SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vcx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
6 / 12 LEU A 116
VAL A 124
ALA A 137
GLU A 157
THR A 187
GLY A 191
H8H  A 401 (-3.7A)
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
None
H8H  A 401 (-3.5A)
H8H  A 401 (-4.4A)
0.84A 1iepB-5vcxA:
18.1
1iepB-5vcxA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
7 / 12 LEU A 116
ALA A 137
GLU A 157
LEU A 185
THR A 187
LEU A 189
ASP A 251
H8H  A 401 (-3.7A)
H8H  A 401 (-3.3A)
None
H8H  A 401 (-4.3A)
H8H  A 401 (-3.5A)
None
EDO  A 402 ( 2.9A)
0.75A 1m17A-5vcxA:
24.5
1m17A-5vcxA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
7 / 12 LEU A 116
ALA A 137
LYS A 139
GLU A 157
LEU A 185
THR A 187
LEU A 189
H8H  A 401 (-3.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-4.9A)
None
H8H  A 401 (-4.3A)
H8H  A 401 (-3.5A)
None
0.89A 1m17A-5vcxA:
24.5
1m17A-5vcxA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
6 / 12 VAL A 124
ALA A 137
GLU A 157
VAL A 171
THR A 187
GLY A 191
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
None
None
H8H  A 401 (-3.5A)
H8H  A 401 (-4.4A)
0.90A 1opjB-5vcxA:
17.6
1opjB-5vcxA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
7 / 12 ALA A 137
GLU A 157
THR A 187
CYH A 190
LEU A 224
HIS A 231
GLY A 250
H8H  A 401 (-3.3A)
None
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
None
None
None
0.65A 1uwhA-5vcxA:
22.7
1uwhA-5vcxA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
6 / 12 ALA A 137
THR A 187
LEU A 224
HIS A 231
GLY A 250
PHE A 240
H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
None
None
None
H8H  A 401 (-4.3A)
1.33A 1uwhA-5vcxA:
22.7
1uwhA-5vcxA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
7 / 12 ALA A 137
GLU A 157
THR A 187
CYH A 190
LEU A 224
HIS A 231
GLY A 250
H8H  A 401 (-3.3A)
None
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
None
None
None
0.65A 1uwhB-5vcxA:
22.6
1uwhB-5vcxA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
8 / 12 VAL A 124
ALA A 137
GLU A 157
THR A 187
CYH A 190
LEU A 224
HIS A 231
GLY A 250
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
None
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
None
None
None
0.66A 1uwjA-5vcxA:
6.9
1uwjA-5vcxA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
8 / 12 VAL A 124
ALA A 137
GLU A 157
THR A 187
CYH A 190
LEU A 224
HIS A 231
GLY A 250
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
None
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
None
None
None
0.66A 1uwjB-5vcxA:
5.6
1uwjB-5vcxA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
5 / 9 LEU A 116
VAL A 124
LEU A 173
LEU A 185
LEU A 189
H8H  A 401 (-3.7A)
H8H  A 401 (-4.7A)
None
H8H  A 401 (-4.3A)
None
0.76A 1xkkA-5vcxA:
22.7
1xkkA-5vcxA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_A_ADNA2001_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
4 / 7 ARG A 316
ALA A 287
PRO A 344
ALA A 286
None
1.07A 2ejfA-5vcxA:
undetectable
2ejfA-5vcxA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
8 / 12 LEU A 116
VAL A 124
ALA A 137
ASP A 233
LYS A 235
ALA A 237
ASN A 238
ASP A 251
H8H  A 401 (-3.7A)
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
None
EDO  A 402 (-3.4A)
H8H  A 401 ( 4.4A)
EDO  A 402 (-3.9A)
EDO  A 402 ( 2.9A)
0.87A 2fumA-5vcxA:
20.8
2fumA-5vcxA:
28.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
5 / 12 LEU A 336
VAL A 335
SER A 329
CYH A 301
LEU A 354
None
1.24A 2zlcA-5vcxA:
undetectable
2zlcA-5vcxA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
8 / 12 VAL A 124
ALA A 137
LEU A 173
THR A 187
LEU A 189
GLY A 191
ASP A 251
PHE A 252
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
None
H8H  A 401 (-3.5A)
None
H8H  A 401 (-4.4A)
EDO  A 402 ( 2.9A)
None
1.29A 3bbtB-5vcxA:
17.3
3bbtB-5vcxA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
