SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vdk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5vdk WEE1-LIKE PROTEIN
KINASE 2
(Homo
sapiens) 		6 / 12 VAL A 226
ALA A 239
GLU A 259
CYH A 292
HIS A 337
GLY A 379
 8X7  A 501 ( 4.5A)
8X7  A 501 ( 3.7A)
PO4  A 502 (-3.8A)
8X7  A 501 (-3.8A)
None
None
 0.85A 1uwjA-5vdkA:
21.7		 1uwjA-5vdkA:
28.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5vdk WEE1-LIKE PROTEIN
KINASE 2
(Homo
sapiens) 		7 / 12 ILE A 218
VAL A 226
ALA A 239
GLU A 259
CYH A 292
HIS A 337
GLY A 379
 8X7  A 501 ( 4.0A)
8X7  A 501 ( 4.5A)
8X7  A 501 ( 3.7A)
PO4  A 502 (-3.8A)
8X7  A 501 (-3.8A)
None
None
 0.97A 1uwjB-5vdkA:
21.7		 1uwjB-5vdkA:
28.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 5vdk WEE1-LIKE PROTEIN
KINASE 2
(Homo
sapiens) 		6 / 11 GLY A 219
GLY A 221
VAL A 226
ALA A 239
TYR A 291
SER A 296
 8X7  A 501 ( 3.8A)
8X7  A 501 (-3.4A)
8X7  A 501 ( 4.5A)
8X7  A 501 ( 3.7A)
8X7  A 501 (-4.2A)
None
 0.55A 2evaA-5vdkA:
16.1		 2evaA-5vdkA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 5vdk WEE1-LIKE PROTEIN
KINASE 2
(Homo
sapiens) 		4 / 5 LEU A 420
ILE A 345
GLY A 326
HIS A 331
 None
 0.84A 2otfA-5vdkA:
undetectable		 2otfA-5vdkA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)		 5vdk WEE1-LIKE PROTEIN
KINASE 2
(Homo
sapiens) 		6 / 12 GLY A 219
VAL A 226
ALA A 239
TYR A 291
GLY A 295
ASP A 380
 8X7  A 501 ( 3.8A)
8X7  A 501 ( 4.5A)
8X7  A 501 ( 3.7A)
8X7  A 501 (-4.2A)
8X7  A 501 (-3.6A)
8X7  A 501 (-4.8A)
 0.55A 2wgjA-5vdkA:
22.5		 2wgjA-5vdkA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 5vdk WEE1-LIKE PROTEIN
KINASE 2
(Homo
sapiens) 		6 / 11 VAL A 226
ALA A 239
VAL A 273
TYR A 291
CYH A 292
GLY A 295
 8X7  A 501 ( 4.5A)
8X7  A 501 ( 3.7A)
8X7  A 501 ( 4.6A)
8X7  A 501 (-4.2A)
8X7  A 501 (-3.8A)
8X7  A 501 (-3.6A)
 0.50A 3g0eA-5vdkA:
20.8		 3g0eA-5vdkA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5vdk WEE1-LIKE PROTEIN
KINASE 2
(Homo
sapiens) 		4 / 6 VAL A 226
LYS A 241
VAL A 273
ILE A 287
 8X7  A 501 ( 4.5A)
PO4  A 502 (-3.6A)
8X7  A 501 ( 4.6A)
PO4  A 502 (-3.4A)
 0.65A 3mssD-5vdkA:
12.2		 3mssD-5vdkA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O5R_A_FK5A1001_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 5vdk WEE1-LIKE PROTEIN
KINASE 2
(Homo
sapiens) 		5 / 11 ILE A 319
TYR A 376
LYS A 350
ILE A 347
PHE A 311
 None
 1.00A 3o5rA-5vdkA:
undetectable		 3o5rA-5vdkA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 5vdk WEE1-LIKE PROTEIN
KINASE 2
(Homo
sapiens) 		5 / 12 ILE A 218
VAL A 226
CYH A 292
PHE A 346
GLY A 382
 8X7  A 501 ( 4.0A)
8X7  A 501 ( 4.5A)
