SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vbc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IA0_B_TXLB502_1
(TUBULIN BETA CHAIN)		 5vbc PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ATXR5
(Ricinus
communis) 		5 / 12 VAL A 273
ASP A 272
ARG A 231
PRO A 304
GLY A 308
 None
 1.40A 1ia0B-5vbcA:
undetectable		 1ia0B-5vbcA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 5vbc PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ATXR5
(Ricinus
communis) 		4 / 8 PHE A 246
SER A 315
ARG A 356
ALA A 183
 None
SAH  A 401 (-3.9A)
None
None
 1.18A 1rqpC-5vbcA:
undetectable		 1rqpC-5vbcA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_C_SAMC500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 5vbc PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ATXR5
(Ricinus
communis) 		4 / 8 PHE A 246
SER A 315
ARG A 356
ALA A 183
 None
SAH  A 401 (-3.9A)
None
None
 1.19A 1rqpA-5vbcA:
undetectable		 1rqpA-5vbcA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUB_B_TXLB501_1
(TUBULIN)		 5vbc PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ATXR5
(Ricinus
communis) 		5 / 12 VAL A 273
ASP A 272
ARG A 231
PRO A 304
GLY A 308
 None
 1.41A 1tubB-5vbcA:
undetectable		 1tubB-5vbcA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5vbc PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ATXR5
(Ricinus
communis) 		5 / 12 ALA A 202
LEU A 290
ARG A 334
SER A 336
LEU A 195
 None
 0.98A 3nrrA-5vbcA:
undetectable		 3nrrA-5vbcA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5vbc PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ATXR5
(Ricinus
communis) 		5 / 12 ALA A 202
LEU A 290
ARG A 334
SER A 336
LEU A 195
 None
 0.95A 3nrrB-5vbcA:
undetectable		 3nrrB-5vbcA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3P_A_ACTA1223_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 5vbc PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ATXR5
(Ricinus
communis) 		4 / 5 ASP A 194
THR A 196
LEU A 195
GLU A 268
 None
 1.47A 4a3pA-5vbcA:
undetectable		 4a3pA-5vbcA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5vbc PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ATXR5
(Ricinus
communis) 		4 / 6 TYR A 361
ASN A 319
GLU A 250
TYR A 358
 SAH  A 401 (-4.9A)
None
SAH  A 401 (-4.2A)
None
 1.18A 4twdG-5vbcA:
undetectable
4twdH-5vbcA:
undetectable		 4twdG-5vbcA:
19.43
4twdH-5vbcA:
19.43