SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vb0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LQP_A_FCNA4002_1
(PROBABLE FOSFOMYCIN
RESISTANCE PROTEIN)		 5vb0 FOSFOMYCIN
RESISTANCE PROTEIN
FOSA3
(Escherichia
coli) 		5 / 10 HIS A  67
LYS A  93
TYR A 103
GLU A 113
ARG A 122
 MN  A 201 (-3.5A)
None
None
MN  A 201 (-2.5A)
None
 0.46A 1lqpA-5vb0A:
19.2
1lqpB-5vb0A:
19.2		 1lqpA-5vb0A:
60.87
1lqpB-5vb0A:
60.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LQP_B_FCNB4001_1
(PROBABLE FOSFOMYCIN
RESISTANCE PROTEIN)		 5vb0 FOSFOMYCIN
RESISTANCE PROTEIN
FOSA3
(Escherichia
coli) 		5 / 10 HIS A  67
LYS A  93
TYR A 103
GLU A 113
ARG A 122
 MN  A 201 (-3.5A)
None
None
MN  A 201 (-2.5A)
None
 0.47A 1lqpA-5vb0A:
19.2
1lqpB-5vb0A:
19.2		 1lqpA-5vb0A:
60.87
1lqpB-5vb0A:
60.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA141_0
(LYSOZYME C)		 5vb0 FOSFOMYCIN
RESISTANCE PROTEIN
FOSA3
(Escherichia
coli) 		4 / 6 GLY A 109
THR A  58
PRO A  59
SER A  63
 None
 0.87A 1n4fA-5vb0A:
undetectable		 1n4fA-5vb0A:
16.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NKI_A_PPFA5001_1
(PROBABLE FOSFOMYCIN
RESISTANCE PROTEIN)		 5vb0 FOSFOMYCIN
RESISTANCE PROTEIN
FOSA3
(Escherichia
coli) 		5 / 9 TYR A  65
HIS A  67
TYR A 103
GLU A 113
ARG A 122
 None
MN  A 201 (-3.5A)
None
MN  A 201 (-2.5A)
None
 0.34A 1nkiA-5vb0A:
19.3
1nkiB-5vb0A:
19.3		 1nkiA-5vb0A:
60.87
1nkiB-5vb0A:
60.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NKI_B_PPFB5002_1
(PROBABLE FOSFOMYCIN
RESISTANCE PROTEIN)		 5vb0 FOSFOMYCIN
RESISTANCE PROTEIN
FOSA3
(Escherichia
coli) 		5 / 9 TYR A  65
HIS A  67
TYR A 103
GLU A 113
ARG A 122
 None
MN  A 201 (-3.5A)
None
MN  A 201 (-2.5A)
None
 0.35A 1nkiA-5vb0A:
19.3
1nkiB-5vb0A:
19.3		 1nkiA-5vb0A:
60.87
1nkiB-5vb0A:
60.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 5vb0 FOSFOMYCIN
RESISTANCE PROTEIN
FOSA3
(Escherichia
coli) 		5 / 12 LEU A  47
LEU A  51
GLY A  37
VAL A  12
ALA A  11
 None
 1.15A 1tlsA-5vb0A:
undetectable		 1tlsA-5vb0A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_A_SALA2006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5vb0 FOSFOMYCIN
RESISTANCE PROTEIN
FOSA3
(Escherichia
coli) 		4 / 6 PHE A 104
VAL A  80
LEU A  83
ALA A  89
 None
 1.06A 2e1qA-5vb0A:
undetectable		 2e1qA-5vb0A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_C_SALC4006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5vb0 FOSFOMYCIN
RESISTANCE PROTEIN
FOSA3
(Escherichia
coli) 		4 / 6 PHE A 104
VAL A  80
LEU A  83
ALA A  89
 None
 1.01A 2e1qC-5vb0A:
undetectable		 2e1qC-5vb0A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0I_A_BEZA990_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 5vb0 FOSFOMYCIN
RESISTANCE PROTEIN
FOSA3
(Escherichia
coli) 		4 / 8 ASP A 106
LEU A 112
HIS A 110
LEU A   8
 None
 1.09A 2q0iA-5vb0A:
undetectable		 2q0iA-5vb0A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 5vb0 FOSFOMYCIN
RESISTANCE PROTEIN
