SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5v9x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5v9x ATP-DEPENDENT DNA
HELICASE
(Mycolicibacteriu
m
smegmatis) 		4 / 5 THR A 145
THR A 144
THR A 154
HIS A 183
 None
 1.38A 1d4fB-5v9xA:
undetectable		 1d4fB-5v9xA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)		 5v9x ATP-DEPENDENT DNA
HELICASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 LEU A 791
ALA A 794
GLU A 805
ALA A 763
LEU A 498
 None
 1.11A 1ictA-5v9xA:
undetectable
1ictC-5v9xA:
undetectable		 1ictA-5v9xA:
19.67
1ictC-5v9xA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_B_ID2B2_0
(THYMIDINE KINASE)		 5v9x ATP-DEPENDENT DNA
HELICASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLU A 267
ILE A 292
ALA A 357
ARG A 296
GLU A 260
 None
 1.45A 1ki7B-5v9xA:
undetectable		 1ki7B-5v9xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_A_ADNA1501_1
(CLASS B ACID
PHOSPHATASE)		 5v9x ATP-DEPENDENT DNA
HELICASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 PHE A  20
LEU A  60
TRP A  35
GLY A  53
THR A  22
 ANP  A 901 ( 4.9A)
None
None
ANP  A 901 (-3.3A)
None
 1.33A 1rmtA-5v9xA:
undetectable		 1rmtA-5v9xA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA502_1
(YKOF)		 5v9x ATP-DEPENDENT DNA
HELICASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 ALA A 847
LEU A 849
ILE A 679
SER A 843
 None
 1.02A 1sbrA-5v9xA:
undetectable
1sbrB-5v9xA:
undetectable		 1sbrA-5v9xA:
15.50
1sbrB-5v9xA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_0
(VP39)		 5v9x ATP-DEPENDENT DNA
HELICASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ILE A 273
VAL A 373
VAL A 358
ALA A 331
LEU A 350
 None
 1.00A 1vptA-5v9xA:
undetectable		 1vptA-5v9xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2003_1
(SERUM ALBUMIN)		 5v9x ATP-DEPENDENT DNA
HELICASE
(Mycolicibacteriu
m
smegmatis) 		5 / 9 LEU A 142
ARG A 122
LEU A 161
ARG A 190
LEU A 191
 None
 1.40A 2bxeA-5v9xA:
undetectable		 2bxeA-5v9xA:
7.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 5v9x ATP-DEPENDENT DNA
HELICASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ARG A 758
GLU A 809
SER A 778
 None
 0.73A 2xctD-5v9xA:
5.4		 2xctD-5v9xA:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 5v9x ATP-DEPENDENT DNA
HELICASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 ARG A 808
ASP A 441
GLN A 783
GLU A 761
 None
 1.15A 2ya7C-5v9xA:
undetectable		 2ya7C-5v9xA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 5v9x ATP-DEPENDENT DNA
HELICASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 SER A 384
GLU A 171
ASP A  91
 None
MG  A 906 ( 3.9A)
None
 0.81A 2zulA-5v9xA:
3.9		 2zulA-5v9xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 5v9x ATP-DEPENDENT DNA
HELICASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 SER A 384
GLU A 171
ASP A  91
 None
MG  A 906 ( 3.9A)
None
 0.83A 3dmhA-5v9xA:
4.0		 3dmhA-5v9xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5v9x ATP-DEPENDENT DNA
HELICASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 ILE A 717
GLY A 685
TYR A 815
ARG A 598
 None
 0.90A 3elzA-5v9xA:
undetectable		 3elzA-5v9xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA424_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5v9x ATP-DEPENDENT DNA
HELICASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ARG A 598
SER A 682
GLY A 690
PRO A 691
 None
 1.08A 3hcrA-5v9xA:
3.0		 3hcrA-5v9xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 5v9x ATP-DEPENDENT DNA
HELICASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A 433
LEU A  85
PRO A  84
SER A 363
ALA A 386
 None
 1.14A 3i5uB-5v9xA:
2.9		 3i5uB-5v9xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 5v9x ATP-DEPENDENT DNA
HELICASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 PRO A 230
GLY A 428
ARG A 424
VAL A 385
ILE A 430
 None
 1.47A 3jb2A-5v9xA:
3.3		 3jb2A-5v9xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)		 5v9x ATP-DEPENDENT DNA
HELICASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 TYR A  81
GLU A 171
PHE A  59
ILE A  38
 None
MG  A 906 ( 3.9A)
None
None
 1.07A 3jz0B-5v9xA:
undetectable		 3jz0B-5v9xA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_0
(GLYCINE
N-METHYLTRANSFERASE)		 5v9x ATP-DEPENDENT DNA
HELICASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 SER A 352
LEU A 350
MET A 370
ARG A  94
 None
None
None
GOL  A 902 (-4.1A)
 1.40A 3thrB-5v9xA:
undetectable		 3thrB-5v9xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_A_SALA404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 5v9x ATP-DEPENDENT DNA
HELICASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 ALA A 819
TYR A 684
ARG A 604
ALA A 610
 None
 1.07A 3twpA-5v9xA:
undetectable		 3twpA-5v9xA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1000_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 5v9x ATP-DEPENDENT DNA
HELICASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 GLU A 838
LYS A 729
TRP A 676
GLU A 836
 None
 1.30A 4a7tA-5v9xA:
undetectable		 4a7tA-5v9xA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5v9x ATP-DEPENDENT DNA
HELICASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 GLU A 558
GLU A 554
HIS A 689
VAL A 817
 None
 1.04A 4a97A-5v9xA:
undetectable		 4a97A-5v9xA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5v9x ATP-DEPENDENT DNA
HELICASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 GLU A 558
GLU A 554
HIS A 689
VAL A 817
 None
 1.10A 4a97D-5v9xA:
undetectable		 4a97D-5v9xA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5v9x ATP-DEPENDENT DNA
HELICASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 GLU A 558
GLU A 554
HIS A 689
VAL A 817
 None
 1.11A 4a97H-5v9xA:
undetectable		 4a97H-5v9xA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 5v9x ATP-DEPENDENT DNA
HELICASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 GLY A 609
ASP A 661
ALA A 614
GLY A 613
VAL A 420
 None
 1.24A 4c5lA-5v9xA:
undetectable		 4c5lA-5v9xA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 5v9x ATP-DEPENDENT DNA
HELICASE
(Mycolicibacteriu
m
smegmatis) 		5 / 9 GLY A 609
ASP A 661
ALA A 614
GLY A 613
VAL A 420
 None
 1.28A 4c5lB-5v9xA:
undetectable		 4c5lB-5v9xA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 5v9x ATP-DEPENDENT DNA
HELICASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 GLY A 609
ASP A 661
ALA A 614
GLY A 613
VAL A 420
 None
 1.19A 4c5lC-5v9xA:
3.2		 4c5lC-5v9xA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 5v9x ATP-DEPENDENT DNA
HELICASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 GLY A 609
ASP A 661
ALA A 614
GLY A 613
VAL A 420
 None
 1.27A 4c5lD-5v9xA:
3.0		 4c5lD-5v9xA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 5v9x ATP-DEPENDENT DNA
HELICASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 GLY A 609
ASP A 661
ALA A 614
GLY A 613
VAL A 420
 None
 1.25A 4c5nB-5v9xA:
undetectable		 4c5nB-5v9xA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 5v9x ATP-DEPENDENT DNA
HELICASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 GLY A 609
ASP A 661
ALA A 614
GLY A 613
VAL A 420
 None
 1.26A 4c5nD-5v9xA:
undetectable		 4c5nD-5v9xA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_A_SVRA301_1
(NUCLEOCAPSID PROTEIN)		 5v9x ATP-DEPENDENT DNA
HELICASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 GLY A 417
