SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ve8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 5ve8 KAP123
(Kluyveromyces
lactis) 		3 / 3 PHE A1015
LEU A1009
SER A 979
 None
 0.87A 1e7aA-5ve8A:
undetectable		 1e7aA-5ve8A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5ve8 KAP123
(Kluyveromyces
lactis) 		5 / 12 ILE A 302
ALA A 305
ALA A 306
LEU A 262
ALA A 265
 None
 0.92A 1fm9A-5ve8A:
undetectable		 1fm9A-5ve8A:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3004_1
(SERUM ALBUMIN)		 5ve8 KAP123
(Kluyveromyces
lactis) 		4 / 7 GLU A 686
LEU A 685
VAL A 720
LEU A 692
 None
 0.96A 1hk3A-5ve8A:
2.1		 1hk3A-5ve8A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_E_ADNE1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5ve8 KAP123
(Kluyveromyces
lactis) 		5 / 11 GLY A 704
GLU A 707
GLU A 765
MET A 768
GLU A 763
 None
 1.50A 1odiE-5ve8A:
undetectable		 1odiE-5ve8A:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_0
(VITAMIN D3 RECEPTOR)		 5ve8 KAP123
(Kluyveromyces
lactis) 		5 / 12 LEU A 499
LEU A 487
ILE A 445
CYH A 510
LEU A 419
 None
 0.94A 1s19A-5ve8A:
undetectable		 1s19A-5ve8A:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_C_T44C601_1
(TRANSTHYRETIN)		 5ve8 KAP123
(Kluyveromyces
lactis) 		5 / 9 LEU A 721
ALA A 724
LEU A 722
LEU A 685
GLU A 689
 None
 1.40A 1sn0A-5ve8A:
undetectable
1sn0C-5ve8A:
undetectable		 1sn0A-5ve8A:
7.53
1sn0C-5ve8A:
7.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_A_9CRA201_1
(RXR-LIKE PROTEIN)		 5ve8 KAP123
(Kluyveromyces
lactis) 		5 / 12 ILE A 302
ALA A 305
ALA A 306
LEU A 262
ALA A 265
 None
 0.95A 1xiuA-5ve8A:
undetectable		 1xiuA-5ve8A:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_A_9CRA801_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5ve8 KAP123
(Kluyveromyces
lactis) 		5 / 12 ILE A 302
ALA A 305
ALA A 306
LEU A 262
ALA A 265
 None
 0.91A 1xlsA-5ve8A:
undetectable		 1xlsA-5ve8A:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_B_9CRB802_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5ve8 KAP123
(Kluyveromyces
lactis) 		5 / 12 ILE A 302
ALA A 305
ALA A 306
LEU A 262
ALA A 265
 None
 0.91A 1xlsB-5ve8A:
undetectable		 1xlsB-5ve8A:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_C_9CRC803_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5ve8 KAP123
(Kluyveromyces
lactis) 		5 / 12 ILE A 302
ALA A 305
ALA A 306
LEU A 262
ALA A 265
 None
 0.90A 1xlsC-5ve8A:
undetectable		 1xlsC-5ve8A:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_D_9CRD804_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5ve8 KAP123
(Kluyveromyces
lactis) 		5 / 12 ILE A 302
ALA A 305
ALA A 306
LEU A 262
ALA A 265
 None
 0.91A 1xlsD-5ve8A:
undetectable		 1xlsD-5ve8A:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_A_NCAA1501_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 5ve8 KAP123
(Kluyveromyces
lactis) 		4 / 7 PHE A 144
ALA A 102
ARG A 105
ASP A  97
 None
 1.26A 2e5dA-5ve8A:
undetectable
2e5dB-5ve8A:
undetectable		 2e5dA-5ve8A:
19.54
2e5dB-5ve8A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_B_NCAB1502_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 5ve8 KAP123
(Kluyveromyces
lactis) 		4 / 7 ASP A  97
PHE A 144
ALA A 102
ARG A 105
 None
 1.22A 2e5dA-5ve8A:
undetectable
2e5dB-5ve8A:
undetectable		 2e5dA-5ve8A:
19.54
