SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vc7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		 5vc7 VCP-LIKE ATPASE
(Thermoplasma
acidophilum) 		5 / 12 ASN A 685
GLY A 683
MET A 652
LEU A 654
LEU A 645
 None
 1.32A 1nhzA-5vc7A:
undetectable		 1nhzA-5vc7A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS6_A_DXCA75_0
(PPCA)		 5vc7 VCP-LIKE ATPASE
(Thermoplasma
acidophilum) 		4 / 8 ILE A 599
LEU A 596
PHE A 627
GLY A 609
 None
 1.04A 1os6A-5vc7A:
undetectable		 1os6A-5vc7A:
6.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA802_1
(TRANSPORTER)		 5vc7 VCP-LIKE ATPASE
(Thermoplasma
acidophilum) 		4 / 6 ILE A 563
SER A 525
ILE A 479
PHE A 504
 None
 1.13A 2q72A-5vc7A:
2.1		 2q72A-5vc7A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 5vc7 VCP-LIKE ATPASE
(Thermoplasma
acidophilum) 		5 / 12 ALA A 243
LEU A 239
LEU A 195
GLN A 198
ILE A 366
 None
ATP  A 801 (-3.8A)
ATP  A 801 (-4.1A)
None
ATP  A 801 ( 4.6A)
 1.18A 3datA-5vc7A:
undetectable		 3datA-5vc7A:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ1_X_DXCX75_0
(CYTOCHROME C7)		 5vc7 VCP-LIKE ATPASE
(Thermoplasma
acidophilum) 		4 / 6 ILE A 599
LEU A 596
PHE A 627
GLY A 609
 None
 0.98A 3sj1X-5vc7A:
undetectable		 3sj1X-5vc7A:
6.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HBF_A_DXCA75_0
(PPCA)		 5vc7 VCP-LIKE ATPASE
(Thermoplasma
acidophilum) 		4 / 7 ILE A 599
LEU A 596
PHE A 627
GLY A 609
 None
 1.04A 4hbfA-5vc7A:
undetectable		 4hbfA-5vc7A:
6.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HC3_A_DXCA75_0
(PPCA)		 5vc7 VCP-LIKE ATPASE
(Thermoplasma
acidophilum) 		4 / 7 ILE A 599
LEU A 596
PHE A 627
GLY A 609
 None
 1.01A 4hc3A-5vc7A:
undetectable		 4hc3A-5vc7A:
6.57