5 / 12 MET A 338
LEU A 218
LEU A 359
ILE A 296
LEU A 332
None
1.04A 3fl9B-5vcxA:
undetectable
3fl9B-5vcxA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_E_TOPE200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
5 / 10 MET A 338
LEU A 218
LEU A 359
ILE A 296
LEU A 332
None
1.05A 3fl9E-5vcxA:
undetectable
3fl9E-5vcxA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
5 / 12 MET A 338
LEU A 218
LEU A 359
ILE A 296
LEU A 332
None
1.12A 3fl9G-5vcxA:
undetectable
3fl9G-5vcxA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
6 / 12 LEU A 116
VAL A 124
ALA A 137
GLU A 157
VAL A 171
THR A 187
H8H  A 401 (-3.7A)
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
None
None
H8H  A 401 (-3.5A)
0.55A 3gvuA-5vcxA:
18.3
3gvuA-5vcxA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
5 / 12 ALA A 137
LYS A 139
GLU A 157
THR A 187
LEU A 189
H8H  A 401 (-3.3A)
H8H  A 401 (-4.9A)
None
H8H  A 401 (-3.5A)
None
0.79A 3hecA-5vcxA:
18.1
3hecA-5vcxA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
5 / 11 LEU A 232
LEU A 254
GLY A 228
HIS A 225
LEU A 224
None
1.27A 3hm1B-5vcxA:
undetectable
3hm1B-5vcxA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
5 / 8 ALA A 137
LYS A 139
GLU A 157
LEU A 185
LEU A 189
H8H  A 401 (-3.3A)
H8H  A 401 (-4.9A)
None
H8H  A 401 (-4.3A)
None
1.07A 3lfaA-5vcxA:
22.1
3lfaA-5vcxA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
5 / 8 ALA A 137
LYS A 139
GLU A 157
THR A 187
LEU A 189
H8H  A 401 (-3.3A)
H8H  A 401 (-4.9A)
None
H8H  A 401 (-3.5A)
None
0.83A 3lfaA-5vcxA:
22.1
3lfaA-5vcxA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
6 / 12 VAL A 124
ALA A 137
LYS A 139
THR A 187
CYH A 190
GLY A 253
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-4.9A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
None
1.13A 3og7A-5vcxA:
18.1
3og7A-5vcxA:
25.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
6 / 12 VAL A 124
ALA A 137
THR A 187
CYH A 190
PHE A 240
GLY A 253
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
H8H  A 401 (-4.3A)
None
0.67A 3og7A-5vcxA:
18.1
3og7A-5vcxA:
25.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
6 / 12 VAL A 124
ALA A 137
THR A 187
CYH A 190
PHE A 240
PHE A 252
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
H8H  A 401 (-4.3A)
None
0.83A 3og7A-5vcxA:
18.1
3og7A-5vcxA:
25.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
5 / 12 GLY A 117
VAL A 124
ALA A 137
LYS A 139
THR A 187
H8H  A 401 ( 3.7A)
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-4.9A)
H8H  A 401 (-3.5A)
0.49A 3ohtB-5vcxA:
18.0
3ohtB-5vcxA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
6 / 12 LEU A 116
VAL A 124
ALA A 137
GLU A 157
THR A 187
GLY A 191
H8H  A 401 (-3.7A)
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
None
H8H  A 401 (-3.5A)
H8H  A 401 (-4.4A)
0.75A 3pyyA-5vcxA:
18.1
3pyyA-5vcxA:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
6 / 12 LEU A 116
VAL A 124
ALA A 137
GLU A 157
VAL A 171
THR A 187
H8H  A 401 (-3.7A)
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
None
None
H8H  A 401 (-3.5A)
0.61A 3pyyB-5vcxA:
18.0
3pyyB-5vcxA:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
8 / 12 LEU A 116
VAL A 124
ALA A 137
LYS A 139
GLU A 157
VAL A 171
THR A 187
ASP A 251
H8H  A 401 (-3.7A)
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-4.9A)
None
None
H8H  A 401 (-3.5A)
EDO  A 402 ( 2.9A)
0.85A 4mxoA-5vcxA:
19.7
4mxoA-5vcxA:
26.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
6 / 12 VAL A 124
ALA A 137
GLU A 157
THR A 187
CYH A 190
GLY A 250
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
None
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
None
0.60A 4r7iA-5vcxA:
22.7
4r7iA-5vcxA:
28.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
6 / 12 ALA A 137
THR A 187
