SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vbl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 5vbl APELIN
RECEPTOR,RUBREDOXIN,
APELIN RECEPTOR
CHIMERA
(Clostridium
pasteurianum;
Homo
sapiens) 		4 / 4 ILE B 297
LEU B  82
VAL B  38
ILE B  34
 None
 0.93A 1fm6D-5vblB:
undetectable		 1fm6D-5vblB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5vbl APELIN
RECEPTOR,RUBREDOXIN,
APELIN RECEPTOR
CHIMERA
(Clostridium
pasteurianum;
Homo
sapiens) 		5 / 11 PHE B  78
SER B 105
TRP B  85
ALA B  86
LEU B  82
 None
 1.43A 1jb0B-5vblB:
2.2		 1jb0B-5vblB:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_B_FK5B401_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 5vbl APELIN
RECEPTOR,RUBREDOXIN,
APELIN RECEPTOR
CHIMERA
(Clostridium
pasteurianum;
Homo
sapiens) 		5 / 10 ASP B 126
LEU B 140
VAL B 132
ILE B 224
ILE B 250
 None
 1.35A 1q6iB-5vblB:
undetectable		 1q6iB-5vblB:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 5vbl APELIN
RECEPTOR,RUBREDOXIN,
APELIN RECEPTOR
CHIMERA
(Clostridium
pasteurianum;
Homo
sapiens) 		3 / 3 ASP B1021
ASN B1022
THR B1028
 None
 0.68A 2pymB-5vblB:
undetectable		 2pymB-5vblB:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSE_A_PQNA1801_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5vbl APELIN
RECEPTOR,RUBREDOXIN,
APELIN RECEPTOR
CHIMERA
(Clostridium
pasteurianum;
Homo
sapiens) 		5 / 9 PHE B  78
SER B 105
TRP B  85
ALA B  86
LEU B  82
 None
 1.46A 2wseA-5vblB:
undetectable		 2wseA-5vblB:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSF_A_PQNA1802_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5vbl APELIN
RECEPTOR,RUBREDOXIN,
APELIN RECEPTOR
CHIMERA
(Clostridium
pasteurianum;
Homo
sapiens) 		5 / 9 PHE B  78
SER B 105
TRP B  85
ALA B  86
LEU B  82
 None
 1.43A 2wsfA-5vblB:
1.0		 2wsfA-5vblB:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_A_ACRA720_1
(ALPHA-AMYLASE, SUSG)		 5vbl APELIN
RECEPTOR,RUBREDOXIN,
APELIN RECEPTOR
CHIMERA
(Clostridium
pasteurianum;
Homo
sapiens) 		4 / 7 TYR B1013
GLU B1016
TRP B1037
LYS B1046
 None
 1.41A 3k8mA-5vblB:
undetectable		 3k8mA-5vblB:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5vbl APELIN
RECEPTOR,RUBREDOXIN,
APELIN RECEPTOR
CHIMERA
(Clostridium
pasteurianum;
Homo
sapiens) 		5 / 11 PHE B  78
SER B 105
TRP B  85
ALA B  86
LEU B  82
 None
 1.42A 3pcqB-5vblB:
2.2		 3pcqB-5vblB:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5vbl APELIN
RECEPTOR,RUBREDOXIN,
APELIN RECEPTOR
CHIMERA
(Clostridium
pasteurianum;
Homo
sapiens) 		5 / 7 PHE B  78
SER B 105
TRP B  85
ALA B  86
LEU B  82
 None
 1.47A 4xk8A-5vblB:
undetectable		 4xk8A-5vblB:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 5vbl APELIN
RECEPTOR,RUBREDOXIN,
APELIN RECEPTOR
CHIMERA
(Clostridium
pasteurianum;
Homo
sapiens) 		4 / 8 ARG B 127
ASP B 126
PHE B 125
VAL B 132
 None
 1.11A 4xqgA-5vblB:
undetectable		 4xqgA-5vblB:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 5vbl APELIN
RECEPTOR,RUBREDOXIN,
APELIN RECEPTOR
CHIMERA
(Clostridium
pasteurianum;
Homo
sapiens) 		4 / 8 ARG B 127
ASP B 126
PHE B 125
VAL B 132
 None
 1.12A 4xqgB-5vblB:
undetectable		 4xqgB-5vblB:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C71_B_NCTB501_1
(AMINE OXIDASE)		 5vbl APELIN
RECEPTOR,RUBREDOXIN,
APELIN RECEPTOR
CHIMERA
(Clostridium
pasteurianum;
Homo
sapiens) 		4 / 8 TRP B 154
LEU B 108
TYR B 107
THR B  77
 None
 0.78A 6c71B-5vblB:
undetectable		 6c71B-5vblB:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_0
(ADENOSYLHOMOCYSTEINA
SE)		 5vbl APELIN
RECEPTOR,RUBREDOXIN,
APELIN RECEPTOR
CHIMERA
(Clostridium
pasteurianum;
Homo
sapiens) 		5 / 12 LEU B 120
THR B 256
ASP B  75
ASN B  46
LEU B 308
 None
 1.23A 6exiC-5vblB:
undetectable		 6exiC-5vblB:
13.82