SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vaz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 5vaz DNA PRIMASE
(Pseudomonas
aeruginosa) 		4 / 5 PRO A 164
ALA A 131
ASP A 205
ASP A 228
 None
 1.14A 2nyuB-5vazA:
undetectable		 2nyuB-5vazA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0I_A_BEZA990_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 5vaz DNA PRIMASE
(Pseudomonas
aeruginosa) 		4 / 8 ASP A 272
ASP A 312
LEU A 343
LEU A 276
 None
 1.07A 2q0iA-5vazA:
undetectable		 2q0iA-5vazA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_3
(HIV-1 PROTEASE)		 5vaz DNA PRIMASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 159
GLY A 223
GLY A 222
VAL A 273
ILE A 274
 None
 0.91A 3cyxB-5vazA:
undetectable		 3cyxB-5vazA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5vaz DNA PRIMASE
(Pseudomonas
aeruginosa) 		4 / 7 ASP A 312
LEU A 352
GLN A 279
LEU A 276
 None
 1.09A 4ib4A-5vazA:
undetectable		 4ib4A-5vazA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 5vaz DNA PRIMASE
(Pseudomonas
aeruginosa) 		5 / 12 MET A 415
PHE A 377
PHE A 376
ALA A 399
ALA A 400
 None
 1.09A 4j6dA-5vazA:
undetectable		 4j6dA-5vazA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 5vaz DNA PRIMASE
(Pseudomonas
aeruginosa) 		5 / 12 MET A 415
PHE A 377
PHE A 376
ALA A 399
ALA A 400
 None
 1.09A 4j6dB-5vazA:
undetectable		 4j6dB-5vazA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_A_ASDA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 5vaz DNA PRIMASE
(Pseudomonas
aeruginosa) 		5 / 12 MET A 415
PHE A 377
PHE A 376
ALA A 399
ALA A 400
 None
 1.11A 4jbtA-5vazA:
undetectable		 4jbtA-5vazA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_1
(TRANSPORTER)		 5vaz DNA PRIMASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 141
TYR A 144
VAL A 142
PHE A 209
GLY A 161
 None
SO4  A 501 (-4.9A)
None
None
None
 1.24A 4mm4B-5vazA:
undetectable		 4mm4B-5vazA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_C_EF2C151_1
(CEREBLON ISOFORM 4)		 5vaz DNA PRIMASE
(Pseudomonas
aeruginosa) 		4 / 7 ASN A 169
PRO A 164
PHE A 162
PHE A 221
 None
 1.41A 4v32C-5vazA:
undetectable		 4v32C-5vazA:
16.00