SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vat'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)		 5vat PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOA
(Haemophilus
influenzae) 		4 / 5 LEU A  67
GLU A 104
ALA A  70
LEU A  68
 None
 1.18A 1eta2-5vatA:
undetectable		 1eta2-5vatA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3003_1
(SERUM ALBUMIN)		 5vat PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOA
(Haemophilus
influenzae) 		3 / 4 LYS A 448
ALA A 445
MET A 481
 None
 0.94A 1hk3A-5vatA:
2.5		 1hk3A-5vatA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 5vat PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOA
(Haemophilus
influenzae) 		4 / 8 GLY A 391
ARG A 465
VAL A 394
PRO A 362
 None
 0.89A 1rxcB-5vatA:
undetectable		 1rxcB-5vatA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_D_URFD2021_1
(URIDINE
PHOSPHORYLASE)		 5vat PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOA
(Haemophilus
influenzae) 		4 / 7 GLY A 391
ARG A 465
VAL A 394
PRO A 362
 None
 0.87A 1rxcD-5vatA:
2.2		 1rxcD-5vatA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_E_URFE2031_1
(URIDINE
PHOSPHORYLASE)		 5vat PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOA
(Haemophilus
influenzae) 		4 / 8 GLY A 391
ARG A 465
VAL A 394
PRO A 362
 None
 0.90A 1rxcE-5vatA:
undetectable		 1rxcE-5vatA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_I_URFI2041_1
(URIDINE
PHOSPHORYLASE)		 5vat PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOA
(Haemophilus
influenzae) 		4 / 8 GLY A 391
ARG A 465
VAL A 394
PRO A 362
 None
 0.88A 1rxcI-5vatA:
undetectable		 1rxcI-5vatA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_K_URFK2061_1
(URIDINE
PHOSPHORYLASE)		 5vat PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOA
(Haemophilus
influenzae) 		4 / 8 GLY A 391
ARG A 465
VAL A 394
PRO A 362
 None
 0.87A 1rxcK-5vatA:
3.2		 1rxcK-5vatA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_L_URFL2071_1
(URIDINE
PHOSPHORYLASE)		 5vat PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOA
(Haemophilus
influenzae) 		4 / 7 GLY A 391
ARG A 465
VAL A 394
PRO A 362
 None
 0.91A 1rxcL-5vatA:
undetectable		 1rxcL-5vatA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_B_STRB402_1
(MINERALOCORTICOID
RECEPTOR)		 5vat PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOA
(Haemophilus
influenzae) 		5 / 12 LEU A 325
ALA A 345
LEU A 343
MET A 519
LEU A 360
 None
 1.48A 2aa6B-5vatA:
undetectable		 2aa6B-5vatA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_1
(POL PROTEIN)		 5vat PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOA
(Haemophilus
influenzae) 		5 / 11 LEU A 261
GLY A 520
ALA A 523
GLY A 359
VAL A 317
 None
 0.98A 2fxdA-5vatA:
undetectable		 2fxdA-5vatA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_A_017A201_1
(PROTEASE)		 5vat PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOA
(Haemophilus
influenzae) 		6 / 12 LEU A 261
GLY A 520
ALA A 523
ASP A 522
GLY A 359
PRO A 319
 None
 1.32A 2hs2A-5vatA:
undetectable		 2hs2A-5vatA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 5vat PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOA
(Haemophilus
influenzae) 		4 / 6 GLY A 269
SER A 297
ILE A 271
ASP A 268
 None
 0.91A 3a7eA-5vatA:
3.5		 3a7eA-5vatA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_1
(PROTEASE)		 5vat PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOA
(Haemophilus
influenzae) 		5 / 12 LEU A 261
GLY A 520
ALA A 523
GLY A 359
VAL A 317
 None
 1.12A 3gguA-5vatA:
undetectable		 3gguA-5vatA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5vat PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOA
(Haemophilus
influenzae) 		4 / 8 LYS A 163
HIS A 171
ASN A 174
ILE A 159
 None
 1.29A 3kp6A-5vatA:
undetectable
3kp6B-5vatA:
undetectable		 3kp6A-5vatA:
14.53
3kp6B-5vatA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_H_DHIH3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 5vat PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOA
(Haemophilus
influenzae) 		3 / 3 LEU A 225
TRP A 228
GLY A 203
 None
 0.76A 3l35A-5vatA:
undetectable
3l35H-5vatA:
undetectable		 3l35A-5vatA:
7.08
3l35H-5vatA:
2.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_K_DHIK3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 5vat PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOA
(Haemophilus
influenzae) 		3 / 3 LEU A 225
TRP A 228
GLY A 203
 None
 0.81A 3l35B-5vatA:
undetectable
3l35K-5vatA:
undetectable		 3l35B-5vatA:
7.08
3l35K-5vatA:
2.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_2
(HIV-1 PROTEASE)		 5vat PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOA
(Haemophilus
influenzae) 		5 / 12 ARG A 401
ASP A 488
ILE A 489
GLY A 546
ILE A 547
 None
 1.08A 3mwsB-5vatA:
undetectable		 3mwsB-5vatA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_2
(PROTEASE)		 5vat PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOA
(Haemophilus
influenzae) 		5 / 10 LEU A 261
GLY A 520
ALA A 523
GLY A 359
VAL A 317
 None
 1.11A 3nu9B-5vatA:
undetectable		 3nu9B-5vatA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_2
(HIV-1 PROTEASE)		 5vat PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOA
(Haemophilus
influenzae) 		5 / 12 ARG A 401
ASP A 488
ILE A 489
GLY A 546
ILE A 547
 None
 1.07A 3spkB-5vatA:
undetectable		 3spkB-5vatA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_1
(POL POLYPROTEIN)		 5vat PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOA
(Haemophilus
influenzae) 		6 / 9 LEU A 261
GLY A 520
ALA A 523
ASP A 522
GLY A 359
VAL A 317
 None
 1.31A 3u7sA-5vatA:
undetectable		 3u7sA-5vatA:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_2
(POL POLYPROTEIN)		 5vat PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOA
(Haemophilus
influenzae) 		5 / 9 ARG A 401
ASP A 488
ILE A 489
GLY A 546
ILE A 547
 None
 1.19A 3u7sB-5vatA:
undetectable		 3u7sB-5vatA:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_2
(POL POLYPROTEIN)		 5vat PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOA
(Haemophilus
influenzae) 		6 / 9 GLY A 520
ALA A 523
ASP A 522
GLY A 359
LEU A 262
VAL A 317
 None
 1.40A 3u7sB-5vatA:
undetectable		 3u7sB-5vatA:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_2
(PROTEASE)		 5vat PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOA
(Haemophilus
influenzae) 		6 / 12 LEU A 261
GLY A 520
ALA A 523
ASP A 522
GLY A 359
VAL A 317
 None
 1.36A 3ucbB-5vatA:
undetectable		 3ucbB-5vatA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_A_URFA1301_1
(URIDINE
PHOSPHORYLASE)		 5vat PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOA
(Haemophilus
influenzae) 		4 / 8 GLY A 391
ARG A 465
VAL A 394
PRO A 362
 None
 0.90A 4e1vA-5vatA:
4.2		 4e1vA-5vatA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_B_URFB1301_1
(URIDINE
PHOSPHORYLASE)		 5vat PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOA
(Haemophilus
influenzae) 		4 / 7 GLY A 391
ARG A 465
VAL A 394
PRO A 362
 None
 0.86A 4e1vB-5vatA:
undetectable		 4e1vB-5vatA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_C_URFC1301_1
(URIDINE
PHOSPHORYLASE)		 5vat PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOA
(Haemophilus
influenzae) 		4 / 8 GLY A 391
ARG A 465
VAL A 394
PRO A 362
 None
 0.88A 4e1vC-5vatA:
undetectable		 4e1vC-5vatA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_D_URFD1301_1
(URIDINE
PHOSPHORYLASE)		 5vat PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOA
(Haemophilus
influenzae) 		4 / 8 GLY A 391
ARG A 465
VAL A 394
PRO A 362
 None
 0.87A 4e1vD-5vatA:
undetectable		 4e1vD-5vatA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_E_URFE1301_1
