SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5va8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_2
(TRANSTHYRETIN)		 5va8 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Paraburkholderia
phymatum) 		4 / 7 LEU A  85
SER A   9
THR A  35
VAL A  62
 None
 0.88A 1dvxB-5va8A:
undetectable		 1dvxB-5va8A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)		 5va8 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Paraburkholderia
phymatum) 		3 / 3 TRP A 248
LEU A 249
LYS A 144
 None
 1.08A 1yajK-5va8A:
2.7		 1yajK-5va8A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1502_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 5va8 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Paraburkholderia
phymatum) 		4 / 5 PRO A  92
GLY A 155
ASN A 154
GLY A 151
 TCE  A 302 ( 4.7A)
None
None
None
 0.98A 1zlqA-5va8A:
0.3		 1zlqA-5va8A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B17_A_DIFA701_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 5va8 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Paraburkholderia
phymatum) 		5 / 10 ALA A  28
ILE A  51
CYH A  23
GLY A  22
CYH A 232
 None
 1.38A 2b17A-5va8A:
undetectable		 2b17A-5va8A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 5va8 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Paraburkholderia
phymatum) 		5 / 11 LEU A  27
VAL A  32
GLY A  31
VAL A  57
ALA A 233
 None
 1.17A 2yy8A-5va8A:
4.2
2yy8B-5va8A:
3.1		 2yy8A-5va8A:
21.66
2yy8B-5va8A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_B_T44B128_1
(TRANSTHYRETIN)		 5va8 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Paraburkholderia
phymatum) 		4 / 7 LEU A  85
SER A   9
THR A  35
VAL A  62
 None
 0.94A 3ozkB-5va8A:
undetectable		 3ozkB-5va8A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SGL_A_SAMA692_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 5va8 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Paraburkholderia
phymatum) 		5 / 12 GLU A  25
GLY A  22
VAL A  12
GLY A 229
PHE A 228
 None
 1.08A 3sglA-5va8A:
5.9		 3sglA-5va8A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5va8 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Paraburkholderia
phymatum) 		4 / 4 PRO A 225
LEU A  19
ILE A 138
ARG A 157
 None
NAP  A 301 (-3.8A)
NAP  A 301 ( 4.9A)
NAP  A 301 ( 3.0A)
 1.50A 4f4dA-5va8A:
2.4		 4f4dA-5va8A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA206_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 5va8 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Paraburkholderia
phymatum) 		4 / 4 ALA A  46
ALA A  49
ALA A  50
ALA A  53
 None
 0.12A 4oadA-5va8A:
undetectable		 4oadA-5va8A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA208_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 5va8 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Paraburkholderia
phymatum) 		4 / 4 ALA A  46
ALA A  49
ALA A  50
ALA A  53
 None
 0.13A 4oaeA-5va8A:
undetectable		 4oaeA-5va8A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_G_CHDG401_0
(BILE SALT HYDROLASE)		 5va8 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Paraburkholderia
phymatum) 		5 / 10 LEU A  44
ILE A  66
LEU A  11
LEU A  27
ALA A  24
 None
NAP  A 301 (-4.2A)
None
None
None
 1.12A 5y7pG-5va8A:
undetectable		 5y7pG-5va8A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA402_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5va8 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Paraburkholderia
phymatum) 		5 / 11 ALA A 231
VAL A 176
ILE A 178
ASN A 179
ILE A 120
 None
 1.25A 5y80A-5va8A:
undetectable		 5y80A-5va8A:
15.10