SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vdn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_0
(NEURAMINIDASE)		 5vdn GLUTATHIONE
OXIDOREDUCTASE
(Yersinia
pestis) 		5 / 12 ARG A 330
GLU A 342
GLU A 333
LYS A 339
TYR A  36
 None
 1.23A 1l7hA-5vdnA:
undetectable		 1l7hA-5vdnA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 5vdn GLUTATHIONE
OXIDOREDUCTASE
(Yersinia
pestis) 		5 / 9 GLY A  56
GLY A 151
GLY A 150
ASP A 313
ARG A 273
 FAD  A 502 (-3.5A)
BDF  A 503 (-4.9A)
FAD  A 502 (-3.3A)
FAD  A 502 (-2.9A)
BDF  A 503 ( 3.6A)
 1.07A 1mxdA-5vdnA:
undetectable		 1mxdA-5vdnA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA442_1
(ALPHA AMYLASE)		 5vdn GLUTATHIONE
OXIDOREDUCTASE
(Yersinia
pestis) 		5 / 11 GLY A  56
GLY A 151
GLY A 150
ASP A 313
ARG A 273
 FAD  A 502 (-3.5A)
BDF  A 503 (-4.9A)
FAD  A 502 (-3.3A)
FAD  A 502 (-2.9A)
BDF  A 503 ( 3.6A)
 1.06A 1mxgA-5vdnA:
undetectable		 1mxgA-5vdnA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 5vdn GLUTATHIONE
OXIDOREDUCTASE
(Yersinia
pestis) 		5 / 12 TYR A  17
GLY A  23
GLY A  26
GLY A  25
ASN A 314
 None
FAD  A 502 (-3.3A)
None
FAD  A 502 (-3.6A)
None
 1.19A 1qzzA-5vdnA:
2.0		 1qzzA-5vdnA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)		 5vdn GLUTATHIONE
OXIDOREDUCTASE
(Yersinia
pestis) 		5 / 9 ILE A 147
ILE A 295
PHE A 127
THR A 285
LEU A 280
 None
None
None
None
FAD  A 502 ( 4.2A)
 1.07A 2m9qA-5vdnA:
undetectable		 2m9qA-5vdnA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB501_1
(CYTOCHROME P450 2C8)		 5vdn GLUTATHIONE
OXIDOREDUCTASE
(Yersinia
pestis) 		5 / 9 GLY A  25
SER A  29
ILE A  20
THR A 285
VAL A 305
 FAD  A 502 (-3.6A)
None
FAD  A 502 (-4.9A)
None
None
 0.82A 2nnhB-5vdnA:
undetectable		 2nnhB-5vdnA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 5vdn GLUTATHIONE
OXIDOREDUCTASE
(Yersinia
pestis) 		5 / 12 GLY A  22
ALA A 148
GLY A 150
LEU A 146
LEU A 113
 None
FAD  A 502 (-4.6A)
FAD  A 502 (-3.3A)
None
None
 1.06A 2nyuB-5vdnA:
2.5		 2nyuB-5vdnA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A500_1
(ORF12)		 5vdn GLUTATHIONE
OXIDOREDUCTASE
(Yersinia
pestis) 		5 / 10 ILE A 359
LEU A 205
LEU A 213
GLY A 186
ALA A 189
 None
 1.14A 2xf3A-5vdnA:
undetectable		 2xf3A-5vdnA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 5vdn GLUTATHIONE
OXIDOREDUCTASE
(Yersinia
pestis) 		5 / 12 TYR A 389
PHE A  89
GLY A 198
GLY A 200
LEU A 196
 None
 1.06A 2zulA-5vdnA:
undetectable		 2zulA-5vdnA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 5vdn GLUTATHIONE
OXIDOREDUCTASE
(Yersinia
pestis) 		4 / 8 VAL A 180
LEU A 196
PRO A 177
TRP A  91
 None
 1.09A 3bgdB-5vdnA:
2.8		 3bgdB-5vdnA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 5vdn GLUTATHIONE
OXIDOREDUCTASE
(Yersinia
pestis) 		5 / 12 TYR A 389
PHE A  89
GLY A 198
GLY A 200
LEU A 196
 None
 1.08A 3dmhA-5vdnA:
3.3		 3dmhA-5vdnA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_1
(PROTEASE)		 5vdn GLUTATHIONE
OXIDOREDUCTASE
(Yersinia
pestis) 		5 / 10 ASP A 168
ILE A 165
ILE A 271
ALA A 193
ILE A 192
 BDF  A 503 (-3.0A)
None
None
None
None
 0.93A 3ekwA-5vdnA:
undetectable		 3ekwA-5vdnA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_B_SAMB600_0
(PCZA361.24)		 5vdn GLUTATHIONE
OXIDOREDUCTASE
(Yersinia
pestis) 		5 / 12 ALA A 324
GLY A 312
