SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5van'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD6_0
(GRAMICIDIN A)		 5van BETA-KLOTHO
(Homo
sapiens) 		3 / 3 TRP A 209
ALA A 256
VAL A 245
 None
 0.99A 1av2C-5vanA:
undetectable
1av2D-5vanA:
undetectable		 1av2C-5vanA:
undetectable
1av2D-5vanA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 5van BETA-KLOTHO
(Homo
sapiens) 		4 / 5 ALA A 791
TYR A 789
ILE A 790
ASP A 846
 None
 1.22A 1upfA-5vanA:
2.0		 1upfA-5vanA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5van BETA-KLOTHO
(Homo
sapiens) 		4 / 5 GLY A 465
GLN A  95
TRP A 468
SER A 461
 None
 1.20A 1zzqB-5vanA:
undetectable		 1zzqB-5vanA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2002_1
(SERUM ALBUMIN)		 5van BETA-KLOTHO
(Homo
sapiens) 		5 / 11 LEU A 138
ILE A 187
ARG A 185
PHE A 148
GLY A  88
 None
 1.21A 2bxmA-5vanA:
undetectable		 2bxmA-5vanA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2003_1
(SERUM ALBUMIN)		 5van BETA-KLOTHO
(Homo
sapiens) 		5 / 10 LEU A 138
ILE A 187
ARG A 185
PHE A 148
GLY A  88
 None
 1.20A 2bxqA-5vanA:
undetectable		 2bxqA-5vanA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_J_BEZJ3352_0
(D-AMINO-ACID OXIDASE)		 5van BETA-KLOTHO
(Homo
sapiens) 		4 / 5 TYR A 457
TYR A 499
ILE A 502
GLY A 456
 None
 1.30A 2du8J-5vanA:
undetectable		 2du8J-5vanA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		 5van BETA-KLOTHO
(Homo
sapiens) 		4 / 8 LEU A 823
LEU A 872
ASP A 745
GLU A 768
 None
 0.96A 2j2pA-5vanA:
undetectable
2j2pB-5vanA:
undetectable		 2j2pA-5vanA:
17.31
2j2pB-5vanA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_2
(MINERALOCORTICOID
RECEPTOR)		 5van BETA-KLOTHO
(Homo
sapiens) 		4 / 5 LEU A 327
LEU A 300
LEU A 273
MET A 363
 None
 1.10A 2oaxF-5vanA:
undetectable		 2oaxF-5vanA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_2
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 5van BETA-KLOTHO
(Homo
sapiens) 		3 / 3 ARG A 397
GLU A 398
GLN A 445
 None
 1.10A 2p16A-5vanA:
undetectable		 2p16A-5vanA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA803_0
(FERROCHELATASE)		 5van BETA-KLOTHO
(Homo
sapiens) 		4 / 5 LEU A 198
PRO A 199
LEU A 202
ILE A 214
 None
 0.77A 2qd4A-5vanA:
undetectable		 2qd4A-5vanA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_A_ASDA1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 5van BETA-KLOTHO
(Homo
sapiens) 		4 / 7 TYR A 841
PRO A 775
LEU A 716
ALA A 712
 None
 0.96A 2vcvA-5vanA:
undetectable		 2vcvA-5vanA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAT_A_CLMA301_0
(XENOBIOTIC
ACETYLTRANSFERASE)		 5van BETA-KLOTHO
(Homo
sapiens) 		3 / 3 GLY A 927
TYR A 929
SER A 526
 None
 0.61A 2xatA-5vanA:
undetectable		 2xatA-5vanA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1413_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 5van BETA-KLOTHO
(Homo
sapiens) 		4 / 6 ALA A 371
ALA A 415
THR A 458
PHE A 148
 None
 0.82A 2xfhA-5vanA:
undetectable		 2xfhA-5vanA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 5van BETA-KLOTHO
(Homo
sapiens) 		5 / 11 LEU A 873
VAL A 869
GLY A 868
GLU A 913
ALA A 917
 None
 0.85A 2yy8A-5vanA:
4.0
2yy8B-5vanA:
2.1		 2yy8A-5vanA:
undetectable
2yy8B-5vanA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 5van BETA-KLOTHO
(Homo
sapiens) 		5 / 12 ALA A 399
PHE A 374
GLY A 301
VAL A 326
TYR A 243
 None
 1.09A 2zifB-5vanA:
undetectable		 2zifB-5vanA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5van BETA-KLOTHO
(Homo
sapiens) 		3 / 3 ASN A 824
HIS A 825
VAL A 869
 None
 0.90A 3elzB-5vanA:
undetectable		 3elzB-5vanA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		 5van BETA-KLOTHO
(Homo
sapiens) 		5 / 12 LEU A 178
LEU A 179
TYR A 174
PHE A 229
LEU A 158
 None
 1.15A 3gwuA-5vanA:
undetectable		 3gwuA-5vanA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEC_A_65BA561_0
(P66 REVERSE