SER A 193
PHE A 240
GLY A 250
GLY A 253
H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 ( 4.4A)
H8H  A 401 (-4.3A)
None
None
1.11A 4rzvA-5vcxA:
5.4
4rzvA-5vcxA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
6 / 12 ALA A 137
THR A 187
SER A 193
PHE A 240
GLY A 250
PHE A 252
H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 ( 4.4A)
H8H  A 401 (-4.3A)
None
None
0.78A 4rzvA-5vcxA:
5.4
4rzvA-5vcxA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
7 / 12 ALA A 137
THR A 187
CYH A 190
SER A 193
PHE A 240
GLY A 250
GLY A 253
H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
H8H  A 401 ( 4.4A)
H8H  A 401 (-4.3A)
None
None
1.17A 4rzvB-5vcxA:
17.4
4rzvB-5vcxA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
7 / 12 ALA A 137
THR A 187
CYH A 190
SER A 193
PHE A 240
GLY A 250
PHE A 252
H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
H8H  A 401 ( 4.4A)
H8H  A 401 (-4.3A)
None
None
0.88A 4rzvB-5vcxA:
17.4
4rzvB-5vcxA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
6 / 12 VAL A 124
ALA A 137
LYS A 139
THR A 187
CYH A 190
GLY A 253
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-4.9A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
None
1.11A 4rzvB-5vcxA:
17.4
4rzvB-5vcxA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
7 / 12 VAL A 124
ALA A 137
THR A 187
CYH A 190
SER A 193
PHE A 240
GLY A 253
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
H8H  A 401 ( 4.4A)
H8H  A 401 (-4.3A)
None
0.96A 4rzvB-5vcxA:
17.4
4rzvB-5vcxA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
7 / 12 VAL A 124
ALA A 137
THR A 187
CYH A 190
SER A 193
PHE A 240
PHE A 252
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
H8H  A 401 ( 4.4A)
H8H  A 401 (-4.3A)
None
0.91A 4rzvB-5vcxA:
17.4
4rzvB-5vcxA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
5 / 12 LEU A 116
ALA A 137
GLU A 157
LEU A 224
HIS A 231
H8H  A 401 (-3.7A)
H8H  A 401 (-3.3A)
None
None
None
0.59A 4uxqA-5vcxA:
22.9
4uxqA-5vcxA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
7 / 12 VAL A 124
ALA A 137
THR A 187
CYH A 190
PHE A 240
GLY A 250
ASP A 251
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
H8H  A 401 (-4.3A)
None
EDO  A 402 ( 2.9A)
0.76A 4xv2A-5vcxA:
18.5
4xv2A-5vcxA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
7 / 12 VAL A 124
ALA A 137
THR A 187
PHE A 240
GLY A 250
ASP A 251
PHE A 252
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
None
EDO  A 402 ( 2.9A)
None
0.81A 4xv2A-5vcxA:
18.5
4xv2A-5vcxA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
6 / 12 ALA A 137
THR A 187
CYH A 190
PHE A 240
GLY A 250
ASP A 251
H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
H8H  A 401 (-4.3A)
None
EDO  A 402 ( 2.9A)
0.67A 4xv2B-5vcxA:
22.6
4xv2B-5vcxA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
6 / 12 ALA A 137
THR A 187
PHE A 240
GLY A 250
ASP A 251
PHE A 252
H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
None
EDO  A 402 ( 2.9A)
None
0.65A 4xv2B-5vcxA:
22.6
4xv2B-5vcxA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
6 / 12 VAL A 124
ALA A 137
THR A 187
CYH A 190
PHE A 240
GLY A 250
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
H8H  A 401 (-4.3A)
None
0.66A 5cswA-5vcxA:
22.0
5cswA-5vcxA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
6 / 12 VAL A 124
ALA A 137
THR A 187
PHE A 240
GLY A 250
PHE A 252
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
None
None
0.84A 5cswA-5vcxA:
22.0
5cswA-5vcxA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
6 / 12 VAL A 124
ALA A 137
THR A 187
CYH A 190
PHE A 240
GLY A 250
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
H8H  A 401 (-4.3A)
None
0.63A 5cswB-5vcxA:
22.4
5cswB-5vcxA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
6 / 12 VAL A 124
ALA A 137
THR A 187
PHE A 240
GLY A 250