FOSA3
(Escherichia
coli) 		5 / 12 TYR A  22
LEU A  47
PHE A  70
LEU A 105
LEU A 112
 None
 0.89A 3vw7A-5vb0A:
undetectable		 3vw7A-5vb0A:
16.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IR0_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 5vb0 FOSFOMYCIN
RESISTANCE PROTEIN
FOSA3
(Escherichia
coli) 		5 / 11 TYR A  65
HIS A  67
TYR A 103
GLU A 113
ARG A 122
 None
MN  A 201 (-3.5A)
None
MN  A 201 (-2.5A)
None
 0.51A 4ir0A-5vb0A:
14.8
4ir0B-5vb0A:
15.3		 4ir0A-5vb0A:
35.10
4ir0B-5vb0A:
35.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IR0_B_FCNB202_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 5vb0 FOSFOMYCIN
RESISTANCE PROTEIN
FOSA3
(Escherichia
coli) 		5 / 11 TYR A  65
HIS A  67
TYR A 103
GLU A 113
ARG A 122
 None
MN  A 201 (-3.5A)
None
MN  A 201 (-2.5A)
None
 0.53A 4ir0A-5vb0A:
14.8
4ir0B-5vb0A:
15.3		 4ir0A-5vb0A:
35.10
4ir0B-5vb0A:
35.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JD1_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 5vb0 FOSFOMYCIN
RESISTANCE PROTEIN
FOSA3
(Escherichia
coli) 		5 / 12 TYR A  65
HIS A  67
TYR A 103
GLU A 113
ARG A 122
 None
MN  A 201 (-3.5A)
None
MN  A 201 (-2.5A)
None
 0.56A 4jd1A-5vb0A:
14.9
4jd1B-5vb0A:
14.8		 4jd1A-5vb0A:
35.10
4jd1B-5vb0A:
35.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JD1_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 5vb0 FOSFOMYCIN
RESISTANCE PROTEIN
FOSA3
(Escherichia
coli) 		5 / 12 TYR A  65
HIS A  67
TYR A 103
GLU A 113
ARG A 122
 None
MN  A 201 (-3.5A)
None
MN  A 201 (-2.5A)
None
 0.48A 4jd1A-5vb0A:
14.9
4jd1B-5vb0A:
14.8		 4jd1A-5vb0A:
35.10
4jd1B-5vb0A:
35.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JH3_A_FCNA204_1
(METALLOTHIOL
TRANSFERASE FOSB)		 5vb0 FOSFOMYCIN
RESISTANCE PROTEIN
FOSA3
(Escherichia
coli) 		5 / 12 TYR A  65
HIS A  67
TYR A 103
GLU A 113
ARG A 122
 None
MN  A 201 (-3.5A)
None
MN  A 201 (-2.5A)
None
 0.50A 4jh3A-5vb0A:
15.8
4jh3B-5vb0A:
15.9		 4jh3A-5vb0A:
34.75
4jh3B-5vb0A:
34.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JH3_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB)		 5vb0 FOSFOMYCIN
RESISTANCE PROTEIN
FOSA3
(Escherichia
coli) 		5 / 11 TYR A  65
HIS A  67
TYR A 103
GLU A 113
ARG A 122
 None
MN  A 201 (-3.5A)
None
MN  A 201 (-2.5A)
None
 0.48A 4jh3A-5vb0A:
15.8
4jh3B-5vb0A:
15.9		 4jh3A-5vb0A:
34.75
4jh3B-5vb0A:
34.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JH4_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB)		 5vb0 FOSFOMYCIN
RESISTANCE PROTEIN
FOSA3
(Escherichia
coli) 		5 / 11 TYR A  65
HIS A  67
TYR A 103
GLU A 113
ARG A 122
 None
MN  A 201 (-3.5A)
None
MN  A 201 (-2.5A)
None
 0.49A 4jh4A-5vb0A:
15.8
4jh4B-5vb0A:
15.7		 4jh4A-5vb0A:
34.75
4jh4B-5vb0A:
34.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JH4_B_FCNB202_1
(METALLOTHIOL
TRANSFERASE FOSB)		 5vb0 FOSFOMYCIN
RESISTANCE PROTEIN
FOSA3
(Escherichia
coli) 		5 / 11 TYR A  65
HIS A  67
TYR A 103
GLU A 113
