SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vbf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 5vbf NAD-DEPENDENT
SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Burkholderia
vietnamiensis) 		5 / 12 GLU A 450
GLY A 445
TYR A 418
MET A 438
ALA A 416
 None
 1.27A 1hvyA-5vbfA:
undetectable		 1hvyA-5vbfA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 5vbf NAD-DEPENDENT
SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Burkholderia
vietnamiensis) 		5 / 12 GLU A 450
GLY A 445
TYR A 418
MET A 438
ALA A 416
 None
 1.28A 1hvyB-5vbfA:
undetectable		 1hvyB-5vbfA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA140_0
(LYSOZYME C)		 5vbf NAD-DEPENDENT
SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Burkholderia
vietnamiensis) 		3 / 3 ASN A 426
ALA A 419
ASN A 442
 None
 0.66A 1n4fA-5vbfA:
undetectable		 1n4fA-5vbfA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_D_PODD701_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 5vbf NAD-DEPENDENT
SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Burkholderia
vietnamiensis) 		5 / 12 VAL A 238
LEU A 249
ALA A 246
LEU A 245
ALA A 152
 None
 1.13A 1sa1C-5vbfA:
undetectable
1sa1D-5vbfA:
undetectable		 1sa1C-5vbfA:
23.12
1sa1D-5vbfA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_2
(POL POLYPROTEIN)		 5vbf NAD-DEPENDENT
SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Burkholderia
vietnamiensis) 		5 / 10 GLY A 212
ASP A  50
ILE A  16
ILE A 190
ALA A 152
 None
 1.00A 1sh9B-5vbfA:
undetectable		 1sh9B-5vbfA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_A_SAMA1501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 5vbf NAD-DEPENDENT
SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Burkholderia
vietnamiensis) 		4 / 7 TYR A   9
GLU A 109
SER A 186
VAL A  31
 None
None
UNX  A 604 ( 4.1A)
None
 1.22A 1tv8A-5vbfA:
undetectable		 1tv8A-5vbfA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)		 5vbf NAD-DEPENDENT
SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Burkholderia
vietnamiensis) 		5 / 10 THR A  96
GLU A 105
GLY A 322
GLY A 330
ILE A 107
 None
 1.00A 1x7pA-5vbfA:
undetectable
1x7pB-5vbfA:
2.8		 1x7pA-5vbfA:
21.54
1x7pB-5vbfA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMY_A_ROCA401_2
(PROTEASE)		 5vbf NAD-DEPENDENT
SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Burkholderia
vietnamiensis) 		5 / 12 GLY A 212
ASP A  50
ILE A  16
ILE A 190
ALA A 152
 None
 0.89A 2nmyB-5vbfA:
undetectable		 2nmyB-5vbfA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SGL_A_SAMA692_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 5vbf NAD-DEPENDENT
SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Burkholderia
vietnamiensis) 		5 / 12 GLY A 330
GLY A 100
THR A  96
LEU A 103
GLY A 320
 None
 1.09A 3sglA-5vbfA:
undetectable		 3sglA-5vbfA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_2
(ADENOSINE KINASE,
PUTATIVE)		 5vbf NAD-DEPENDENT
SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Burkholderia
vietnamiensis) 		4 / 5 LEU A 415
ALA A 261
MET A 446
ASN A 440
 None
 1.24A 3uq6A-5vbfA:
undetectable		 3uq6A-5vbfA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA206_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 5vbf NAD-DEPENDENT
SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Burkholderia
vietnamiensis) 		4 / 4 ALA A  54
ALA A  57
ALA A  58
ALA A  61
 None
 0.09A 4oadA-5vbfA:
undetectable		 4oadA-5vbfA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA208_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 5vbf NAD-DEPENDENT
SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Burkholderia
vietnamiensis) 		4 / 4 ALA A  54
ALA A  57
ALA A  58
ALA A  61
 None
 0.11A 4oaeA-5vbfA:
undetectable		 4oaeA-5vbfA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB301_1
(CHITOSANASE)		 5vbf NAD-DEPENDENT
SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Burkholderia
vietnamiensis) 		3 / 3 GLY A 330
PRO A 331
GLN A 288
 None
 0.37A 4oltB-5vbfA:
undetectable		 4oltB-5vbfA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB305_1
(CHITOSANASE)		 5vbf NAD-DEPENDENT
SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Burkholderia
vietnamiensis) 		3 / 3 GLY A 330
PRO A 331
GLN A 288
 None
 0.32A 4qwpB-5vbfA:
undetectable		 4qwpB-5vbfA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5vbf NAD-DEPENDENT
SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Burkholderia
vietnamiensis) 		4 / 6 SER A 162
GLU A 109
GLY A 462
GLY A 454
 None
 0.77A 5cdnT-5vbfA:
undetectable
5cdnU-5vbfA:
undetectable		 5cdnT-5vbfA:
23.14
5cdnU-5vbfA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5vbf NAD-DEPENDENT
SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Burkholderia
vietnamiensis) 		5 / 10 SER A 155
GLY A 182
ILE A  95
ALA A 189
LEU A 193
 None
 1.08A 5zjiA-5vbfA:
undetectable
5zjiJ-5vbfA:
undetectable		 5zjiA-5vbfA:
9.55
5zjiJ-5vbfA:
7.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_B_P2EB1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 5vbf NAD-DEPENDENT
SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Burkholderia
vietnamiensis) 		4 / 5 PRO A 371
VAL A 314
GLY A 376
VAL A 393
 None
 1.02A 6ak3B-5vbfA:
undetectable		 6ak3B-5vbfA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11802_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
UL4
RIBOSOMAL PROTEIN
UL15
RIBOSOMAL PROTEIN
EL15)		 5vbf NAD-DEPENDENT
SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Burkholderia
vietnamiensis) 		3 / 3 ARG A 410
LYS A 457
ARG A 379
 None
 1.29A 6az3C-5vbfA:
0.3
6az3L-5vbfA:
undetectable
6az3M-5vbfA:
undetectable		 6az3C-5vbfA:
10.40
6az3L-5vbfA:
10.85
6az3M-5vbfA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_D_EY4D500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5vbf NAD-DEPENDENT
SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Burkholderia
vietnamiensis) 		4 / 7 ILE A 341
VAL A 345
PRO A 388
THR A 357
 None
 0.99A 6cduC-5vbfA:
undetectable
6cduD-5vbfA:
undetectable		 6cduC-5vbfA:
20.75
6cduD-5vbfA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 5vbf NAD-DEPENDENT
SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Burkholderia
vietnamiensis) 		5 / 12 PRO A 237
GLY A 460
GLY A 259
GLY A 414
ASP A 386
 None
 1.03A 6nj9K-5vbfA:
5.2		 6nj9K-5vbfA:
22.86