SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vcu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5vcu RAS-RELATED C3
BOTULINUM TOXIN
SUBSTRATE 1 ISOFORM
X2
(Naegleria
fowleri) 		5 / 12 PHE A  28
THR A 161
PHE A 169
ILE A 155
ASP A 118
 GDP  A 301 (-4.5A)
None
None
None
GDP  A 301 (-2.9A)
 1.13A 3iv6B-5vcuA:
undetectable		 3iv6B-5vcuA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5vcu RAS-RELATED C3
BOTULINUM TOXIN
SUBSTRATE 1 ISOFORM
X2
(Naegleria
fowleri) 		5 / 10 LEU A  55
LEU A  20
ILE A   4
THR A  58
VAL A 111
 None
 1.41A 4mk4A-5vcuA:
2.6		 4mk4A-5vcuA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)		 5vcu RAS-RELATED C3
BOTULINUM TOXIN
SUBSTRATE 1 ISOFORM
X2
(Naegleria
fowleri) 		5 / 11 VAL A 113
GLY A 114
SER A 158
ALA A 168
LEU A  79
 None
None
GDP  A 301 (-3.5A)
None
None
 1.23A 5x6yA-5vcuA:
2.5		 5x6yA-5vcuA:
12.05