LEU A 146
LEU A 320
GLY A  23
 FAD  A 502 ( 3.8A)
FAD  A 502 (-3.3A)
None
FAD  A 502 (-3.7A)
FAD  A 502 (-3.3A)
 1.10A 3g2oB-5vdnA:
3.2		 3g2oB-5vdnA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 5vdn GLUTATHIONE
OXIDOREDUCTASE
(Yersinia
pestis) 		5 / 12 PRO A 358
GLY A 419
PRO A 212
VAL A 182
LEU A 205
 None
 0.99A 3m6wA-5vdnA:
2.4		 3m6wA-5vdnA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_B_SALB1345_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5vdn GLUTATHIONE
OXIDOREDUCTASE
(Yersinia
pestis) 		4 / 8 LEU A  94
PHE A  89
VAL A 195
ALA A  70
 None
 0.80A 3uniB-5vdnA:
undetectable		 3uniB-5vdnA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M83_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 5vdn GLUTATHIONE
OXIDOREDUCTASE
(Yersinia
pestis) 		5 / 11 ASN A 302
ILE A 145
TYR A  17
LEU A 282
ALA A  19
 None
 1.49A 4m83A-5vdnA:
undetectable		 4m83A-5vdnA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_1
(NEURAMINIDASE)		 5vdn GLUTATHIONE
OXIDOREDUCTASE
(Yersinia
pestis) 		5 / 12 ARG A 330
GLU A 342
GLU A 333
LYS A 339
TYR A  36
 None
 1.13A 4mwxA-5vdnA:
undetectable		 4mwxA-5vdnA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_1
(ADENOSINE KINASE)		 5vdn GLUTATHIONE
OXIDOREDUCTASE
(Yersinia
pestis) 		5 / 12 GLY A  26
GLY A  25
ALA A 327
ASN A 314
GLY A 150
 None
FAD  A 502 (-3.6A)
None
None
FAD  A 502 (-3.3A)
 0.94A 4n09D-5vdnA:
3.4		 4n09D-5vdnA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_1
(ADENOSINE KINASE)		 5vdn GLUTATHIONE
OXIDOREDUCTASE
(Yersinia
pestis) 		5 / 12 LEU A 344
GLY A  26
ALA A 327
ASN A 314
GLY A 150
 None
None
None
None
FAD  A 502 (-3.3A)
 0.99A 4n09D-5vdnA:
3.4		 4n09D-5vdnA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5vdn GLUTATHIONE
OXIDOREDUCTASE
(Yersinia
pestis) 		5 / 12 ALA A 142
GLY A 307
ILE A 295
THR A 289
LEU A 282
 None
 0.92A 4n48B-5vdnA:
undetectable		 4n48B-5vdnA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5vdn GLUTATHIONE
OXIDOREDUCTASE
(Yersinia
pestis) 		5 / 12 ALA A 142
GLY A 307
ILE A 295
THR A 289
LEU A 282
 None
 0.96A 4n49A-5vdnA:
undetectable		 4n49A-5vdnA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5vdn GLUTATHIONE
OXIDOREDUCTASE
(Yersinia
pestis) 		5 / 12 LEU A  48
ASN A  31
ILE A  27
ILE A  30
GLY A 112
 None
 1.11A 4nkvA-5vdnA:
undetectable		 4nkvA-5vdnA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5vdn GLUTATHIONE
OXIDOREDUCTASE
(Yersinia
pestis) 		5 / 12 LEU A  48
ASN A  31
ILE A  27
ILE A  30
GLY A 112
 None
 1.12A 4nkvC-5vdnA:
undetectable		 4nkvC-5vdnA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5vdn GLUTATHIONE
OXIDOREDUCTASE
(Yersinia
pestis) 		5 / 12 LEU A  48
ASN A  31
ILE A  27
ILE A  30
GLY A 112
 None
 1.14A 4nkvD-5vdnA:
undetectable		 4nkvD-5vdnA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 5vdn GLUTATHIONE
OXIDOREDUCTASE
(Yersinia
pestis) 		5 / 12 ALA A 148
GLY A 312
LEU A  18
GLY A  26
SER A  29
 FAD  A 502 (-4.6A)
FAD  A 502 (-3.3A)
None
None
None
 1.44A 5jglB-5vdnA:
undetectable		 5jglB-5vdnA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)		 5vdn GLUTATHIONE
OXIDOREDUCTASE
(Yersinia
pestis) 		5 / 12 HIS A 416
VAL A 221
LEU A 320
VAL A 318
GLY A 363
 None
None
FAD  A 502 (-3.7A)
None
None
 1.19A 6brdA-5vdnA:
11.9		 6brdA-5vdnA:
10.96