SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vad'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD8_0
(GRAMICIDIN A)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		3 / 3 VAL A1151
VAL A1101
TRP A1153
 None
 0.97A 1av2C-5vadA:
undetectable
1av2D-5vadA:
undetectable		 1av2C-5vadA:
4.32
1av2D-5vadA:
4.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		6 / 12 ILE A1457
ALA A1476
THR A1211
ILE A1481
PRO A1482
THR A1461
 None
 1.29A 1dhfA-5vadA:
undetectable		 1dhfA-5vadA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		4 / 8 SER A1272
SER A1122
HIS A1173
PHE A1216
 PRO  A1602 (-3.3A)
None
PRO  A1602 ( 4.5A)
PRO  A1602 (-4.3A)
 1.13A 1eqbA-5vadA:
undetectable
1eqbB-5vadA:
undetectable		 1eqbA-5vadA:
22.81
1eqbB-5vadA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		4 / 8 PHE A1216
SER A1272
SER A1122
HIS A1173
 PRO  A1602 (-4.3A)
PRO  A1602 (-3.3A)
None
PRO  A1602 ( 4.5A)
 1.13A 1eqbA-5vadA:
undetectable
1eqbB-5vadA:
undetectable		 1eqbA-5vadA:
22.81
1eqbB-5vadA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		4 / 8 SER A1272
SER A1122
HIS A1173
PHE A1216
 PRO  A1602 (-3.3A)
None
PRO  A1602 ( 4.5A)
PRO  A1602 (-4.3A)
 1.14A 1eqbC-5vadA:
undetectable
1eqbD-5vadA:
undetectable		 1eqbC-5vadA:
22.81
1eqbD-5vadA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		4 / 8 PHE A1216
SER A1272
SER A1122
HIS A1173
 PRO  A1602 (-4.3A)
PRO  A1602 (-3.3A)
None
PRO  A1602 ( 4.5A)
 1.13A 1eqbC-5vadA:
undetectable
1eqbD-5vadA:
undetectable		 1eqbC-5vadA:
22.81
1eqbD-5vadA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1502_0
(FERROCHELATASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		4 / 8 LEU A1192
PRO A1141
VAL A1073
GLY A1072
 None
 0.95A 1hrkA-5vadA:
2.7		 1hrkA-5vadA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2502_0
(FERROCHELATASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		4 / 8 LEU A1192
PRO A1141
VAL A1073
GLY A1072
 None
 0.97A 1hrkB-5vadA:
2.4		 1hrkB-5vadA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE9_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		5 / 12 TYR A1028
LEU A1295
LEU A1293
VAL A1294
VAL A1299
 None
 1.12A 1ie9A-5vadA:
undetectable		 1ie9A-5vadA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRG_A_ADNA300_1
(ALPHA-MOMORCHARIN)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		5 / 9 TYR A1028
GLY A1281
TYR A1512
ILE A1229
ALA A1231
 None
 1.22A 1mrgA-5vadA:
undetectable		 1mrgA-5vadA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI517_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		4 / 7 TYR A1127
ILE A1142
PHE A1078
ALA A1129
 None
 1.07A 1oniG-5vadA:
undetectable
1oniI-5vadA:
undetectable		 1oniG-5vadA:
15.48
1oniI-5vadA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_2
(DIHYDROFOLATE
REDUCTASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		4 / 4 SER A1044
ILE A1043
VAL A1151
THR A1277
 None
 1.16A 1u70A-5vadA:
undetectable		 1u70A-5vadA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_D_DVAD8_0
(GRAMICIDIN D)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		3 / 3 VAL A1151
VAL A1101
TRP A1153
 None
 0.97A 1w5uC-5vadA:
undetectable
1w5uD-5vadA:
undetectable		 1w5uC-5vadA:
4.32
1w5uD-5vadA:
4.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOX_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		4 / 8 PHE A1176
GLU A1185
TYR A1130
TYR A1127
 None
 1.35A 2aoxA-5vadA:
undetectable		 2aoxA-5vadA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA8_0
(GRAMICIDIN D)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		3 / 3 VAL A1101
TRP A1153
VAL A1151
 None
 0.80A 2izqA-5vadA:
undetectable
2izqB-5vadA:
undetectable		 2izqA-5vadA:
4.32
2izqB-5vadA:
4.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		5 / 12 ILE A1404
LEU A1401
PHE A1379
ALA A1381
VAL A1382
 None
 0.98A 2oc8A-5vadA:
undetectable		 2oc8A-5vadA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		5 / 11 ALA A1476
THR A1211
ILE A1481
PRO A1482
THR A1461
 None
 1.06A 2w3aA-5vadA:
undetectable		 2w3aA-5vadA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		6 / 12 ILE A1457
ALA A1476
LEU A1479
THR A1211
ILE A1481
PRO A1482
 None
 1.31A 2w3bA-5vadA:
undetectable		 2w3bA-5vadA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		6 / 12 ILE A1457
ALA A1476
THR A1211
ILE A1481
PRO A1482
THR A1461
 None
 1.37A 2w3bA-5vadA:
undetectable		 2w3bA-5vadA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_2
(NEURAMINIDASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		4 / 6 ASP A1455
TRP A1456
ILE A1457
SER A1478
 None
 1.32A 3ckzA-5vadA:
undetectable		 3ckzA-5vadA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_1
(VITAMIN D3 RECEPTOR)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		5 / 12 TYR A1028
LEU A1295
LEU A1293
VAL A1294
VAL A1299
 None
 1.06A 3m7rA-5vadA:
undetectable		 3m7rA-5vadA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_0
(MNMC2)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		5 / 12 TYR A1127
GLY A1245
GLY A1219
ALA A1182
PHE A1248
 None
 1.23A 3vywD-5vadA:
undetectable		 3vywD-5vadA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA502_0
(OXIDOREDUCTASE,
