SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5va3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)		 5va3 POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 2
(Homo
sapiens) 		5 / 12 GLY A 522
ASP A 456
LEU A 417
VAL A 418
LEU A 529
 None
 0.96A 1r30A-5va3A:
undetectable		 1r30A-5va3A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5va3 POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 2
(Homo
sapiens) 		4 / 7 LEU A 779
PHE A 781
LEU A 856
PHE A 758
 None
 1.00A 1wrlE-5va3A:
undetectable
1wrlF-5va3A:
undetectable		 1wrlE-5va3A:
9.21
1wrlF-5va3A:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1435_1
(CHITINASE)		 5va3 POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 2
(Homo
sapiens) 		3 / 3 TRP A 412
GLU A 544
TYR A 545
 None
 1.06A 2a3aA-5va3A:
undetectable		 2a3aA-5va3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_A_ASDA1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 5va3 POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 2
(Homo
sapiens) 		4 / 8 ILE A 571
GLY A 572
LEU A 586
LEU A 589
 None
 0.71A 2vctA-5va3A:
undetectable		 2vctA-5va3A:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_B_ASDB1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 5va3 POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 2
(Homo
sapiens) 		4 / 8 ILE A 571
GLY A 572
LEU A 586
LEU A 589
 None
 0.68A 2vctB-5va3A:
undetectable		 2vctB-5va3A:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)		 5va3 POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 2
(Homo
sapiens) 		4 / 5 SER A 636
LEU A 586
GLY A 584
GLU A 575
 None
 1.13A 3aiaA-5va3A:
undetectable
3aiaB-5va3A:
undetectable		 3aiaA-5va3A:
14.06
3aiaB-5va3A:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 5va3 POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 2
(Homo
sapiens) 		5 / 12 LEU A 779
LEU A 754
LEU A 842
ILE A 804
ILE A 858
 None
 0.98A 4odrA-5va3A:
undetectable
4odrB-5va3A:
undetectable		 4odrA-5va3A:
8.22
4odrB-5va3A:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 5va3 POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 2
(Homo
sapiens) 		5 / 12 PHE A 125
ILE A  30
ILE A 123
ALA A  34
PRO A 114
 None
 1.06A 5e72A-5va3A:
undetectable		 5e72A-5va3A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_1
(CYTOCHROME P450 3A4)		 5va3 POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 2
(Homo
sapiens) 		5 / 12 PHE A 781
ILE A 804
PHE A 758
THR A 760
PHE A 852
 None
 1.18A 5vcgA-5va3A:
0.4		 5vcgA-5va3A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5va3 POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 2
(Homo
sapiens) 		5 / 12 LEU A 622
ILE A 560
ILE A 655
MET A 651
LEU A 415
 None
 1.01A 5ycnA-5va3A:
undetectable		 5ycnA-5va3A:
17.32