SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vcs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		 5vcs ALPHA-1,6-MANNOSYL-G
LYCOPROTEIN
2-BETA-N-ACETYLGLUCO
SAMINYLTRANSFERASE
(Homo
sapiens) 		4 / 4 HIS A 233
LEU A 131
LEU A 134
LEU A 256
 None
 1.22A 1a4lD-5vcsA:
undetectable		 1a4lD-5vcsA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_B_ADNB1502_1
(CLASS B ACID
PHOSPHATASE)		 5vcs ALPHA-1,6-MANNOSYL-G
LYCOPROTEIN
2-BETA-N-ACETYLGLUCO
SAMINYLTRANSFERASE
(Homo
sapiens) 		4 / 7 PHE A 338
LEU A 353
THR A 340
TYR A 341
 None
 1.09A 1rmtB-5vcsA:
1.3		 1rmtB-5vcsA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_D_ADND1504_1
(CLASS B ACID
PHOSPHATASE)		 5vcs ALPHA-1,6-MANNOSYL-G
LYCOPROTEIN
2-BETA-N-ACETYLGLUCO
SAMINYLTRANSFERASE
(Homo
sapiens) 		4 / 8 PHE A 338
LEU A 353
THR A 340
TYR A 341
 None
 1.03A 1rmtD-5vcsA:
undetectable		 1rmtD-5vcsA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_B_CFFB2434_1
(CHITINASE)		 5vcs ALPHA-1,6-MANNOSYL-G
LYCOPROTEIN
2-BETA-N-ACETYLGLUCO
SAMINYLTRANSFERASE
(Homo
sapiens) 		4 / 6 TYR A 443
ASP A 436
PHE A 188
ARG A 223
 None
 1.14A 2a3bB-5vcsA:
undetectable		 2a3bB-5vcsA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)		 5vcs ALPHA-1,6-MANNOSYL-G
LYCOPROTEIN
2-BETA-N-ACETYLGLUCO
SAMINYLTRANSFERASE
(Homo
sapiens) 		4 / 6 PRO A 216
ASP A 192
ASP A 195
TYR A 222
 None
 1.34A 2lh8A-5vcsA:
undetectable		 2lh8A-5vcsA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 5vcs ALPHA-1,6-MANNOSYL-G
LYCOPROTEIN
2-BETA-N-ACETYLGLUCO
SAMINYLTRANSFERASE
(Homo
sapiens) 		5 / 10 LEU A 256
VAL A 364
VAL A 366
PRO A 367
VAL A 288
 None
 1.00A 2nnjA-5vcsA:
undetectable		 2nnjA-5vcsA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5vcs ALPHA-1,6-MANNOSYL-G
LYCOPROTEIN
2-BETA-N-ACETYLGLUCO
SAMINYLTRANSFERASE
(Homo
sapiens) 		5 / 11 ILE A 395
PHE A 373
ASN A 402
ILE A 369
LEU A 399
 None
 1.26A 3qg2B-5vcsA:
undetectable		 3qg2B-5vcsA:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_4
(PROTEASE)		 5vcs ALPHA-1,6-MANNOSYL-G
LYCOPROTEIN
2-BETA-N-ACETYLGLUCO
SAMINYLTRANSFERASE
(Homo
sapiens) 		4 / 4 ASP A 433
ASP A 436
GLY A 430
THR A 349
 None
None
NAG  A 501 ( 3.2A)
None
 1.08A 3tl9B-5vcsA:
undetectable		 3tl9B-5vcsA:
29.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5V_A_ACTA511_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5vcs ALPHA-1,6-MANNOSYL-G
LYCOPROTEIN
2-BETA-N-ACETYLGLUCO
SAMINYLTRANSFERASE
(Homo
sapiens) 		4 / 4 ASN A 126
PHE A 155
SER A 157
GLN A 182
 DMS  A 508 ( 4.8A)
None
DMS  A 508 (-3.2A)
None
 1.29A 3v5vA-5vcsA:
undetectable		 3v5vA-5vcsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_2
(NEURAMINIDASE)		 5vcs ALPHA-1,6-MANNOSYL-G
LYCOPROTEIN
2-BETA-N-ACETYLGLUCO
SAMINYLTRANSFERASE
(Homo
sapiens) 		3 / 3 ARG A 444
ARG A 445
ILE A 332
 None
 0.86A 4b7qA-5vcsA:
undetectable		 4b7qA-5vcsA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_2
(NEURAMINIDASE)		 5vcs ALPHA-1,6-MANNOSYL-G
LYCOPROTEIN
2-BETA-N-ACETYLGLUCO
SAMINYLTRANSFERASE
(Homo
sapiens) 		3 / 3 ARG A 444
ARG A 445
ILE A 332
 None
 0.75A 4b7qC-5vcsA:
undetectable		 4b7qC-5vcsA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_D_ACTD1113_0
(BLR5658 PROTEIN)		 5vcs ALPHA-1,6-MANNOSYL-G
LYCOPROTEIN
2-BETA-N-ACETYLGLUCO
SAMINYLTRANSFERASE
(Homo
sapiens) 		4 / 4 TRP A 234
LEU A 331
LEU A 353
THR A 349
 None
 1.42A 4bboD-5vcsA:
undetectable		 4bboD-5vcsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 5vcs ALPHA-1,6-MANNOSYL-G
LYCOPROTEIN
2-BETA-N-ACETYLGLUCO
SAMINYLTRANSFERASE
(Homo
sapiens) 		5 / 12 LEU A 134
VAL A 124
HIS A 153
VAL A 172
GLY A 166
 None
 1.23A 5i8fA-5vcsA:
undetectable		 5i8fA-5vcsA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_A_DAHA60_1
(PUTATIVE CYTOCHROME
C)		 5vcs ALPHA-1,6-MANNOSYL-G
LYCOPROTEIN
2-BETA-N-ACETYLGLUCO
SAMINYLTRANSFERASE
(Homo
sapiens) 		4 / 6 HIS A 239
ASN A  99
VAL A 245
GLN A 102
 None
 1.34A 5xdhA-5vcsA:
undetectable
5xdhC-5vcsA:
undetectable		 5xdhA-5vcsA:
21.35
5xdhC-5vcsA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_C_DAHC60_1
(PUTATIVE CYTOCHROME
C)		 5vcs ALPHA-1,6-MANNOSYL-G
LYCOPROTEIN
2-BETA-N-ACETYLGLUCO
SAMINYLTRANSFERASE
(Homo
sapiens) 		4 / 6 GLN A 102
HIS A 239
ASN A  99
VAL A 245
 None
 1.33A 5xdhA-5vcsA:
undetectable
5xdhC-5vcsA:
undetectable		 5xdhA-5vcsA:
21.35
5xdhC-5vcsA:
21.35