TRANSCRIPTASE)		 5van BETA-KLOTHO
(Homo
sapiens) 		5 / 12 VAL A 280
TYR A 284
TRP A 236
LEU A 193
TYR A 221
 None
 1.24A 3mecA-5vanA:
undetectable		 3mecA-5vanA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_2
(PROTEASE)		 5van BETA-KLOTHO
(Homo
sapiens) 		4 / 6 ILE A 502
ILE A 190
GLY A  88
VAL A 454
 None
 0.87A 3n3iA-5vanA:
undetectable		 3n3iA-5vanA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_B_ACTB601_0
(CHOLINE OXIDASE)		 5van BETA-KLOTHO
(Homo
sapiens) 		4 / 5 TRP A 402
ILE A 305
HIS A 303
VAL A 326
 None
 1.03A 3nneB-5vanA:
undetectable		 3nneB-5vanA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_D_ACTD601_0
(CHOLINE OXIDASE)		 5van BETA-KLOTHO
(Homo
sapiens) 		4 / 5 TRP A 402
ILE A 305
HIS A 303
VAL A 326
 None
 1.01A 3nneD-5vanA:
0.0		 3nneD-5vanA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_F_ACTF601_0
(CHOLINE OXIDASE)		 5van BETA-KLOTHO
(Homo
sapiens) 		4 / 4 TRP A 402
ILE A 305
HIS A 303
VAL A 326
 None
 1.09A 3nneF-5vanA:
0.0		 3nneF-5vanA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_B_ASDB501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 5van BETA-KLOTHO
(Homo
sapiens) 		4 / 8 TYR A 701
TYR A 642
LEU A 655
TRP A 603
 None
 1.31A 3uzzB-5vanA:
3.9		 3uzzB-5vanA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB501_1
(HEMOLYTIC LECTIN
CEL-III)		 5van BETA-KLOTHO
(Homo
sapiens) 		4 / 5 ASP A 844
SER A 839
GLY A 838
ASP A 846
 None
 1.19A 3w9tB-5vanA:
undetectable		 3w9tB-5vanA:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1003_1
(HEMOLYTIC LECTIN
CEL-III)		 5van BETA-KLOTHO
(Homo
sapiens) 		4 / 5 ASP A 844
SER A 839
GLY A 838
ASP A 846
 None
 1.20A 3w9tC-5vanA:
undetectable		 3w9tC-5vanA:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD501_1
(HEMOLYTIC LECTIN
CEL-III)		 5van BETA-KLOTHO
(Homo
sapiens) 		4 / 5 ASP A 844
SER A 839
GLY A 838
ASP A 846
 None
 1.21A 3w9tD-5vanA:
undetectable		 3w9tD-5vanA:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 5van BETA-KLOTHO
(Homo
sapiens) 		4 / 7 PRO A 257
ILE A 109
GLN A 203
GLY A 208
 None
 0.98A 4a3uB-5vanA:
8.1		 4a3uB-5vanA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5van BETA-KLOTHO
(Homo
sapiens) 		4 / 4 LEU A 198
PRO A 199
LEU A 202
ILE A 214
 None
 0.84A 4f4dB-5vanA:
undetectable		 4f4dB-5vanA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_A_ACTA502_0
(RNA-DEPENDENT RNA
POLYMERASE)		 5van BETA-KLOTHO
(Homo
sapiens) 		4 / 5 LYS A 632
LEU A 633
GLU A 629
LEU A 586
 None
 1.08A 4k4yA-5vanA:
undetectable		 4k4yA-5vanA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_E_ACTE503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 5van BETA-KLOTHO
(Homo
sapiens) 		4 / 4 LYS A 632
LEU A 633
GLU A 629
LEU A 586
 None
 1.09A 4k4yE-5vanA:
undetectable		 4k4yE-5vanA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_I_ACTI503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 5van BETA-KLOTHO
(Homo
sapiens) 		4 / 5 LYS A 632
LEU A 633
GLU A 629
LEU A 586
 None
 1.11A 4k4yI-5vanA:
undetectable		 4k4yI-5vanA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5van BETA-KLOTHO
(Homo
sapiens) 		3 / 3 SER A 605
TYR A 623
PRO A 652
 None
 0.97A 4kahA-5vanA:
3.3		 4kahA-5vanA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5van BETA-KLOTHO
(Homo
sapiens) 		3 / 3 SER A 605
TYR A 623
PRO A 652
 None
 0.97A 4kbeA-5vanA:
3.1		 4kbeA-5vanA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOW_A_CFXA204_1
(UNCHARACTERIZED
PROTEIN)		 5van BETA-KLOTHO
(Homo
sapiens) 		5 / 12 PHE A 379
ASN A 438
MET A 436
PHE A 374
TYR A 457
 None
 1.11A 4kowA-5vanA:
undetectable		 4kowA-5vanA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)		 5van BETA-KLOTHO
(Homo
sapiens) 		5 / 12 ILE A 412
ILE A 237
PHE A 370
PRO A 242
LEU A 327
 None
 1.00A 4m2xA-5vanA:
undetectable		 4m2xA-5vanA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_A_29EA603_1