2e5dB-5ve8A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G78_A_REAA200_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 5ve8 KAP123
(Kluyveromyces
lactis) 		5 / 12 LEU A 947
ILE A 942
VAL A 939
VAL A 996
LEU A1024
 None
 1.14A 2g78A-5ve8A:
undetectable		 2g78A-5ve8A:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5ve8 KAP123
(Kluyveromyces
lactis) 		5 / 12 LEU A 869
LEU A 887
ILE A 890
ALA A 804
PHE A 861
 None
 0.99A 2h42C-5ve8A:
undetectable		 2h42C-5ve8A:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_1
(PROTEASE)		 5ve8 KAP123
(Kluyveromyces
lactis) 		5 / 12 LEU A 165
GLY A 199
ILE A 201
VAL A 191
ILE A 161
 None
 1.06A 2r5pA-5ve8A:
undetectable		 2r5pA-5ve8A:
7.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_1
(PROTEASE)		 5ve8 KAP123
(Kluyveromyces
lactis) 		5 / 12 LEU A 165
GLY A 199
ILE A 201
VAL A 191
ILE A 161
 None
 1.06A 2r5pC-5ve8A:
undetectable		 2r5pC-5ve8A:
7.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5ve8 KAP123
(Kluyveromyces
lactis) 		4 / 5 LEU A 384
GLN A 395
THR A 392
THR A 303
 None
 1.31A 2zj0C-5ve8A:
undetectable		 2zj0C-5ve8A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5ve8 KAP123
(Kluyveromyces
lactis) 		4 / 4 LEU A 384
GLN A 395
THR A 392
THR A 303
 None
 1.38A 2zj0D-5ve8A:
undetectable		 2zj0D-5ve8A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 5ve8 KAP123
(Kluyveromyces
lactis) 		3 / 3 SER A 702
GLU A 665
ASP A 587
 None
 0.68A 2zulA-5ve8A:
undetectable		 2zulA-5ve8A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_2
(NEURAMINIDASE)		 5ve8 KAP123
(Kluyveromyces
lactis) 		4 / 6 ASP A 798
ARG A 802
ILE A 788
ARG A 753
 None
 1.07A 3ckzA-5ve8A:
undetectable		 3ckzA-5ve8A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		 5ve8 KAP123
(Kluyveromyces
lactis) 		5 / 12 LEU A 576
PHE A 522
ALA A 563
VAL A 564
ILE A 533
 None
 1.05A 3czhB-5ve8A:
undetectable		 3czhB-5ve8A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1X_A_ROCA201_2
(HIV-1 PROTEASE)		 5ve8 KAP123
(Kluyveromyces
lactis) 		5 / 12 LEU A 871
ALA A 886
ILE A 845
VAL A 867
ILE A 868
 None
 0.99A 3d1xB-5ve8A:
undetectable		 3d1xB-5ve8A:
7.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 5ve8 KAP123
(Kluyveromyces
lactis) 		3 / 3 SER A 702
GLU A 665
ASP A 587
 None
 0.67A 3dmhA-5ve8A:
undetectable		 3dmhA-5ve8A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		 5ve8 KAP123
(Kluyveromyces
lactis) 		5 / 12 GLY A 856
GLY A 855
VAL A 854
LEU A 797
MET A 789
 None
 1.24A 3h52B-5ve8A:
undetectable		 3h52B-5ve8A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_3
(HIV-1 PROTEASE)		 5ve8 KAP123
(Kluyveromyces
lactis) 		5 / 12 LEU A 871
ALA A 886
ILE A 845
VAL A 867
ILE A 868
 None
 0.99A 3k4vD-5ve8A:
undetectable		 3k4vD-5ve8A:
7.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5ve8 KAP123
(Kluyveromyces
lactis) 		5 / 10 ILE A 557
PHE A 610
SER A 680
ALA A 672
ALA A 603
 None
 1.29A 3lw5B-5ve8A:
undetectable		 3lw5B-5ve8A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 5ve8 KAP123
(Kluyveromyces
lactis) 		5 / 11 ILE A 533
PHE A 554
THR A 586
ILE A 584
VAL A 536
 None
 1.01A 3n0hA-5ve8A:
undetectable		 3n0hA-5ve8A:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_A_ROCA101_2
(PROTEASE)		 5ve8 KAP123
(Kluyveromyces
lactis) 		5 / 12 LEU A 871
ALA A 886
ILE A 845
VAL A 867
ILE A 868
 None
 0.96A 3nduB-5ve8A:
