SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5v96'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D4F_A_ADNA601_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 12 HIS A  59
ASP A 136
LYS A 227
ASP A 231
LEU A 389
 ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.7A)
 1.30A 1d4fA-5v96A:
56.0		 1d4fA-5v96A:
57.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D4F_A_ADNA601_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		12 / 12 LEU A  58
HIS A  59
THR A  61
GLU A  63
ASP A 136
LYS A 227
ASP A 231
LEU A 386
LEU A 389
GLY A 394
MET A 400
PHE A 404
 None
ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.6A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.30A 1d4fA-5v96A:
56.0		 1d4fA-5v96A:
57.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D4F_A_ADNA601_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		4 / 5 THR A  64
GLU A 197
THR A 198
HIS A 395
 ADN  A 502 (-4.4A)
ADN  A 502 (-3.5A)
NAD  A 501 ( 2.9A)
ADN  A 502 ( 3.4A)
 0.55A 1d4fA-5v96A:
56.0		 1d4fA-5v96A:
57.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D4F_B_ADNB602_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 12 HIS A  59
ASP A 136
LYS A 227
ASP A 231
LEU A 389
 ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.7A)
 1.38A 1d4fB-5v96A:
56.1		 1d4fB-5v96A:
57.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D4F_B_ADNB602_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		11 / 12 LEU A  58
HIS A  59
GLU A  63
ASP A 136
LYS A 227
ASP A 231
LEU A 386
LEU A 389
GLY A 394
MET A 400
PHE A 404
 None
ADN  A 502 ( 3.9A)
ADN  A 502 (-3.6A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.35A 1d4fB-5v96A:
56.1		 1d4fB-5v96A:
57.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D4F_B_ADNB602_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 5 THR A  61
THR A  64
GLU A 197
THR A 198
HIS A 395
 ADN  A 502 (-2.9A)
ADN  A 502 (-4.4A)
ADN  A 502 (-3.5A)
NAD  A 501 ( 2.9A)
ADN  A 502 ( 3.4A)
 0.61A 1d4fB-5v96A:
56.1		 1d4fB-5v96A:
57.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D4F_C_ADNC603_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		12 / 12 LEU A  58
HIS A  59
THR A  61
GLU A  63
ASP A 136
LYS A 227
ASP A 231
LEU A 386
GLY A 394
HIS A 395
MET A 400
PHE A 404
 None
ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.6A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.32A 1d4fC-5v96A:
29.1		 1d4fC-5v96A:
57.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D4F_C_ADNC603_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		4 / 5 THR A  64
GLU A 197
THR A 198
LEU A 389
 ADN  A 502 (-4.4A)
ADN  A 502 (-3.5A)
NAD  A 501 ( 2.9A)
ADN  A 502 ( 4.7A)
 0.54A 1d4fC-5v96A:
29.1		 1d4fC-5v96A:
57.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D4F_D_ADND604_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		12 / 12 LEU A  58
HIS A  59
THR A  61
GLU A  63
ASP A 136
LYS A 227
ASP A 231
LEU A 386
LEU A 389
GLY A 394
MET A 400
PHE A 404
 None
ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.6A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.36A 1d4fD-5v96A:
55.8		 1d4fD-5v96A:
57.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D4F_D_ADND604_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		4 / 5 THR A  64
GLU A 197
THR A 198
HIS A 395
 ADN  A 502 (-4.4A)
ADN  A 502 (-3.5A)
NAD  A 501 ( 2.9A)
ADN  A 502 ( 3.4A)
 0.65A 1d4fD-5v96A:
55.8		 1d4fD-5v96A:
57.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_B_FOLB187_0
(DIHYDROFOLATE
REDUCTASE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 12 ILE A 336
THR A 315
ILE A 340
ASN A 388
LEU A 240
 None
None
NAD  A 501 (-4.4A)
NAD  A 501 (-3.1A)
None
 1.18A 1dhfB-5v96A:
3.6		 1dhfB-5v96A:
17.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V8B_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 12 ASP A 136
LYS A 227
ASP A 231
LEU A 386
HIS A 395
 ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 3.4A)
 1.31A 1v8bA-5v96A:
60.9		 1v8bA-5v96A:
55.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V8B_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		12 / 12 LEU A  58
HIS A  59
THR A  61
ASP A 136
THR A 198
LYS A 227
ASP A 231
LEU A 389
GLY A 394
HIS A 395
MET A 400
PHE A 404
 None
ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
NAD  A 501 ( 2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.27A 1v8bA-5v96A:
60.9		 1v8bA-5v96A:
55.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V8B_B_ADNB1502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		6 / 12 HIS A  59
ASP A 136
LYS A 227
ASP A 231
LEU A 386
HIS A 395
 ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 3.4A)
 1.46A 1v8bB-5v96A:
60.8		 1v8bB-5v96A:
55.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V8B_B_ADNB1502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		12 / 12 LEU A  58
HIS A  59
THR A  61
ASP A 136
THR A 198
LYS A 227
ASP A 231
LEU A 389
GLY A 394
HIS A 395
MET A 400
PHE A 404
 None
ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
NAD  A 501 ( 2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.26A 1v8bB-5v96A:
60.8		 1v8bB-5v96A:
55.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V8B_C_ADNC2502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		6 / 12 HIS A  59
ASP A 136
LYS A 227
ASP A 231
LEU A 386
HIS A 395
 ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 3.4A)
 1.47A 1v8bC-5v96A:
61.0		 1v8bC-5v96A:
55.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V8B_C_ADNC2502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		12 / 12 LEU A  58
HIS A  59
THR A  61
GLU A  63
ASP A 136
LYS A 227
ASP A 231
LEU A 389
GLY A 394
HIS A 395
MET A 400
PHE A 404
 None
ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.6A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.26A 1v8bC-5v96A:
61.0		 1v8bC-5v96A:
55.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V8B_C_ADNC2502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		3 / 3 GLU A 197
THR A 198
LEU A 386
 ADN  A 502 (-3.5A)
NAD  A 501 ( 2.9A)
NAD  A 501 (-3.9A)
 0.18A 1v8bC-5v96A:
61.0		 1v8bC-5v96A:
55.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V8B_D_ADND3502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		6 / 12 HIS A  59
ASP A 136
LYS A 227
ASP A 231
LEU A 386
HIS A 395
 ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 3.4A)
 1.47A 1v8bD-5v96A:
57.6		 1v8bD-5v96A:
55.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V8B_D_ADND3502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 12 HIS A  59
THR A  64
ASP A 136
THR A 198
HIS A 395
 ADN  A 502 ( 3.9A)
ADN  A 502 (-4.4A)
ADN  A 502 (-2.9A)
NAD  A 501 ( 2.9A)
ADN  A 502 ( 3.4A)
 1.38A 1v8bD-5v96A:
57.6		 1v8bD-5v96A:
55.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V8B_D_ADND3502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		12 / 12 LEU A  58
HIS A  59
THR A  61
ASP A 136
THR A 198
LYS A 227
ASP A 231
LEU A 389
GLY A 394
HIS A 395
MET A 400
PHE A 404
 None
ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
NAD  A 501 ( 2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.29A 1v8bD-5v96A:
57.6		 1v8bD-5v96A:
55.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 12 PRO A 102
GLY A  56
ASP A 135
PHE A 404
SER A  57
 None
None
None
ADN  A 502 (-4.9A)
None
 1.21A 1wg8A-5v96A:
2.9		 1wg8A-5v96A:
20.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_A_ADNA433_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		8 / 12 LEU A  58
GLU A  63
ASP A 231
LEU A 386
LEU A 389
GLY A 394
MET A 400
PHE A 404
 None
ADN  A 502 (-3.6A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 1.00A 1xwfA-5v96A:
51.5		 1xwfA-5v96A:
57.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_A_ADNA433_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		9 / 12 LEU A  58
HIS A  59
GLU A  63
ASP A 136
ASP A 231
LEU A 389
GLY A 394
MET A 400
PHE A 404
 None
ADN  A 502 ( 3.9A)
ADN  A 502 (-3.6A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.97A 1xwfA-5v96A:
51.5		 1xwfA-5v96A:
57.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_A_ADNA433_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		9 / 12 LEU A  58
HIS A  59
THR A  61
GLU A  63
ASP A 136
ASP A 231
GLY A 394
MET A 400
PHE A 404
 None
ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.6A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 (-3.7A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.82A 1xwfA-5v96A:
51.5		 1xwfA-5v96A:
57.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_A_ADNA433_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		8 / 12 LEU A  58
THR A  61
GLU A  63
ASP A 231
LEU A 386
GLY A 394
MET A 400
PHE A 404
 None
ADN  A 502 (-2.9A)
ADN  A 502 (-3.6A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 (-3.7A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.97A 1xwfA-5v96A:
51.5		 1xwfA-5v96A:
57.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_B_ADNB433_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		7 / 12 LEU A  58
ASP A 231
LEU A 386
LEU A 389
GLY A 394
MET A 400
PHE A 404
 None
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 1.00A 1xwfB-5v96A:
51.6		 1xwfB-5v96A:
57.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_B_ADNB433_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		8 / 12 LEU A  58
HIS A  59
ASP A 136
ASP A 231
LEU A 389
GLY A 394
MET A 400
