SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5v9p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_2
(VITAMIN D NUCLEAR
RECEPTOR)		 5v9p LYSINE-SPECIFIC
DEMETHYLASE 5A
(Homo
sapiens) 		4 / 6 LEU A  80
TRP A 503
TYR A 504
VAL A 407
 None
90S  A 904 (-4.7A)
None
None
 1.11A 1db1A-5v9pA:
undetectable		 1db1A-5v9pA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_C_DMEC997_1
(ACETYLCHOLINESTERASE)		 5v9p LYSINE-SPECIFIC
DEMETHYLASE 5A
(Homo
sapiens) 		5 / 12 GLY A 560
PHE A 562
PHE A 422
TYR A 438
HIS A 496
 None
 1.36A 1maaC-5v9pA:
undetectable		 1maaC-5v9pA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 5v9p LYSINE-SPECIFIC
DEMETHYLASE 5A
(Homo
sapiens) 		5 / 11 LEU A 514
GLY A 505
SER A 572
LEU A 545
MET A 546
 None
 1.11A 1mx1A-5v9pA:
undetectable		 1mx1A-5v9pA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA734_1
(ALPHA AMYLASE)		 5v9p LYSINE-SPECIFIC
DEMETHYLASE 5A
(Homo
sapiens) 		4 / 6 ASN A 444
TRP A  57
TYR A 494
GLY A 421
 None
 1.41A 1mxdA-5v9pA:
undetectable		 1mxdA-5v9pA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUA_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 5v9p LYSINE-SPECIFIC
DEMETHYLASE 5A
(Homo
sapiens) 		5 / 10 ALA A 581
TRP A 503
LEU A 495
GLY A 560
PHE A 562
 None
90S  A 904 (-4.7A)
None
None
None
 1.35A 1ruaH-5v9pA:
undetectable
1ruaL-5v9pA:
undetectable		 1ruaH-5v9pA:
15.25
1ruaL-5v9pA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		 5v9p LYSINE-SPECIFIC
DEMETHYLASE 5A
(Homo
sapiens) 		5 / 12 ILE A 484
LEU A 545
VAL A 506
GLU A 515
LEU A 514
 None
 1.12A 2bxfA-5v9pA:
undetectable		 2bxfA-5v9pA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		 5v9p LYSINE-SPECIFIC
DEMETHYLASE 5A
(Homo
sapiens) 		5 / 12 ILE A 484
LEU A 545
VAL A 506
GLU A 515
LEU A 514
 None
 1.12A 2bxfB-5v9pA:
undetectable		 2bxfB-5v9pA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5v9p LYSINE-SPECIFIC
DEMETHYLASE 5A
(Homo
sapiens) 		4 / 8 ALA A 569
TRP A 482
GLY A  47
ILE A  48
 None
 0.62A 2zm9A-5v9pA:
undetectable		 2zm9A-5v9pA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX94_0
(PROTEIN S100-B)		 5v9p LYSINE-SPECIFIC
DEMETHYLASE 5A
(Homo
sapiens) 		3 / 3 PHE A  22
CYH A  49
PHE A 566
 None
 0.98A 3cr5X-5v9pA:
undetectable		 3cr5X-5v9pA:
7.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 5v9p LYSINE-SPECIFIC
DEMETHYLASE 5A
(Homo
sapiens) 		4 / 6 PHE A  70
TYR A 361
VAL A 407
PHE A 366
 None
 1.38A 3ltwA-5v9pA:
undetectable		 3ltwA-5v9pA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 5v9p LYSINE-SPECIFIC
DEMETHYLASE 5A
(Homo
sapiens) 		4 / 4 LEU A 146
GLY A 147
GLY A 143
THR A 154
 None
 0.72A 3si7A-5v9pA:
undetectable		 3si7A-5v9pA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 5v9p LYSINE-SPECIFIC
DEMETHYLASE 5A
(Homo
sapiens) 		4 / 5 LEU A 146
GLY A 147
GLY A 143
THR A 154
 None
 0.70A 3si7C-5v9pA:
undetectable
3si7D-5v9pA:
undetectable		 3si7C-5v9pA:
16.43