undetectable		 3nduB-5ve8A:
6.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_2
(PROTEASE)		 5ve8 KAP123
(Kluyveromyces
lactis) 		5 / 12 LEU A 871
ALA A 886
ILE A 845
VAL A 867
ILE A 868
 None
 0.92A 3nduD-5ve8A:
undetectable		 3nduD-5ve8A:
6.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_1
(PROTEASE)		 5ve8 KAP123
(Kluyveromyces
lactis) 		5 / 9 ALA A 514
ILE A 471
GLY A 508
ILE A 507
ILE A 476
 None
 1.09A 3nu4A-5ve8A:
undetectable		 3nu4A-5ve8A:
7.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_3
(PROTEASE)		 5ve8 KAP123
(Kluyveromyces
lactis) 		5 / 12 LEU A 871
ALA A 886
ILE A 845
VAL A 867
ILE A 868
 None
 0.95A 3oxcB-5ve8A:
undetectable		 3oxcB-5ve8A:
7.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 5ve8 KAP123
(Kluyveromyces
lactis) 		5 / 12 ILE A 456
GLN A 415
ALA A 418
LEU A 419
ILE A 377
 None
 1.14A 3ozwB-5ve8A:
2.7		 3ozwB-5ve8A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 5ve8 KAP123
(Kluyveromyces
lactis) 		5 / 12 ILE A 533
PHE A 554
THR A 586
ILE A 584
VAL A 536
 None
 1.03A 3s3vA-5ve8A:
undetectable		 3s3vA-5ve8A:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5ve8 KAP123
(Kluyveromyces
lactis) 		3 / 3 THR A 427
VAL A 423
GLU A 469
 None
 0.40A 3v4tA-5ve8A:
undetectable
3v4tD-5ve8A:
undetectable		 3v4tA-5ve8A:
17.81
3v4tD-5ve8A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_B_ADNB301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 5ve8 KAP123
(Kluyveromyces
lactis) 		5 / 10 ALA A 848
LEU A 800
LEU A 780
LEU A 853
ILE A 788
 None
 1.09A 3wdmB-5ve8A:
undetectable		 3wdmB-5ve8A:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_D_ADND301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 5ve8 KAP123
(Kluyveromyces
lactis) 		5 / 10 ALA A 848
LEU A 800
LEU A 780
LEU A 853
ILE A 788
 None
 1.04A 3wdmD-5ve8A:
undetectable		 3wdmD-5ve8A:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA804_1
(CATALASE-PEROXIDASE)		 5ve8 KAP123
(Kluyveromyces
lactis) 		3 / 3 ASN A 370
GLU A 373
ARG A 374
 None
 1.07A 3wxoA-5ve8A:
undetectable		 3wxoA-5ve8A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_D_NCTD501_1
(CYTOCHROME P450 2A13)		 5ve8 KAP123
(Kluyveromyces
lactis) 		4 / 6 PHE A 861
PHE A 857
ALA A 886
LEU A 808
 None
 0.97A 4ejgD-5ve8A:
undetectable		 4ejgD-5ve8A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5ve8 KAP123
(Kluyveromyces
lactis) 		4 / 6 LEU A 887
LYS A 865
LEU A 904
GLU A 903
 None
 1.06A 4f3tA-5ve8A:
undetectable		 4f3tA-5ve8A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_A_NCAA1201_0
(TANKYRASE-2)		 5ve8 KAP123
(Kluyveromyces
lactis) 		4 / 7 GLY A 704
SER A 702
TYR A 703
GLU A 628
 None
 0.82A 4hyfA-5ve8A:
undetectable		 4hyfA-5ve8A:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 5ve8 KAP123
(Kluyveromyces
lactis) 		4 / 8 GLY A 704
SER A 702
TYR A 703
GLU A 628
 None
 0.82A 4hyfB-5ve8A:
undetectable		 4hyfB-5ve8A:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 5ve8 KAP123
(Kluyveromyces
lactis) 		4 / 8 GLY A 704
SER A 702
TYR A 703
GLU A 628
 None
 0.82A 4hyfC-5ve8A:
undetectable		 4hyfC-5ve8A:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 5ve8 KAP123
(Kluyveromyces
lactis) 		4 / 5 GLN A 395
THR A 392
LEU A 366
LEU A 362
 None
 0.91A 4lvcB-5ve8A:
undetectable		 4lvcB-5ve8A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5ve8 KAP123