PHE A 404
 None
ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.95A 1xwfB-5v96A:
51.6		 1xwfB-5v96A:
57.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_B_ADNB433_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		9 / 12 LEU A  58
HIS A  59
THR A  61
GLU A  63
ASP A 136
ASP A 231
GLY A 394
MET A 400
PHE A 404
 None
ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.6A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 (-3.7A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.83A 1xwfB-5v96A:
51.6		 1xwfB-5v96A:
57.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_B_ADNB433_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		8 / 12 LEU A  58
THR A  61
GLU A  63
ASP A 231
LEU A 386
GLY A 394
MET A 400
PHE A 404
 None
ADN  A 502 (-2.9A)
ADN  A 502 (-3.6A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 (-3.7A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.99A 1xwfB-5v96A:
51.6		 1xwfB-5v96A:
57.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_C_ADNC433_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		7 / 12 GLU A  63
ASP A 231
LEU A 386
LEU A 389
GLY A 394
MET A 400
PHE A 404
 ADN  A 502 (-3.6A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.99A 1xwfC-5v96A:
51.4		 1xwfC-5v96A:
57.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_C_ADNC433_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		9 / 12 LEU A  58
HIS A  59
GLU A  63
ASP A 136
ASP A 231
LEU A 389
GLY A 394
MET A 400
PHE A 404
 None
ADN  A 502 ( 3.9A)
ADN  A 502 (-3.6A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 1.00A 1xwfC-5v96A:
51.4		 1xwfC-5v96A:
57.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_C_ADNC433_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		9 / 12 LEU A  58
HIS A  59
THR A  61
GLU A  63
ASP A 136
ASP A 231
GLY A 394
MET A 400
PHE A 404
 None
ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.6A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 (-3.7A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.84A 1xwfC-5v96A:
51.4		 1xwfC-5v96A:
57.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_C_ADNC433_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		7 / 12 THR A  61
GLU A  63
ASP A 231
LEU A 386
GLY A 394
MET A 400
PHE A 404
 ADN  A 502 (-2.9A)
ADN  A 502 (-3.6A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 (-3.7A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.99A 1xwfC-5v96A:
51.4		 1xwfC-5v96A:
57.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_D_ADND433_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		6 / 12 ASP A 231
LEU A 386
LEU A 389
GLY A 394
MET A 400
PHE A 404
 ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.94A 1xwfD-5v96A:
51.4		 1xwfD-5v96A:
57.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_D_ADND433_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		6 / 12 GLU A  63
ASP A 231
LEU A 386
GLY A 394
MET A 400
PHE A 404
 ADN  A 502 (-3.6A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 (-3.7A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.96A 1xwfD-5v96A:
51.4		 1xwfD-5v96A:
57.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_D_ADND433_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		8 / 12 LEU A  58
HIS A  59
ASP A 136
ASP A 231
LEU A 389
GLY A 394
MET A 400
PHE A 404
 None
ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.99A 1xwfD-5v96A:
51.4		 1xwfD-5v96A:
57.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_D_ADND433_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		9 / 12 LEU A  58
HIS A  59
THR A  61
GLU A  63
ASP A 136
ASP A 231
GLY A 394
MET A 400
PHE A 404
 None
ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.6A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 (-3.7A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.85A 1xwfD-5v96A:
51.4		 1xwfD-5v96A:
57.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_A_017A201_1
(PROTEASE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 12 LEU A 240
ALA A 316
ILE A 323
VAL A 387
ILE A 340
 None
None
None
None
NAD  A 501 (-4.4A)
 0.85A 2hs2A-5v96A:
undetectable		 2hs2A-5v96A:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 12 LEU A 240
ALA A 316
ILE A 323
VAL A 387
ILE A 340
 None
None
None
None
NAD  A 501 (-4.4A)
 0.98A 2pymA-5v96A:
undetectable		 2pymA-5v96A:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 12 LEU A 240
ALA A 316
ILE A 323
VAL A 387
ILE A 340
 None
None
None
None
NAD  A 501 (-4.4A)
 0.96A 2pymB-5v96A:
undetectable		 2pymB-5v96A:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 12 LEU A 240
ALA A 316
ILE A 323
VAL A 387
ILE A 340
 None
None
None
None
NAD  A 501 (-4.4A)
 0.96A 2pynA-5v96A:
undetectable		 2pynA-5v96A:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 12 LEU A 240
ALA A 316
ILE A 323
VAL A 387
ILE A 340
 None
None
None
None
NAD  A 501 (-4.4A)
 0.94A 2pynB-5v96A:
undetectable		 2pynB-5v96A:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 12 LEU A 240
ALA A 316
ILE A 323
VAL A 387
ILE A 340
 None
None
None
None
NAD  A 501 (-4.4A)
 0.98A 2q63B-5v96A:
undetectable		 2q63B-5v96A:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 11 LEU A 132
ILE A 412
THR A  70
MET A 400
LEU A  67
 None
None
None
ADN  A 502 (-3.8A)
None
 1.38A 2v0mD-5v96A:
undetectable		 2v0mD-5v96A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		4 / 6 LEU A  58
SER A 224
ASP A 431
GLU A 197
 None
None
None
ADN  A 502 (-3.5A)
 0.89A 2vn1B-5v96A:
undetectable		 2vn1B-5v96A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1353_1
(PROSTAGLANDIN
REDUCTASE 2)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 9 THR A  70
PHE A 404
GLU A  69
MET A  33
GLU A  27
 None
ADN  A 502 (-4.9A)
None
None
None
 1.37A 2w98A-5v96A:
9.2		 2w98A-5v96A:
22.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZJ0_A_2FAA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 12 ASP A 136
LYS A 227
ASP A 231
LEU A 386
HIS A 395
 ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 3.4A)
 1.47A 2zj0A-5v96A:
58.3		 2zj0A-5v96A:
58.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZJ0_A_2FAA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 12 HIS A  59
THR A  64
ASP A 136
ASP A 231
HIS A 395
 ADN  A 502 ( 3.9A)
ADN  A 502 (-4.4A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 3.4A)
 1.17A 2zj0A-5v96A:
58.3		 2zj0A-5v96A:
58.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZJ0_A_2FAA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		12 / 12 LEU A  58
HIS A  59
THR A  61
ASP A 136
GLU A 197
LYS A 227
ASP A 231
LEU A 389
GLY A 394
HIS A 395
MET A 400
PHE A 404
 None
ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.51A 2zj0A-5v96A:
58.3		 2zj0A-5v96A:
58.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		12 / 12 HIS A  59
THR A  61
ASP A 136
GLU A 197
LYS A 227
ASP A 231
LEU A 386
LEU A 389
GLY A 394
HIS A 395
MET A 400
PHE A 404
 ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.65A 2zj0B-5v96A:
58.5		 2zj0B-5v96A:
58.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 12 HIS A  59
THR A  64
ASP A 136
ASP A 231
HIS A 395
 ADN  A 502 ( 3.9A)
ADN  A 502 (-4.4A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 3.4A)
 1.21A 2zj0B-5v96A:
58.5		 2zj0B-5v96A:
58.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZJ0_C_2FAC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		12 / 12 HIS A  59
THR A  61
ASP A 136
GLU A 197
LYS A 227
ASP A 231
LEU A 386
LEU A 389
GLY A 394
HIS A 395
MET A 400
PHE A 404
 ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.59A 2zj0C-5v96A:
58.5		 2zj0C-5v96A:
58.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZJ0_D_2FAD500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 12 ASP A 136
LYS A 227
ASP A 231
LEU A 386
HIS A 395
 ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 3.4A)
 1.45A 2zj0D-5v96A:
58.7		 2zj0D-5v96A:
58.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZJ0_D_2FAD500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		11 / 12 HIS A  59
THR A  61
ASP A 136
GLU A 197
LYS A 227
ASP A 231
LEU A 389
GLY A 394
HIS A 395
MET A 400
PHE A 404
 ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.49A 2zj0D-5v96A:
58.7		 2zj0D-5v96A:
58.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZJ0_D_2FAD500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 12 HIS A  59
THR A  64
ASP A 136
ASP A 231
HIS A 395
 ADN  A 502 ( 3.9A)
ADN  A 502 (-4.4A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 3.4A)
 1.21A 2zj0D-5v96A:
58.7		 2zj0D-5v96A:
58.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CE6_A_ADNA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 12 HIS A  59
THR A  64
ASP A 136
ASP A 231
HIS A 395
 ADN  A 502 ( 3.9A)
ADN  A 502 (-4.4A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 3.4A)
 1.20A 3ce6A-5v96A:
60.4		 3ce6A-5v96A:
58.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CE6_A_ADNA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		12 / 12 LEU A  58
HIS A  59
THR A  61
ASP A 136
GLU A 197
LYS A 227
ASP A 231
LEU A 389
GLY A 394
HIS A 395
MET A 400
PHE A 404
 None
ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.52A 3ce6A-5v96A:
60.4		 3ce6A-5v96A:
58.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CE6_B_ADNB500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 12 ASP A 136
GLU A 197
LYS A 227
ASP A 231