8X7  A 501 (-3.8A)
8X7  A 501 (-3.7A)
None
 0.78A 3og7A-5vdkA:
22.7		 3og7A-5vdkA:
28.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 5vdk WEE1-LIKE PROTEIN
KINASE 2
(Homo
sapiens) 		6 / 12 VAL A 226
ALA A 239
VAL A 273
ILE A 287
TYR A 291
GLY A 295
 8X7  A 501 ( 4.5A)
8X7  A 501 ( 3.7A)
8X7  A 501 ( 4.6A)
PO4  A 502 (-3.4A)
8X7  A 501 (-4.2A)
8X7  A 501 (-3.6A)
 0.42A 3sxrA-5vdkA:
17.8		 3sxrA-5vdkA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_2
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 5vdk WEE1-LIKE PROTEIN
KINASE 2
(Homo
sapiens) 		4 / 4 PRO A 413
LEU A 338
HIS A 258
LEU A 257
 None
 1.28A 3vw7A-5vdkA:
1.6		 3vw7A-5vdkA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5vdk WEE1-LIKE PROTEIN
KINASE 2
(Homo
sapiens) 		4 / 8 VAL A 272
VAL A 273
ILE A 378
ASP A 380
 PO4  A 503 (-4.6A)
8X7  A 501 ( 4.6A)
None
8X7  A 501 (-4.8A)
 0.36A 3wzeA-5vdkA:
22.5		 3wzeA-5vdkA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRH_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 5vdk WEE1-LIKE PROTEIN
KINASE 2
(Homo
sapiens) 		5 / 12 ILE A 319
TYR A 376
LYS A 350
ILE A 347
PHE A 311
 None
 0.98A 4drhA-5vdkA:
undetectable		 4drhA-5vdkA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)		 5vdk WEE1-LIKE PROTEIN
KINASE 2
(Homo
sapiens) 		5 / 11 ILE A 319
TYR A 376
LYS A 350
ILE A 347
PHE A 311
 None
 1.16A 4drjA-5vdkA:
undetectable		 4drjA-5vdkA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5vdk WEE1-LIKE PROTEIN
KINASE 2
(Homo
sapiens) 		4 / 6 ASN A 252
GLU A 249
GLU A 253
GLU A 393
 None
 1.40A 4mi4A-5vdkA:
undetectable		 4mi4A-5vdkA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5vdk WEE1-LIKE PROTEIN
KINASE 2
(Homo
sapiens) 		7 / 12 VAL A 226
ALA A 239
VAL A 273
ILE A 287
TYR A 291
GLY A 295
ASP A 380
 8X7  A 501 ( 4.5A)
8X7  A 501 ( 3.7A)
8X7  A 501 ( 4.6A)
PO4  A 502 (-3.4A)
8X7  A 501 (-4.2A)
8X7  A 501 (-3.6A)
8X7  A 501 (-4.8A)
 0.66A 4mxoA-5vdkA:
18.1		 4mxoA-5vdkA:
26.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NNR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2)		 5vdk WEE1-LIKE PROTEIN
KINASE 2
(Homo
sapiens) 		5 / 12 ILE A 319
TYR A 376
LYS A 350
ILE A 347
PHE A 311
 None
 1.07A 4nnrA-5vdkA:
undetectable
4nnrB-5vdkA:
undetectable		 4nnrA-5vdkA:
19.73
4nnrB-5vdkA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NNR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2)		 5vdk WEE1-LIKE PROTEIN
KINASE 2
(Homo
sapiens) 		5 / 10 ILE A 319
TYR A 376
LYS A 350
ILE A 347
PHE A 311
 None
 1.13A 4nnrB-5vdkA:
undetectable		 4nnrB-5vdkA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 5vdk WEE1-LIKE PROTEIN