(Kluyveromyces
lactis) 		4 / 6 GLU A 626
GLU A 629
TYR A 703
GLU A 701
 None
 1.40A 4mi4A-5ve8A:
undetectable		 4mi4A-5ve8A:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QCK_A_ASDA404_1
(3-KETOSTEROID-9-ALPH
A-MONOOXYGENASE
OXYGENASE SUBUNIT)		 5ve8 KAP123
(Kluyveromyces
lactis) 		5 / 12 ASN A 237
GLN A 186
LEU A 178
ALA A 185
LEU A 220
 None
 1.29A 4qckA-5ve8A:
undetectable		 4qckA-5ve8A:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5ve8 KAP123
(Kluyveromyces
lactis) 		5 / 12 GLU A 889
LEU A 904
GLU A 919
GLU A 903
LEU A 843
 None
 1.01A 4retC-5ve8A:
undetectable		 4retC-5ve8A:
22.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ve8 KAP123
(Kluyveromyces
lactis) 		5 / 12 VAL A 946
LEU A 950
TYR A 943
GLY A 927
LEU A 905
 None
 1.10A 4rrwA-5ve8A:
undetectable		 4rrwA-5ve8A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ve8 KAP123
(Kluyveromyces
lactis) 		5 / 12 VAL A 946
LEU A 950
TYR A 943
GLY A 927
LEU A 905
 None
 1.14A 4rrwB-5ve8A:
undetectable		 4rrwB-5ve8A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ve8 KAP123
(Kluyveromyces
lactis) 		5 / 12 VAL A 946
LEU A 950
TYR A 943
GLY A 927
LEU A 905
 None
 1.10A 4rrzA-5ve8A:
undetectable		 4rrzA-5ve8A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ve8 KAP123
(Kluyveromyces
lactis) 		5 / 12 VAL A 946
LEU A 950
TYR A 943
GLY A 927
LEU A 905
 None
 1.14A 4rrzB-5ve8A:
undetectable		 4rrzB-5ve8A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_A_ADNA301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 5ve8 KAP123
(Kluyveromyces
lactis) 		5 / 9 LEU A 853
GLY A 856
ILE A 788
SER A 794
VAL A 860
 None
 1.45A 4x3mA-5ve8A:
undetectable		 4x3mA-5ve8A:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5ve8 KAP123
(Kluyveromyces
lactis) 		5 / 10 GLY A 983
VAL A 985
VAL A 981
LEU A1009
LEU A 954
 None
 1.20A 4yb6A-5ve8A:
undetectable
4yb6E-5ve8A:
undetectable		 4yb6A-5ve8A:
15.88
4yb6E-5ve8A:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5ve8 KAP123
(Kluyveromyces
lactis) 		5 / 10 GLY A 983
VAL A 985
VAL A 981
LEU A1009
LEU A 954
 None
 1.18A 4yb6B-5ve8A:
undetectable
4yb6C-5ve8A:
undetectable		 4yb6B-5ve8A:
15.88
4yb6C-5ve8A:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5ve8 KAP123
(Kluyveromyces
lactis) 		5 / 10 LEU A1009
LEU A 954
GLY A 983
VAL A 985
VAL A 981
 None
 1.20A 4yb6B-5ve8A:
undetectable
4yb6F-5ve8A:
undetectable		 4yb6B-5ve8A:
15.88
4yb6F-5ve8A:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_G_IPHG101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 5ve8 KAP123
(Kluyveromyces
lactis) 		4 / 6 LEU A 757
CYH A 801
HIS A 796
LEU A 797
 None
 1.19A 5hrqD-5ve8A:
undetectable
5hrqG-5ve8A:
undetectable
5hrqH-5ve8A:
undetectable		 5hrqD-5ve8A:
2.49
5hrqG-5ve8A:
1.84
5hrqH-5ve8A:
2.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQD_C_RIOC600_0
(BIFUNCTIONAL AAC/APH)		 5ve8 KAP123
(Kluyveromyces
lactis) 		5 / 12 ASP A 465
SER A 505
ASN A 556
GLU A 548
GLU A 555
 None
 1.30A 5iqdC-5ve8A:
1.2		 5iqdC-5ve8A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQE_D_NMYD600_1
(BIFUNCTIONAL AAC/APH)		 5ve8 KAP123
(Kluyveromyces
lactis) 		5 / 12 ASP A 465
SER A 505
ASN A 556
GLU A 548
GLU A 555
 None
 1.30A 5iqeD-5ve8A:
0.0		 5iqeD-5ve8A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 5ve8 KAP123
(Kluyveromyces
lactis) 		5 / 12 GLU A 889