LEU A 389
 ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.7A)
 1.14A 3ce6B-5v96A:
58.8		 3ce6B-5v96A:
58.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CE6_B_ADNB500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		12 / 12 HIS A  59
THR A  61
ASP A 136
GLU A 197
LYS A 227
ASP A 231
LEU A 386
LEU A 389
GLY A 394
HIS A 395
MET A 400
PHE A 404
 ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.63A 3ce6B-5v96A:
58.8		 3ce6B-5v96A:
58.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CE6_B_ADNB500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 12 HIS A  59
THR A  64
ASP A 136
ASP A 231
HIS A 395
 ADN  A 502 ( 3.9A)
ADN  A 502 (-4.4A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 3.4A)
 1.20A 3ce6B-5v96A:
58.8		 3ce6B-5v96A:
58.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CE6_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 12 HIS A  59
THR A  64
ASP A 136
ASP A 231
HIS A 395
 ADN  A 502 ( 3.9A)
ADN  A 502 (-4.4A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 3.4A)
 1.19A 3ce6C-5v96A:
58.9		 3ce6C-5v96A:
58.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CE6_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		12 / 12 LEU A  58
HIS A  59
THR A  61
ASP A 136
GLU A 197
LYS A 227
ASP A 231
LEU A 389
GLY A 394
HIS A 395
MET A 400
PHE A 404
 None
ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.51A 3ce6C-5v96A:
58.9		 3ce6C-5v96A:
58.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CE6_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		12 / 12 HIS A  59
THR A  61
ASP A 136
GLU A 197
THR A 198
LYS A 227
ASP A 231
LEU A 389
GLY A 394
HIS A 395
MET A 400
PHE A 404
 ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
NAD  A 501 ( 2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.51A 3ce6D-5v96A:
59.0		 3ce6D-5v96A:
58.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CE6_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		6 / 12 HIS A  59
THR A  64
ASP A 136
THR A 198
ASP A 231
HIS A 395
 ADN  A 502 ( 3.9A)
ADN  A 502 (-4.4A)
ADN  A 502 (-2.9A)
NAD  A 501 ( 2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 3.4A)
 1.22A 3ce6D-5v96A:
59.0		 3ce6D-5v96A:
58.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CE6_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 12 THR A 199
LYS A 227
ASP A 231
LEU A 386
HIS A 395
 NAD  A 501 (-3.0A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 3.4A)
 1.28A 3ce6D-5v96A:
59.0		 3ce6D-5v96A:
58.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G1U_A_ADNA438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		9 / 12 LEU A  58
HIS A  59
THR A  61
ASP A 136
GLU A 197
ASN A 232
LEU A 386
LEU A 389
PHE A 404
 None
ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
NAD  A 501 (-3.5A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-4.9A)
 0.80A 3g1uA-5v96A:
56.4		 3g1uA-5v96A:
57.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G1U_A_ADNA438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		11 / 12 LEU A  58
HIS A  59
THR A  61
ASP A 136
GLU A 197
LEU A 386
LEU A 389
GLY A 394
HIS A 395
MET A 400
PHE A 404
 None
ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.61A 3g1uA-5v96A:
56.4		 3g1uA-5v96A:
57.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G1U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 12 HIS A  59
THR A  64
ASP A 136
THR A 198
HIS A 395
 ADN  A 502 ( 3.9A)
ADN  A 502 (-4.4A)
ADN  A 502 (-2.9A)
NAD  A 501 ( 2.9A)
ADN  A 502 ( 3.4A)
 1.31A 3g1uB-5v96A:
56.5		 3g1uB-5v96A:
57.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G1U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		11 / 12 LEU A  58
HIS A  59
THR A  61
ASP A 136
THR A 198
LEU A 386
LEU A 389
GLY A 394
HIS A 395
MET A 400
PHE A 404
 None
ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
NAD  A 501 ( 2.9A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.41A 3g1uB-5v96A:
56.5		 3g1uB-5v96A:
57.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G1U_C_ADNC438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		6 / 12 HIS A  59
ASP A 136
GLU A 197
LYS A 227
ASP A 231
LEU A 386
 ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
 1.37A 3g1uC-5v96A:
56.4		 3g1uC-5v96A:
57.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G1U_C_ADNC438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		6 / 12 LEU A  58
ASP A 136
GLU A 197
LYS A 227
ASP A 231
LEU A 389
 None
ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.7A)
 0.96A 3g1uC-5v96A:
56.4		 3g1uC-5v96A:
57.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G1U_C_ADNC438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		12 / 12 LEU A  58
HIS A  59
THR A  61
ASP A 136
GLU A 197
LYS A 227
ASP A 231
LEU A 386
LEU A 389
GLY A 394
MET A 400
PHE A 404
 None
ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.44A 3g1uC-5v96A:
56.4		 3g1uC-5v96A:
57.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G1U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 12 LEU A  58
ASP A 136
THR A 198
ASP A 231
LEU A 389
 None
ADN  A 502 (-2.9A)
NAD  A 501 ( 2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.7A)
 1.20A 3g1uD-5v96A:
56.9		 3g1uD-5v96A:
57.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G1U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		12 / 12 LEU A  58
HIS A  59
THR A  61
ASP A 136
THR A 198
ASP A 231
LEU A 386
LEU A 389
GLY A 394
HIS A 395
MET A 400
PHE A 404
 None
ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
NAD  A 501 ( 2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.39A 3g1uD-5v96A:
56.9		 3g1uD-5v96A:
57.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GLQ_A_RABA602_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 12 LEU A  58
ASP A 136
LYS A 227
ASP A 231
LEU A 389
 None
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.7A)
 1.08A 3glqA-5v96A:
59.4		 3glqA-5v96A:
58.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GLQ_A_RABA602_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		12 / 12 LEU A  58
HIS A  59
THR A  61
ASP A 136
LYS A 227
ASP A 231
LEU A 386
LEU A 389
GLY A 394
HIS A 395
MET A 400
PHE A 404
 None
ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.39A 3glqA-5v96A:
59.4		 3glqA-5v96A:
58.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GLQ_B_RABB602_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 12 ASP A 136
LYS A 227
ASP A 231
LEU A 386
HIS A 395
 ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 3.4A)
 1.38A 3glqB-5v96A:
59.6		 3glqB-5v96A:
58.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GLQ_B_RABB602_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 12 LEU A  58
ASP A 136
LYS A 227
ASP A 231
LEU A 389
 None
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.7A)
 1.08A 3glqB-5v96A:
59.6		 3glqB-5v96A:
58.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GLQ_B_RABB602_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		12 / 12 LEU A  58
HIS A  59
THR A  61
ASP A 136
LYS A 227
ASP A 231
LEU A 386
LEU A 389
GLY A 394
HIS A 395
MET A 400
PHE A 404
 None
ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.41A 3glqB-5v96A:
59.6		 3glqB-5v96A:
58.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRV_A_ADNA300_1
(DIMETHYLADENOSINE
TRANSFERASE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		6 / 11 GLY A 261
GLY A 263
GLU A 284
ILE A 285
ASP A 286
ILE A 322
 NAD  A 501 (-3.6A)
NAD  A 501 (-3.1A)
NAD  A 501 (-2.8A)
NAD  A 501 (-4.0A)
None
NAD  A 501 (-4.8A)
 1.18A 3grvA-5v96A:
3.6		 3grvA-5v96A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRY_A_SAMA300_0
(DIMETHYLADENOSINE
TRANSFERASE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 12 GLY A 261
GLY A 263
GLU A 284
ILE A 285
ASP A 286
 NAD  A 501 (-3.6A)
NAD  A 501 (-3.1A)
NAD  A 501 (-2.8A)
NAD  A 501 (-4.0A)
None
 0.57A 3gryA-5v96A:
3.8		 3gryA-5v96A:
21.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H9U_A_ADNA439_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		9 / 10 LEU A  58
HIS A  59
THR A  61
THR A  64
LEU A 389
GLY A 394
HIS A 395
MET A 400
PHE A 404
 None
ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-4.4A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.15A 3h9uA-5v96A:
56.9		 3h9uA-5v96A:
55.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H9U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		9 / 10 HIS A  59
THR A  61
THR A  64
ASN A 388
LEU A 389
GLY A 394
HIS A 395
MET A 400
PHE A 404
 ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-4.4A)
NAD  A 501 (-3.1A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.18A 3h9uB-5v96A:
56.9		 3h9uB-5v96A:
55.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H9U_C_ADNC438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		9 / 10 LEU A  58
HIS A  59
THR A  61
THR A  64
LEU A 389
GLY A 394
HIS A 395
MET A 400
PHE A 404
 None
ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-4.4A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.15A 3h9uC-5v96A:
57.0		 3h9uC-5v96A:
55.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H9U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		9 / 10 LEU A  58
HIS A  59
THR A  61
THR A  64
LEU A 389
GLY A 394
HIS A 395
MET A 400
PHE A 404
 None
ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-4.4A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.15A 3h9uD-5v96A:
57.1		 3h9uD-5v96A:
55.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 11 ILE A 340
ILE A 336
LEU A 244
VAL A 387
THR A 317
 NAD  A 501 (-4.4A)
None
None
None
NAD  A 501 (-4.1A)
 1.09A 3n0hA-5v96A:
undetectable		 3n0hA-5v96A:
17.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N58_A_ADNA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 12 LEU A  58
ASP A 136
LYS A 227
ASP A 231
LEU A 389
 None
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.7A)
 1.01A 3n58A-5v96A:
59.3		 3n58A-5v96A:
60.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N58_A_ADNA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		12 / 12 LEU A  58
HIS A  59
THR A  61
ASP A 136
LYS A 227
ASP A 231
LEU A 386
LEU A 389
GLY A 394
HIS A 395
MET A 400
PHE A 404
 None
ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.36A 3n58A-5v96A:
59.3		 3n58A-5v96A:
60.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N58_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 12 ASP A 136
THR A 198
LYS A 227
ASP A 231
LEU A 389
 ADN  A 502 (-2.9A)
NAD  A 501 ( 2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.7A)
 1.15A 3n58C-5v96A:
59.4		 3n58C-5v96A:
60.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N58_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		12 / 12 HIS A  59
THR A  61
ASP A 136
THR A 198
LYS A 227
ASP A 231
LEU A 386
LEU A 389
GLY A 394
HIS A 395
MET A 400
PHE A 404
 ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
NAD  A 501 ( 2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.36A 3n58C-5v96A:
59.4		 3n58C-5v96A:
60.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N58_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 12 HIS A  59
THR A  64
ASP A 136
THR A 198
ASP A 231
 ADN  A 502 ( 3.9A)
ADN  A 502 (-4.4A)
ADN  A 502 (-2.9A)
NAD  A 501 ( 2.9A)
ADN  A 502 (-2.8A)
 1.25A 3n58C-5v96A:
59.4		 3n58C-5v96A:
60.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N58_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 12 THR A  64
ASP A 136
THR A 198
ASP A 231
LEU A 389
 ADN  A 502 (-4.4A)
ADN  A 502 (-2.9A)
NAD  A 501 ( 2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.7A)
 1.38A 3n58C-5v96A:
59.4		 3n58C-5v96A:
60.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N58_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 12 ASP A 136
THR A 198
LYS A 227
ASP A 231
LEU A 389
 ADN  A 502 (-2.9A)
NAD  A 501 ( 2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.7A)
 1.13A 3n58D-5v96A:
62.4		 3n58D-5v96A:
60.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N58_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 12 HIS A  59
THR A  64
ASP A 136
THR A 198
ASP A 231
 ADN  A 502 ( 3.9A)
ADN  A 502 (-4.4A)
ADN  A 502 (-2.9A)
NAD  A 501 ( 2.9A)
ADN  A 502 (-2.8A)
 1.27A 3n58D-5v96A:
62.4		 3n58D-5v96A:
60.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N58_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		12 / 12 LEU A  58
HIS A  59
THR A  61
ASP A 136
THR A 198
LYS A 227
ASP A 231
LEU A 386
LEU A 389
HIS A 395
MET A 400
PHE A 404
 None
ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
NAD  A 501 ( 2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 4.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.31A 3n58D-5v96A:
62.4		 3n58D-5v96A:
60.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N58_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 12 THR A  64
ASP A 136
THR A 198
ASP A 231
LEU A 389
 ADN  A 502 (-4.4A)
ADN  A 502 (-2.9A)
NAD  A 501 ( 2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.7A)
 1.40A 3n58D-5v96A:
62.4		 3n58D-5v96A:
60.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OND_A_ADNA506_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 12 GLU A 197
THR A 198
GLY A 235
MET A 400
PHE A 404
 ADN  A 502 (-3.5A)
NAD  A 501 ( 2.9A)
None
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 1.46A 3ondA-5v96A:
60.9		 3ondA-5v96A:
65.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OND_A_ADNA506_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		7 / 12 HIS A  59
ASP A 136
GLU A 197
LYS A 227
ASP A 231
LEU A 386
HIS A 395
 ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 3.4A)
 1.42A 3ondA-5v96A:
60.9		 3ondA-5v96A:
65.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OND_A_ADNA506_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		12 / 12 HIS A  59
THR A  61
ASP A 136
GLU A 197
THR A 198
LYS A 227
ASP A 231
LEU A 389
GLY A 394
HIS A 395
MET A 400
PHE A 404
 ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
NAD  A 501 ( 2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.13A 3ondA-5v96A:
60.9		 3ondA-5v96A:
65.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OND_A_ADNA506_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 12 HIS A  59
THR A  64
ASP A 136
THR A 198
ASP A 231
 ADN  A 502 ( 3.9A)
ADN  A 502 (-4.4A)
ADN  A 502 (-2.9A)
NAD  A 501 ( 2.9A)
ADN  A 502 (-2.8A)
 1.25A 3ondA-5v96A:
60.9		 3ondA-5v96A:
65.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OND_B_ADNB507_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		6 / 12 ASP A 136
GLU A 197
LYS A 227
ASP A 231
LEU A 386
HIS A 395
 ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 3.4A)
 1.30A 3ondB-5v96A:
58.6		 3ondB-5v96A:
65.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OND_B_ADNB507_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 12 GLU A 197
THR A 198
GLY A 235
MET A 400
PHE A 404
 ADN  A 502 (-3.5A)
NAD  A 501 ( 2.9A)
None
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 1.46A 3ondB-5v96A:
58.6		 3ondB-5v96A:
65.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OND_B_ADNB507_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		12 / 12 HIS A  59
THR A  61
ASP A 136
GLU A 197
THR A 198
LYS A 227
ASP A 231
LEU A 389
GLY A 394
HIS A 395
MET A 400
PHE A 404
 ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
NAD  A 501 ( 2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.13A 3ondB-5v96A:
58.6		 3ondB-5v96A:
65.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OND_B_ADNB507_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 12 HIS A  59
THR A  64
ASP A 136
THR A 198
ASP A 231
 ADN  A 502 ( 3.9A)
ADN  A 502 (-4.4A)
ADN  A 502 (-2.9A)
NAD  A 501 ( 2.9A)
ADN  A 502 (-2.8A)
 1.25A 3ondB-5v96A:
58.6		 3ondB-5v96A:
65.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OND_B_ADNB507_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 12 THR A 199
LYS A 227
ASP A 231
LEU A 386
HIS A 395
 NAD  A 501 (-3.0A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 3.4A)
 1.28A 3ondB-5v96A:
58.6		 3ondB-5v96A:
65.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		4 / 6 GLY A 201
THR A 200
GLU A 196
ASP A 139
 None
NAD  A 501 (-3.6A)
None
EDO  A 512 (-3.3A)
 1.01A 3ps9A-5v96A:
3.3		 3ps9A-5v96A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 12 ILE A 340
ILE A 336
LEU A 244
VAL A 387
THR A 317
 NAD  A 501 (-4.4A)
None
None
None
NAD  A 501 (-4.1A)
 1.10A 3s3vA-5v96A:
undetectable		 3s3vA-5v96A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_B_RBVB601_1
(RNA POLYMERASE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 9 THR A 200
GLY A 137
ASP A 139
LEU A 386
ARG A 385
 NAD  A 501 (-3.6A)
PO4  A 503 ( 4.5A)
EDO  A 512 (-3.3A)
NAD  A 501 (-3.9A)
EDO  A 509 (-3.6A)
 1.32A 3sfuB-5v96A:
undetectable		 3sfuB-5v96A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYS_A_ACTA402_0
(MCCC FAMILY PROTEIN)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		4 / 6 SER A 224
ASP A 223
SER A 228
GLU A 197
 None
None
None
ADN  A 502 (-3.5A)
 1.24A 4eysA-5v96A:
2.7		 4eysA-5v96A:
22.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LVC_A_ADNA501_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		7 / 12 HIS A  59
ASP A 136
GLU A 197
LYS A 227
ASP A 231
LEU A 386
HIS A 395
 ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 3.4A)
 1.43A 4lvcA-5v96A:
62.3		 4lvcA-5v96A:
62.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LVC_A_ADNA501_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		12 / 12 LEU A  58
HIS A  59
THR A  61
ASP A 136
GLU A 197
LYS A 227
ASP A 231
LEU A 389
GLY A 394
HIS A 395
MET A 400
PHE A 404
 None
ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.15A 4lvcA-5v96A:
62.3		 4lvcA-5v96A:
62.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LVC_B_ADNB501_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		11 / 12 LEU A  58
HIS A  59
THR A  61
ASP A 136
GLU A 197
LYS A 227
ASP A 231
GLY A 394
HIS A 395
MET A 400
PHE A 404
 None
ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.14A 4lvcB-5v96A:
60.6		 4lvcB-5v96A:
62.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LVC_B_ADNB501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		4 / 5 THR A  64
THR A 198
LEU A 386
LEU A 389
 ADN  A 502 (-4.4A)
NAD  A 501 ( 2.9A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 4.7A)
 0.18A 4lvcB-5v96A:
60.6		 4lvcB-5v96A:
62.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LVC_C_ADNC501_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		7 / 12 HIS A  59
ASP A 136
GLU A 197
LYS A 227
ASP A 231
LEU A 386
HIS A 395
 ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 3.4A)
 1.42A 4lvcC-5v96A:
62.1		 4lvcC-5v96A:
62.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LVC_C_ADNC501_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		12 / 12 LEU A  58