KINASE 2
(Homo
sapiens) 		6 / 9 ILE A 218
GLY A 221
VAL A 226
ALA A 239
CYH A 292
ASN A 344
 8X7  A 501 ( 4.0A)
8X7  A 501 (-3.4A)
8X7  A 501 ( 4.5A)
8X7  A 501 ( 3.7A)
8X7  A 501 (-3.8A)
8X7  A 501 ( 4.7A)
 0.76A 4ogrI-5vdkA:
26.0		 4ogrI-5vdkA:
23.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 5vdk WEE1-LIKE PROTEIN
KINASE 2
(Homo
sapiens) 		7 / 12 ILE A 218
ALA A 239
LYS A 241
GLU A 259
ILE A 287
TYR A 291
ASP A 380
 8X7  A 501 ( 4.0A)
8X7  A 501 ( 3.7A)
PO4  A 502 (-3.6A)
PO4  A 502 (-3.8A)
PO4  A 502 (-3.4A)
8X7  A 501 (-4.2A)
8X7  A 501 (-4.8A)
 0.80A 4qmnA-5vdkA:
26.9		 4qmnA-5vdkA:
30.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 5vdk WEE1-LIKE PROTEIN
KINASE 2
(Homo
sapiens) 		6 / 11 ILE A 218
ALA A 239
GLU A 259
ILE A 287
TYR A 291
ASP A 380
 8X7  A 501 ( 4.0A)
8X7  A 501 ( 3.7A)
PO4  A 502 (-3.8A)
PO4  A 502 (-3.4A)
8X7  A 501 (-4.2A)
8X7  A 501 (-4.8A)
 0.84A 4qmsA-5vdkA:
19.0		 4qmsA-5vdkA:
30.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5vdk WEE1-LIKE PROTEIN
KINASE 2
(Homo
sapiens) 		5 / 12 ALA A 239
ILE A 287
SER A 296
PHE A 346
GLY A 379
 8X7  A 501 ( 3.7A)
PO4  A 502 (-3.4A)
None
8X7  A 501 (-3.7A)
None
 0.70A 4rzvA-5vdkA:
22.4		 4rzvA-5vdkA:
26.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5vdk WEE1-LIKE PROTEIN
KINASE 2
(Homo
sapiens) 		6 / 12 VAL A 226
ALA A 239
CYH A 292
PHE A 346
GLY A 379
GLY A 382
 8X7  A 501 ( 4.5A)
8X7  A 501 ( 3.7A)
8X7  A 501 (-3.8A)
8X7  A 501 (-3.7A)
None
None
 1.17A 4rzvB-5vdkA:
22.1		 4rzvB-5vdkA:
26.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5vdk WEE1-LIKE PROTEIN
KINASE 2
(Homo
sapiens) 		6 / 12 VAL A 226
ALA A 239
CYH A 292
SER A 296
PHE A 346
GLY A 379
 8X7  A 501 ( 4.5A)
8X7  A 501 ( 3.7A)
8X7  A 501 (-3.8A)
None
8X7  A 501 (-3.7A)
None
 0.91A 4rzvB-5vdkA:
22.1		 4rzvB-5vdkA:
26.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5vdk WEE1-LIKE PROTEIN
KINASE 2
(Homo
sapiens) 		5 / 12 VAL A 226
ALA A 239
CYH A 292
PHE A 346
GLY A 379
 8X7  A 501 ( 4.5A)
8X7  A 501 ( 3.7A)
8X7  A 501 (-3.8A)
8X7  A 501 (-3.7A)
None
 0.51A 4xv2A-5vdkA:
16.4		 4xv2A-5vdkA:
27.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5vdk WEE1-LIKE PROTEIN
KINASE 2
(Homo
sapiens) 		5 / 12 ALA A 239
CYH A 292
PHE A 346
GLY A 379
ASP A 380
 8X7  A 501 ( 3.7A)
8X7  A 501 (-3.8A)
8X7  A 501 (-3.7A)
None
8X7  A 501 (-4.8A)
 0.74A 4xv2B-5vdkA:
22.8		 4xv2B-5vdkA:
27.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5vdk WEE1-LIKE PROTEIN
KINASE 2
(Homo
sapiens) 		5 / 12 VAL A 226
ALA A 239
CYH A 292
PHE A 346
GLY A 379
 8X7  A 501 ( 4.5A)
8X7  A 501 ( 3.7A)