PHE A 252
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
None
None
0.83A 5cswB-5vcxA:
22.4
5cswB-5vcxA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
7 / 12 LEU A 116
VAL A 124
ALA A 137
THR A 187
LEU A 189
GLY A 250
ASP A 251
H8H  A 401 (-3.7A)
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
None
None
EDO  A 402 ( 2.9A)
0.65A 5h2uD-5vcxA:
17.1
5h2uD-5vcxA:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
7 / 12 ALA A 137
GLU A 157
THR A 187
CYH A 190
LEU A 224
HIS A 231
GLY A 250
H8H  A 401 (-3.3A)
None
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
None
None
None
0.71A 5hi2A-5vcxA:
22.3
5hi2A-5vcxA:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
7 / 12 ALA A 137
LYS A 139
GLU A 157
THR A 187
CYH A 190
HIS A 231
GLY A 250
H8H  A 401 (-3.3A)
H8H  A 401 (-4.9A)
None
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
None
None
0.80A 5hi2A-5vcxA:
22.3
5hi2A-5vcxA:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
5 / 12 VAL A 124
ALA A 137
THR A 187
PHE A 240
GLY A 250
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
None
0.64A 5hieA-5vcxA:
7.0
5hieA-5vcxA:
27.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
5 / 12 VAL A 124
ALA A 137
THR A 187
PHE A 240
GLY A 250
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
None
0.66A 5hieB-5vcxA:
6.9
5hieB-5vcxA:
27.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
6 / 12 GLY A 117
VAL A 124
ALA A 137
THR A 187
PHE A 240
GLY A 250
H8H  A 401 ( 3.7A)
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
None
0.75A 5hieC-5vcxA:
21.2
5hieC-5vcxA:
27.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
6 / 12 VAL A 124
ALA A 137
THR A 187
PHE A 240
GLY A 250
ASP A 251
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
None
EDO  A 402 ( 2.9A)
0.81A 5hieC-5vcxA:
21.2
5hieC-5vcxA:
27.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
5 / 12 VAL A 124
ALA A 137
THR A 187
PHE A 240
GLY A 250
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
None
0.65A 5hieD-5vcxA:
21.0
5hieD-5vcxA:
27.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
5 / 7 GLY A 117
GLY A 119
SER A 120
VAL A 124
LYS A 139
H8H  A 401 ( 3.7A)
None
None
H8H  A 401 (-4.7A)
H8H  A 401 (-4.9A)
0.80A 5izjA-5vcxA:
24.3
5izjA-5vcxA:
26.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
5 / 7 GLY A 117
GLY A 119
SER A 120
VAL A 124
LYS A 139
H8H  A 401 ( 3.7A)
None
None
H8H  A 401 (-4.7A)
H8H  A 401 (-4.9A)
0.66A 5j5xA-5vcxA:
24.1
5j5xA-5vcxA:
26.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
4 / 8 ALA A 137
GLU A 157
CYH A 190
ASP A 251
H8H  A 401 (-3.3A)
None
H8H  A 401 (-4.3A)
EDO  A 402 ( 2.9A)
0.53A 5owrA-5vcxA:
15.2
5owrA-5vcxA:
27.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
6 / 12 ALA A 137
GLU A 157
CYH A 190
GLY A 191
PHE A 240
ASP A 251
H8H  A 401 (-3.3A)
None
H8H  A 401 (-4.3A)
H8H  A 401 (-4.4A)
H8H  A 401 (-4.3A)
EDO  A 402 ( 2.9A)
0.97A 5vc3A-5vcxA:
24.0
5vc3A-5vcxA:
32.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VC3_A_DB8A601_2
(WEE1-LIKE PROTEIN
KINASE)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
4 / 4 VAL A 124
LYS A 139
VAL A 171
ASN A 238
H8H  A 401 (-4.7A)
H8H  A 401 (-4.9A)
None
EDO  A 402 (-3.9A)
0.37A 5vc3A-5vcxA:
24.0
5vc3A-5vcxA:
32.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
12 / 12 LEU A 116
ALA A 137
LYS A 139
GLU A 157
VAL A 171
LEU A 185
THR A 187
GLY A 191
PRO A 192
GLN A 196
PHE A 240
GLY A 250
H8H  A 401 (-3.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-4.9A)
None
None
H8H  A 401 (-4.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.4A)
H8H  A 401 ( 4.1A)
H8H  A 401 ( 4.4A)
H8H  A 401 (-4.3A)
None
0.59A 5vcvA-5vcxA:
43.9
5vcvA-5vcxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VCV_A_1N1A404_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