ALA A 614
VAL A 420
GLN A 423
PRO A 409
 None
 1.33A 4j4vA-5v9xA:
undetectable		 4j4vA-5v9xA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_D_SVRD301_1
(NUCLEOCAPSID PROTEIN)		 5v9x ATP-DEPENDENT DNA
HELICASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 GLY A 417
ALA A 614
VAL A 420
GLN A 423
PHE A 636
 None
 1.34A 4j4vD-5v9xA:
undetectable
4j4vE-5v9xA:
undetectable		 4j4vD-5v9xA:
16.98
4j4vE-5v9xA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_D_SVRD301_1
(NUCLEOCAPSID PROTEIN)		 5v9x ATP-DEPENDENT DNA
HELICASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 GLY A 417
ALA A 614
VAL A 420
GLN A 423
PRO A 409
 None
 1.31A 4j4vD-5v9xA:
undetectable
4j4vE-5v9xA:
undetectable		 4j4vD-5v9xA:
16.98
4j4vE-5v9xA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_E_SVRE301_1
(NUCLEOCAPSID PROTEIN)		 5v9x ATP-DEPENDENT DNA
HELICASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 GLY A 417
ALA A 614
VAL A 420
GLN A 423
PRO A 409
 None
 1.31A 4j4vA-5v9xA:
0.0
4j4vE-5v9xA:
undetectable		 4j4vA-5v9xA:
16.98
4j4vE-5v9xA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		 5v9x ATP-DEPENDENT DNA
HELICASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 GLY A 613
ASP A 661
GLY A 617
GLU A 618
 None
 0.95A 4koeA-5v9xA:
5.4
4koeB-5v9xA:
5.6
4koeD-5v9xA:
undetectable		 4koeA-5v9xA:
9.49
4koeB-5v9xA:
9.49
4koeD-5v9xA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_2
(ANCESTRAL STEROID
RECEPTOR 2)		 5v9x ATP-DEPENDENT DNA
HELICASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 MET A 246
ALA A 247
THR A 616
VAL A 612
 None
 0.86A 4ltwA-5v9xA:
undetectable		 4ltwA-5v9xA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKN_B_KANB403_1
(L-LACTATE
DEHYDROGENASE A
CHAIN)		 5v9x ATP-DEPENDENT DNA
HELICASE
(Mycolicibacteriu
m
smegmatis) 		5 / 9 ASP A  64
ALA A  67
ARG A 165
ILE A 117
ILE A 103
 None
 1.38A 4oknB-5v9xA:
2.8		 4oknB-5v9xA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_0
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 5v9x ATP-DEPENDENT DNA
HELICASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 PHE A 275
SER A 384
ILE A 377
LEU A 389
VAL A 392
 None
 1.01A 4qdjA-5v9xA:
3.8		 4qdjA-5v9xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		 5v9x ATP-DEPENDENT DNA
HELICASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ILE A 706
LEU A 721
LEU A 733
PHE A 734
 None
 0.80A 4qopC-5v9xA:
undetectable		 4qopC-5v9xA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_1
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 5v9x ATP-DEPENDENT DNA
HELICASE
(Mycolicibacteriu
m
smegmatis) 		4 / 4 THR A  16
GLY A  10
ASP A   7
SER A  13
 None
 1.18A 4rfqA-5v9xA:
2.6		 4rfqA-5v9xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_1
(HYDG PROTEIN)		 5v9x ATP-DEPENDENT DNA
HELICASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 GLU A  93
ARG A  97
GLN A 130
 None
 0.71A 4rtbA-5v9xA:
undetectable		 4rtbA-5v9xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5v9x ATP-DEPENDENT DNA
HELICASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 ILE A 416
VAL A 241
PHE A 636
ARG A 630
 None
 1.19A 4xe5A-5v9xA:
undetectable		 4xe5A-5v9xA:
5.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5v9x ATP-DEPENDENT DNA
HELICASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 PRO A 139
ILE A 143
VAL A 167
PHE A  59
 None
 1.19A 4xe5A-5v9xA:
undetectable		 4xe5A-5v9xA:
5.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 5v9x ATP-DEPENDENT DNA
HELICASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A 381
PRO A 383
GLU A 431
SER A 387
LEU A 407
 None
 1.43A 4xqeA-5v9xA:
3.0		 4xqeA-5v9xA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B504_1
(HOMOSPERMIDINE
SYNTHASE)		 5v9x ATP-DEPENDENT DNA
HELICASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A 381
PRO A 383
GLU A 431
SER A 387
LEU A 407
 None
 1.44A 4xqeB-5v9xA:
3.0		 4xqeB-5v9xA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XRG_B_AG2B502_1
(HOMOSPERMIDINE
SYNTHASE)		 5v9x ATP-DEPENDENT DNA
HELICASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A 381
PRO A 383
GLU A 431
SER A 387
LEU A 407
 None
 1.47A 4xrgB-5v9xA:
2.9		 4xrgB-5v9xA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5v9x ATP-DEPENDENT DNA
HELICASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A 509
PHE A 150
LEU A 486
PHE A 479
THR A 510
 None
 1.00A 4zdyA-5v9xA:
undetectable		 4zdyA-5v9xA:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5v9x ATP-DEPENDENT DNA
HELICASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A 509
PHE A 150
LEU A 486
PHE A 479
THR A 510
 None
 0.99A 4ze1A-5v9xA:
undetectable		 4ze1A-5v9xA:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5v9x ATP-DEPENDENT DNA
HELICASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 SER A 337
ASP A 600
ARG A 531
GLY A 532
 None
 1.03A 5cdqA-5v9xA:
2.9
5cdqC-5v9xA:
2.9
5cdqD-5v9xA:
1.6		 5cdqA-5v9xA:
10.37
5cdqC-5v9xA:
10.37
5cdqD-5v9xA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5v9x ATP-DEPENDENT DNA
HELICASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A 509
PHE A 150
LEU A 486
PHE A 479
THR A 510
 None
 1.08A 5eqbA-5v9xA:
undetectable		 5eqbA-5v9xA:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA303_1
(CHITOSANASE)		 5v9x ATP-DEPENDENT DNA
HELICASE
(Mycolicibacteriu
m
smegmatis) 		4 / 5 ASP A 715
VAL A 420
GLY A 609
ALA A 611
 None
 0.94A 5hwaA-5v9xA:
undetectable		 5hwaA-5v9xA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 5v9x ATP-DEPENDENT DNA
HELICASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 LEU A  88
SER A 205
THR A 144
GLY A 181
LEU A 184
 None
 1.27A 5m5cE-5v9xA:
2.2		 5m5cE-5v9xA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND2_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 5v9x ATP-DEPENDENT DNA
HELICASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 VAL A 239
LEU A 648
ALA A 419
PHE A 615
ARG A 624
 None
 0.98A 5nd2B-5v9xA:
undetectable		 5nd2B-5v9xA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)		 5v9x ATP-DEPENDENT DNA
HELICASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 VAL A 612
GLY A 613
SER A 682
ASP A 714
LEU A 608
 None
 1.05A 5x6yA-5v9xA:
3.1		 5x6yA-5v9xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 5v9x ATP-DEPENDENT DNA
HELICASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ASP A 715
ALA A 712
GLY A 603
GLY A 685
SER A 384
 None
 1.30A 6clxA-5v9xA:
3.1		 6clxA-5v9xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5v9x ATP-DEPENDENT DNA
HELICASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A 509
PHE A 150
LEU A 486
PHE A 479
THR A 510
 None
 0.97A 6e8qA-5v9xA:
undetectable		 6e8qA-5v9xA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I0Y_A_TRPA3001_0
(23S RIBOSOMAL RNA
TRYPTOPHANASE OPERON
LEADER PEPTIDE)		 5v9x ATP-DEPENDENT DNA
HELICASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 TRP A  61
ILE A  63
ASP A  64
 None
 0.66A 6i0y7-5v9xA:
undetectable		 6i0y7-5v9xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JI6_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME)		 5v9x ATP-DEPENDENT DNA
HELICASE
(Mycolicibacteriu
m
smegmatis) 		4 / 5 GLY A 367
LEU A 366
SER A  83
TYR A  81
 ANP  A 901 (-3.5A)
None
None
None
 1.31A 6ji6A-5v9xA:
undetectable		 6ji6A-5v9xA:
undetectable