SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5v8w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AW1_A_COXA264_1
(CARBONIC ANHYDRASE
II)		 5v8w INTEGRATOR COMPLEX
SUBUNIT 9
(Homo
sapiens) 		5 / 12 ILE A 635
LEU A 619
VAL A 617
LEU A 598
THR A 597
 None
 1.00A 2aw1A-5v8wA:
undetectable		 2aw1A-5v8wA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA508_0
(CHORISMATE SYNTHASE)		 5v8w INTEGRATOR COMPLEX
SUBUNIT 9
(Homo
sapiens) 		4 / 5 LEU A 643
ARG A 644
ALA A 622
ILE A 635
 None
 1.14A 2qhfA-5v8wA:
undetectable		 2qhfA-5v8wA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)		 5v8w INTEGRATOR COMPLEX
SUBUNIT 9
INTEGRATOR COMPLEX
SUBUNIT 11
(Homo
sapiens;
Homo
sapiens) 		4 / 6 GLN B 497
LEU B 499
GLU B 496
LEU A 584
 None
 0.82A 3h5gA-5v8wB:
undetectable
3h5gC-5v8wB:
undetectable		 3h5gA-5v8wB:
17.43
3h5gC-5v8wB:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC2_1
(CYTOCHROME P450 2D6)		 5v8w INTEGRATOR COMPLEX
SUBUNIT 9
(Homo
sapiens) 		5 / 10 THR A 624
LEU A 598
THR A 597
LEU A 643
VAL A 645
 None
 1.30A 3tbgC-5v8wA:
undetectable		 3tbgC-5v8wA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		 5v8w INTEGRATOR COMPLEX
SUBUNIT 9
(Homo
sapiens) 		5 / 12 VAL A 608
THR A 597
PHE A 654
ILE A 589
PHE A 594
 None
 1.40A 5hgcA-5v8wA:
undetectable		 5hgcA-5v8wA:
15.60