LEU A 887
ASP A 840
ALA A 864
PHE A 857
 None
 1.15A 5kc4A-5ve8A:
2.1		 5kc4A-5ve8A:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5ve8 KAP123
(Kluyveromyces
lactis) 		4 / 4 GLN A 395
THR A 392
LEU A 366
LEU A 362
 None
 0.91A 5m5kB-5ve8A:
undetectable		 5m5kB-5ve8A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_1
(SCRFP-TAG,GP41)		 5ve8 KAP123
(Kluyveromyces
lactis) 		5 / 12 LEU A 673
LYS A 718
LYS A 681
GLU A 686
LEU A 685
 None
 1.13A 5nwvA-5ve8A:
undetectable		 5nwvA-5ve8A:
3.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_2_PQN2843_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5ve8 KAP123
(Kluyveromyces
lactis) 		5 / 12 ILE A 557
PHE A 610
SER A 680
ALA A 672
ALA A 603
 None
 1.14A 5oy02-5ve8A:
undetectable		 5oy02-5ve8A:
5.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_2_PQN2843_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5ve8 KAP123
(Kluyveromyces
lactis) 		5 / 12 PHE A 610
SER A 680
ILE A 621
ALA A 672
ALA A 603
 None
 1.27A 5oy02-5ve8A:
undetectable		 5oy02-5ve8A:
5.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_1
(CYTOCHROME P450 3A4)		 5ve8 KAP123
(Kluyveromyces
lactis) 		5 / 12 ILE A 557
PHE A 569
ALA A 600
ILE A 617
GLU A 582
 None
 0.95A 5vceA-5ve8A:
undetectable		 5vceA-5ve8A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5ve8 KAP123
(Kluyveromyces
lactis) 		5 / 12 ILE A 302
ALA A 305
ALA A 306
LEU A 262
ALA A 265
 None
 0.95A 5z12B-5ve8A:
undetectable		 5z12B-5ve8A:
6.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_C_9CRC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5ve8 KAP123
(Kluyveromyces
lactis) 		5 / 12 ILE A 302
ALA A 305
ALA A 306
LEU A 262
ALA A 265
 None
 0.93A 5z12C-5ve8A:
undetectable		 5z12C-5ve8A:
6.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5ve8 KAP123
(Kluyveromyces
lactis) 		5 / 12 ILE A 302
ALA A 305
ALA A 306
LEU A 262
ALA A 265
 None
 0.94A 6a5yD-5ve8A:
undetectable		 6a5yD-5ve8A:
5.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_C_ACTC609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5ve8 KAP123
(Kluyveromyces
lactis) 		4 / 5 PHE A 144
GLU A 179
ASP A  97
HIS A 101
 None
 1.36A 6b58C-5ve8A:
2.5		 6b58C-5ve8A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C5U_A_RIOA600_0
(BIFUNCTIONAL AAC/APH)		 5ve8 KAP123
(Kluyveromyces
lactis) 		5 / 10 ASP A 465
SER A 505
ASN A 556
GLU A 548
GLU A 555
 None
 1.31A 6c5uA-5ve8A:
1.9		 6c5uA-5ve8A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C5U_D_RIOD600_0
(BIFUNCTIONAL AAC/APH)		 5ve8 KAP123
(Kluyveromyces
lactis) 		5 / 10 ASP A 465
SER A 505
ASN A 556
GLU A 548
GLU A 555
 None
 1.33A 6c5uD-5ve8A:
0.6		 6c5uD-5ve8A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C71_B_NCTB501_1
(AMINE OXIDASE)		 5ve8 KAP123
(Kluyveromyces
lactis) 		4 / 8 LEU A 947
TYR A 943
THR A1001
ASN A 994
 None
 1.22A 6c71B-5ve8A:
undetectable		 6c71B-5ve8A:
6.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CGG_D_84GD600_0
(BIFUNCTIONAL AAC/APH)		 5ve8 KAP123
(Kluyveromyces
lactis) 		5 / 11 ASP A 465
SER A 505
ASN A 556
GLU A 548
GLU A 555
 None
 1.34A 6cggD-5ve8A:
3.5		 6cggD-5ve8A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_1
(PROTEASE)		 5ve8 KAP123
(Kluyveromyces
lactis) 		5 / 12 LEU A 871
ALA A 886
ILE A 845
VAL A 867
ILE A 868
 None
 1.13A 6dgxB-5ve8A:
undetectable		 6dgxB-5ve8A:
6.88