SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vba'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA6_0
(GRAMICIDIN A)		 5vba LYSOZYME, ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPG1
CHIMERA
(Mycobacterium
kansasii;
Escherichia
virus
T4) 		3 / 3 ALA A 220
VAL A 200
TRP A 199
 None
 0.89A 1c4dA-5vbaA:
undetectable
1c4dB-5vbaA:
undetectable		 1c4dA-5vbaA:
3.28
1c4dB-5vbaA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB6_0
(GRAMICIDIN A)		 5vba LYSOZYME, ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPG1
CHIMERA
(Mycobacterium
kansasii;
Escherichia
virus
T4) 		3 / 3 TRP A 199
ALA A 220
VAL A 200
 None
 0.86A 1c4dA-5vbaA:
undetectable
1c4dB-5vbaA:
undetectable		 1c4dA-5vbaA:
3.28
1c4dB-5vbaA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_A_REAA502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5vba LYSOZYME, ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPG1
CHIMERA
(Escherichia
virus
T4;
Mycobacterium
kansasii) 		5 / 12 ALA A1129
PHE A1153
LEU A1133
ALA A1130
ILE A1078
 None
 1.02A 2aclA-5vbaA:
undetectable
2aclE-5vbaA:
undetectable		 2aclA-5vbaA:
22.27
2aclE-5vbaA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 5vba LYSOZYME, ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPG1
CHIMERA
(Escherichia
virus
T4;
Mycobacterium
kansasii) 		3 / 3 ALA A1160
THR A1151
PHE A 999
 None
 0.76A 2c6nB-5vbaA:
undetectable		 2c6nB-5vbaA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)		 5vba LYSOZYME, ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPG1
CHIMERA
(Mycobacterium
kansasii;
Escherichia
virus
T4) 		5 / 12 LEU A1039
GLY A1023
THR A1026
LEU A1033
ALA A1042
 None
 1.01A 2egvA-5vbaA:
undetectable		 2egvA-5vbaA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB927_0
(FERROCHELATASE)		 5vba LYSOZYME, ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPG1
CHIMERA
(Mycobacterium
kansasii;
Escherichia
virus
T4) 		3 / 3 LEU A 264
PRO A 265
ARG A 207
 None
 0.53A 2qd4B-5vbaA:
undetectable		 2qd4B-5vbaA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		 5vba LYSOZYME, ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPG1
CHIMERA
(Escherichia
virus
T4;
Mycobacterium
kansasii) 		4 / 6 LEU A 263
LEU A 260
ILE A 236
ARG A 235
 CL  A1205 ( 4.4A)
None
None
None
 0.98A 2rlfA-5vbaA:
undetectable
2rlfB-5vbaA:
undetectable		 2rlfA-5vbaA:
6.33
2rlfB-5vbaA:
6.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		 5vba LYSOZYME, ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPG1
CHIMERA
(Escherichia
virus
T4;
Mycobacterium
kansasii) 		4 / 6 LEU A 263
LEU A 260
ILE A 236
ARG A 235
 CL  A1205 ( 4.4A)
None
None
None
 0.94A 2rlfC-5vbaA:
undetectable
2rlfD-5vbaA:
undetectable		 2rlfC-5vbaA:
6.33
2rlfD-5vbaA:
6.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5vba LYSOZYME, ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPG1
CHIMERA
(Escherichia
virus
T4;
Mycobacterium
kansasii) 		4 / 8 THR A1034
TYR A1025
ILE A1017
SER A1036
 None
 1.13A 2xytE-5vbaA:
undetectable		 2xytE-5vbaA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5vba LYSOZYME, ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPG1
CHIMERA
(Escherichia
virus
T4;
Mycobacterium
kansasii) 		4 / 8 THR A1034
TYR A1025
ILE A1017
SER A1036
 None
 1.06A 2xytH-5vbaA:
undetectable		 2xytH-5vbaA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5vba LYSOZYME, ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPG1
CHIMERA
(Mycobacterium
kansasii;
Escherichia
virus
T4) 		3 / 3 TYR A1025
ASP A1020
ASP A  72
 None
 0.95A 3ou7B-5vbaA:
undetectable		 3ou7B-5vbaA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PEO_F_CU9F301_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5vba LYSOZYME, ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPG1
CHIMERA
(Escherichia
virus
T4;
Mycobacterium
kansasii) 		4 / 6 THR A1034
TYR A1025
ILE A1017
SER A1036
 None
 1.30A 3peoG-5vbaA:
undetectable		 3peoG-5vbaA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_B_QELB1_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 5vba LYSOZYME, ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPG1
CHIMERA
(Escherichia
virus
T4;
Mycobacterium
kansasii) 		5 / 11 TYR A 189
THR A 190
LEU A 223
ALA A 168
GLU A 201
 None
 1.34A 3qelA-5vbaA:
undetectable
3qelB-5vbaA:
undetectable		 3qelA-5vbaA:
21.71
3qelB-5vbaA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 5vba LYSOZYME, ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPG1
CHIMERA
(Mycobacterium
kansasii;
Escherichia
virus
T4) 		5 / 12 PRO A  39
PHE A  38
LEU A  29
VAL A  21
ALA A 123
 None
 1.24A 4a84A-5vbaA:
undetectable		 4a84A-5vbaA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZW_A_SAMA1451_0
(WBDD)		 5vba LYSOZYME, ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPG1
CHIMERA
(Mycobacterium
kansasii;
Escherichia
virus
T4) 		5 / 12 GLY A  69
ALA A  67
GLN A1141
GLU A1011
LEU A  71
 None
 0.97A 4azwA-5vbaA:
undetectable		 4azwA-5vbaA:
25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_H_9CRH501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5vba LYSOZYME, ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPG1
CHIMERA
(Escherichia
virus
T4;
Mycobacterium
kansasii) 		5 / 12 ILE A 202
LEU A 260
ALA A 259
ILE A 122
LEU A 149
 None
 1.03A 4nqaH-5vbaA:
undetectable		 4nqaH-5vbaA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_2
(ESTROGEN RECEPTOR)		 5vba LYSOZYME, ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPG1
CHIMERA
(Escherichia
virus
T4;
Mycobacterium
kansasii) 		4 / 6 LEU A  29
ASP A  86
ILE A  23
PRO A  91
 None
 1.01A 4xi3C-5vbaA:
undetectable		 4xi3C-5vbaA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_B_QELB503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 5vba LYSOZYME, ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPG1
CHIMERA
(Escherichia
virus
T4;
Mycobacterium
kansasii) 		5 / 11 TYR A 189
THR A 190
LEU A 223
ALA A 168
GLU A 201
 None
 1.30A 5ewjA-5vbaA:
undetectable
5ewjB-5vbaA:
undetectable		 5ewjA-5vbaA:
21.68
5ewjB-5vbaA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 5vba LYSOZYME, ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPG1
CHIMERA
(Escherichia
virus
T4;
Mycobacterium
kansasii) 		5 / 12 TYR A 189
THR A 190
LEU A 223
ALA A 168
GLU A 201
 None
 1.29A 5ewjC-5vbaA:
undetectable
5ewjD-5vbaA:
undetectable		 5ewjC-5vbaA:
21.68
5ewjD-5vbaA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_2
(CYTOCHROME P450 2C9)		 5vba LYSOZYME, ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPG1
CHIMERA
(Escherichia
virus
T4;
Mycobacterium
kansasii) 		4 / 4 PHE A  38
LEU A  65
LEU A  33
VAL A  21
 None
 1.25A 5xxiA-5vbaA:
undetectable		 5xxiA-5vbaA:
21.90