8X7  A 501 (-3.8A)
8X7  A 501 (-3.7A)
None
 0.51A 5cswA-5vdkA:
22.2		 5cswA-5vdkA:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5vdk WEE1-LIKE PROTEIN
KINASE 2
(Homo
sapiens) 		5 / 12 VAL A 226
ALA A 239
CYH A 292
PHE A 346
GLY A 379
 8X7  A 501 ( 4.5A)
8X7  A 501 ( 3.7A)
8X7  A 501 (-3.8A)
8X7  A 501 (-3.7A)
None
 0.55A 5cswB-5vdkA:
16.4		 5cswB-5vdkA:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5vdk WEE1-LIKE PROTEIN
KINASE 2
(Homo
sapiens) 		6 / 12 GLY A 221
VAL A 226
ALA A 239
ILE A 287
PHE A 346
GLY A 379
 8X7  A 501 (-3.4A)
8X7  A 501 ( 4.5A)
8X7  A 501 ( 3.7A)
PO4  A 502 (-3.4A)
8X7  A 501 (-3.7A)
None
 0.83A 5hieA-5vdkA:
22.0		 5hieA-5vdkA:
29.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5vdk WEE1-LIKE PROTEIN
KINASE 2
(Homo
sapiens) 		6 / 12 GLY A 221
VAL A 226
ALA A 239
ILE A 287
PHE A 346
GLY A 379
 8X7  A 501 (-3.4A)
8X7  A 501 ( 4.5A)
8X7  A 501 ( 3.7A)
PO4  A 502 (-3.4A)
8X7  A 501 (-3.7A)
None
 0.86A 5hieB-5vdkA:
21.9		 5hieB-5vdkA:
29.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5vdk WEE1-LIKE PROTEIN
KINASE 2
(Homo
sapiens) 		6 / 12 GLY A 219
GLY A 221
VAL A 226
ALA A 239
PHE A 346
GLY A 379
 8X7  A 501 ( 3.8A)
8X7  A 501 (-3.4A)
8X7  A 501 ( 4.5A)
8X7  A 501 ( 3.7A)
8X7  A 501 (-3.7A)
None
 0.81A 5hieC-5vdkA:
22.4		 5hieC-5vdkA:
29.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5vdk WEE1-LIKE PROTEIN
KINASE 2
(Homo
sapiens) 		6 / 12 GLY A 221
VAL A 226
ALA A 239
ILE A 287
PHE A 346
GLY A 379
 8X7  A 501 (-3.4A)
8X7  A 501 ( 4.5A)
8X7  A 501 ( 3.7A)
PO4  A 502 (-3.4A)
8X7  A 501 (-3.7A)
None
 0.85A 5hieD-5vdkA:
22.1		 5hieD-5vdkA:
29.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 5vdk WEE1-LIKE PROTEIN
KINASE 2
(Homo
sapiens) 		6 / 12 ILE A 218
ALA A 239
LYS A 241
ILE A 287
TYR A 291
GLY A 295
 8X7  A 501 ( 4.0A)
8X7  A 501 ( 3.7A)
PO4  A 502 (-3.6A)
PO4  A 502 (-3.4A)
8X7  A 501 (-4.2A)
8X7  A 501 (-3.6A)
 0.57A 5i9xA-5vdkA:
22.7		 5i9xA-5vdkA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_I_BEZI1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 5vdk WEE1-LIKE PROTEIN
KINASE 2
(Homo
sapiens) 		3 / 3 SER A 277
TYR A 276
TYR A 275
 None
 0.66A 5lakA-5vdkA:
undetectable
5lakI-5vdkA:
undetectable		 5lakA-5vdkA:
19.44
5lakI-5vdkA:
1.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_J_BEZJ1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 5vdk WEE1-LIKE PROTEIN
KINASE 2
(Homo
sapiens) 		3 / 3 SER A 277
TYR A 276
TYR A 275
 None
 0.57A 5lakC-5vdkA:
undetectable
5lakJ-5vdkA:
undetectable		 5lakC-5vdkA:
19.44
5lakJ-5vdkA:
1.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 5vdk WEE1-LIKE PROTEIN
