SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5v8j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		 5v8j CYCLIC GMP-AMP
SYNTHASE
(Homo
sapiens) 		5 / 11 ALA A 323
LEU A 322
LEU A 324
LEU A 262
ALA A 273
 None
 1.15A 1h9zA-5v8jA:
undetectable		 1h9zA-5v8jA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_1
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 5v8j CYCLIC GMP-AMP
SYNTHASE
(Homo
sapiens) 		3 / 3 ARG A 353
ARG A 349
ILE A 386
 None
 0.61A 1uobA-5v8jA:
undetectable		 1uobA-5v8jA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5v8j CYCLIC GMP-AMP
SYNTHASE
(Homo
sapiens) 		4 / 6 PHE A 519
VAL A 168
LEU A 172
PHE A 464
 None
 1.05A 1wrlB-5v8jA:
undetectable		 1wrlB-5v8jA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB928_0
(FERROCHELATASE)		 5v8j CYCLIC GMP-AMP
SYNTHASE
(Homo
sapiens) 		5 / 12 LEU A 377
PHE A 379
LEU A 359
ARG A 353
VAL A 234
 None
 1.31A 2qd4B-5v8jA:
undetectable		 2qd4B-5v8jA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 5v8j CYCLIC GMP-AMP
SYNTHASE
(Homo
sapiens) 		5 / 12 CYH A 474
PHE A 471
LEU A 495
ILE A 496
LEU A 504
 None
 1.26A 4k38B-5v8jA:
undetectable		 4k38B-5v8jA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 5v8j CYCLIC GMP-AMP
SYNTHASE
(Homo
sapiens) 		4 / 7 LYS A 173
TYR A 415
LEU A 412
PHE A 464
 None
 1.24A 4yv5B-5v8jA:
undetectable		 4yv5B-5v8jA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)		 5v8j CYCLIC GMP-AMP
SYNTHASE
(Homo
sapiens) 		4 / 6 ALA A 222
SER A 221
SER A 435
ASP A 227
 None
 1.05A 5c6pA-5v8jA:
undetectable		 5c6pA-5v8jA:
20.38