3si7D-5v9pA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SOA_A_DB8A445_1
(CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER)		 5v9p LYSINE-SPECIFIC
DEMETHYLASE 5A
(Homo
sapiens) 		4 / 6 LEU A  77
VAL A 405
PHE A 373
PHE A 378
 None
 1.14A 3soaA-5v9pA:
undetectable		 3soaA-5v9pA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)		 5v9p LYSINE-SPECIFIC
DEMETHYLASE 5A
(Homo
sapiens) 		4 / 5 ARG A  87
LEU A 536
VAL A 537
ASP A 116
 None
 1.08A 3ufnA-5v9pA:
undetectable
3ufnB-5v9pA:
undetectable		 3ufnA-5v9pA:
9.59
3ufnB-5v9pA:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5v9p LYSINE-SPECIFIC
DEMETHYLASE 5A
(Homo
sapiens) 		4 / 7 GLU A 614
PHE A 666
HIS A 702
VAL A 653
 None
None
ZN  A 902 (-3.8A)
None
 1.02A 4a97A-5v9pA:
3.3		 4a97A-5v9pA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5v9p LYSINE-SPECIFIC
DEMETHYLASE 5A
(Homo
sapiens) 		4 / 6 GLU A 614
PHE A 666
HIS A 702
VAL A 653
 None
None
ZN  A 902 (-3.8A)
None
 1.11A 4a97E-5v9pA:
3.3		 4a97E-5v9pA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 5v9p LYSINE-SPECIFIC
DEMETHYLASE 5A
(Homo
sapiens) 		3 / 4 SER A 420
GLY A 442
GLU A 452
 None
 0.60A 4juoA-5v9pA:
2.3
4juoC-5v9pA:
undetectable		 4juoA-5v9pA:
20.10
4juoC-5v9pA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 5v9p LYSINE-SPECIFIC
DEMETHYLASE 5A
(Homo
sapiens) 		4 / 6 LEU A  88
MET A 540
LEU A 533
ILE A 107
 None
 1.12A 4okxA-5v9pA:
undetectable		 4okxA-5v9pA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5v9p LYSINE-SPECIFIC
DEMETHYLASE 5A
(Homo
sapiens) 		4 / 6 TYR A 438
TYR A 494
LEU A 445
PHE A 562
 None
 1.20A 4twdD-5v9pA:
3.3
4twdE-5v9pA:
3.3		 4twdD-5v9pA:
16.69
4twdE-5v9pA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5v9p LYSINE-SPECIFIC
DEMETHYLASE 5A
(Homo
sapiens) 		4 / 7 TYR A 494
LEU A 445
PHE A 562
TYR A 438
 None
 1.20A 4twdF-5v9pA:
undetectable
4twdJ-5v9pA:
undetectable		 4twdF-5v9pA:
16.69
4twdJ-5v9pA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5v9p LYSINE-SPECIFIC
DEMETHYLASE 5A
(Homo
sapiens) 		4 / 6 TYR A 438
TYR A 494
LEU A 445
PHE A 562
 None
 1.22A 4twdF-5v9pA:
undetectable
4twdG-5v9pA:
0.8		 4twdF-5v9pA:
16.69
4twdG-5v9pA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5v9p LYSINE-SPECIFIC
DEMETHYLASE 5A
(Homo
sapiens) 		4 / 6 TYR A 438
TYR A 494
LEU A 445
PHE A 562
 None
 1.20A 4twdI-5v9pA:
undetectable
4twdJ-5v9pA:
undetectable		 4twdI-5v9pA:
16.69
4twdJ-5v9pA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_0
(REGULATORY PROTEIN
TETR)		 5v9p LYSINE-SPECIFIC
DEMETHYLASE 5A
(Homo
sapiens) 		5 / 12 ALA A 125
SER A 121
LEU A 166
VAL A 142
TYR A 148
 None
 1.39A 5vlmB-5v9pA:
undetectable		 5vlmB-5v9pA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WY0_A_SAMA800_0
(SMALL RNA
2'-O-METHYLTRANSFERA
SE)		 5v9p LYSINE-SPECIFIC
DEMETHYLASE 5A
(Homo
sapiens) 		6 / 12 GLY A 155
GLY A 153
VAL A 142
LEU A 158
HIS A 161
LEU A 120
 None
 1.43A 5wy0A-5v9pA:
undetectable		 5wy0A-5v9pA:
16.07