KINASE 2
(Homo
sapiens) 		8 / 12 GLU A 216
ILE A 218
ALA A 239
GLU A 259
TYR A 291
GLY A 295
PHE A 346
ASP A 380
 8X7  A 501 ( 4.9A)
8X7  A 501 ( 4.0A)
8X7  A 501 ( 3.7A)
PO4  A 502 (-3.8A)
8X7  A 501 (-4.2A)
8X7  A 501 (-3.6A)
8X7  A 501 (-3.7A)
8X7  A 501 (-4.8A)
 0.98A 5vc3A-5vdkA:
34.0		 5vc3A-5vdkA:
62.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 5vdk WEE1-LIKE PROTEIN
KINASE 2
(Homo
sapiens) 		10 / 12 GLU A 216
ILE A 218
GLY A 219
ALA A 239
ASN A 289
TYR A 291
CYH A 292
GLY A 295
PHE A 346
ASP A 380
 8X7  A 501 ( 4.9A)
8X7  A 501 ( 4.0A)
8X7  A 501 ( 3.8A)
8X7  A 501 ( 3.7A)
PO4  A 502 (-3.2A)
8X7  A 501 (-4.2A)
8X7  A 501 (-3.8A)
8X7  A 501 (-3.6A)
8X7  A 501 (-3.7A)
8X7  A 501 (-4.8A)
 0.69A 5vc3A-5vdkA:
34.0		 5vc3A-5vdkA:
62.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VC3_A_DB8A601_2
(WEE1-LIKE PROTEIN
KINASE)		 5vdk WEE1-LIKE PROTEIN
KINASE 2
(Homo
sapiens) 		4 / 4 VAL A 226
LYS A 241
VAL A 273
ASN A 344
 8X7  A 501 ( 4.5A)
PO4  A 502 (-3.6A)
8X7  A 501 ( 4.6A)
8X7  A 501 ( 4.7A)
 0.44A 5vc3A-5vdkA:
34.0		 5vc3A-5vdkA:
62.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 5vdk WEE1-LIKE PROTEIN
KINASE 2
(Homo
sapiens) 		7 / 12 ALA A 239
LYS A 241
GLU A 259
VAL A 273
GLY A 295
PHE A 346
GLY A 379
 8X7  A 501 ( 3.7A)
PO4  A 502 (-3.6A)
PO4  A 502 (-3.8A)
8X7  A 501 ( 4.6A)
8X7  A 501 (-3.6A)
8X7  A 501 (-3.7A)
None
 1.02A 5vcvA-5vdkA:
30.8		 5vcvA-5vdkA:
31.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 5vdk WEE1-LIKE PROTEIN
KINASE 2
(Homo
sapiens) 		6 / 12 VAL A 226
ALA A 239
LYS A 241
CYH A 292
GLY A 294
PHE A 346
 8X7  A 501 ( 4.5A)
8X7  A 501 ( 3.7A)
PO4  A 502 (-3.6A)
8X7  A 501 (-3.8A)
None
8X7  A 501 (-3.7A)
 0.76A 5vcyA-5vdkA:
30.3		 5vcyA-5vdkA:
31.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 5vdk WEE1-LIKE PROTEIN
KINASE 2
(Homo
sapiens) 		6 / 12 VAL A 226
ALA A 239
LYS A 241
GLU A 259
CYH A 292
PHE A 346
 8X7  A 501 ( 4.5A)
8X7  A 501 ( 3.7A)
PO4  A 502 (-3.6A)
PO4  A 502 (-3.8A)
8X7  A 501 (-3.8A)
8X7  A 501 (-3.7A)
 0.64A 5vcyA-5vdkA:
30.3		 5vcyA-5vdkA:
31.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5vdk WEE1-LIKE PROTEIN
KINASE 2
(Homo
sapiens) 		4 / 9 ILE A 417
ILE A 323
ILE A 319
LEU A 316
 None
 0.84A 5vkqB-5vdkA:
undetectable
5vkqC-5vdkA:
undetectable		 5vkqB-5vdkA:
10.89
5vkqC-5vdkA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZOV_A_ASCA501_0
(PTS
ASCORBATE-SPECIFIC
SUBUNIT IIBC)		 5vdk WEE1-LIKE PROTEIN
KINASE 2
(Homo
sapiens) 		5 / 10 ILE A 330
HIS A 331
ASP A 416
ALA A 415
ILE A 387
 None
 1.47A 5zovA-5vdkA:
undetectable		 5zovA-5vdkA:
21.64