HIS A  59
THR A  61
ASP A 136
GLU A 197
LYS A 227
ASP A 231
LEU A 389
GLY A 394
HIS A 395
MET A 400
PHE A 404
 None
ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.15A 4lvcC-5v96A:
62.1		 4lvcC-5v96A:
62.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PFJ_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		12 / 12 LEU A  58
HIS A  59
THR A  61
ASP A 136
GLU A 197
LYS A 227
ASP A 231
LEU A 389
GLY A 394
HIS A 395
MET A 400
PHE A 404
 None
ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.22A 4pfjA-5v96A:
59.2		 4pfjA-5v96A:
56.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PFJ_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		6 / 7 GLU A  63
THR A  64
THR A 198
LEU A 386
ASN A 388
SER A 403
 ADN  A 502 (-3.6A)
ADN  A 502 (-4.4A)
NAD  A 501 ( 2.9A)
NAD  A 501 (-3.9A)
NAD  A 501 (-3.1A)
ADN  A 502 ( 4.6A)
 0.52A 4pfjA-5v96A:
59.2		 4pfjA-5v96A:
56.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PFJ_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		12 / 12 HIS A  59
THR A  61
ASP A 136
GLU A 197
LYS A 227
ASP A 231
LEU A 386
LEU A 389
GLY A 394
HIS A 395
MET A 400
PHE A 404
 ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.62A 4pfjB-5v96A:
56.9		 4pfjB-5v96A:
56.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PFJ_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 6 GLU A  63
THR A  64
GLN A  89
THR A 198
ASN A 388
 ADN  A 502 (-3.6A)
ADN  A 502 (-4.4A)
None
NAD  A 501 ( 2.9A)
NAD  A 501 (-3.1A)
 0.23A 4pfjB-5v96A:
56.9		 4pfjB-5v96A:
56.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGF_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		12 / 12 LEU A  58
HIS A  59
ASP A 136
GLU A 197
LYS A 227
ASP A 231
LEU A 386
ASN A 388
GLY A 394
HIS A 395
MET A 400
PHE A 404
 None
ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
NAD  A 501 (-3.1A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.44A 4pgfA-5v96A:
58.8		 4pgfA-5v96A:
56.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGF_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 6 THR A  61
GLU A  63
THR A  64
THR A 198
LEU A 389
 ADN  A 502 (-2.9A)
ADN  A 502 (-3.6A)
ADN  A 502 (-4.4A)
NAD  A 501 ( 2.9A)
ADN  A 502 ( 4.7A)
 0.18A 4pgfA-5v96A:
58.8		 4pgfA-5v96A:
56.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGF_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		12 / 12 HIS A  59
GLU A  63
ASP A 136
GLU A 197
LYS A 227
ASP A 231
LEU A 386
LEU A 389
GLY A 394
HIS A 395
MET A 400
PHE A 404
 ADN  A 502 ( 3.9A)
ADN  A 502 (-3.6A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.64A 4pgfB-5v96A:
56.3		 4pgfB-5v96A:
56.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGF_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		4 / 5 THR A  61
THR A  64
THR A 198
ASN A 388
 ADN  A 502 (-2.9A)
ADN  A 502 (-4.4A)
NAD  A 501 ( 2.9A)
NAD  A 501 (-3.1A)
 0.30A 4pgfB-5v96A:
56.3		 4pgfB-5v96A:
56.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1006_1
(SERUM ALBUMIN)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		4 / 7 ILE A 340
LEU A 240
GLY A 268
LYS A 267
 NAD  A 501 (-4.4A)
None
None
None
 0.97A 4z69A-5v96A:
undetectable		 4z69A-5v96A:
22.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXA_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		6 / 12 ASP A 136
GLU A 197
LYS A 227
ASP A 231
LEU A 386
HIS A 395
 ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 3.4A)
 1.32A 5axaA-5v96A:
58.0		 5axaA-5v96A:
57.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXA_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		12 / 12 LEU A  58
HIS A  59
THR A  61
ASP A 136
GLU A 197
LYS A 227
ASP A 231
LEU A 389
GLY A 394
HIS A 395
MET A 400
PHE A 404
 None
ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.14A 5axaA-5v96A:
58.0		 5axaA-5v96A:
57.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXA_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 5 GLU A  63
THR A  64
THR A 198
HIS A 342
LEU A 386
 ADN  A 502 (-3.6A)
ADN  A 502 (-4.4A)
NAD  A 501 ( 2.9A)
NAD  A 501 ( 4.9A)
NAD  A 501 (-3.9A)
 0.15A 5axaA-5v96A:
58.0		 5axaA-5v96A:
57.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXA_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		7 / 12 HIS A  59
ASP A 136
GLU A 197
LYS A 227
ASP A 231
LEU A 386
HIS A 395
 ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 3.4A)
 1.45A 5axaC-5v96A:
57.9		 5axaC-5v96A:
57.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXA_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 12 HIS A  59
THR A  64
ASP A 136
ASP A 231
HIS A 395
 ADN  A 502 ( 3.9A)
ADN  A 502 (-4.4A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 3.4A)
 1.18A 5axaC-5v96A:
57.9		 5axaC-5v96A:
57.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXA_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		12 / 12 LEU A  58
HIS A  59
THR A  61
ASP A 136
GLU A 197
LYS A 227
ASP A 231
LEU A 389
GLY A 394
HIS A 395
MET A 400
PHE A 404
 None
ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.14A 5axaC-5v96A:
57.9		 5axaC-5v96A:
57.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXA_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 5 GLU A  63
THR A  64
THR A 198
HIS A 342
LEU A 386
 ADN  A 502 (-3.6A)
ADN  A 502 (-4.4A)
NAD  A 501 ( 2.9A)
NAD  A 501 ( 4.9A)
NAD  A 501 (-3.9A)
 0.18A 5axaC-5v96A:
57.9		 5axaC-5v96A:
57.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXD_A_RBVA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		6 / 12 ASP A 136
GLU A 197
LYS A 227
ASP A 231
LEU A 386
HIS A 395
 ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 3.4A)
 1.29A 5axdA-5v96A:
58.1		 5axdA-5v96A:
57.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXD_A_RBVA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		12 / 12 HIS A  59
THR A  61
GLU A  63
ASP A 136
GLU A 197
THR A 198
LYS A 227
ASP A 231
LEU A 389
GLY A 394
HIS A 395
MET A 400
 ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.6A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
NAD  A 501 ( 2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
 0.12A 5axdA-5v96A:
58.1		 5axdA-5v96A:
57.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXD_A_RBVA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 12 HIS A  59
THR A  64
ASP A 136
THR A 198
ASP A 231
 ADN  A 502 ( 3.9A)
ADN  A 502 (-4.4A)
ADN  A 502 (-2.9A)
NAD  A 501 ( 2.9A)
ADN  A 502 (-2.8A)
 1.25A 5axdA-5v96A:
58.1		 5axdA-5v96A:
57.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		3 / 3 THR A  64
HIS A 342
LEU A 386
 ADN  A 502 (-4.4A)
NAD  A 501 ( 4.9A)
NAD  A 501 (-3.9A)
 0.12A 5axdA-5v96A:
58.1		 5axdA-5v96A:
57.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXD_C_RBVC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		6 / 12 ASP A 136
GLU A 197
LYS A 227
ASP A 231
LEU A 386
HIS A 395
 ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 3.4A)
 1.30A 5axdC-5v96A:
58.0		 5axdC-5v96A:
57.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXD_C_RBVC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		12 / 12 HIS A  59
THR A  61
GLU A  63
ASP A 136
GLU A 197
THR A 198
LYS A 227
ASP A 231
LEU A 389
GLY A 394
HIS A 395
MET A 400
 ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.6A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
NAD  A 501 ( 2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
 0.13A 5axdC-5v96A:
58.0		 5axdC-5v96A:
57.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXD_C_RBVC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 12 HIS A  59
THR A  64
ASP A 136
THR A 198
ASP A 231
 ADN  A 502 ( 3.9A)
ADN  A 502 (-4.4A)
ADN  A 502 (-2.9A)
NAD  A 501 ( 2.9A)
ADN  A 502 (-2.8A)
 1.26A 5axdC-5v96A:
58.0		 5axdC-5v96A:
57.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		6 / 12 HIS A  59
ASP A 136
LYS A 227
ASP A 231
LEU A 386
HIS A 395
 ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 3.4A)
 1.48A 5hm8A-5v96A:
55.4		 5hm8A-5v96A:
54.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		11 / 12 LEU A  58
HIS A  59
THR A  61
ASP A 136
LYS A 227
ASP A 231
LEU A 389
GLY A 394
HIS A 395
MET A 400
PHE A 404
 None
ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.19A 5hm8A-5v96A:
55.4		 5hm8A-5v96A:
54.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 5 GLU A  63
THR A  64
GLU A 197
THR A 198
LEU A 386
 ADN  A 502 (-3.6A)
ADN  A 502 (-4.4A)
ADN  A 502 (-3.5A)
NAD  A 501 ( 2.9A)
NAD  A 501 (-3.9A)
 0.19A 5hm8A-5v96A:
55.4		 5hm8A-5v96A:
54.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_B_ADNB501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		6 / 12 HIS A  59
ASP A 136
LYS A 227
ASP A 231
LEU A 386
HIS A 395
 ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 3.4A)
 1.49A 5hm8B-5v96A:
55.5		 5hm8B-5v96A:
54.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_B_ADNB501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		11 / 12 LEU A  58
HIS A  59
THR A  61
ASP A 136
LYS A 227
ASP A 231
LEU A 389
GLY A 394
HIS A 395
MET A 400
PHE A 404
 None
ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.19A 5hm8B-5v96A:
55.5		 5hm8B-5v96A:
54.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_B_ADNB501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 5 GLU A  63
THR A  64
GLU A 197
THR A 198
LEU A 386
 ADN  A 502 (-3.6A)
ADN  A 502 (-4.4A)
ADN  A 502 (-3.5A)
