SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vbb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)		 5vbb RNA PSEUDOURIDYLATE
SYNTHASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 7 GLY A  72
LEU A 213
LYS A  97
TYR A  99
 None
None
GOL  A 306 (-3.1A)
GOL  A 306 (-3.8A)
 0.88A 1gtiD-5vbbA:
undetectable		 1gtiD-5vbbA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)		 5vbb RNA PSEUDOURIDYLATE
SYNTHASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 7 GLY A  72
LEU A 213
LYS A  97
TYR A  99
 None
None
GOL  A 306 (-3.1A)
GOL  A 306 (-3.8A)
 0.88A 1gtiE-5vbbA:
undetectable		 1gtiE-5vbbA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_A_DESA129_1
(TRANSTHYRETIN)		 5vbb RNA PSEUDOURIDYLATE
SYNTHASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 4 LYS A 167
LEU A 169
LEU A 145
SER A 115
 None
 1.12A 1tt6A-5vbbA:
undetectable		 1tt6A-5vbbA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_B_DESB128_1
(TRANSTHYRETIN)		 5vbb RNA PSEUDOURIDYLATE
SYNTHASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 5 LYS A 167
LEU A 169
LEU A 145
SER A 115
 None
 1.14A 1tt6B-5vbbA:
undetectable		 1tt6B-5vbbA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_D_DESD128_1
(TRANSTHYRETIN)		 5vbb RNA PSEUDOURIDYLATE
SYNTHASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 4 LYS A 167
LEU A 169
LEU A 145
SER A 115
 None
 1.28A 1tz8D-5vbbA:
undetectable		 1tz8D-5vbbA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1217_1
(LIPOPROTEIN LPPX)		 5vbb RNA PSEUDOURIDYLATE
SYNTHASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 4 VAL A 222
LEU A  40
ILE A  29
LEU A  66
 None
 0.96A 2byoA-5vbbA:
undetectable		 2byoA-5vbbA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RGU_A_356A901_1
(DIPEPTIDYL PEPTIDASE
4)		 5vbb RNA PSEUDOURIDYLATE
SYNTHASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 12 GLU A 109
SER A 162
VAL A 164
VAL A 150
HIS A 153
 None
 1.33A 2rguA-5vbbA:
undetectable		 2rguA-5vbbA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RGU_B_356B902_1
(DIPEPTIDYL PEPTIDASE
4)		 5vbb RNA PSEUDOURIDYLATE
SYNTHASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 11 GLU A 109
SER A 162
VAL A 164
VAL A 150
HIS A 153
 None
 1.32A 2rguB-5vbbA:
undetectable		 2rguB-5vbbA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_A_BJMA1_1
(DIPEPTIDYL PEPTIDASE
4)		 5vbb RNA PSEUDOURIDYLATE
SYNTHASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 12 GLU A 109
SER A 162
VAL A 164
VAL A 150
HIS A 153
 None
 1.36A 3bjmA-5vbbA:
undetectable		 3bjmA-5vbbA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_B_BJMB2_1
(DIPEPTIDYL PEPTIDASE
4)		 5vbb RNA PSEUDOURIDYLATE
SYNTHASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 12 GLU A 109
SER A 162
VAL A 164
VAL A 150
HIS A 153
 None
 1.32A 3bjmB-5vbbA:
undetectable		 3bjmB-5vbbA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_1
(UNCHARACTERIZED
PROTEIN RPA2492)		 5vbb RNA PSEUDOURIDYLATE
SYNTHASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		3 / 3 TYR A  99
ASP A  67
HIS A  64
 GOL  A 306 (-3.8A)
SO4  A 301 (-4.5A)
None
 0.97A 3e23A-5vbbA:
undetectable		 3e23A-5vbbA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)		 5vbb RNA PSEUDOURIDYLATE
SYNTHASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 8 ASP A  17
SER A  15
CYH A  89
ASP A 218
 None
 0.97A 3m0wE-5vbbA:
undetectable
3m0wF-5vbbA:
undetectable
3m0wG-5vbbA:
undetectable
3m0wH-5vbbA:
undetectable		 3m0wE-5vbbA:
14.56
3m0wF-5vbbA:
14.56
3m0wG-5vbbA:
14.56
3m0wH-5vbbA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_A_LF7A801_1
(DIPEPTIDYL PEPTIDASE
4)		 5vbb RNA PSEUDOURIDYLATE
SYNTHASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 12 GLU A 109
SER A 162
VAL A 164
VAL A 150
HIS A 153
 None
 1.34A 3w2tA-5vbbA:
undetectable		 3w2tA-5vbbA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 5vbb RNA PSEUDOURIDYLATE
SYNTHASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 12 GLU A 109
SER A 162
VAL A 164
VAL A 150
HIS A 153
 None
 1.30A 3w2tB-5vbbA:
undetectable		 3w2tB-5vbbA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		 5vbb RNA PSEUDOURIDYLATE
SYNTHASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 6 LYS A 167
LEU A 169
LEU A 145
SER A 115
 None
 1.08A 4d7bB-5vbbA:
undetectable		 4d7bB-5vbbA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5vbb RNA PSEUDOURIDYLATE
SYNTHASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 12 CYH A  63
LEU A 213
VAL A  95
PHE A  18
LEU A  78
 None
 1.45A 4o8fB-5vbbA:
undetectable		 4o8fB-5vbbA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		 5vbb RNA PSEUDOURIDYLATE
SYNTHASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 6 SER A 246
LEU A 247
ASP A 248
LEU A 151
 None
 0.71A 4wozA-5vbbA:
undetectable
4wozB-5vbbA:
undetectable		 4wozA-5vbbA:
21.10
4wozB-5vbbA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_2
(CDL2.3B)		 5vbb RNA PSEUDOURIDYLATE
SYNTHASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 9 PRO A 168
MET A 206
VAL A 187
LEU A 103
LEU A 250
 GOL  A 306 (-3.7A)
None
None
None
None
 1.34A 5iepA-5vbbA:
undetectable		 5iepA-5vbbA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		 5vbb RNA PSEUDOURIDYLATE
SYNTHASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 6 LYS A 167
LEU A 169
LEU A 145
SER A 115
 None
 1.08A 5l4iB-5vbbA:
undetectable		 5l4iB-5vbbA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5vbb RNA PSEUDOURIDYLATE
SYNTHASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 4 LEU A 148
LEU A 166
SER A 162
ALA A 101
 None
 1.13A 5uunA-5vbbA:
undetectable		 5uunA-5vbbA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZSF_A_6T0A910_0
(TOLL-LIKE RECEPTOR 7)		 5vbb RNA PSEUDOURIDYLATE
SYNTHASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 7 THR A 170
LEU A 145
ILE A 114
THR A 113
 SO4  A 302 ( 4.0A)
None
None
None
 0.88A 5zsfA-5vbbA:
undetectable
5zsfB-5vbbA:
undetectable		 5zsfA-5vbbA:
14.47
5zsfB-5vbbA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B1E_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 5vbb RNA PSEUDOURIDYLATE
SYNTHASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 12 GLU A 109
SER A 162
VAL A 164
VAL A 150
HIS A 153
 None
 1.33A 6b1eB-5vbbA:
undetectable		 6b1eB-5vbbA:
18.25