SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vbn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)		 5vbn DNA POLYMERASE
EPSILON SUBUNIT 2
(Homo
sapiens) 		4 / 8 LEU A 451
HIS A 450
ASP A 466
LEU A 469
 None
 1.06A 1e7cA-5vbnA:
undetectable		 1e7cA-5vbnA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5vbn DNA POLYMERASE
EPSILON CATALYTIC
SUBUNIT A
(Homo
sapiens) 		3 / 3 LYS B2209
ASP B2166
CYH B2164
 None
 1.49A 2br4F-5vbnB:
undetectable		 2br4F-5vbnB:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5vbn DNA POLYMERASE
EPSILON SUBUNIT 2
(Homo
sapiens) 		5 / 12 VAL A 511
LEU A 321
PHE A 509
SER A 508
LEU A 524
 None
 1.18A 2oipC-5vbnA:
undetectable		 2oipC-5vbnA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_2
(PHOSPHOLIPASE A2)		 5vbn DNA POLYMERASE
EPSILON SUBUNIT 2
(Homo
sapiens) 		4 / 7 VAL A 420
ILE A 445
GLY A 449
LEU A 137
 None
 0.90A 3bjwB-5vbnA:
undetectable		 3bjwB-5vbnA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5vbn DNA POLYMERASE
EPSILON SUBUNIT 2
(Homo
sapiens) 		4 / 4 ILE A 412
GLN A 406
ILE A 320
LEU A 275
 None
 1.34A 3dzyD-5vbnA:
undetectable		 3dzyD-5vbnA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5vbn DNA POLYMERASE
EPSILON SUBUNIT 2
(Homo
sapiens) 		5 / 12 VAL A 511
LEU A 321
PHE A 509
SER A 508
LEU A 524
 None
 1.22A 3hj3C-5vbnA:
undetectable		 3hj3C-5vbnA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 5vbn DNA POLYMERASE
EPSILON SUBUNIT 2
(Homo
sapiens) 		5 / 12 THR A 317
PRO A 316
PRO A 514
ILE A 497
VAL A 519
 None
 1.42A 4eb6B-5vbnA:
undetectable
4eb6C-5vbnA:
undetectable		 4eb6B-5vbnA:
20.80
4eb6C-5vbnA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5vbn DNA POLYMERASE
EPSILON SUBUNIT 2
(Homo
sapiens) 		5 / 8 HIS A 440
PRO A 431
LYS A 443
SER A 447
PHE A 242
 None
 1.45A 4kttA-5vbnA:
undetectable		 4kttA-5vbnA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5vbn DNA POLYMERASE
EPSILON SUBUNIT 2
(Homo
sapiens) 		5 / 8 HIS A 440
PRO A 431
LYS A 443
SER A 447
PHE A 242
 None
 1.48A 4kttC-5vbnA:
undetectable		 4kttC-5vbnA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTV_A_ADNA403_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5vbn DNA POLYMERASE
EPSILON SUBUNIT 2
(Homo
sapiens) 		5 / 12 HIS A 440
PRO A 431
LYS A 443
SER A 447
PHE A 242
 None
 1.45A 4ktvA-5vbnA:
undetectable
4ktvB-5vbnA:
undetectable		 4ktvA-5vbnA:
21.97
4ktvB-5vbnA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_A_8PRA603_1
(TRANSPORTER)		 5vbn DNA POLYMERASE
EPSILON SUBUNIT 2
(Homo
sapiens) 		5 / 12 VAL A 183
ALA A 226
GLY A 228
ASP A 199
THR A 167
 None
 1.32A 4mm4A-5vbnA:
undetectable		 4mm4A-5vbnA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 5vbn DNA POLYMERASE
EPSILON SUBUNIT 2
(Homo
sapiens) 		5 / 12 ASN A 324
PRO A 402
ASP A 482
LEU A 478
ILE A 480
 None
 1.11A 5dv4A-5vbnA:
2.0		 5dv4A-5vbnA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD15_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)		 5vbn DNA POLYMERASE
EPSILON CATALYTIC
SUBUNIT A
(Homo
sapiens) 		3 / 3 GLY B2240
CYH B2238
CYH B2236
 None
ZN  B2302 (-2.3A)
ZN  B2302 (-2.3A)
 0.86A 5inzB-5vbnB:
undetectable		 5inzB-5vbnB:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 5vbn DNA POLYMERASE
EPSILON SUBUNIT 2
(Homo
sapiens) 		3 / 3 ARG A 404
PRO A  95
ASN A 259
 None
 1.07A 5jwaA-5vbnA:
undetectable
5jwaH-5vbnA:
undetectable		 5jwaA-5vbnA:
21.53
5jwaH-5vbnA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 5vbn DNA POLYMERASE
EPSILON SUBUNIT 2
(Homo
sapiens) 		5 / 12 LEU A 345
ILE A 349
ILE A 355
PHE A 319
VAL A 293
 None
 1.30A 5uanB-5vbnA:
undetectable		 5uanB-5vbnA:
20.07