2
(Saccharomyces
cerevisiae) 		4 / 6 ASP B 428
ARG B 323
ASN B 324
ASN B 426
 None
 1.16A 5l6eA-5v8fB:
undetectable		 5l6eA-5v8fB:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 5v8f DNA REPLICATION
LICENSING FACTOR
MCM7
(Saccharomyces
cerevisiae) 		5 / 12 HIS 7 334
SER 7 249
THR 7 352
GLY 7 337
LEU 7 339
 None
 1.22A 5m50B-5v8f7:
undetectable		 5m50B-5v8f7:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 5v8f DNA REPLICATION
LICENSING FACTOR
MCM7
(Saccharomyces
cerevisiae) 		5 / 12 HIS 7 334
SER 7 249
THR 7 352
GLY 7 337
LEU 7 339
 None
 1.22A 5m50E-5v8f7:
undetectable		 5m50E-5v8f7:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5v8f DNA REPLICATION
LICENSING FACTOR
MCM7
(Saccharomyces
cerevisiae) 		4 / 4 GLN 7 543
THR 7 545
THR 7 535
LEU 7 493
 None
 1.22A 5m5kA-5v8f7:
undetectable		 5m5kA-5v8f7:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA511_1
(PROTON-GATED ION
CHANNEL)		 5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 5
(Saccharomyces
cerevisiae) 		4 / 8 ILE E 349
ILE E 389
ALA E 392
ILE E 393
 None
 0.74A 5mvmA-5v8fE:
undetectable
5mvmB-5v8fE:
undetectable		 5mvmA-5v8fE:
10.45
5mvmB-5v8fE:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_A_SAMA901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 3
(Saccharomyces
cerevisiae) 		5 / 12 LEU C 285
HIS C 405
SER C 304
ILE C 433
ASP C 437
 None
 1.26A 6bxnA-5v8fC:
undetectable		 6bxnA-5v8fC:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5v8f DNA REPLICATION
LICENSING FACTOR
MCM7
(Saccharomyces
cerevisiae) 		5 / 10 MET 7 600
SER 7 723
ASP 7 427
PRO 7 580
SER 7 726
 None
 1.02A 6dlzB-5v8f7:
undetectable
6dlzC-5v8f7:
undetectable		 6dlzB-5v8f7:
6.52
6dlzC-5v8f7:
6.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5v8f DNA REPLICATION
LICENSING FACTOR
MCM7
(Saccharomyces
cerevisiae) 		5 / 11 PRO 7 580
SER 7 726
MET 7 600
SER 7 723
ASP 7 427
 None
 1.02A 6dlzA-5v8f7:
2.6
6dlzD-5v8f7:
undetectable		 6dlzA-5v8f7:
6.52
6dlzD-5v8f7:
6.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5v8f DNA REPLICATION
LICENSING FACTOR
MCM7
(Saccharomyces
cerevisiae) 		5 / 10 MET 7 600
SER 7 723
ASP 7 427
PRO 7 580
SER 7 726
 None
 1.03A 6dm1B-5v8f7:
undetectable
6dm1C-5v8f7:
undetectable		 6dm1B-5v8f7:
6.52
6dm1C-5v8f7:
6.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5v8f DNA REPLICATION
LICENSING FACTOR
MCM7
(Saccharomyces
cerevisiae) 		5 / 11 PRO 7 580
SER 7 726
MET 7 600
SER 7 723
ASP 7 427
 None
 1.02A 6dm1A-5v8f7:
2.3
6dm1D-5v8f7:
undetectable		 6dm1A-5v8f7:
6.52
6dm1D-5v8f7:
6.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5v8f DNA REPLICATION
LICENSING FACTOR
MCM7
(Saccharomyces
cerevisiae) 		5 / 10 MET 7 600
SER 7 723
ASP 7 427
PRO 7 580
SER 7 726
 None
 1.02A 6dm2B-5v8f7:
undetectable
6dm2C-5v8f7:
undetectable		 6dm2B-5v8f7:
6.52
6dm2C-5v8f7:
6.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5v8f DNA REPLICATION
LICENSING FACTOR
MCM7
(Saccharomyces
cerevisiae) 		5 / 10 PRO 7 580
SER 7 726
MET 7 600
SER 7 723
ASP 7 427
 None
 1.02A 6dm2A-5v8f7:
undetectable
6dm2D-5v8f7:
undetectable		 6dm2A-5v8f7:
6.52
6dm2D-5v8f7:
6.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 3
(Saccharomyces
cerevisiae) 		3 / 3 LEU C  60
GLN C  63
LYS C 291
 None
 0.86A 6exiB-5v8fC:
undetectable		 6exiB-5v8fC:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_0
(ADENOSYLHOMOCYSTEINA
SE)		 5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 3
(Saccharomyces
cerevisiae) 		3 / 3 LEU C  60
GLN C  63
LYS C 291
 None
 0.87A 6exiA-5v8fC:
undetectable		 6exiA-5v8fC:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA826_0
(GEPHYRIN)		 5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 3
(Saccharomyces
cerevisiae) 		3 / 3 HIS C 405
ARG C 398
ILE C 402
 None
 0.85A 6fgdA-5v8fC:
undetectable		 6fgdA-5v8fC:
19.56