NAD  A 501 ( 2.9A)
NAD  A 501 (-3.9A)
 0.19A 5hm8B-5v96A:
55.5		 5hm8B-5v96A:
54.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_C_ADNC501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		6 / 12 HIS A  59
ASP A 136
LYS A 227
ASP A 231
LEU A 386
HIS A 395
 ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 3.4A)
 1.48A 5hm8C-5v96A:
56.1		 5hm8C-5v96A:
54.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_C_ADNC501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		11 / 12 LEU A  58
HIS A  59
THR A  61
ASP A 136
LYS A 227
ASP A 231
LEU A 389
GLY A 394
HIS A 395
MET A 400
PHE A 404
 None
ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.19A 5hm8C-5v96A:
56.1		 5hm8C-5v96A:
54.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_C_ADNC501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 5 GLU A  63
THR A  64
GLU A 197
THR A 198
LEU A 386
 ADN  A 502 (-3.6A)
ADN  A 502 (-4.4A)
ADN  A 502 (-3.5A)
NAD  A 501 ( 2.9A)
NAD  A 501 (-3.9A)
 0.19A 5hm8C-5v96A:
56.1		 5hm8C-5v96A:
54.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_D_ADND501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		6 / 12 HIS A  59
ASP A 136
LYS A 227
ASP A 231
LEU A 386
HIS A 395
 ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 3.4A)
 1.48A 5hm8D-5v96A:
55.6		 5hm8D-5v96A:
54.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_D_ADND501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		11 / 12 LEU A  58
HIS A  59
THR A  61
ASP A 136
LYS A 227
ASP A 231
LEU A 389
GLY A 394
HIS A 395
MET A 400
PHE A 404
 None
ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.19A 5hm8D-5v96A:
55.6		 5hm8D-5v96A:
54.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_D_ADND501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 5 GLU A  63
THR A  64
GLU A 197
THR A 198
LEU A 386
 ADN  A 502 (-3.6A)
ADN  A 502 (-4.4A)
ADN  A 502 (-3.5A)
NAD  A 501 ( 2.9A)
NAD  A 501 (-3.9A)
 0.19A 5hm8D-5v96A:
55.6		 5hm8D-5v96A:
54.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_E_ADNE501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		6 / 12 HIS A  59
ASP A 136
LYS A 227
ASP A 231
LEU A 386
HIS A 395
 ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 3.4A)
 1.48A 5hm8E-5v96A:
55.9		 5hm8E-5v96A:
54.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_E_ADNE501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		11 / 12 LEU A  58
HIS A  59
THR A  61
ASP A 136
LYS A 227
ASP A 231
LEU A 389
GLY A 394
HIS A 395
MET A 400
PHE A 404
 None
ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.20A 5hm8E-5v96A:
55.9		 5hm8E-5v96A:
54.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_E_ADNE501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 5 GLU A  63
THR A  64
GLU A 197
THR A 198
LEU A 386
 ADN  A 502 (-3.6A)
ADN  A 502 (-4.4A)
ADN  A 502 (-3.5A)
NAD  A 501 ( 2.9A)
NAD  A 501 (-3.9A)
 0.19A 5hm8E-5v96A:
55.9		 5hm8E-5v96A:
54.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_F_ADNF501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		6 / 12 HIS A  59
ASP A 136
LYS A 227
ASP A 231
LEU A 386
HIS A 395
 ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 3.4A)
 1.48A 5hm8F-5v96A:
55.5		 5hm8F-5v96A:
54.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_F_ADNF501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		11 / 12 LEU A  58
HIS A  59
THR A  61
ASP A 136
LYS A 227
ASP A 231
LEU A 389
GLY A 394
HIS A 395
MET A 400
PHE A 404
 None
ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.19A 5hm8F-5v96A:
55.5		 5hm8F-5v96A:
54.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_F_ADNF501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 5 GLU A  63
THR A  64
GLU A 197
THR A 198
LEU A 386
 ADN  A 502 (-3.6A)
ADN  A 502 (-4.4A)
ADN  A 502 (-3.5A)
NAD  A 501 ( 2.9A)
NAD  A 501 (-3.9A)
 0.19A 5hm8F-5v96A:
55.5		 5hm8F-5v96A:
54.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_G_ADNG501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		6 / 12 HIS A  59
ASP A 136
LYS A 227
ASP A 231
LEU A 386
HIS A 395
 ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 3.4A)
 1.48A 5hm8G-5v96A:
55.4		 5hm8G-5v96A:
54.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_G_ADNG501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		11 / 12 LEU A  58
HIS A  59
THR A  61
ASP A 136
LYS A 227
ASP A 231
LEU A 389
GLY A 394
HIS A 395
MET A 400
PHE A 404
 None
ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.19A 5hm8G-5v96A:
55.4		 5hm8G-5v96A:
54.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_G_ADNG501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 5 GLU A  63
THR A  64
GLU A 197
THR A 198
LEU A 386
 ADN  A 502 (-3.6A)
ADN  A 502 (-4.4A)
ADN  A 502 (-3.5A)
NAD  A 501 ( 2.9A)
NAD  A 501 (-3.9A)
 0.47A 5hm8G-5v96A:
55.4		 5hm8G-5v96A:
54.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_H_ADNH501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		6 / 12 HIS A  59
ASP A 136
LYS A 227
ASP A 231
LEU A 386
HIS A 395
 ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 3.4A)
 1.49A 5hm8H-5v96A:
56.0		 5hm8H-5v96A:
54.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_H_ADNH501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		11 / 12 LEU A  58
HIS A  59
THR A  61
ASP A 136
LYS A 227
ASP A 231
LEU A 389
GLY A 394
HIS A 395
MET A 400
PHE A 404
 None
ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.19A 5hm8H-5v96A:
56.0		 5hm8H-5v96A:
54.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_H_ADNH501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 5 GLU A  63
THR A  64
GLU A 197
THR A 198
LEU A 386
 ADN  A 502 (-3.6A)
ADN  A 502 (-4.4A)
ADN  A 502 (-3.5A)
NAD  A 501 ( 2.9A)
NAD  A 501 (-3.9A)
 0.19A 5hm8H-5v96A:
56.0		 5hm8H-5v96A:
54.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_2
(PROTEASE E35D-SQV)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 9 LEU A 386
ASN A 339
ILE A 259
GLY A 261
ILE A 340
 NAD  A 501 (-3.9A)
None
None
NAD  A 501 (-3.6A)
NAD  A 501 (-4.4A)
 1.05A 5kqxB-5v96A:
undetectable		 5kqxB-5v96A:
12.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M5K_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		6 / 12 ASP A 136
GLU A 197
LYS A 227
ASP A 231
LEU A 386
HIS A 395
 ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 3.4A)
 1.28A 5m5kA-5v96A:
62.5		 5m5kA-5v96A:
62.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M5K_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		12 / 12 LEU A  58
HIS A  59
THR A  61
ASP A 136
GLU A 197
LYS A 227
ASP A 231
LEU A 389
GLY A 394
HIS A 395
MET A 400
PHE A 404
 None
ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.12A 5m5kA-5v96A:
62.5		 5m5kA-5v96A:
62.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M5K_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 12 GLU A 197
THR A 198
GLY A 235
MET A 400
PHE A 404
 ADN  A 502 (-3.5A)
NAD  A 501 ( 2.9A)
None
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 1.47A 5m5kB-5v96A:
62.4		 5m5kB-5v96A:
62.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M5K_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		6 / 12 HIS A  59
THR A  64
ASP A 136
THR A 198
ASP A 231
HIS A 395
 ADN  A 502 ( 3.9A)
ADN  A 502 (-4.4A)
ADN  A 502 (-2.9A)
NAD  A 501 ( 2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 3.4A)
 1.30A 5m5kB-5v96A:
62.4		 5m5kB-5v96A:
62.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M5K_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		12 / 12 LEU A  58
HIS A  59
THR A  61
ASP A 136
GLU A 197
THR A 198
LYS A 227
ASP A 231
GLY A 394
HIS A 395
MET A 400
PHE A 404
 None
ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
NAD  A 501 ( 2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.34A 5m5kB-5v96A:
62.4		 5m5kB-5v96A:
62.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M5K_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		7 / 12 HIS A  59
ASP A 136
GLU A 197
LYS A 227
ASP A 231
LEU A 386
HIS A 395
 ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 3.4A)
 1.44A 5m5kC-5v96A:
58.8		 5m5kC-5v96A:
62.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M5K_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 12 HIS A  59
THR A  64
ASP A 136
ASP A 231
HIS A 395
 ADN  A 502 ( 3.9A)
ADN  A 502 (-4.4A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 3.4A)
 1.21A 5m5kC-5v96A:
58.8		 5m5kC-5v96A:
62.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M5K_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		12 / 12 LEU A  58
HIS A  59
THR A  61
ASP A 136
GLU A 197
LYS A 227
ASP A 231
LEU A 389
GLY A 394
HIS A 395
MET A 400
PHE A 404
 None
ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.14A 5m5kC-5v96A:
58.8		 5m5kC-5v96A:
62.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M66_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 12 HIS A  59
THR A  64
ASP A 136
THR A 198
ASP A 231
 ADN  A 502 ( 3.9A)
ADN  A 502 (-4.4A)
ADN  A 502 (-2.9A)
NAD  A 501 ( 2.9A)
ADN  A 502 (-2.8A)
 1.22A 5m66A-5v96A:
62.6		 5m66A-5v96A:
62.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M66_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		12 / 12 LEU A  58
HIS A  59
THR A  61
ASP A 136
THR A 198
LYS A 227
ASP A 231
LEU A 389
GLY A 394
HIS A 395
MET A 400
PHE A 404
 None
ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
