SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5v91'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA141_0
(LYSOZYME C)		 5v91 FOSFOMYCIN
RESISTANCE PROTEIN
(Klebsiella
pneumoniae) 		4 / 6 GLY A 109
THR A  58
PRO A  59
SER A  63
 None
 0.95A 1n4fA-5v91A:
undetectable		 1n4fA-5v91A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 5v91 FOSFOMYCIN
RESISTANCE PROTEIN
(Klebsiella
pneumoniae) 		4 / 7 LEU A  25
GLN A  24
LEU A  84
PHE A 104
 None
 1.09A 1v55C-5v91A:
undetectable
1v55J-5v91A:
undetectable		 1v55C-5v91A:
20.65
1v55J-5v91A:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5v91 FOSFOMYCIN
RESISTANCE PROTEIN
(Klebsiella
pneumoniae) 		4 / 7 LEU A  25
GLN A  24
LEU A  84
PHE A 104
 None
 1.05A 2eijC-5v91A:
undetectable
2eijJ-5v91A:
undetectable		 2eijC-5v91A:
20.65
2eijJ-5v91A:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5v91 FOSFOMYCIN
RESISTANCE PROTEIN
(Klebsiella
pneumoniae) 		4 / 7 LEU A  25
GLN A  24
LEU A  84
PHE A 104
 None
 1.03A 2eimC-5v91A:
undetectable
2eimJ-5v91A:
undetectable		 2eimC-5v91A:
20.65
2eimJ-5v91A:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5v91 FOSFOMYCIN
RESISTANCE PROTEIN
(Klebsiella
pneumoniae) 		4 / 7 LEU A  25
GLN A  24
LEU A  84
PHE A 104
 None
 1.05A 2einC-5v91A:
undetectable
2einJ-5v91A:
undetectable		 2einC-5v91A:
20.65
2einJ-5v91A:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5v91 FOSFOMYCIN
RESISTANCE PROTEIN
(Klebsiella
pneumoniae) 		4 / 6 LEU A  25
GLN A  24
LEU A  84
PHE A 104
 None
 1.08A 2einP-5v91A:
undetectable
2einW-5v91A:
undetectable		 2einP-5v91A:
20.65
2einW-5v91A:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0I_A_BEZA990_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 5v91 FOSFOMYCIN
RESISTANCE PROTEIN
(Klebsiella
pneumoniae) 		4 / 8 ASP A 106
LEU A 112
HIS A 110
LEU A   8
 None
 1.07A 2q0iA-5v91A:
undetectable		 2q0iA-5v91A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 5v91 FOSFOMYCIN
RESISTANCE PROTEIN
(Klebsiella
pneumoniae) 		5 / 12 LEU A   8
PHE A  21
LEU A 114
ASP A 106
PHE A  80
 None
 1.35A 3tbgA-5v91A:
undetectable		 3tbgA-5v91A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 5v91 FOSFOMYCIN
RESISTANCE PROTEIN
(Klebsiella
pneumoniae) 		5 / 12 TYR A  22
LEU A  47
PHE A  70
LEU A 105
LEU A 112
 None
 0.90A 3vw7A-5v91A:
undetectable		 3vw7A-5v91A:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)		 5v91 FOSFOMYCIN
RESISTANCE PROTEIN
(Klebsiella
pneumoniae) 		4 / 5 ILE A  72
ALA A  81
HIS A 115
ARG A  96
 None
 0.99A 4ac9B-5v91A:
undetectable
4ac9C-5v91A:
undetectable		 4ac9B-5v91A:
14.70
4ac9C-5v91A:
14.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JD1_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 5v91 FOSFOMYCIN
RESISTANCE PROTEIN
(Klebsiella
pneumoniae) 		5 / 12 TYR A  65
HIS A  67
TYR A 103
GLU A 113
TYR A 131
 None
ZN  A 201 (-3.2A)
None
ZN  A 201 (-2.3A)
None
 1.42A 4jd1A-5v91A:
15.6
4jd1B-5v91A:
15.6		 4jd1A-5v91A:
32.21
4jd1B-5v91A:
32.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JD1_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 5v91 FOSFOMYCIN
RESISTANCE PROTEIN
(Klebsiella
pneumoniae) 		5 / 12 TYR A 131
TYR A  65
HIS A  67
TYR A 103
GLU A 113
 None
None
ZN  A 201 (-3.2A)
None
ZN  A 201 (-2.3A)
 1.41A 4jd1A-5v91A:
15.6
4jd1B-5v91A:
15.6		 4jd1A-5v91A:
32.21
4jd1B-5v91A:
32.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JH3_A_FCNA204_1
(METALLOTHIOL
TRANSFERASE FOSB)		 5v91 FOSFOMYCIN
RESISTANCE PROTEIN
(Klebsiella
pneumoniae) 		5 / 12 TYR A  65
HIS A  67
TYR A 103
GLU A 113
TYR A 131
 None
ZN  A 201 (-3.2A)
None
ZN  A 201 (-2.3A)
None
 1.40A 4jh3A-5v91A:
16.5
4jh3B-5v91A:
16.7		 4jh3A-5v91A:
38.57
4jh3B-5v91A:
38.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 5v91 FOSFOMYCIN
RESISTANCE PROTEIN
(Klebsiella
pneumoniae) 		5 / 12 ASP A 106
ASP A 108
HIS A 110
PHE A  70
PHE A 104
 None
 1.41A 4wh5A-5v91A:
3.3		 4wh5A-5v91A:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5v91 FOSFOMYCIN
RESISTANCE PROTEIN
(Klebsiella
pneumoniae) 		4 / 7 LEU A  25
GLN A  24
LEU A  84
PHE A 104
 None
 1.00A 5b1bP-5v91A:
undetectable
5b1bW-5v91A:
undetectable		 5b1bP-5v91A:
20.65
5b1bW-5v91A:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OTR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5v91 FOSFOMYCIN
RESISTANCE PROTEIN
(Klebsiella
pneumoniae) 		4 / 5 VAL A  12
ASP A  52
PRO A  53
ALA A  11
 None
 1.10A 5otrA-5v91A:
undetectable		 5otrA-5v91A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5v91 FOSFOMYCIN
RESISTANCE PROTEIN
(Klebsiella
pneumoniae) 		4 / 8 HIS A 110
PHE A  21
MET A  28
LEU A  84
 None
 1.07A 5y2tB-5v91A:
undetectable		 5y2tB-5v91A:
undetectable