ARG A 122
 None
MN  A 201 (-3.5A)
None
MN  A 201 (-2.5A)
None
 0.51A 4jh4A-5vb0A:
15.8
4jh4B-5vb0A:
15.7		 4jh4A-5vb0A:
34.75
4jh4B-5vb0A:
34.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JH5_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB)		 5vb0 FOSFOMYCIN
RESISTANCE PROTEIN
FOSA3
(Escherichia
coli) 		5 / 11 TYR A  65
HIS A  67
TYR A 103
GLU A 113
ARG A 122
 None
MN  A 201 (-3.5A)
None
MN  A 201 (-2.5A)
None
 0.48A 4jh5A-5vb0A:
15.9
4jh5B-5vb0A:
15.7		 4jh5A-5vb0A:
34.75
4jh5B-5vb0A:
34.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JH5_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB)		 5vb0 FOSFOMYCIN
RESISTANCE PROTEIN
FOSA3
(Escherichia
coli) 		5 / 11 TYR A  65
HIS A  67
TYR A 103
GLU A 113
ARG A 122
 None
MN  A 201 (-3.5A)
None
MN  A 201 (-2.5A)
None
 0.51A 4jh5A-5vb0A:
15.9
4jh5B-5vb0A:
15.7		 4jh5A-5vb0A:
34.75
4jh5B-5vb0A:
34.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JH6_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB)		 5vb0 FOSFOMYCIN
RESISTANCE PROTEIN
FOSA3
(Escherichia
coli) 		5 / 10 TYR A  65
HIS A  67
TYR A 103
GLU A 113
ARG A 122
 None
MN  A 201 (-3.5A)
None
MN  A 201 (-2.5A)
None
 0.48A 4jh6A-5vb0A:
15.9
4jh6B-5vb0A:
15.7		 4jh6A-5vb0A:
34.75
4jh6B-5vb0A:
34.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JH6_B_FCNB202_1
(METALLOTHIOL
TRANSFERASE FOSB)		 5vb0 FOSFOMYCIN
RESISTANCE PROTEIN
FOSA3
(Escherichia
coli) 		5 / 10 TYR A  65
HIS A  67
TYR A 103
GLU A 113
ARG A 122
 None
MN  A 201 (-3.5A)
None
MN  A 201 (-2.5A)
None
 0.48A 4jh6A-5vb0A:
15.9
4jh6B-5vb0A:
15.7		 4jh6A-5vb0A:
34.75
4jh6B-5vb0A:
34.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JH8_A_FCNA204_1
(METALLOTHIOL
TRANSFERASE FOSB)		 5vb0 FOSFOMYCIN
RESISTANCE PROTEIN
FOSA3
(Escherichia
coli) 		5 / 10 TYR A  65
HIS A  67
TYR A 103
GLU A 113
ARG A 122
 None
MN  A 201 (-3.5A)
None
MN  A 201 (-2.5A)
None
 0.50A 4jh8A-5vb0A:
15.8
4jh8B-5vb0A:
15.6		 4jh8A-5vb0A:
34.75
4jh8B-5vb0A:
34.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JH8_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB)		 5vb0 FOSFOMYCIN
RESISTANCE PROTEIN
FOSA3
(Escherichia
coli) 		5 / 10 TYR A  65
HIS A  67
TYR A 103
GLU A 113
ARG A 122
 None
MN  A 201 (-3.5A)
None
MN  A 201 (-2.5A)
None
 0.52A 4jh8A-5vb0A:
15.8
4jh8B-5vb0A:
15.6		 4jh8A-5vb0A:
34.75
4jh8B-5vb0A:
34.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V3D_A_FCNA205_1
(FOSFOMYCIN
RESISTANCE PROTEIN)		 5vb0 FOSFOMYCIN
RESISTANCE PROTEIN
FOSA3
(Escherichia
coli) 		5 / 10 TYR A  65
HIS A  67
TYR A 103
GLU A 113
ARG A 122
 None
MN  A 201 (-3.5A)
None
MN  A 201 (-2.5A)
None
 0.23A 5v3dA-5vb0A:
21.0
5v3dB-5vb0A:
21.0		 5v3dA-5vb0A:
80.00
5v3dB-5vb0A:
80.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5vb0 FOSFOMYCIN
RESISTANCE PROTEIN
FOSA3
(Escherichia
coli) 		4 / 8 HIS A 110
PHE A  21
MET A  28
LEU A  84
 None
 1.09A 5y2tB-5vb0A:
undetectable		 5y2tB-5vb0A:
undetectable