NAD  A 501 ( 2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.13A 5m66A-5v96A:
62.6		 5m66A-5v96A:
62.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M66_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 12 THR A 199
LYS A 227
ASP A 231
LEU A 386
HIS A 395
 NAD  A 501 (-3.0A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 3.4A)
 1.25A 5m66A-5v96A:
62.6		 5m66A-5v96A:
62.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M66_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		7 / 12 HIS A  59
ASP A 136
GLU A 197
LYS A 227
ASP A 231
LEU A 386
HIS A 395
 ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 3.4A)
 1.41A 5m66B-5v96A:
63.0		 5m66B-5v96A:
62.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M66_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		12 / 12 LEU A  58
HIS A  59
THR A  61
ASP A 136
GLU A 197
LYS A 227
ASP A 231
LEU A 389
GLY A 394
HIS A 395
MET A 400
PHE A 404
 None
ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.15A 5m66B-5v96A:
63.0		 5m66B-5v96A:
62.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M66_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		11 / 12 HIS A  59
THR A  61
ASP A 136
THR A 198
LYS A 227
ASP A 231
LEU A 389
GLY A 394
HIS A 395
MET A 400
PHE A 404
 ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
NAD  A 501 ( 2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.12A 5m66C-5v96A:
63.0		 5m66C-5v96A:
62.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M66_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 12 HIS A  59
THR A  64
ASP A 136
THR A 198
ASP A 231
 ADN  A 502 ( 3.9A)
ADN  A 502 (-4.4A)
ADN  A 502 (-2.9A)
NAD  A 501 ( 2.9A)
ADN  A 502 (-2.8A)
 1.23A 5m66C-5v96A:
63.0		 5m66C-5v96A:
62.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M66_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		7 / 12 HIS A  59
ASP A 136
GLU A 197
LYS A 227
ASP A 231
LEU A 386
HIS A 395
 ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 3.4A)
 1.44A 5m66D-5v96A:
62.1		 5m66D-5v96A:
62.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M66_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		11 / 12 HIS A  59
THR A  61
ASP A 136
GLU A 197
LYS A 227
ASP A 231
LEU A 389
GLY A 394
HIS A 395
MET A 400
PHE A 404
 ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.15A 5m66D-5v96A:
62.1		 5m66D-5v96A:
62.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M66_D_ADND502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		3 / 3 THR A  64
THR A 198
LEU A 386
 ADN  A 502 (-4.4A)
NAD  A 501 ( 2.9A)
NAD  A 501 (-3.9A)
 0.22A 5m66D-5v96A:
62.1		 5m66D-5v96A:
62.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UTU_F_ADNF503_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 12 ASP A 136
LYS A 227
ASP A 231
LEU A 386
HIS A 395
 ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 3.4A)
 1.34A 5utuF-5v96A:
56.2		 5utuF-5v96A:
54.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UTU_F_ADNF503_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		12 / 12 LEU A  58
HIS A  59
THR A  61
ASP A 136
THR A 198
LYS A 227
ASP A 231
LEU A 389
GLY A 394
HIS A 395
MET A 400
PHE A 404
 None
ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
NAD  A 501 ( 2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.23A 5utuF-5v96A:
56.2		 5utuF-5v96A:
54.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UTU_F_ADNF503_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 12 THR A 199
LYS A 227
ASP A 231
LEU A 386
HIS A 395
 NAD  A 501 (-3.0A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 3.4A)
 1.22A 5utuF-5v96A:
56.2		 5utuF-5v96A:
54.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UTU_F_ADNF503_2
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		4 / 4 GLU A  63
THR A  64
GLU A 197
HIS A 342
 ADN  A 502 (-3.6A)
ADN  A 502 (-4.4A)
ADN  A 502 (-3.5A)
NAD  A 501 ( 4.9A)
 0.28A 5utuF-5v96A:
56.2		 5utuF-5v96A:
54.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UTU_H_ADNH503_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 12 ASP A 136
LYS A 227
ASP A 231
LEU A 386
HIS A 395
 ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 3.4A)
 1.35A 5utuH-5v96A:
56.7		 5utuH-5v96A:
54.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UTU_H_ADNH503_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		12 / 12 LEU A  58
HIS A  59
THR A  61
GLU A  63
ASP A 136
LYS A 227
ASP A 231
LEU A 389
GLY A 394
HIS A 395
MET A 400
PHE A 404
 None
ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.6A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.19A 5utuH-5v96A:
56.7		 5utuH-5v96A:
54.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UTU_H_ADNH503_2
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 5 THR A  64
GLU A 197
THR A 198
HIS A 342
LEU A 386
 ADN  A 502 (-4.4A)
ADN  A 502 (-3.5A)
NAD  A 501 ( 2.9A)
NAD  A 501 ( 4.9A)
NAD  A 501 (-3.9A)
 0.38A 5utuH-5v96A:
56.7		 5utuH-5v96A:
54.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6APH_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		6 / 12 LEU A  58
ASP A 136
GLU A 197
LYS A 227
ASP A 231
LEU A 389
 None
ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.7A)
 0.99A 6aphA-5v96A:
56.9		 6aphA-5v96A:
58.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6APH_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		12 / 12 LEU A  58
HIS A  59
THR A  61
ASP A 136
GLU A 197
LYS A 227
ASP A 231
LEU A 386
GLY A 394
HIS A 395
MET A 400
PHE A 404
 None
ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.42A 6aphA-5v96A:
56.9		 6aphA-5v96A:
58.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		4 / 6 TYR A 472
VAL A 434
GLU A 432
ALA A 467
 None
None
None
EDO  A 505 ( 4.6A)
 1.24A 6djzB-5v96A:
undetectable		 6djzB-5v96A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_0
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		10 / 12 HIS A  59
THR A  61
THR A  64
ASP A 231
ASN A 388
LEU A 389
GLY A 394
HIS A 395
MET A 400
PHE A 404
 ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-4.4A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.1A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.26A 6exiA-5v96A:
61.0		 6exiA-5v96A:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		7 / 10 GLY A 261
GLY A 263
GLU A 284
ASP A 286
THR A 317
ASN A 319
ILE A 322
 NAD  A 501 (-3.6A)
NAD  A 501 (-3.1A)
NAD  A 501 (-2.8A)
None
NAD  A 501 (-4.1A)
NAD  A 501 (-3.9A)
NAD  A 501 (-4.8A)
 0.16A 6exiA-5v96A:
61.0		 6exiA-5v96A:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		3 / 3 LEU A 449
GLN A 453
LYS A 466
 None
 0.20A 6exiB-5v96A:
56.7		 6exiB-5v96A:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB502_0
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		10 / 12 HIS A  59
THR A  61
THR A  64
LYS A 227
ASP A 231
ASN A 388
LEU A 389
HIS A 395
MET A 400
PHE A 404
 ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-4.4A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.1A)
ADN  A 502 ( 4.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.69A 6exiB-5v96A:
56.7		 6exiB-5v96A:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_0
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		3 / 3 LEU A 449
GLN A 453
LYS A 466
 None
 0.23A 6exiA-5v96A:
61.0		 6exiA-5v96A:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		7 / 10 GLY A 261
GLY A 263
GLU A 284
ASP A 286
THR A 317
ASN A 319
ILE A 322
 NAD  A 501 (-3.6A)
NAD  A 501 (-3.1A)
NAD  A 501 (-2.8A)
None
NAD  A 501 (-4.1A)
NAD  A 501 (-3.9A)
NAD  A 501 (-4.8A)
 0.17A 6exiB-5v96A:
56.7		 6exiB-5v96A:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_0
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		9 / 12 LEU A  58
HIS A  59
THR A  61
THR A  64
ASP A 231
ASN A 388
LEU A 389
HIS A 395
MET A 400
 None
ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-4.4A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.1A)
ADN  A 502 ( 4.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
 0.26A 6exiC-5v96A:
58.0		 6exiC-5v96A:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_0
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 12 LEU A  58
THR A  64
ASP A 231
ASN A 232
MET A 400
 None
ADN  A 502 (-4.4A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.5A)
ADN  A 502 (-3.8A)
 0.83A 6exiC-5v96A:
58.0		 6exiC-5v96A:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		7 / 12 GLY A 261
GLY A 263
GLU A 284
ASP A 286
THR A 317
ASN A 319
ILE A 322
 NAD  A 501 (-3.6A)
NAD  A 501 (-3.1A)
NAD  A 501 (-2.8A)
None
NAD  A 501 (-4.1A)
NAD  A 501 (-3.9A)
NAD  A 501 (-4.8A)
 0.17A 6exiC-5v96A:
58.0
6exiD-5v96A:
57.4		 6exiC-5v96A:
13.09
6exiD-5v96A:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_0
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		10 / 12 HIS A  59
THR A  61
THR A  64
ASP A 231
ASN A 388
LEU A 389
GLY A 394
HIS A 395
MET A 400
PHE A 404
 ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-4.4A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.1A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.35A 6exiD-5v96A:
57.4		 6exiD-5v96A:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND503_0
(ADENOSYLHOMOCYSTEINA
SE)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		7 / 12 GLY A 261
GLY A 263
GLU A 284
ASP A 286
THR A 317
ASN A 319
ILE A 322
 NAD  A 501 (-3.6A)
NAD  A 501 (-3.1A)
NAD  A 501 (-2.8A)
None
NAD  A 501 (-4.1A)