(URIDINE
PHOSPHORYLASE)		 5vat PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOA
(Haemophilus
influenzae) 		4 / 8 GLY A 391
ARG A 465
VAL A 394
PRO A 362
 None
 0.87A 4e1vE-5vatA:
undetectable		 4e1vE-5vatA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_G_URFG1301_1
(URIDINE
PHOSPHORYLASE)		 5vat PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOA
(Haemophilus
influenzae) 		4 / 8 GLY A 391
ARG A 465
VAL A 394
PRO A 362
 None
 1.00A 4e1vG-5vatA:
undetectable		 4e1vG-5vatA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		 5vat PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOA
(Haemophilus
influenzae) 		5 / 11 LEU A 245
ALA A 237
ALA A 236
ILE A 159
VAL A 155
 None
 1.18A 4h1nA-5vatA:
undetectable		 4h1nA-5vatA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 5vat PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOA
(Haemophilus
influenzae) 		4 / 7 GLN A  63
THR A  64
LEU A  38
THR A  35
 None
 0.99A 4mbsA-5vatA:
undetectable		 4mbsA-5vatA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_K_CHDK103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5vat PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOA
(Haemophilus
influenzae) 		5 / 11 GLU A 104
LEU A 102
TYR A 137
LEU A  98
LEU A 129
 None
 1.22A 4wg0I-5vatA:
undetectable
4wg0J-5vatA:
undetectable
4wg0K-5vatA:
undetectable		 4wg0I-5vatA:
2.96
4wg0J-5vatA:
2.96
4wg0K-5vatA:
2.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_F_TR6F101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 5vat PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOA
(Haemophilus
influenzae) 		4 / 5 GLY A 391
ARG A 393
GLY A 395
GLU A 363
 None
 1.18A 4z2eB-5vatA:
undetectable
4z2eC-5vatA:
4.5		 4z2eB-5vatA:
22.32
4z2eC-5vatA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 5vat PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOA
(Haemophilus
influenzae) 		5 / 12 LEU A 262
ILE A 276
GLY A 520
ASP A 522
LEU A 316
 None
 1.16A 5h5fA-5vatA:
2.6		 5h5fA-5vatA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 5vat PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOA
(Haemophilus
influenzae) 		4 / 8 ILE A 289
VAL A 256
THR A 315
ILE A 313
 None
 0.94A 5mzrE-5vatA:
2.2		 5mzrE-5vatA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_A_08JA602_1
(CYTOCHROME P450 3A4)		 5vat PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOA
(Haemophilus
influenzae) 		4 / 7 ALA A 419
THR A 422
ILE A 454
LEU A 451
 None
 0.98A 5te8A-5vatA:
undetectable		 5te8A-5vatA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_1
(REGULATORY PROTEIN
TETR)		 5vat PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOA
(Haemophilus
influenzae) 		4 / 7 GLY A 546
GLN A 512
ASP A 488
TYR A 563
 None
 1.23A 5vlmG-5vatA:
2.0		 5vlmG-5vatA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5vat PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOA
(Haemophilus
influenzae) 		5 / 12 LEU A 207
ILE A 208
LEU A 205
GLY A 202
GLY A 203
 None
 0.97A 5wyqB-5vatA:
undetectable		 5wyqB-5vatA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CB4_A_BEZA501_0
(CANAVALIN)		 5vat PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOA
(Haemophilus
influenzae) 		4 / 8 ASN A 429
VAL A 455
LEU A 451
ILE A 454
 None
 0.94A 6cb4A-5vatA:
undetectable		 6cb4A-5vatA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		 5vat PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOA
(Haemophilus
influenzae) 		3 / 3 THR A 140
ALA A 109
LYS A 111
 None
 0.69A 6fgcA-5vatA:
undetectable		 6fgcA-5vatA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		 5vat PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOA
(Haemophilus
influenzae) 		3 / 3 THR A 140
ALA A 109
LYS A 111
 None
 0.69A 6fgdA-5vatA:
5.1		 6fgdA-5vatA:
21.97