SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vaw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_A_IPBA600_0
(ODORANT-BINDING
PROTEIN)		 5vaw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TYPE IV
PILIN PILA
(Acinetobacter
baumannii;
Escherichia
coli) 		4 / 6 VAL A   8
VAL A  50
ILE A  60
ASN A 267
 None
 0.95A 1e06A-5vawA:
undetectable		 1e06A-5vawA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_B_T44B602_1
(TRANSTHYRETIN)		 5vaw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TYPE IV
PILIN PILA
(Acinetobacter
baumannii;
Escherichia
coli) 		4 / 7 LYS A 277
GLU A 281
ALA A 276
ALA A  77
 None
 1.16A 1sn0B-5vawA:
undetectable
1sn0D-5vawA:
undetectable		 1sn0B-5vawA:
23.20
1sn0D-5vawA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 5vaw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TYPE IV
PILIN PILA
(Acinetobacter
baumannii;
Escherichia
coli) 		5 / 12 GLY A1041
SER A1042
ILE A1047
GLU A1136
ALA A1106
 None
 1.03A 1vq1B-5vawA:
undetectable		 1vq1B-5vawA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)		 5vaw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TYPE IV
PILIN PILA
(Acinetobacter
baumannii;
Escherichia
coli) 		5 / 10 LEU A 192
LEU A 195
ILE A 161
GLU A 153
LEU A 151
 None
 1.22A 1wopA-5vawA:
0.0		 1wopA-5vawA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_D_H4BD1290_1
(PTERIDINE REDUCTASE
1)		 5vaw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TYPE IV
PILIN PILA
(Acinetobacter
baumannii;
Escherichia
coli) 		4 / 8 PHE A  85
LEU A  89
LEU A 290
LEU A 284
 None
 1.04A 2bfpD-5vawA:
undetectable		 2bfpD-5vawA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5vaw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TYPE IV
PILIN PILA
(Acinetobacter
baumannii;
Escherichia
coli) 		5 / 12 LEU A 262
ILE A 108
VAL A  97
LEU A  76
ILE A  79
 SER  A1205 (-3.9A)
None
None
None
None
 0.95A 2h42C-5vawA:
undetectable		 2h42C-5vawA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA702_0
(FERROCHELATASE)		 5vaw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TYPE IV
PILIN PILA
(Acinetobacter
baumannii;
Escherichia
coli) 		4 / 7 LEU A 192
PRO A 331
VAL A 343
TRP A 340
 None
MPD  A1201 ( 4.8A)
None
None
 1.33A 2hrcA-5vawA:
undetectable		 2hrcA-5vawA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_A_REAA1445_1
(PUTATIVE CYTOCHROME
P450 120)		 5vaw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TYPE IV
PILIN PILA
(Acinetobacter
baumannii;
Escherichia
coli) 		5 / 12 ALA A 264
LEU A 280
PHE A 279
VAL A 293
GLY A  16
 None
 1.10A 2ve3A-5vawA:
undetectable		 2ve3A-5vawA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)		 5vaw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TYPE IV
PILIN PILA
(Acinetobacter
baumannii;
Escherichia
coli) 		5 / 12 ILE A 108
LEU A 262
ILE A  59
VAL A  23
LEU A  20
 None
SER  A1205 (-3.9A)
None
None
None
 0.97A 3a51C-5vawA:
undetectable		 3a51C-5vawA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 5vaw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TYPE IV
PILIN PILA
(Acinetobacter
baumannii;
Escherichia
coli) 		4 / 7 GLN A 253
GLY A 187
GLY A 165
ALA A 190
 None
 0.77A 3fpjB-5vawA:
undetectable		 3fpjB-5vawA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB301_0
(DISULFIDE
INTERCHANGE PROTEIN)		 5vaw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TYPE IV
PILIN PILA
(Acinetobacter
baumannii;
Escherichia
coli) 		4 / 6 LEU A 147
ALA A 223
PRO A 125
PRO A 126
 None
 1.36A 3gv1A-5vawA:
undetectable
3gv1B-5vawA:
undetectable		 3gv1A-5vawA:
undetectable
3gv1B-5vawA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_1
(HIV-1 PROTEASE)		 5vaw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TYPE IV
PILIN PILA
(Acinetobacter
baumannii;
Escherichia
coli) 		5 / 11 GLY A 300
ALA A 301
VAL A 259
GLY A 260
THR A  93
 None
 0.85A 3ufnA-5vawA:
undetectable		 3ufnA-5vawA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VFJ_A_ACTA410_0
(MALTOSE-BINDING
PERIPLASMIC PROTEIN,
C-TERMINAL FUSED BY
CYS-LYS-D-ALA-D-ALA)		 5vaw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TYPE IV
PILIN PILA
(Acinetobacter
baumannii;
Escherichia
coli) 		4 / 4 LYS A  15
ALA A  63
GLU A 111
LEU A 262
 SER  A1205 (-3.1A)
SER  A1205 (-3.2A)
SER  A1205 ( 4.5A)
SER  A1205 (-3.9A)
 0.59A 3vfjA-5vawA:
51.6		 3vfjA-5vawA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_1
(MNMC2)		 5vaw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TYPE IV
PILIN PILA
(Acinetobacter
baumannii;
Escherichia
coli) 		4 / 5 GLU A 308
ASP A 314
ASP A 287
ASN A 294
 None
 1.39A 3vywD-5vawA:
undetectable		 3vywD-5vawA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 5vaw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TYPE IV
PILIN PILA
(Acinetobacter
baumannii;
Escherichia
coli) 		5 / 11 ILE A 132
LEU A 139
LEU A 122
ALA A 223
LEU A 115
 None
 1.08A 4p65E-5vawA:
undetectable
4p65F-5vawA:
undetectable
4p65J-5vawA:
undetectable
4p65L-5vawA:
undetectable		 4p65E-5vawA:
undetectable
4p65F-5vawA:
undetectable
4p65J-5vawA:
undetectable
4p65L-5vawA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 5vaw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TYPE IV
PILIN PILA
(Acinetobacter
baumannii;
Escherichia
coli) 		5 / 12 LEU A 115
ILE A 132
LEU A 139
LEU A 122
ALA A 223
 None
 0.99A 4p65B-5vawA:
undetectable
4p65D-5vawA:
undetectable
4p65I-5vawA:
undetectable
4p65J-5vawA:
undetectable		 4p65B-5vawA:
undetectable
4p65D-5vawA:
undetectable
4p65I-5vawA:
undetectable
4p65J-5vawA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)		 5vaw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TYPE IV
PILIN PILA
(Acinetobacter
baumannii;
Escherichia
coli) 		5 / 12 LEU A 115
ILE A 132
LEU A 139
LEU A 122
ALA A 223
 None
 0.95A 4p65F-5vawA:
undetectable
4p65H-5vawA:
undetectable
4p65K-5vawA:
undetectable
4p65L-5vawA:
undetectable		 4p65F-5vawA:
undetectable
4p65H-5vawA:
undetectable
4p65K-5vawA:
undetectable
4p65L-5vawA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_B_SALB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5vaw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TYPE IV
PILIN PILA
(Acinetobacter
baumannii;
Escherichia
coli) 		4 / 7 LEU A  76
GLY A 265
ALA A 264
SER A 263
 None
 0.92A 5f1aB-5vawA:
undetectable		 5f1aB-5vawA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA603_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5vaw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TYPE IV
PILIN PILA
(Acinetobacter
baumannii;
Escherichia
coli) 		3 / 3 TYR A 155
ASN A 227
LEU A 113
 None
 0.81A 6b58A-5vawA:
undetectable		 6b58A-5vawA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)		 5vaw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TYPE IV
PILIN PILA
(Acinetobacter
baumannii;
Escherichia
coli) 		5 / 11 PRO A 133
GLU A 130
PRO A 254
ALA A 163
PRO A 159
 None
 1.45A 6bm5A-5vawA:
undetectable		 6bm5A-5vawA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_D_EY4D500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5vaw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TYPE IV
PILIN PILA
(Acinetobacter
baumannii;
Escherichia
coli) 		4 / 7 ILE A1074
VAL A1033
ALA A1139
THR A1138
 None
 0.99A 6cduC-5vawA:
undetectable
6cduD-5vawA:
undetectable		 6cduC-5vawA:
undetectable
6cduD-5vawA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_H_EY4H500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5vaw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TYPE IV
PILIN PILA
(Acinetobacter
baumannii;
Escherichia
coli) 		4 / 7 VAL A1033
ALA A1029
THR A1026
TYR A1027
 None
None
None
GLU  A1203 (-4.0A)
 0.95A 6cduH-5vawA:
undetectable
6cduI-5vawA:
undetectable		 6cduH-5vawA:
undetectable
6cduI-5vawA:
undetectable