SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vbu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB8_0
(GRAMICIDIN A)		 5vbu CYTOCHROME P450
21-HYDROXYLASE
(Homo
sapiens) 		3 / 3 VAL A 359
VAL A 470
TRP A 303
 HEM  A 501 (-4.7A)
None
None
 0.98A 1bdwA-5vbuA:
undetectable
1bdwB-5vbuA:
undetectable		 1bdwA-5vbuA:
6.52
1bdwB-5vbuA:
6.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_2
(ESTROGEN RECEPTOR)		 5vbu CYTOCHROME P450
21-HYDROXYLASE
(Homo
sapiens) 		4 / 6 LEU A 216
LEU A 224
HIS A 204
LEU A  38
 None
 0.77A 1errA-5vbuA:
undetectable		 1errA-5vbuA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_2
(HIV-1 PROTEASE)		 5vbu CYTOCHROME P450
21-HYDROXYLASE
(Homo
sapiens) 		3 / 3 ARG A 234
THR A 201
VAL A 198
 3QZ  A 502 (-3.8A)
None
3QZ  A 502 (-4.6A)
 1.01A 1hxbA-5vbuA:
undetectable		 1hxbA-5vbuA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_2
(PROTEASE RETROPEPSIN)		 5vbu CYTOCHROME P450
21-HYDROXYLASE
(Homo
sapiens) 		3 / 3 ARG A 234
THR A 201
VAL A 198
 3QZ  A 502 (-3.8A)
None
3QZ  A 502 (-4.6A)
 0.94A 2q64A-5vbuA:
undetectable		 2q64A-5vbuA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEO_A_LNRA200_1
(D7R4 PROTEIN)		 5vbu CYTOCHROME P450
21-HYDROXYLASE
(Homo
sapiens) 		5 / 12 ILE A 237
VAL A 238
TYR A 191
PHE A 178
ASP A 256
 None
 1.43A 2qeoA-5vbuA:
undetectable		 2qeoA-5vbuA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 5vbu CYTOCHROME P450
21-HYDROXYLASE
(Homo
sapiens) 		5 / 12 LEU A 439
LEU A 452
PRO A 454
PHE A 477
VAL A 359
 None
None
None
None
HEM  A 501 (-4.7A)
 0.96A 2ygqA-5vbuA:
undetectable		 2ygqA-5vbuA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_1
(PHOSPHOLIPASE A2)		 5vbu CYTOCHROME P450
21-HYDROXYLASE
(Homo
sapiens) 		4 / 5 VAL A 442
VAL A 441
THR A 300
ARG A 445
 None
None
HEM  A 501 (-3.4A)
None
 1.13A 3bjwA-5vbuA:
undetectable		 3bjwA-5vbuA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACHG301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5vbu CYTOCHROME P450
21-HYDROXYLASE
(Homo
sapiens) 		4 / 8 THR A 157
ARG A 480
LEU A 481
MET A 151
 None
 1.11A 3wipG-5vbuA:
undetectable
3wipH-5vbuA:
undetectable		 3wipG-5vbuA:
17.72
3wipH-5vbuA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_J_ACHJ301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5vbu CYTOCHROME P450
21-HYDROXYLASE
(Homo
sapiens) 		4 / 8 ARG A 480
LEU A 481
MET A 151
THR A 157
 None
 1.18A 3wipF-5vbuA:
undetectable
3wipJ-5vbuA:
undetectable		 3wipF-5vbuA:
17.72
3wipJ-5vbuA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		 5vbu CYTOCHROME P450
21-HYDROXYLASE
(Homo
sapiens) 		5 / 12 VAL A 360
ALA A 363
GLY A 431
GLY A 423
THR A 296
 HEM  A 501 ( 4.3A)
HEM  A 501 ( 3.7A)
HEM  A 501 (-3.6A)
HEM  A 501 ( 4.4A)
HEM  A 501 (-3.7A)
 1.21A 4mm8A-5vbuA:
undetectable		 4mm8A-5vbuA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA205_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 5vbu CYTOCHROME P450
21-HYDROXYLASE
(Homo
sapiens) 		5 / 12 PHE A 422
ASN A 388
ALA A 392
GLY A 391
LEU A 394
 HEM  A 501 (-4.0A)
None
None
None
None
 1.37A 4oadA-5vbuA:
undetectable		 4oadA-5vbuA:
15.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WNV_A_QI9A602_0
(CYTOCHROME P450 2D6)		 5vbu CYTOCHROME P450
21-HYDROXYLASE
(Homo
sapiens) 		5 / 9 PHE A 165
LEU A 168
VAL A 479
PHE A 450
LEU A 452
 None
 1.22A 4wnvA-5vbuA:
39.4		 4wnvA-5vbuA:
32.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Y8W_A_STRA604_1
(CYTOCHROME P450
21-HYDROXYLASE)		 5vbu CYTOCHROME P450
21-HYDROXYLASE
(Homo
sapiens) 		12 / 12 VAL A 101
ASP A 107
SER A 109
VAL A 198
LEU A 199
TRP A 202
ARG A 234
ASP A 288
ILE A 291
GLY A 292
VAL A 360
LEU A 364
 3QZ  A 502 (-4.5A)
3QZ  A 502 ( 3.8A)
3QZ  A 502 ( 3.5A)
3QZ  A 502 (-4.6A)
3QZ  A 502 ( 4.7A)
3QZ  A 502 ( 3.9A)
3QZ  A 502 (-3.8A)
3QZ  A 502 (-4.0A)
3QZ  A 502 (-4.3A)
3QZ  A 502 ( 3.2A)
HEM  A 501 ( 4.3A)
3QZ  A 502 (-4.1A)
 0.31A 4y8wA-5vbuA:
63.3		 4y8wA-5vbuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Y8W_B_STRB603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 5vbu CYTOCHROME P450
21-HYDROXYLASE
(Homo
sapiens) 		12 / 12 VAL A 101
ASP A 107
SER A 109
VAL A 198
LEU A 199
TRP A 202
ARG A 234
ASP A 288
ILE A 291
GLY A 292
VAL A 360
LEU A 364
 3QZ  A 502 (-4.5A)
3QZ  A 502 ( 3.8A)
3QZ  A 502 ( 3.5A)
3QZ  A 502 (-4.6A)
3QZ  A 502 ( 4.7A)
3QZ  A 502 ( 3.9A)
3QZ  A 502 (-3.8A)
3QZ  A 502 (-4.0A)
3QZ  A 502 (-4.3A)
3QZ  A 502 ( 3.2A)
HEM  A 501 ( 4.3A)
3QZ  A 502 (-4.1A)
 0.32A 4y8wB-5vbuA:
63.5		 4y8wB-5vbuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Y8W_C_STRC603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 5vbu CYTOCHROME P450
21-HYDROXYLASE
(Homo
sapiens) 		12 / 12 VAL A 101
ASP A 107
SER A 109
LEU A 110
VAL A 198
TRP A 202
ILE A 231
ARG A 234
ILE A 291
GLY A 292
VAL A 360
LEU A 364
 3QZ  A 502 (-4.5A)
3QZ  A 502 ( 3.8A)
3QZ  A 502 ( 3.5A)
3QZ  A 502 ( 4.8A)
3QZ  A 502 (-4.6A)
3QZ  A 502 ( 3.9A)
3QZ  A 502 (-4.8A)
3QZ  A 502 (-3.8A)
3QZ  A 502 (-4.3A)
3QZ  A 502 ( 3.2A)
HEM  A 501 ( 4.3A)
3QZ  A 502 (-4.1A)
 0.20A 4y8wC-5vbuA:
64.5		 4y8wC-5vbuA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5vbu CYTOCHROME P450
21-HYDROXYLASE
(Homo
sapiens) 		4 / 5 PHE A 477
PRO A 158
VAL A 479
ALA A 160
 None
 1.23A 4z4cA-5vbuA:
undetectable		 4z4cA-5vbuA:
21.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X23_A_LSNA503_1
(CYTOCHROME P450 2C9)		 5vbu CYTOCHROME P450
21-HYDROXYLASE
(Homo
sapiens) 		4 / 5 PRO A  58
GLY A  57
THR A  53
LYS A  55
 None
 1.23A 5x23A-5vbuA:
43.7		 5x23A-5vbuA:
32.26