5 / 5 VAL A 124
HIS A 161
LEU A 189
CYH A 190
ASP A 251
H8H  A 401 (-4.7A)
None
None
H8H  A 401 (-4.3A)
EDO  A 402 ( 2.9A)
0.50A 5vcvA-5vcxA:
44.0
5vcvA-5vcxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
12 / 12 LEU A 116
VAL A 124
ALA A 137
LYS A 139
GLU A 157
LEU A 185
THR A 187
CYH A 190
GLY A 191
PRO A 192
GLN A 196
PHE A 240
H8H  A 401 (-3.7A)
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-4.9A)
None
H8H  A 401 (-4.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
H8H  A 401 (-4.4A)
H8H  A 401 ( 4.1A)
H8H  A 401 ( 4.4A)
H8H  A 401 (-4.3A)
0.53A 5vcyA-5vcxA:
42.4
5vcyA-5vcxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VCY_A_DB8A401_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
4 / 4 VAL A 171
LEU A 189
ASN A 238
ASP A 251
None
None
EDO  A 402 (-3.9A)
EDO  A 402 ( 2.9A)
0.75A 5vcyA-5vcxA:
42.4
5vcyA-5vcxA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
7 / 12 LEU A 116
VAL A 124
ALA A 137
LYS A 139
GLU A 157
LEU A 189
CYH A 190
H8H  A 401 (-3.7A)
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-4.9A)
None
None
H8H  A 401 (-4.3A)
0.44A 5y7zA-5vcxA:
23.4
5y7zA-5vcxA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
7 / 12 LEU A 116
VAL A 124
ALA A 137
LYS A 139
GLU A 157
LEU A 189
CYH A 190
H8H  A 401 (-3.7A)
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-4.9A)
None
None
H8H  A 401 (-4.3A)
0.44A 5y7zA-5vcxA:
23.4
5y7zA-5vcxA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
7 / 12 VAL A 124
ALA A 137
LYS A 139
GLU A 157
LEU A 189
CYH A 190
GLY A 191
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-4.9A)
None
None
H8H  A 401 (-4.3A)
H8H  A 401 (-4.4A)
0.95A 5y7zA-5vcxA:
23.4
5y7zA-5vcxA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
7 / 12 VAL A 124
ALA A 137
LYS A 139
GLU A 157
LEU A 189
CYH A 190
GLY A 191
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-4.9A)
None
None
H8H  A 401 (-4.3A)
H8H  A 401 (-4.4A)
0.95A 5y7zA-5vcxA:
23.4
5y7zA-5vcxA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
8 / 12 LEU A 116
ALA A 137
GLU A 157
LEU A 185
LEU A 189
CYH A 190
GLY A 191
ASP A 251
H8H  A 401 (-3.7A)
H8H  A 401 (-3.3A)
None
H8H  A 401 (-4.3A)
None
H8H  A 401 (-4.3A)
H8H  A 401 (-4.4A)
EDO  A 402 ( 2.9A)
0.89A 5y7zB-5vcxA:
23.5
5y7zB-5vcxA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
8 / 12 LEU A 116
ALA A 137
LYS A 139
GLU A 157
LEU A 185
LEU A 189
CYH A 190
GLY A 191
H8H  A 401 (-3.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-4.9A)
None
H8H  A 401 (-4.3A)
None
H8H  A 401 (-4.3A)
H8H  A 401 (-4.4A)
0.99A 5y7zB-5vcxA:
23.5
5y7zB-5vcxA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
9 / 12 LEU A 116
VAL A 124
ALA A 137
GLU A 157
THR A 187
LEU A 189
CYH A 190
GLY A 191
ASP A 251
H8H  A 401 (-3.7A)
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
None
H8H  A 401 (-3.5A)
None
H8H  A 401 (-4.3A)
H8H  A 401 (-4.4A)
EDO  A 402 ( 2.9A)
0.82A 5y80A-5vcxA:
22.7
5y80A-5vcxA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
9 / 12 LEU A 116
VAL A 124
ALA A 137
LYS A 139
GLU A 157
THR A 187
LEU A 189
CYH A 190
GLY A 191
H8H  A 401 (-3.7A)
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-4.9A)
None
H8H  A 401 (-3.5A)
None
H8H  A 401 (-4.3A)
H8H  A 401 (-4.4A)
0.93A 5y80A-5vcxA:
22.7
5y80A-5vcxA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA411_0
(UNCHARACTERIZED
PROTEIN KDOO)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
3 / 3 LYS A 126
LEU A 135
ARG A 128
None
0.88A 5yw0A-5vcxA:
undetectable
5yw0A-5vcxA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo
sapiens)
7 / 12 LEU A 116
VAL A 124
ALA A 137
LYS A 139
GLU A 157
VAL A 171
THR A 187
H8H  A 401 (-3.7A)
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-4.9A)
None
None
H8H  A 401 (-3.5A)
0.71A 6hd6B-5vcxA:
17.5
6hd6B-5vcxA:
13.27