NAD  A 501 (-3.9A)
NAD  A 501 (-4.8A)
 0.17A 6exiC-5v96A:
58.0
6exiD-5v96A:
57.4		 6exiC-5v96A:
13.09
6exiD-5v96A:
13.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3M_A_ADNA502_1
(-)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		6 / 12 ASP A 136
GLU A 197
LYS A 227
ASP A 231
LEU A 389
HIS A 395
 ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.7A)
ADN  A 502 ( 3.4A)
 1.17A 6f3mA-5v96A:
53.4		 6f3mA-5v96A:
46.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3M_A_ADNA502_1
(-)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		11 / 12 HIS A  59
THR A  61
ASP A 136
GLU A 197
LYS A 227
ASP A 231
LEU A 386
GLY A 394
HIS A 395
MET A 400
PHE A 404
 ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.33A 6f3mA-5v96A:
53.4		 6f3mA-5v96A:
46.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3M_B_ADNB502_1
(-)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		7 / 12 HIS A  59
ASP A 136
GLU A 197
LYS A 227
ASP A 231
LEU A 386
HIS A 395
 ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 3.4A)
 1.44A 6f3mB-5v96A:
52.8		 6f3mB-5v96A:
46.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3M_B_ADNB502_1
(-)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		11 / 12 HIS A  59
THR A  61
ASP A 136
GLU A 197
LYS A 227
ASP A 231
LEU A 389
GLY A 394
HIS A 395
MET A 400
PHE A 404
 ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.19A 6f3mB-5v96A:
52.8		 6f3mB-5v96A:
46.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3M_C_ADNC502_1
(-)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 12 ASP A 136
GLU A 197
LYS A 227
ASP A 231
LEU A 389
 ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.7A)
 0.92A 6f3mC-5v96A:
52.7		 6f3mC-5v96A:
46.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3M_C_ADNC502_1
(-)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		11 / 12 HIS A  59
THR A  61
ASP A 136
GLU A 197
LYS A 227
ASP A 231
LEU A 386
GLY A 394
HIS A 395
MET A 400
PHE A 404
 ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.34A 6f3mC-5v96A:
52.7		 6f3mC-5v96A:
46.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3M_D_ADND502_1
(-)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		7 / 12 HIS A  59
ASP A 136
GLU A 197
LYS A 227
ASP A 231
LEU A 386
HIS A 395
 ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 3.4A)
 1.45A 6f3mD-5v96A:
52.8		 6f3mD-5v96A:
46.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3M_D_ADND502_1
(-)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		11 / 12 HIS A  59
THR A  61
ASP A 136
GLU A 197
LYS A 227
ASP A 231
LEU A 389
GLY A 394
HIS A 395
MET A 400
PHE A 404
 ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.18A 6f3mD-5v96A:
52.8		 6f3mD-5v96A:
46.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_A_ADNA505_1
(-)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		7 / 12 HIS A  59
ASP A 136
GLU A 197
LYS A 227
ASP A 231
LEU A 386
HIS A 395
 ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 3.4A)
 1.46A 6f3nA-5v96A:
52.8		 6f3nA-5v96A:
46.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_A_ADNA505_1
(-)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		12 / 12 HIS A  59
THR A  61
ASP A 136
GLU A 197
LYS A 227
ASP A 231
LEU A 386
LEU A 389
GLY A 394
HIS A 395
MET A 400
PHE A 404
 ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.39A 6f3nA-5v96A:
52.8		 6f3nA-5v96A:
46.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_B_ADNB505_1
(-)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 12 GLU A 197
THR A 198
GLY A 235
MET A 400
PHE A 404
 ADN  A 502 (-3.5A)
NAD  A 501 ( 2.9A)
None
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 1.46A 6f3nB-5v96A:
52.9		 6f3nB-5v96A:
46.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_B_ADNB505_1
(-)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		7 / 12 HIS A  59
ASP A 136
GLU A 197
LYS A 227
ASP A 231
LEU A 386
HIS A 395
 ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 3.4A)
 1.46A 6f3nB-5v96A:
52.9		 6f3nB-5v96A:
46.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_B_ADNB505_1
(-)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		12 / 12 HIS A  59
THR A  61
ASP A 136
GLU A 197
THR A 198
LYS A 227
ASP A 231
LEU A 389
GLY A 394
HIS A 395
MET A 400
PHE A 404
 ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
NAD  A 501 ( 2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.18A 6f3nB-5v96A:
52.9		 6f3nB-5v96A:
46.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_B_ADNB505_1
(-)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 12 HIS A  59
THR A  64
ASP A 136
THR A 198
ASP A 231
 ADN  A 502 ( 3.9A)
ADN  A 502 (-4.4A)
ADN  A 502 (-2.9A)
NAD  A 501 ( 2.9A)
ADN  A 502 (-2.8A)
 1.23A 6f3nB-5v96A:
52.9		 6f3nB-5v96A:
46.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_C_ADNC505_1
(-)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		12 / 12 HIS A  59
THR A  61
ASP A 136
GLU A 197
LYS A 227
ASP A 231
LEU A 386
LEU A 389
GLY A 394
HIS A 395
MET A 400
PHE A 404
 ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.29A 6f3nC-5v96A:
52.8		 6f3nC-5v96A:
46.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_C_ADNC505_1
(-)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 12 HIS A  59
THR A  64
ASP A 136
ASP A 231
LEU A 389
 ADN  A 502 ( 3.9A)
ADN  A 502 (-4.4A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.7A)
 1.35A 6f3nC-5v96A:
52.8		 6f3nC-5v96A:
46.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_D_ADND506_1
(-)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		7 / 12 HIS A  59
ASP A 136
GLU A 197
LYS A 227
ASP A 231
LEU A 386
HIS A 395
 ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 3.4A)
 1.46A 6f3nD-5v96A:
53.6		 6f3nD-5v96A:
46.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_D_ADND506_1
(-)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		12 / 12 HIS A  59
THR A  61
ASP A 136
GLU A 197
LYS A 227
ASP A 231
LEU A 386
LEU A 389
GLY A 394
HIS A 395
MET A 400
PHE A 404
 ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.39A 6f3nD-5v96A:
53.6		 6f3nD-5v96A:
46.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GBN_A_ADNA501_1
(-)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		7 / 12 HIS A  59
ASP A 136
GLU A 197
LYS A 227
ASP A 231
LEU A 386
HIS A 395
 ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 3.4A)
 1.46A 6gbnA-5v96A:
56.6		 6gbnA-5v96A:
54.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GBN_A_ADNA501_1
(-)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		12 / 12 LEU A  58
HIS A  59
THR A  61
ASP A 136
GLU A 197
LYS A 227
ASP A 231
LEU A 389
GLY A 394
HIS A 395
MET A 400
PHE A 404
 None
ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.18A 6gbnA-5v96A:
56.6		 6gbnA-5v96A:
54.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GBN_B_ADNB501_1
(-)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		6 / 12 HIS A  59
ASP A 136
GLU A 197
LYS A 227
ASP A 231
LEU A 389
 ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.7A)
 1.28A 6gbnB-5v96A:
59.1		 6gbnB-5v96A:
54.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GBN_B_ADNB501_1
(-)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		12 / 12 LEU A  58
HIS A  59
THR A  61
ASP A 136
GLU A 197
LYS A 227
ASP A 231
LEU A 386
GLY A 394
HIS A 395
MET A 400
PHE A 404
 None
ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.23A 6gbnB-5v96A:
59.1		 6gbnB-5v96A:
54.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GBN_C_ADNC501_1
(-)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		7 / 12 HIS A  59
ASP A 136
GLU A 197
LYS A 227
ASP A 231
LEU A 386
HIS A 395
 ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 3.4A)
 1.48A 6gbnC-5v96A:
56.7		 6gbnC-5v96A:
54.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GBN_C_ADNC501_1
(-)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		12 / 12 LEU A  58
HIS A  59
THR A  61
ASP A 136
GLU A 197
LYS A 227
ASP A 231
LEU A 386
LEU A 389
HIS A 395
MET A 400
PHE A 404
 None
ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 4.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.22A 6gbnC-5v96A:
56.7		 6gbnC-5v96A:
54.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GBN_D_ADND501_1
(-)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		7 / 12 HIS A  59
ASP A 136
GLU A 197
LYS A 227
ASP A 231
LEU A 386
HIS A 395
 ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.9A)
ADN  A 502 ( 3.4A)
 1.46A 6gbnD-5v96A:
56.0		 6gbnD-5v96A:
54.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GBN_D_ADND501_1
(-)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		12 / 12 LEU A  58
HIS A  59
THR A  61
ASP A 136
GLU A 197
LYS A 227
ASP A 231
LEU A 389
GLY A 394
HIS A 395
MET A 400
PHE A 404
 None
ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-3.5A)
ADN  A 502 (-2.9A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.20A 6gbnD-5v96A:
56.0		 6gbnD-5v96A:
54.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCO_A_FY5A1003_0
(ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2)		 5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(Naegleria
fowleri) 		5 / 11 THR A 198
ASN A 222
VAL A 134
THR A  64
PHE A 404
 NAD  A 501 ( 2.9A)
NAD  A 501 ( 4.7A)
None
ADN  A 502 (-4.4A)
ADN  A 502 (-4.9A)
 1.49A 6hcoA-5v96A:
undetectable
6hcoB-5v96A:
undetectable		 6hcoA-5v96A:
21.68
6hcoB-5v96A:
21.68