FMN-BINDING)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		4 / 7 THR A1121
TYR A1127
LEU A1244
PHE A1097
 PRO  A1602 (-3.5A)
None
None
None
 1.29A 4awuA-5vadA:
undetectable		 4awuA-5vadA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY7_B_E20B605_1
(ACETYLCHOLINESTERASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		5 / 11 TRP A1169
TYR A1193
GLU A1123
SER A1272
HIS A1173
 None
None
PRO  A1602 (-2.8A)
PRO  A1602 (-3.3A)
PRO  A1602 ( 4.5A)
 1.48A 4ey7B-5vadA:
undetectable		 4ey7B-5vadA:
22.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HVC_A_HFGA1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		9 / 12 GLU A1100
VAL A1101
TRP A1169
GLU A1171
HIS A1173
PHE A1216
THR A1240
SER A1272
GLY A1274
 None
None
None
PRO  A1602 ( 4.7A)
PRO  A1602 ( 4.5A)
PRO  A1602 (-4.3A)
91Y  A1601 (-4.2A)
PRO  A1602 (-3.3A)
PRO  A1602 (-3.7A)
 0.87A 4hvcA-5vadA:
54.1		 4hvcA-5vadA:
98.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HVC_A_HFGA1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		5 / 12 GLU A1154
PHE A1216
THR A1240
SER A1272
GLY A1274
 91Y  A1601 (-4.6A)
PRO  A1602 (-4.3A)
91Y  A1601 (-4.2A)
PRO  A1602 (-3.3A)
PRO  A1602 (-3.7A)
 0.84A 4hvcA-5vadA:
54.1		 4hvcA-5vadA:
98.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HVC_A_HFGA1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		9 / 12 VAL A1101
PRO A1120
TRP A1169
GLU A1171
HIS A1173
PHE A1216
THR A1240
SER A1272
GLY A1274
 None
None
None
PRO  A1602 ( 4.7A)
PRO  A1602 ( 4.5A)
PRO  A1602 (-4.3A)
91Y  A1601 (-4.2A)
PRO  A1602 (-3.3A)
PRO  A1602 (-3.7A)
 0.64A 4hvcA-5vadA:
54.1		 4hvcA-5vadA:
98.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HVC_A_HFGA1602_1
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		4 / 4 THR A1121
GLU A1123
ARG A1152
HIS A1242
 PRO  A1602 (-3.5A)
PRO  A1602 (-2.8A)
PRO  A1602 ( 3.4A)
PRO  A1602 (-4.1A)
 0.45A 4hvcA-5vadA:
54.1		 4hvcA-5vadA:
98.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HVC_B_HFGB1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		5 / 12 GLU A1154
PHE A1216
THR A1240
SER A1272
GLY A1274
 91Y  A1601 (-4.6A)
PRO  A1602 (-4.3A)
91Y  A1601 (-4.2A)
PRO  A1602 (-3.3A)
PRO  A1602 (-3.7A)
 0.94A 4hvcB-5vadA:
54.2		 4hvcB-5vadA:
98.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HVC_B_HFGB1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		10 / 12 LEU A1087
GLU A1100
VAL A1101
PRO A1120
GLU A1171
HIS A1173
PHE A1216
THR A1240
SER A1272
GLY A1274
 None
None
None
None
PRO  A1602 ( 4.7A)
PRO  A1602 ( 4.5A)
PRO  A1602 (-4.3A)
91Y  A1601 (-4.2A)
PRO  A1602 (-3.3A)
PRO  A1602 (-3.7A)
 0.86A 4hvcB-5vadA:
54.2		 4hvcB-5vadA:
98.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HVC_B_HFGB1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		10 / 12 LEU A1087
GLU A1100
VAL A1101
PRO A1120
TRP A1169
GLU A1171
HIS A1173
THR A1240
SER A1272
GLY A1274
 None
None
None
None
None
PRO  A1602 ( 4.7A)
PRO  A1602 ( 4.5A)
91Y  A1601 (-4.2A)
PRO  A1602 (-3.3A)
PRO  A1602 (-3.7A)
 0.66A 4hvcB-5vadA:
54.2		 4hvcB-5vadA:
98.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HVC_B_HFGB1602_1
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		4 / 5 THR A1121
GLU A1123
ARG A1152
HIS A1242
 PRO  A1602 (-3.5A)
PRO  A1602 (-2.8A)
PRO  A1602 ( 3.4A)
PRO  A1602 (-4.1A)
 0.40A 4hvcB-5vadA:
54.2		 4hvcB-5vadA:
98.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		5 / 8 ARG A1152
PHE A1167
GLN A1237
GLY A1238
THR A1276
 PRO  A1602 ( 3.4A)
91Y  A1601 (-3.8A)
91Y  A1601 (-4.1A)
None
91Y  A1601 (-3.0A)
 1.21A 4k87A-5vadA:
54.9		 4k87A-5vadA:
96.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		7 / 8 ARG A1152
PHE A1167
GLN A1237
GLY A1239
THR A1240
THR A1276
ARG A1278
 PRO  A1602 ( 3.4A)
91Y  A1601 (-3.8A)
91Y  A1601 (-4.1A)
91Y  A1601 ( 4.1A)
91Y  A1601 (-4.2A)
91Y  A1601 (-3.0A)
91Y  A1601 (-3.4A)
 0.35A 4k87A-5vadA:
54.9		 4k87A-5vadA:
96.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4K88_A_HFGA602_0
(PROLINE--TRNA LIGASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		7 / 12 GLU A1154
PRO A1120
GLU A1123
GLU A1171
PHE A1216
HIS A1242
SER A1272
 91Y  A1601 (-4.6A)
None
PRO  A1602 (-2.8A)
PRO  A1602 ( 4.7A)
PRO  A1602 (-4.3A)
PRO  A1602 (-4.1A)
PRO  A1602 (-3.3A)
 1.05A 4k88A-5vadA:
51.8		 4k88A-5vadA:
96.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4K88_A_HFGA602_0
(PROLINE--TRNA LIGASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		9 / 12 GLU A1154
PRO A1120
THR A1121
GLU A1123
ARG A1152
TRP A1169
GLU A1171
HIS A1242
SER A1272
 91Y  A1601 (-4.6A)
None
PRO  A1602 (-3.5A)
PRO  A1602 (-2.8A)
PRO  A1602 ( 3.4A)
None
PRO  A1602 ( 4.7A)
PRO  A1602 (-4.1A)
PRO  A1602 (-3.3A)
 0.94A 4k88A-5vadA:
51.8		 4k88A-5vadA:
96.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4K88_A_HFGA602_0
(PROLINE--TRNA LIGASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		7 / 12 VAL A1101
PRO A1120
GLU A1123
GLU A1171
PHE A1216
HIS A1242
SER A1272
 None
None
PRO  A1602 (-2.8A)
PRO  A1602 ( 4.7A)
PRO  A1602 (-4.3A)
PRO  A1602 (-4.1A)
PRO  A1602 (-3.3A)
 0.83A 4k88A-5vadA:
51.8		 4k88A-5vadA:
96.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4K88_A_HFGA602_0