(TRANSPORTER)		 5van BETA-KLOTHO
(Homo
sapiens) 		5 / 10 PRO A 242
VAL A 245
ALA A 246
TYR A 250
GLY A 270
 None
 1.25A 4mmdA-5vanA:
undetectable		 4mmdA-5vanA:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_A_ADNA303_1
(5'/3'-NUCLEOTIDASE
SURE)		 5van BETA-KLOTHO
(Homo
sapiens) 		5 / 10 GLY A 171
TYR A 174
ALA A  93
ILE A 153
LEU A 158
 None
 1.19A 4xj7A-5vanA:
undetectable
4xj7B-5vanA:
undetectable		 4xj7A-5vanA:
13.86
4xj7B-5vanA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)		 5van BETA-KLOTHO
(Homo
sapiens) 		3 / 3 LEU A 873
ARG A 874
ARG A 877
 None
 0.84A 4yiaB-5vanA:
undetectable		 4yiaB-5vanA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 5van BETA-KLOTHO
(Homo
sapiens) 		3 / 3 ALA A 711
ASN A 714
LEU A 715
 None
 0.41A 5i1oC-5vanA:
undetectable		 5i1oC-5vanA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 5van BETA-KLOTHO
(Homo
sapiens) 		3 / 3 ALA A 711
ASN A 714
LEU A 715
 None
 0.39A 5i1pA-5vanA:
undetectable		 5i1pA-5vanA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		 5van BETA-KLOTHO
(Homo
sapiens) 		3 / 3 TYR A 622
TYR A 597
GLN A 585
 None
 0.97A 5jsdA-5vanA:
undetectable
5jsdB-5vanA:
undetectable		 5jsdA-5vanA:
8.40
5jsdB-5vanA:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		 5van BETA-KLOTHO
(Homo
sapiens) 		3 / 3 TYR A 622
TYR A 597
GLN A 585
 None
 0.98A 5jsdB-5vanA:
undetectable
5jsdC-5vanA:
undetectable		 5jsdB-5vanA:
8.40
5jsdC-5vanA:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_CE9A402_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 5van BETA-KLOTHO
(Homo
sapiens) 		5 / 12 ALA A 718
HIS A 719
LEU A 721
ALA A 722
LEU A 641
 None
 0.79A 5k9dA-5vanA:
7.2		 5k9dA-5vanA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_E_ASCE1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 5van BETA-KLOTHO
(Homo
sapiens) 		4 / 7 HIS A 825
ILE A 865
VAL A 864
TYR A 910
 None
 1.24A 5kkzC-5vanA:
undetectable
5kkzE-5vanA:
undetectable		 5kkzC-5vanA:
undetectable
5kkzE-5vanA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 5van BETA-KLOTHO
(Homo
sapiens) 		4 / 7 ILE A 865
VAL A 864
TYR A 910
HIS A 825
 None
 1.24A 5kkzK-5vanA:
undetectable
5kkzQ-5vanA:
undetectable		 5kkzK-5vanA:
undetectable
5kkzQ-5vanA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 5van BETA-KLOTHO
(Homo
sapiens) 		4 / 8 LEU A 814
LEU A 721
ILE A 689
THR A 690
 None
 1.04A 5ljbA-5vanA:
undetectable		 5ljbA-5vanA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 5van BETA-KLOTHO
(Homo
sapiens) 		5 / 12 VAL A 738
ASP A 819
HIS A 719
ALA A 722
ARG A 731
 None
 1.12A 5m54B-5vanA:
3.2		 5m54B-5vanA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 5van BETA-KLOTHO
(Homo
sapiens) 		5 / 12 VAL A 738
ASP A 819
HIS A 719
ALA A 722
ARG A 731
 None
 1.12A 5m54E-5vanA:
2.6		 5m54E-5vanA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_A_ESTA601_1
(ESTROGEN RECEPTOR
BETA)		 5van BETA-KLOTHO
(Homo
sapiens) 		5 / 12 LEU A 716
LEU A 715
ALA A 718
LEU A 740
LEU A 813
 None
 1.05A 5toaA-5vanA:
undetectable		 5toaA-5vanA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_1
(REGULATORY PROTEIN
TETR)		 5van BETA-KLOTHO
(Homo
sapiens) 		4 / 7 GLY A 249
TRP A 329
TYR A 340
TYR A 194
 None
 1.25A 5vlmG-5vanA:
undetectable		 5vlmG-5vanA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5van BETA-KLOTHO
(Homo
sapiens) 		4 / 5 TYR A 407
VAL A 443
MET A 323
GLY A 328
 None
 1.10A 6hd4A-5vanA:
undetectable		 6hd4A-5vanA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5van BETA-KLOTHO
(Homo
sapiens) 		4 / 5 TYR A 928
VAL A 685
PHE A 944
GLY A 891
 None
 1.37A 6hd4A-5vanA:
undetectable		 6hd4A-5vanA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5van BETA-KLOTHO
(Homo
sapiens) 		4 / 6 LYS A 170
GLN A 173
LEU A 158
PHE A 159
 None
 1.21A 6nmpC-5vanA:
undetectable
6nmpJ-5vanA:
undetectable		 6nmpC-5vanA:
undetectable
6nmpJ-5vanA:
undetectable