SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vae'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_1
(DIHYDROFOLATE
REDUCTASE)		 5vae ACCESSORY SEC SYSTEM
PROTEIN ASP1
(Streptococcus
gordonii) 		3 / 3 GLU A 375
ILE A 378
ARG A 410
 None
 0.72A 1cd2A-5vaeA:
undetectable		 1cd2A-5vaeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_1
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN))		 5vae ACCESSORY SEC SYSTEM
PROTEIN ASP1
(Streptococcus
gordonii) 		4 / 6 LEU A 426
PHE A 326
TYR A 360
VAL A 356
 None
 1.25A 1ibgH-5vaeA:
undetectable		 1ibgH-5vaeA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_C_ADNC2502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5vae ACCESSORY SEC SYSTEM
PROTEIN ASP1
(Streptococcus
gordonii) 		3 / 3 GLU A  73
THR A  72
LEU A  53
 None
 0.62A 1v8bC-5vaeA:
4.6		 1v8bC-5vaeA:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5vae ACCESSORY SEC SYSTEM
PROTEIN ASP1
(Streptococcus
gordonii) 		5 / 12 LEU A 422
GLY A 451
ALA A 450
SER A 449
LEU A 312
 None
 1.01A 2aylA-5vaeA:
undetectable		 2aylA-5vaeA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5vae ACCESSORY SEC SYSTEM
PROTEIN ASP1
(Streptococcus
gordonii) 		5 / 12 LEU A 422
GLY A 451
ALA A 450
SER A 449
LEU A 312
 None
 1.01A 2aylB-5vaeA:
undetectable		 2aylB-5vaeA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5vae ACCESSORY SEC SYSTEM
PROTEIN ASP3
(Streptococcus
gordonii) 		4 / 7 LYS B  99
GLN B 134
LEU B  84
PHE B 122
 None
 1.03A 2eijC-5vaeB:
undetectable
2eijJ-5vaeB:
undetectable		 2eijC-5vaeB:
undetectable
2eijJ-5vaeB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5vae ACCESSORY SEC SYSTEM
PROTEIN ASP1
(Streptococcus
gordonii) 		5 / 9 LEU A 246
LEU A 247
PHE A 231
LEU A  52
ILE A   5
 None
 0.96A 2f78A-5vaeA:
undetectable		 2f78A-5vaeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5vae ACCESSORY SEC SYSTEM
PROTEIN ASP1
(Streptococcus
gordonii) 		5 / 9 LEU A 246
LEU A 247
PHE A 231
LEU A  52
ILE A   5
 None
 0.92A 2f7aA-5vaeA:
undetectable		 2f7aA-5vaeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_A_ANWA99_0
(PROTEIN S100-A13)		 5vae ACCESSORY SEC SYSTEM
PROTEIN ASP1
(Streptococcus
gordonii) 		4 / 7 MET A   1
VAL A 232
PHE A   4
LYS A  50
 None
 1.21A 2kotA-5vaeA:
undetectable		 2kotA-5vaeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		 5vae ACCESSORY SEC SYSTEM
PROTEIN ASP1
(Streptococcus
gordonii) 		4 / 7 ILE A 413
ARG A 412
PHE A 326
GLU A 425
 None
 0.93A 2qebA-5vaeA:
undetectable		 2qebA-5vaeA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		 5vae ACCESSORY SEC SYSTEM
PROTEIN ASP1
(Streptococcus
gordonii) 		4 / 7 ILE A 413
ARG A 412
PHE A 326
GLU A 425
 None
 0.90A 2qebB-5vaeA:
undetectable		 2qebB-5vaeA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)		 5vae ACCESSORY SEC SYSTEM
PROTEIN ASP1
(Streptococcus
gordonii) 		5 / 10 VAL A 356
GLY A 358
THR A 429
LEU A 426
THR A 443
 None
 1.30A 3bexA-5vaeA:
undetectable
3bexB-5vaeA:
undetectable		 3bexA-5vaeA:
undetectable
3bexB-5vaeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 5vae ACCESSORY SEC SYSTEM
PROTEIN ASP1
(Streptococcus
gordonii) 		5 / 11 VAL A 356
GLY A 358
THR A 429
LEU A 426
THR A 443
 None
 1.29A 3bexC-5vaeA:
2.3
3bexD-5vaeA:
undetectable		 3bexC-5vaeA:
undetectable
3bexD-5vaeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 5vae ACCESSORY SEC SYSTEM
PROTEIN ASP1
(Streptococcus
gordonii) 		5 / 11 THR A 429
LEU A 426
THR A 443
VAL A 356
GLY A 358
 None
 1.30A 3bexE-5vaeA:
undetectable
3bexF-5vaeA:
undetectable		 3bexE-5vaeA:
undetectable
3bexF-5vaeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)		 5vae ACCESSORY SEC SYSTEM
PROTEIN ASP1
(Streptococcus
gordonii) 		5 / 11 VAL A 356
GLY A 358
THR A 429
LEU A 426
THR A 443
 None
 1.29A 3bf1A-5vaeA:
undetectable
3bf1B-5vaeA:
undetectable		 3bf1A-5vaeA:
undetectable
3bf1B-5vaeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 5vae ACCESSORY SEC SYSTEM
PROTEIN ASP1
(Streptococcus
gordonii) 		5 / 11 VAL A 356
GLY A 358
THR A 429
LEU A 426
THR A 443
 None
 1.25A 3bf1C-5vaeA:
undetectable
3bf1D-5vaeA:
undetectable		 3bf1C-5vaeA:
undetectable
3bf1D-5vaeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 5vae ACCESSORY SEC SYSTEM
PROTEIN ASP1
(Streptococcus
gordonii) 		5 / 11 THR A 429
LEU A 426
THR A 443
VAL A 356
GLY A 358
 None
 1.25A 3bf1C-5vaeA:
undetectable
3bf1D-5vaeA:
undetectable		 3bf1C-5vaeA:
undetectable
3bf1D-5vaeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 5vae ACCESSORY SEC SYSTEM
PROTEIN ASP1
(Streptococcus
gordonii) 		5 / 11 VAL A 356
GLY A 358
THR A 429
LEU A 426
THR A 443
 None
 1.30A 3bf1E-5vaeA:
2.3
3bf1F-5vaeA:
undetectable		 3bf1E-5vaeA:
undetectable
3bf1F-5vaeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 5vae ACCESSORY SEC SYSTEM
PROTEIN ASP1
(Streptococcus
gordonii) 		5 / 11 THR A 429
LEU A 426
THR A 443
VAL A 356
GLY A 358
 None
 1.30A 3bf1E-5vaeA:
2.3
3bf1F-5vaeA:
undetectable		 3bf1E-5vaeA:
undetectable
3bf1F-5vaeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_C_OBNC1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5vae ACCESSORY SEC SYSTEM
PROTEIN ASP1
(Streptococcus
gordonii) 		5 / 11 LEU A 244
VAL A 233
ALA A 234
PHE A 257
PHE A 287
 None
 1.41A 3n23C-5vaeA:
6.5		 3n23C-5vaeA:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8W_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5vae ACCESSORY SEC SYSTEM
PROTEIN ASP1
(Streptococcus
gordonii) 		5 / 12 LEU A 422
GLY A 451
ALA A 450
SER A 449
LEU A 312
 None
 1.05A 3n8wA-5vaeA:
undetectable		 3n8wA-5vaeA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5vae ACCESSORY SEC SYSTEM
PROTEIN ASP1
(Streptococcus
gordonii) 		5 / 12 PHE A   4
ALA A 234
ASP A  34
ARG A  40
LEU A  51
 None
 1.11A 3nrrA-5vaeA:
undetectable		 3nrrA-5vaeA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 5vae ACCESSORY SEC SYSTEM
PROTEIN ASP1
(Streptococcus
gordonii) 		5 / 12 LEU A 422
GLY A 451
ALA A 450
SER A 449
LEU A 312
 None
 1.06A 3nt1A-5vaeA:
undetectable		 3nt1A-5vaeA:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_B_NPSB4_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 5vae ACCESSORY SEC SYSTEM
PROTEIN ASP1
(Streptococcus
gordonii) 		5 / 12 LEU A 422
GLY A 451
ALA A 450
SER A 449
LEU A 312
 None
 1.08A 3nt1B-5vaeA:
undetectable		 3nt1B-5vaeA:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		 5vae ACCESSORY SEC SYSTEM
PROTEIN ASP1
(Streptococcus
gordonii) 		5 / 10 ILE A 433
ALA A 481
LEU A 435
ASN A 456
LEU A 472
 None
 1.19A 3o02A-5vaeA:
undetectable
3o02B-5vaeA:
undetectable		 3o02A-5vaeA:
13.04
3o02B-5vaeA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_A_FLPA701_1
(CYCLOOXYGENASE-2)		 5vae ACCESSORY SEC SYSTEM
PROTEIN ASP1
(Streptococcus
gordonii) 		5 / 12 LEU A 422
GLY A 451
ALA A 450
SER A 449
LEU A 312
 None
 1.18A 3pghA-5vaeA:
undetectable		 3pghA-5vaeA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R55_A_PZAA598_0
(LACTOPEROXIDASE)		 5vae ACCESSORY SEC SYSTEM
PROTEIN ASP3
(Streptococcus
gordonii) 		3 / 3 GLU B 109
PHE B 103
GLN B 134
 None
 0.78A 3r55A-5vaeB:
undetectable		 3r55A-5vaeB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5vae ACCESSORY SEC SYSTEM
PROTEIN ASP1
(Streptococcus
gordonii) 		5 / 12 LEU A 422
GLY A 451
ALA A 450
SER A 449
LEU A 312
 None
 1.03A 3rr3A-5vaeA:
undetectable		 3rr3A-5vaeA:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5vae ACCESSORY SEC SYSTEM
PROTEIN ASP1
(Streptococcus
gordonii) 		5 / 12 LEU A 422
GLY A 451
ALA A 450
SER A 449
LEU A 312
 None
 1.02A 3rr3B-5vaeA:
undetectable		 3rr3B-5vaeA:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_C_C2FC1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 5vae ACCESSORY SEC SYSTEM
PROTEIN ASP1
ACCESSORY SEC SYSTEM
PROTEIN ASP3
(Streptococcus
gordonii;
Streptococcus
gordonii) 		3 / 3 ARG A  61
PRO B  74
PHE A  70
 None
 1.04A 3thrC-5vaeA:
undetectable		 3thrC-5vaeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 5vae ACCESSORY SEC SYSTEM
PROTEIN ASP1
(Streptococcus
gordonii) 		4 / 8 VAL A  49
HIS A  43
PRO A   6
TRP A   8
 None
 1.37A 3v35A-5vaeA:
3.0		 3v35A-5vaeA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1Y_A_RBFA1176_1
(PUTATIVE PROTEASE I)		 5vae ACCESSORY SEC SYSTEM
PROTEIN ASP1
(Streptococcus
gordonii) 		4 / 8 TRP A 515
GLN A 510
ASN A 506
THR A 507
 None
 0.96A 4d1yA-5vaeA:
8.2
4d1yB-5vaeA:
8.2		 4d1yA-5vaeA:
16.22
4d1yB-5vaeA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5vae ACCESSORY SEC SYSTEM
PROTEIN ASP1
(Streptococcus
gordonii) 		3 / 3 TYR A 462
HIS A 259
ARG A 284
 None
 1.06A 4htfA-5vaeA:
3.9		 4htfA-5vaeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7A_A_MXDA1002_1
(ANDROGEN RECEPTOR)		 5vae ACCESSORY SEC SYSTEM
PROTEIN ASP1
(Streptococcus
gordonii) 		3 / 3 GLU A 182
TRP A  16
LYS A 185
 None
 1.32A 4k7aA-5vaeA:
undetectable		 4k7aA-5vaeA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA602_1
(SERUM ALBUMIN)		 5vae ACCESSORY SEC SYSTEM
PROTEIN ASP1
(Streptococcus
gordonii) 		4 / 6 ARG A 152
ALA A  60
ASP A 150
LEU A  53
 None
 0.98A 4ot2A-5vaeA:
undetectable		 4ot2A-5vaeA:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 5vae ACCESSORY SEC SYSTEM
PROTEIN ASP1
(Streptococcus
gordonii) 		4 / 5 GLN A  54
SER A   9
ASP A  33
ASP A 283
 None
 1.45A 4qtuB-5vaeA:
undetectable		 4qtuB-5vaeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0
(FAD:PROTEIN FMN
TRANSFERASE)		 5vae ACCESSORY SEC SYSTEM
PROTEIN ASP1
(Streptococcus
gordonii) 		4 / 5 ILE A 367
VAL A 359
ILE A 357
VAL A 370
 None
 0.72A 4xdtA-5vaeA:
undetectable		 4xdtA-5vaeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_A_SAMA1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 5vae ACCESSORY SEC SYSTEM
PROTEIN ASP1
(Streptococcus
gordonii) 		5 / 12 TYR A 462
TYR A 442
TYR A 498
ALA A 495
TYR A 485
 None
 1.50A 4ymgA-5vaeA:
undetectable		 4ymgA-5vaeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 5vae ACCESSORY SEC SYSTEM
PROTEIN ASP1
(Streptococcus
gordonii) 		3 / 3 ARG A 261
THR A  35
ASP A  33
 None
 0.58A 5g5gA-5vaeA:
undetectable
5g5gB-5vaeA:
undetectable		 5g5gA-5vaeA:
undetectable
5g5gB-5vaeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H1E_A_VDXA501_1
(VITAMIN D3 RECEPTOR)		 5vae ACCESSORY SEC SYSTEM
PROTEIN ASP1
(Streptococcus
gordonii) 		5 / 12 TYR A 462
PHE A  32
SER A 449
ILE A 503
SER A 306
 None
 1.47A 5h1eA-5vaeA:
undetectable		 5h1eA-5vaeA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5vae ACCESSORY SEC SYSTEM
PROTEIN ASP1
(Streptococcus
gordonii) 		5 / 12 LEU A 422
GLY A 451
ALA A 450
SER A 449
LEU A 312
 None
 1.10A 5ikrB-5vaeA:
undetectable		 5ikrB-5vaeA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 5vae ACCESSORY SEC SYSTEM
PROTEIN ASP1
(Streptococcus
gordonii) 		4 / 5 HIS A 465
ALA A 481
GLY A 469
TYR A 485
 None
 1.25A 5yodB-5vaeA:
undetectable		 5yodB-5vaeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 5vae ACCESSORY SEC SYSTEM
PROTEIN ASP1
(Streptococcus
gordonii) 		4 / 8 ILE A 416
GLN A 328
GLU A 333
SER A 332
 None
 1.07A 6c06C-5vaeA:
undetectable		 6c06C-5vaeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBF_A_ACTA507_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 5vae ACCESSORY SEC SYSTEM
PROTEIN ASP3
(Streptococcus
gordonii) 		3 / 3 LYS B 132
SER B  60
SER B  61
 None
 1.09A 6gbfA-5vaeB:
undetectable		 6gbfA-5vaeB:
undetectable