(PROLINE--TRNA LIGASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		9 / 12 VAL A1101
PRO A1120
THR A1121
GLU A1123
ARG A1152
TRP A1169
GLU A1171
HIS A1242
SER A1272
 None
None
PRO  A1602 (-3.5A)
PRO  A1602 (-2.8A)
PRO  A1602 ( 3.4A)
None
PRO  A1602 ( 4.7A)
PRO  A1602 (-4.1A)
PRO  A1602 (-3.3A)
 0.64A 4k88A-5vadA:
51.8		 4k88A-5vadA:
96.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		6 / 12 ILE A1457
ALA A1476
LEU A1479
THR A1211
ILE A1481
PRO A1482
 None
 1.27A 4m6kA-5vadA:
undetectable		 4m6kA-5vadA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		6 / 12 ILE A1457
ALA A1476
THR A1211
ILE A1481
PRO A1482
THR A1461
 None
 1.33A 4m6kA-5vadA:
undetectable		 4m6kA-5vadA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		4 / 8 GLU A1226
GLU A1214
GLU A1454
TYR A1505
 None
 1.19A 4mj8A-5vadA:
undetectable
4mj8C-5vadA:
undetectable		 4mj8A-5vadA:
17.35
4mj8C-5vadA:
17.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OLF_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		10 / 12 GLU A1100
VAL A1101
TRP A1169
GLU A1171
HIS A1173
PHE A1216
THR A1240
SER A1272
TRP A1273
GLY A1274
 None
None
None
PRO  A1602 ( 4.7A)
PRO  A1602 ( 4.5A)
PRO  A1602 (-4.3A)
91Y  A1601 (-4.2A)
PRO  A1602 (-3.3A)
None
PRO  A1602 (-3.7A)
 0.74A 4olfA-5vadA:
49.5		 4olfA-5vadA:
50.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OLF_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		7 / 12 GLU A1154
TRP A1169
PHE A1216
THR A1240
SER A1272
TRP A1273
GLY A1274
 91Y  A1601 (-4.6A)
None
PRO  A1602 (-4.3A)
91Y  A1601 (-4.2A)
PRO  A1602 (-3.3A)
None
PRO  A1602 (-3.7A)
 0.89A 4olfA-5vadA:
49.5		 4olfA-5vadA:
50.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OLF_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		10 / 12 VAL A1101
PRO A1120
TRP A1169
GLU A1171
HIS A1173
PHE A1216
THR A1240
SER A1272
TRP A1273
GLY A1274
 None
None
None
PRO  A1602 ( 4.7A)
PRO  A1602 ( 4.5A)
PRO  A1602 (-4.3A)
91Y  A1601 (-4.2A)
PRO  A1602 (-3.3A)
None
PRO  A1602 (-3.7A)
 0.56A 4olfA-5vadA:
49.5		 4olfA-5vadA:
50.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OLF_A_HFGA802_1
(PROLINE--TRNA LIGASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		4 / 4 THR A1121
GLU A1123
ARG A1152
HIS A1242
 PRO  A1602 (-3.5A)
PRO  A1602 (-2.8A)
PRO  A1602 ( 3.4A)
PRO  A1602 (-4.1A)
 0.51A 4olfA-5vadA:
49.5		 4olfA-5vadA:
50.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		10 / 12 LEU A1087
GLU A1100
VAL A1101
PRO A1120
THR A1121
ARG A1152
TRP A1169
HIS A1173
SER A1272
GLY A1274
 None
None
None
None
PRO  A1602 (-3.5A)
PRO  A1602 ( 3.4A)
None
PRO  A1602 ( 4.5A)
PRO  A1602 (-3.3A)
PRO  A1602 (-3.7A)
 0.78A 4q15A-5vadA:
48.5		 4q15A-5vadA:
50.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		9 / 12 LEU A1087
GLU A1100
VAL A1101
PRO A1120
TRP A1169
HIS A1173
PHE A1216
SER A1272
GLY A1274
 None
None
None
None
None
PRO  A1602 ( 4.5A)
PRO  A1602 (-4.3A)
PRO  A1602 (-3.3A)
PRO  A1602 (-3.7A)
 0.95A 4q15A-5vadA:
48.5		 4q15A-5vadA:
50.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Q15_A_HFGA803_1
(PROLINE--TRNA LIGASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		3 / 3 GLU A1123
THR A1240
HIS A1242
 PRO  A1602 (-2.8A)
91Y  A1601 (-4.2A)
PRO  A1602 (-4.1A)
 0.45A 4q15A-5vadA:
48.5		 4q15A-5vadA:
50.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		9 / 12 LEU A1087
GLU A1100
VAL A1101
PRO A1120
THR A1121
ARG A1152
TRP A1169
GLU A1171
GLY A1274
 None
None
None
None
PRO  A1602 (-3.5A)
PRO  A1602 ( 3.4A)
None
PRO  A1602 ( 4.7A)
PRO  A1602 (-3.7A)
 0.74A 4q15B-5vadA:
48.5		 4q15B-5vadA:
50.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		8 / 12 LEU A1087
GLU A1100
VAL A1101
PRO A1120
TRP A1169
GLU A1171
PHE A1216
GLY A1274
 None
None
None
None
None
PRO  A1602 ( 4.7A)
PRO  A1602 (-4.3A)
PRO  A1602 (-3.7A)
 0.95A 4q15B-5vadA:
48.5		 4q15B-5vadA:
50.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		9 / 12 LEU A1087
VAL A1101
PRO A1120
THR A1121
ARG A1152
TRP A1169
GLU A1171
SER A1272
GLY A1274
 None
None
None
PRO  A1602 (-3.5A)
PRO  A1602 ( 3.4A)
None
PRO  A1602 ( 4.7A)
PRO  A1602 (-3.3A)
PRO  A1602 (-3.7A)
 0.56A 4q15B-5vadA:
48.5		 4q15B-5vadA:
50.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		8 / 12 LEU A1087
VAL A1101
PRO A1120
TRP A1169
GLU A1171
PHE A1216
SER A1272
GLY A1274
 None
None
None
None
PRO  A1602 ( 4.7A)
PRO  A1602 (-4.3A)
PRO  A1602 (-3.3A)
PRO  A1602 (-3.7A)
 0.76A 4q15B-5vadA:
48.5		 4q15B-5vadA:
50.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Q15_B_HFGB803_1
(PROLINE--TRNA LIGASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		3 / 3 GLU A1123
THR A1240
HIS A1242
 PRO  A1602 (-2.8A)
91Y  A1601 (-4.2A)
PRO  A1602 (-4.1A)
 0.50A 4q15B-5vadA:
48.5		 4q15B-5vadA:
50.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		5 / 12 GLU A1154
ARG A1152
TRP A1169
SER A1272
GLY A1274
 91Y  A1601 (-4.6A)
PRO  A1602 ( 3.4A)
None
PRO  A1602 (-3.3A)
PRO  A1602 (-3.7A)
 1.12A 4ydqA-5vadA:
49.2		 4ydqA-5vadA:
50.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		6 / 12 LEU A1087
GLU A1100
VAL A1101
ARG A1152
GLU A1171
GLY A1274
 None
None
None
PRO  A1602 ( 3.4A)
PRO  A1602 ( 4.7A)
PRO  A1602 (-3.7A)
 0.87A 4ydqA-5vadA:
49.2		 4ydqA-5vadA:
50.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		6 / 12 LEU A1087
GLU A1100
VAL A1101
ARG A1152
TRP A1169
GLY A1274
 None
None
None
PRO  A1602 ( 3.4A)
None
PRO  A1602 (-3.7A)
 1.06A 4ydqA-5vadA:
49.2		 4ydqA-5vadA:
50.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		5 / 12 LEU A1087
PHE A1097
VAL A1101
PHE A1216
GLY A1172
 None
None
None
PRO  A1602 (-4.3A)
None
 1.30A 4ydqA-5vadA:
49.2		 4ydqA-5vadA:
50.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		8 / 12 LEU A1087
VAL A1101
PRO A1120
ARG A1152
GLU A1171
HIS A1173
SER A1272
GLY A1274
 None
None
None
PRO  A1602 ( 3.4A)
PRO  A1602 ( 4.7A)
PRO  A1602 ( 4.5A)
PRO  A1602 (-3.3A)
PRO  A1602 (-3.7A)
 0.61A 4ydqA-5vadA:
49.2		 4ydqA-5vadA:
50.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		7 / 12 LEU A1087
VAL A1101
PRO A1120
ARG A1152
TRP A1169
SER A1272
GLY A1274
 None
None
None
PRO  A1602 ( 3.4A)
None
PRO  A1602 (-3.3A)
PRO  A1602 (-3.7A)
 0.86A 4ydqA-5vadA:
49.2		 4ydqA-5vadA:
50.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		8 / 12 LEU A1087
VAL A1101
PRO A1120
GLU A1171
HIS A1173
PHE A1216
SER A1272
GLY A1274
 None
None
None
PRO  A1602 ( 4.7A)
PRO  A1602 ( 4.5A)
PRO  A1602 (-4.3A)
PRO  A1602 (-3.3A)
PRO  A1602 (-3.7A)
 0.76A 4ydqA-5vadA:
49.2		 4ydqA-5vadA:
50.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YDQ_A_HFGA802_1
(PROLINE--TRNA LIGASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		4 / 4 THR A1121
GLU A1123
THR A1240
HIS A1242
 PRO  A1602 (-3.5A)
PRO  A1602 (-2.8A)
91Y  A1601 (-4.2A)
PRO  A1602 (-4.1A)
 0.54A 4ydqA-5vadA:
49.2		 4ydqA-5vadA:
50.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YDQ_B_HFGB802_0
(PROLINE--TRNA LIGASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		5 / 12 GLU A1154
ARG A1152
TRP A1169
SER A1272
GLY A1274
 91Y  A1601 (-4.6A)
PRO  A1602 ( 3.4A)
None
PRO  A1602 (-3.3A)
PRO  A1602 (-3.7A)
 1.12A 4ydqB-5vadA:
49.2		 4ydqB-5vadA:
50.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YDQ_B_HFGB802_0
(PROLINE--TRNA LIGASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		8 / 12 VAL A1101
PRO A1120
THR A1121
ARG A1152
GLU A1171
HIS A1173
SER A1272
GLY A1274
 None
None
PRO  A1602 (-3.5A)
PRO  A1602 ( 3.4A)
PRO  A1602 ( 4.7A)
PRO  A1602 ( 4.5A)
PRO  A1602 (-3.3A)
PRO  A1602 (-3.7A)
 0.49A 4ydqB-5vadA:
49.2		 4ydqB-5vadA:
50.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YDQ_B_HFGB802_0
(PROLINE--TRNA LIGASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		8 / 12 VAL A1101
PRO A1120
THR A1121
ARG A1152
TRP A1169
HIS A1173
SER A1272
GLY A1274
 None
None
PRO  A1602 (-3.5A)
PRO  A1602 ( 3.4A)
None
PRO  A1602 ( 4.5A)
PRO  A1602 (-3.3A)
PRO  A1602 (-3.7A)
 0.79A 4ydqB-5vadA:
49.2		 4ydqB-5vadA:
50.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YDQ_B_HFGB802_0
(PROLINE--TRNA LIGASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		8 / 12 VAL A1101
PRO A1120
THR A1121
GLU A1171
HIS A1173
PHE A1216
SER A1272
GLY A1274
 None
None
PRO  A1602 (-3.5A)
PRO  A1602 ( 4.7A)
PRO  A1602 ( 4.5A)
PRO  A1602 (-4.3A)
PRO  A1602 (-3.3A)
PRO  A1602 (-3.7A)
 0.69A 4ydqB-5vadA:
49.2		 4ydqB-5vadA:
50.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YDQ_B_HFGB802_1
(PROLINE--TRNA LIGASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		3 / 3 GLU A1123
THR A1240
HIS A1242
 PRO  A1602 (-2.8A)
91Y  A1601 (-4.2A)
PRO  A1602 (-4.1A)
 0.40A 4ydqB-5vadA:
49.2		 4ydqB-5vadA:
50.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5F9Z_A_HFGA702_0
(AMINOACYL-TRNA
SYNTHETASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		9 / 12 LEU A1087
GLU A1100
VAL A1101
ARG A1152
TRP A1169
GLU A1171
PHE A1216
SER A1272
GLY A1274
 None
None
None
PRO  A1602 ( 3.4A)
None
PRO  A1602 ( 4.7A)
PRO  A1602 (-4.3A)
PRO  A1602 (-3.3A)
PRO  A1602 (-3.7A)
 0.93A 5f9zA-5vadA:
47.9		 5f9zA-5vadA:
54.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5F9Z_A_HFGA702_0
(AMINOACYL-TRNA
SYNTHETASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		9 / 12 LEU A1087
VAL A1101
PRO A1120
ARG A1152
TRP A1169
GLU A1171
PHE A1216
SER A1272
GLY A1274
 None
None
None
PRO  A1602 ( 3.4A)
None
PRO  A1602 ( 4.7A)
PRO  A1602 (-4.3A)
PRO  A1602 (-3.3A)
PRO  A1602 (-3.7A)
 0.72A 5f9zA-5vadA:
47.9		 5f9zA-5vadA:
54.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5F9Z_A_HFGA702_1
(AMINOACYL-TRNA
SYNTHETASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		4 / 4 THR A1121
GLU A1123
THR A1240
HIS A1242
 PRO  A1602 (-3.5A)
PRO  A1602 (-2.8A)
91Y  A1601 (-4.2A)
PRO  A1602 (-4.1A)
 0.52A 5f9zA-5vadA:
47.9		 5f9zA-5vadA:
54.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		9 / 12 LEU A1087
GLU A1100
VAL A1101
PRO A1120
ARG A1152
TRP A1169
GLU A1171
SER A1272
GLY A1274
 None
None
None
None
PRO  A1602 ( 3.4A)
None
PRO  A1602 ( 4.7A)
PRO  A1602 (-3.3A)
PRO  A1602 (-3.7A)
 0.77A 5f9zB-5vadA:
48.4		 5f9zB-5vadA:
54.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		8 / 12 LEU A1087
VAL A1101
PRO A1120
TRP A1169
GLU A1171
PHE A1216
SER A1272
GLY A1274
 None
None
None
None
PRO  A1602 ( 4.7A)
PRO  A1602 (-4.3A)
PRO  A1602 (-3.3A)
PRO  A1602 (-3.7A)
 0.72A 5f9zB-5vadA:
48.4		 5f9zB-5vadA:
54.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5F9Z_B_HFGB703_1
(AMINOACYL-TRNA
SYNTHETASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		4 / 4 THR A1121
GLU A1123
THR A1240
HIS A1242
 PRO  A1602 (-3.5A)
PRO  A1602 (-2.8A)
91Y  A1601 (-4.2A)
PRO  A1602 (-4.1A)
 0.52A 5f9zB-5vadA:
48.4		 5f9zB-5vadA:
54.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		4 / 8 GLU A1198
GLY A1238
THR A1284
PHE A1413
 None
 0.98A 5flcB-5vadA:
undetectable		 5flcB-5vadA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		4 / 8 GLU A1198
GLY A1238
THR A1284
PHE A1413
 None
 0.98A 5flcF-5vadA:
undetectable		 5flcF-5vadA:
17.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IFU_A_GBMA801_1
(PROLINE--TRNA LIGASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		7 / 12 TYR A1028
LEU A1049
THR A1277
ARG A1278
ILE A1280
GLY A1281
TYR A1512
 None
None
None
91Y  A1601 (-3.4A)
None
None
None
 0.44A 5ifuA-5vadA:
44.4		 5ifuA-5vadA:
50.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IFU_A_GBMA801_1
(PROLINE--TRNA LIGASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		7 / 12 TYR A1028
LEU A1049
THR A1277
ILE A1280
GLY A1281
MET A1285
TYR A1512
 None
 0.70A 5ifuA-5vadA:
44.4		 5ifuA-5vadA:
50.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IFU_B_GBMB801_1
(PROLINE--TRNA LIGASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		7 / 9 TYR A1028
ILE A1038
LEU A1049
THR A1277
ARG A1278
ILE A1280
GLY A1281
 None
None
None
None
91Y  A1601 (-3.4A)
None
None
 0.55A 5ifuB-5vadA:
43.3		 5ifuB-5vadA:
50.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		5 / 12 ILE A1442
GLY A1509
ALA A1235
MET A1424
VAL A1206
 None
 0.80A 5n0tB-5vadA:
undetectable		 5n0tB-5vadA:
22.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIO_A_HFGA801_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		9 / 12 GLU A1154
PRO A1120
ARG A1152
TRP A1169
GLU A1171
HIS A1173
THR A1240
SER A1272
GLY A1274
 91Y  A1601 (-4.6A)
None
PRO  A1602 ( 3.4A)
None
PRO  A1602 ( 4.7A)
PRO  A1602 ( 4.5A)
91Y  A1601 (-4.2A)
PRO  A1602 (-3.3A)
PRO  A1602 (-3.7A)
 0.88A 5xioA-5vadA:
48.3		 5xioA-5vadA:
54.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIO_A_HFGA801_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		8 / 12 GLU A1154
PRO A1120
GLU A1171
HIS A1173
PHE A1216
THR A1240
SER A1272
GLY A1274
 91Y  A1601 (-4.6A)
None
PRO  A1602 ( 4.7A)
PRO  A1602 ( 4.5A)
PRO  A1602 (-4.3A)
91Y  A1601 (-4.2A)
PRO  A1602 (-3.3A)
PRO  A1602 (-3.7A)
 0.96A 5xioA-5vadA:
48.3		 5xioA-5vadA:
54.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIO_A_HFGA801_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		6 / 12 VAL A1101
PRO A1120
ARG A1152
HIS A1173
THR A1222
SER A1272
 None
None
PRO  A1602 ( 3.4A)
PRO  A1602 ( 4.5A)
None
PRO  A1602 (-3.3A)
 1.42A 5xioA-5vadA:
48.3		 5xioA-5vadA:
54.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIO_A_HFGA801_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		9 / 12 VAL A1101
PRO A1120
ARG A1152
TRP A1169
GLU A1171
HIS A1173
THR A1240
SER A1272
GLY A1274
 None
None
PRO  A1602 ( 3.4A)
None
PRO  A1602 ( 4.7A)
PRO  A1602 ( 4.5A)
91Y  A1601 (-4.2A)
PRO  A1602 (-3.3A)
PRO  A1602 (-3.7A)
 0.60A 5xioA-5vadA:
48.3		 5xioA-5vadA:
54.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIO_A_HFGA801_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		8 / 12 VAL A1101
PRO A1120
GLU A1171
HIS A1173
PHE A1216
THR A1240
SER A1272
GLY A1274
 None
None
PRO  A1602 ( 4.7A)
PRO  A1602 ( 4.5A)
PRO  A1602 (-4.3A)
91Y  A1601 (-4.2A)
PRO  A1602 (-3.3A)
PRO  A1602 (-3.7A)
 0.79A 5xioA-5vadA:
48.3		 5xioA-5vadA:
54.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		3 / 3 THR A1121
GLU A1123
HIS A1242
 PRO  A1602 (-3.5A)
PRO  A1602 (-2.8A)
PRO  A1602 (-4.1A)
 0.51A 5xioA-5vadA:
48.3		 5xioA-5vadA:
54.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIO_B_HFGB802_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		6 / 12 GLU A1100
VAL A1101
ARG A1152
TRP A1169
GLU A1171
THR A1240
 None
None
PRO  A1602 ( 3.4A)
None
PRO  A1602 ( 4.7A)
91Y  A1601 (-4.2A)
 0.82A 5xioB-5vadA:
48.5		 5xioB-5vadA:
54.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIO_B_HFGB802_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		9 / 12 GLU A1154
PRO A1120
THR A1121
ARG A1152
TRP A1169
GLU A1171
HIS A1173
THR A1240
HIS A1242
 91Y  A1601 (-4.6A)
None
PRO  A1602 (-3.5A)
PRO  A1602 ( 3.4A)
None
PRO  A1602 ( 4.7A)
PRO  A1602 ( 4.5A)
91Y  A1601 (-4.2A)
PRO  A1602 (-4.1A)
 0.75A 5xioB-5vadA:
48.5		 5xioB-5vadA:
54.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIO_B_HFGB802_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		7 / 12 GLU A1154
THR A1121
GLU A1171
HIS A1173
PHE A1216
THR A1240
HIS A1242
 91Y  A1601 (-4.6A)
PRO  A1602 (-3.5A)
PRO  A1602 ( 4.7A)
PRO  A1602 ( 4.5A)
PRO  A1602 (-4.3A)
91Y  A1601 (-4.2A)
PRO  A1602 (-4.1A)
 0.84A 5xioB-5vadA:
48.5		 5xioB-5vadA:
54.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIO_B_HFGB802_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		5 / 12 PHE A1097
GLU A1154
PHE A1216
THR A1240
HIS A1242
 None
91Y  A1601 (-4.6A)
PRO  A1602 (-4.3A)
91Y  A1601 (-4.2A)
PRO  A1602 (-4.1A)
 1.34A 5xioB-5vadA:
48.5		 5xioB-5vadA:
54.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIO_B_HFGB802_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		5 / 12 PHE A1097
VAL A1101
PHE A1216
THR A1240
HIS A1242
 None
None
PRO  A1602 (-4.3A)
91Y  A1601 (-4.2A)
PRO  A1602 (-4.1A)
 1.38A 5xioB-5vadA:
48.5		 5xioB-5vadA:
54.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIO_B_HFGB802_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		9 / 12 VAL A1101
PRO A1120
THR A1121
ARG A1152
TRP A1169
GLU A1171
HIS A1173
THR A1240
HIS A1242
 None
None
PRO  A1602 (-3.5A)
PRO  A1602 ( 3.4A)
None
PRO  A1602 ( 4.7A)
PRO  A1602 ( 4.5A)
91Y  A1601 (-4.2A)
PRO  A1602 (-4.1A)
 0.59A 5xioB-5vadA:
48.5		 5xioB-5vadA:
54.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIO_B_HFGB802_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		5 / 12 VAL A1101
PRO A1120
THR A1121
GLU A1171
PHE A1248
 None
None
PRO  A1602 (-3.5A)
PRO  A1602 ( 4.7A)
None
 1.29A 5xioB-5vadA:
48.5		 5xioB-5vadA:
54.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIO_B_HFGB802_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		7 / 12 VAL A1101
THR A1121
GLU A1171
HIS A1173
PHE A1216
THR A1240
HIS A1242
 None
PRO  A1602 (-3.5A)
PRO  A1602 ( 4.7A)
PRO  A1602 ( 4.5A)
PRO  A1602 (-4.3A)
91Y  A1601 (-4.2A)
PRO  A1602 (-4.1A)
 0.70A 5xioB-5vadA:
48.5		 5xioB-5vadA:
54.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		5 / 12 GLU A1154
PHE A1216
THR A1240
SER A1272
GLY A1274
 91Y  A1601 (-4.6A)
PRO  A1602 (-4.3A)
91Y  A1601 (-4.2A)
PRO  A1602 (-3.3A)
PRO  A1602 (-3.7A)
 0.71A 5xipA-5vadA:
49.0		 5xipA-5vadA:
55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		9 / 12 LEU A1087
GLU A1100
PRO A1120
THR A1121
ARG A1152
HIS A1173
THR A1240
SER A1272
GLY A1274
 None
None
None
PRO  A1602 (-3.5A)
PRO  A1602 ( 3.4A)
PRO  A1602 ( 4.5A)
91Y  A1601 (-4.2A)
PRO  A1602 (-3.3A)
PRO  A1602 (-3.7A)
 0.74A 5xipA-5vadA:
49.0		 5xipA-5vadA:
55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		6 / 12 LEU A1087
GLU A1100
VAL A1101
PRO A1120
HIS A1173
THR A1222
 None
None
None
None
PRO  A1602 ( 4.5A)
None
 1.48A 5xipA-5vadA:
49.0		 5xipA-5vadA:
55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		9 / 12 LEU A1087
GLU A1100
VAL A1101
PRO A1120
THR A1121
ARG A1152
HIS A1173
THR A1240
GLY A1274
 None
None
None
None
PRO  A1602 (-3.5A)
PRO  A1602 ( 3.4A)
PRO  A1602 ( 4.5A)
91Y  A1601 (-4.2A)
PRO  A1602 (-3.7A)
 0.71A 5xipA-5vadA:
49.0		 5xipA-5vadA:
55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		8 / 12 LEU A1087
PRO A1120
THR A1121
HIS A1173
PHE A1216
THR A1240
SER A1272
GLY A1274
 None
None
PRO  A1602 (-3.5A)
PRO  A1602 ( 4.5A)
PRO  A1602 (-4.3A)
91Y  A1601 (-4.2A)
PRO  A1602 (-3.3A)
PRO  A1602 (-3.7A)
 0.72A 5xipA-5vadA:
49.0		 5xipA-5vadA:
55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		5 / 12 VAL A1101
PRO A1120
THR A1121
HIS A1173
PHE A1248
 None
None
PRO  A1602 (-3.5A)
PRO  A1602 ( 4.5A)
None
 1.25A 5xipA-5vadA:
49.0		 5xipA-5vadA:
55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIP_A_HFGA1003_1
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		3 / 3 GLU A1123
TRP A1169
HIS A1242
 PRO  A1602 (-2.8A)
None
PRO  A1602 (-4.1A)
 0.42A 5xipA-5vadA:
49.0		 5xipA-5vadA:
55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIP_B_HFGB1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		9 / 12 GLU A1100
VAL A1101
PRO A1120
THR A1121
GLU A1123
ARG A1152
TRP A1169
HIS A1173
THR A1240
 None
None
None
PRO  A1602 (-3.5A)
PRO  A1602 (-2.8A)
PRO  A1602 ( 3.4A)
None
PRO  A1602 ( 4.5A)
91Y  A1601 (-4.2A)
 0.67A 5xipB-5vadA:
48.9		 5xipB-5vadA:
55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIP_B_HFGB1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		7 / 12 GLU A1100
VAL A1101
PRO A1120
THR A1121
GLU A1123
HIS A1173
THR A1222
 None
None
None
PRO  A1602 (-3.5A)
PRO  A1602 (-2.8A)
PRO  A1602 ( 4.5A)
None
 1.10A 5xipB-5vadA:
48.9		 5xipB-5vadA:
55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIP_B_HFGB1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		7 / 12 GLU A1154
THR A1121
ARG A1152
TRP A1169
HIS A1173
THR A1240
HIS A1242
 91Y  A1601 (-4.6A)
PRO  A1602 (-3.5A)
PRO  A1602 ( 3.4A)
None
PRO  A1602 ( 4.5A)
91Y  A1601 (-4.2A)
PRO  A1602 (-4.1A)
 0.91A 5xipB-5vadA:
48.9		 5xipB-5vadA:
55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIP_B_HFGB1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		6 / 12 GLU A1154
TRP A1169
HIS A1173
PHE A1216
THR A1240
HIS A1242
 91Y  A1601 (-4.6A)
None
PRO  A1602 ( 4.5A)
PRO  A1602 (-4.3A)
91Y  A1601 (-4.2A)
PRO  A1602 (-4.1A)
 0.91A 5xipB-5vadA:
48.9		 5xipB-5vadA:
55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIP_B_HFGB1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		7 / 12 PRO A1120
GLU A1123
TRP A1169
HIS A1173
PHE A1216
THR A1240
HIS A1242
 None
PRO  A1602 (-2.8A)
None
PRO  A1602 ( 4.5A)
PRO  A1602 (-4.3A)
91Y  A1601 (-4.2A)
PRO  A1602 (-4.1A)
 0.64A 5xipB-5vadA:
48.9		 5xipB-5vadA:
55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIP_B_HFGB1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		9 / 12 VAL A1101
PRO A1120
THR A1121
GLU A1123
ARG A1152
TRP A1169
HIS A1173
THR A1240
HIS A1242
 None
None
PRO  A1602 (-3.5A)
PRO  A1602 (-2.8A)
PRO  A1602 ( 3.4A)
None
PRO  A1602 ( 4.5A)
91Y  A1601 (-4.2A)
PRO  A1602 (-4.1A)
 0.58A 5xipB-5vadA:
48.9		 5xipB-5vadA:
55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIP_B_HFGB1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		5 / 12 VAL A1101
PRO A1120
THR A1121
HIS A1173
PHE A1248
 None
None
PRO  A1602 (-3.5A)
PRO  A1602 ( 4.5A)
None
 1.24A 5xipB-5vadA:
48.9		 5xipB-5vadA:
55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		7 / 12 LEU A1087
GLU A1100
VAL A1101
PRO A1120
GLU A1123
HIS A1173
THR A1222
 None
None
None
None
PRO  A1602 (-2.8A)
PRO  A1602 ( 4.5A)
None
 1.40A 5xipC-5vadA:
48.7		 5xipC-5vadA:
55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		11 / 12 LEU A1087
GLU A1100
VAL A1101
PRO A1120
THR A1121
GLU A1123
TRP A1169
GLU A1171
HIS A1173
THR A1240
GLY A1274
 None
None
None
None
PRO  A1602 (-3.5A)
PRO  A1602 (-2.8A)
None
PRO  A1602 ( 4.7A)
PRO  A1602 ( 4.5A)
91Y  A1601 (-4.2A)
PRO  A1602 (-3.7A)
 0.64A 5xipC-5vadA:
48.7		 5xipC-5vadA:
55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		11 / 12 LEU A1087
VAL A1101
PRO A1120
THR A1121
GLU A1123
TRP A1169
GLU A1171
HIS A1173
PHE A1216
THR A1240
GLY A1274
 None
None
None
PRO  A1602 (-3.5A)
PRO  A1602 (-2.8A)
None
PRO  A1602 ( 4.7A)
PRO  A1602 ( 4.5A)
PRO  A1602 (-4.3A)
91Y  A1601 (-4.2A)
PRO  A1602 (-3.7A)
 0.63A 5xipC-5vadA:
48.7		 5xipC-5vadA:
55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		5 / 12 VAL A1101
PRO A1120
THR A1121
GLU A1171
PHE A1248
 None
None
PRO  A1602 (-3.5A)
PRO  A1602 ( 4.7A)
None
 1.23A 5xipC-5vadA:
48.7		 5xipC-5vadA:
55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIP_D_HFGD1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		11 / 12 LEU A1087
GLU A1100
VAL A1101
PRO A1120
THR A1121
GLU A1123
ARG A1152
TRP A1169
GLU A1171
THR A1240
TRP A1273
 None
None
None
None
PRO  A1602 (-3.5A)
PRO  A1602 (-2.8A)
PRO  A1602 ( 3.4A)
None
PRO  A1602 ( 4.7A)
91Y  A1601 (-4.2A)
None
 0.73A 5xipD-5vadA:
48.5		 5xipD-5vadA:
55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIP_D_HFGD1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		7 / 12 LEU A1087
GLU A1100
VAL A1101
PRO A1120
THR A1121
GLU A1123
THR A1222
 None
None
None
None
PRO  A1602 (-3.5A)
PRO  A1602 (-2.8A)
None
 1.36A 5xipD-5vadA:
48.5		 5xipD-5vadA:
55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIP_D_HFGD1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		10 / 12 LEU A1087
VAL A1101
PRO A1120
GLU A1123
ARG A1152
TRP A1169
GLU A1171
PHE A1216
THR A1240
TRP A1273
 None
None
None
PRO  A1602 (-2.8A)
PRO  A1602 ( 3.4A)
None
PRO  A1602 ( 4.7A)
PRO  A1602 (-4.3A)
91Y  A1601 (-4.2A)
None
 0.71A 5xipD-5vadA:
48.5		 5xipD-5vadA:
55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIP_D_HFGD1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		6 / 12 VAL A1101
PRO A1120
THR A1121
GLU A1171
PHE A1248
TRP A1273
 None
None
PRO  A1602 (-3.5A)
PRO  A1602 ( 4.7A)
None
None
 1.42A 5xipD-5vadA:
48.5		 5xipD-5vadA:
55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		5 / 12 GLU A1154
PHE A1216
THR A1240
SER A1272
GLY A1274
 91Y  A1601 (-4.6A)
PRO  A1602 (-4.3A)
91Y  A1601 (-4.2A)
PRO  A1602 (-3.3A)
PRO  A1602 (-3.7A)
 0.84A 5xiqA-5vadA:
49.7		 5xiqA-5vadA:
55.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		8 / 12 LEU A1087
GLU A1100
VAL A1101
TRP A1169
GLU A1171
HIS A1173
THR A1240
GLY A1274
 None
None
None
None
PRO  A1602 ( 4.7A)
PRO  A1602 ( 4.5A)
91Y  A1601 (-4.2A)
PRO  A1602 (-3.7A)
 0.74A 5xiqA-5vadA:
49.7		 5xiqA-5vadA:
55.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		9 / 12 LEU A1087
VAL A1101
PRO A1120
TRP A1169
GLU A1171
HIS A1173
THR A1240
SER A1272
GLY A1274
 None
None
None
None
PRO  A1602 ( 4.7A)
PRO  A1602 ( 4.5A)
91Y  A1601 (-4.2A)
PRO  A1602 (-3.3A)
PRO  A1602 (-3.7A)
 0.58A 5xiqA-5vadA:
49.7		 5xiqA-5vadA:
55.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		9 / 12 LEU A1087
VAL A1101
TRP A1169
GLU A1171
HIS A1173
PHE A1216
THR A1240
SER A1272
GLY A1274
 None
None
None
PRO  A1602 ( 4.7A)
PRO  A1602 ( 4.5A)
PRO  A1602 (-4.3A)
91Y  A1601 (-4.2A)
PRO  A1602 (-3.3A)
PRO  A1602 (-3.7A)
 0.72A 5xiqA-5vadA:
49.7		 5xiqA-5vadA:
55.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIQ_A_HFGA1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		4 / 4 THR A1121
GLU A1123
ARG A1152
HIS A1242
 PRO  A1602 (-3.5A)
PRO  A1602 (-2.8A)
PRO  A1602 ( 3.4A)
PRO  A1602 (-4.1A)
 0.59A 5xiqA-5vadA:
49.7		 5xiqA-5vadA:
55.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIQ_B_HFGB1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		8 / 12 LEU A1087
GLU A1100
VAL A1101
ARG A1152
TRP A1169
GLU A1171
HIS A1173
THR A1240
 None
None
None
PRO  A1602 ( 3.4A)
None
PRO  A1602 ( 4.7A)
PRO  A1602 ( 4.5A)
91Y  A1601 (-4.2A)
 0.78A 5xiqB-5vadA:
49.9		 5xiqB-5vadA:
55.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIQ_B_HFGB1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		9 / 12 LEU A1087
VAL A1101
PRO A1120
ARG A1152
TRP A1169
GLU A1171
HIS A1173
THR A1240
SER A1272
 None
None
None
PRO  A1602 ( 3.4A)
None
PRO  A1602 ( 4.7A)
PRO  A1602 ( 4.5A)
91Y  A1601 (-4.2A)
PRO  A1602 (-3.3A)
 0.59A 5xiqB-5vadA:
49.9		 5xiqB-5vadA:
55.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIQ_B_HFGB1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		6 / 12 LEU A1087
VAL A1101
PRO A1120
HIS A1173
THR A1222
SER A1272
 None
None
None
PRO  A1602 ( 4.5A)
None
PRO  A1602 (-3.3A)
 1.44A 5xiqB-5vadA:
49.9		 5xiqB-5vadA:
55.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIQ_B_HFGB1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		9 / 12 LEU A1087
VAL A1101
PRO A1120
TRP A1169
GLU A1171
HIS A1173
PHE A1216
THR A1240
SER A1272
 None
None
None
None
PRO  A1602 ( 4.7A)
PRO  A1602 ( 4.5A)
PRO  A1602 (-4.3A)
91Y  A1601 (-4.2A)
PRO  A1602 (-3.3A)
 0.73A 5xiqB-5vadA:
49.9		 5xiqB-5vadA:
55.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		3 / 3 THR A1121
GLU A1123
HIS A1242
 PRO  A1602 (-3.5A)
PRO  A1602 (-2.8A)
PRO  A1602 (-4.1A)
 0.48A 5xiqB-5vadA:
49.9		 5xiqB-5vadA:
55.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIQ_C_HFGC1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		7 / 12 GLU A1100
VAL A1101
PRO A1120
THR A1121
ARG A1152
THR A1222
SER A1272
 None
None
None
PRO  A1602 (-3.5A)
PRO  A1602 ( 3.4A)
None
PRO  A1602 (-3.3A)
 1.41A 5xiqC-5vadA:
49.7		 5xiqC-5vadA:
55.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIQ_C_HFGC1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		10 / 12 GLU A1100
VAL A1101
PRO A1120
THR A1121
ARG A1152
TRP A1169
GLU A1171
HIS A1173
THR A1240
SER A1272
 None
None
None
PRO  A1602 (-3.5A)
PRO  A1602 ( 3.4A)
None
PRO  A1602 ( 4.7A)
PRO  A1602 ( 4.5A)
91Y  A1601 (-4.2A)
PRO  A1602 (-3.3A)
 0.77A 5xiqC-5vadA:
49.7		 5xiqC-5vadA:
55.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIQ_C_HFGC1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		10 / 12 GLU A1100
VAL A1101
PRO A1120
THR A1121
TRP A1169
GLU A1171
HIS A1173
PHE A1216
THR A1240
SER A1272
 None
None
None
PRO  A1602 (-3.5A)
None
PRO  A1602 ( 4.7A)
PRO  A1602 ( 4.5A)
PRO  A1602 (-4.3A)
91Y  A1601 (-4.2A)
PRO  A1602 (-3.3A)
 0.88A 5xiqC-5vadA:
49.7		 5xiqC-5vadA:
55.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		10 / 12 LEU A1087
GLU A1100
VAL A1101
PRO A1120
ARG A1152
TRP A1169
GLU A1171
HIS A1173
THR A1240
GLY A1274
 None
None
None
None
PRO  A1602 ( 3.4A)
None
PRO  A1602 ( 4.7A)
PRO  A1602 ( 4.5A)
91Y  A1601 (-4.2A)
PRO  A1602 (-3.7A)
 0.76A 5xiqD-5vadA:
49.6		 5xiqD-5vadA:
55.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		5 / 12 LEU A1087
GLU A1100
VAL A1101
PRO A1120
THR A1222
 None
 1.12A 5xiqD-5vadA:
49.6		 5xiqD-5vadA:
55.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		10 / 12 LEU A1087
GLU A1100
VAL A1101
PRO A1120
TRP A1169
GLU A1171
HIS A1173
PHE A1216
THR A1240
GLY A1274
 None
None
None
None
None
PRO  A1602 ( 4.7A)
PRO  A1602 ( 4.5A)
PRO  A1602 (-4.3A)
91Y  A1601 (-4.2A)
PRO  A1602 (-3.7A)
 0.90A 5xiqD-5vadA:
49.6		 5xiqD-5vadA:
55.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		5 / 12 VAL A1101
PRO A1120
GLU A1171
HIS A1173
PHE A1248
 None
None
PRO  A1602 ( 4.7A)
PRO  A1602 ( 4.5A)
None
 1.33A 5xiqD-5vadA:
49.6		 5xiqD-5vadA:
55.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		3 / 3 THR A1121
GLU A1123
HIS A1242
 PRO  A1602 (-3.5A)
PRO  A1602 (-2.8A)
PRO  A1602 (-4.1A)
 0.52A 5xiqD-5vadA:
49.6		 5xiqD-5vadA:
55.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		4 / 6 GLY A1292
THR A1284
VAL A1031
TRP A1027
 None
 0.90A 5ysiA-5vadA:
undetectable		 5ysiA-5vadA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZOV_B_ASCB501_0
(PTS
ASCORBATE-SPECIFIC
SUBUNIT IIBC)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		5 / 12 PRO A1160
TYR A1040
ASP A1026
ALA A1018
ILE A1032
 None
 1.49A 5zovB-5vadA:
undetectable		 5zovB-5vadA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_B_P2EB1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		4 / 5 PRO A1079
VAL A1125
GLY A1274
VAL A1150
 None
None
PRO  A1602 (-3.7A)
None
 0.99A 6ak3B-5vadA:
undetectable		 6ak3B-5vadA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		4 / 7 ILE A1068
GLN A1170
GLU A1171
VAL A1073
 None
None
PRO  A1602 ( 4.7A)
None
 1.18A 6j20A-5vadA:
undetectable		 6j20A-5vadA:
21.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		5 / 12 GLU A1154
THR A1240
SER A1272
TRP A1273
GLY A1274
 91Y  A1601 (-4.6A)
91Y  A1601 (-4.2A)
PRO  A1602 (-3.3A)
None
PRO  A1602 (-3.7A)
 0.69A 6mn8A-5vadA:
45.7		 6mn8A-5vadA:
59.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		11 / 12 LEU A1087
GLU A1100
VAL A1101
PRO A1120
TRP A1169
GLU A1171
HIS A1173
THR A1240
SER A1272
TRP A1273
GLY A1274
 None
None
None
None
None
PRO  A1602 ( 4.7A)
PRO  A1602 ( 4.5A)
91Y  A1601 (-4.2A)
PRO  A1602 (-3.3A)
None
PRO  A1602 (-3.7A)
 0.69A 6mn8A-5vadA:
45.7		 6mn8A-5vadA:
59.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6MN8_A_HFGA603_1
(UNCHARACTERIZED
PROTEIN)		 5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens) 		4 / 4 THR A1121
GLU A1123
ARG A1152
HIS A1242
 PRO  A1602 (-3.5A)
PRO  A1602 (-2.8A)
PRO  A1602 ( 3.4A)
PRO  A1602 (-4.1A)
 0.45A 6mn8A-5vadA:
45.7		 6mn8A-5vadA:
59.07