SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5vef'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_A_NIOA604_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		4 / 5 SER A 443
THR A 404
GLU A 507
GLY A 511
 ACT  A 602 (-3.4A)
ACT  A 602 (-3.3A)
ACT  A 602 (-3.9A)
None
 0.90A 1icrA-5vefA:
undetectable
1icrB-5vefA:
undetectable		 1icrA-5vefA:
21.98
1icrB-5vefA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_B_NIOB602_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		4 / 5 GLU A 507
GLY A 511
SER A 443
THR A 404
 ACT  A 602 (-3.9A)
None
ACT  A 602 (-3.4A)
ACT  A 602 (-3.3A)
 0.89A 1icrA-5vefA:
undetectable
1icrB-5vefA:
undetectable		 1icrA-5vefA:
21.98
1icrB-5vefA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_A_NIOA221_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		4 / 6 SER A 443
THR A 404
GLU A 507
GLY A 511
 ACT  A 602 (-3.4A)
ACT  A 602 (-3.3A)
ACT  A 602 (-3.9A)
None
 0.92A 1icuA-5vefA:
undetectable
1icuB-5vefA:
undetectable		 1icuA-5vefA:
21.98
1icuB-5vefA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_B_NIOB219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		4 / 6 GLU A 507
GLY A 511
SER A 443
THR A 404
 ACT  A 602 (-3.9A)
None
ACT  A 602 (-3.4A)
ACT  A 602 (-3.3A)
 0.92A 1icuA-5vefA:
undetectable
1icuB-5vefA:
undetectable		 1icuA-5vefA:
21.98
1icuB-5vefA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_C_NIOC225_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		4 / 6 SER A 443
THR A 404
GLU A 507
GLY A 511
 ACT  A 602 (-3.4A)
ACT  A 602 (-3.3A)
ACT  A 602 (-3.9A)
None
 0.93A 1icuC-5vefA:
undetectable
1icuD-5vefA:
undetectable		 1icuC-5vefA:
21.98
1icuD-5vefA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_C_NIOC708_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		4 / 5 SER A 443
THR A 404
GLU A 507
GLY A 511
 ACT  A 602 (-3.4A)
ACT  A 602 (-3.3A)
ACT  A 602 (-3.9A)
None
 0.91A 1icvC-5vefA:
undetectable
1icvD-5vefA:
undetectable		 1icvC-5vefA:
21.98
1icvD-5vefA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_D_NIOD706_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		4 / 5 GLU A 507
GLY A 511
SER A 443
THR A 404
 ACT  A 602 (-3.9A)
None
ACT  A 602 (-3.4A)
ACT  A 602 (-3.3A)
 0.94A 1icvC-5vefA:
undetectable
1icvD-5vefA:
undetectable		 1icvC-5vefA:
21.98
1icvD-5vefA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_A_BEZA524_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		4 / 6 SER A 443
THR A 404
GLU A 507
GLY A 511
 ACT  A 602 (-3.4A)
ACT  A 602 (-3.3A)
ACT  A 602 (-3.9A)
None
 0.89A 1kqbA-5vefA:
undetectable
1kqbB-5vefA:
undetectable		 1kqbA-5vefA:
21.34
1kqbB-5vefA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_B_BEZB525_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		4 / 5 GLU A 507
GLY A 511
SER A 443
THR A 404
 ACT  A 602 (-3.9A)
None
ACT  A 602 (-3.4A)
ACT  A 602 (-3.3A)
 0.92A 1kqbA-5vefA:
undetectable
1kqbB-5vefA:
undetectable		 1kqbA-5vefA:
21.34
1kqbB-5vefA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_C_BEZC522_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		4 / 6 SER A 443
THR A 404
GLU A 507
GLY A 511
 ACT  A 602 (-3.4A)
ACT  A 602 (-3.3A)
ACT  A 602 (-3.9A)
None
 0.87A 1kqbC-5vefA:
undetectable
1kqbD-5vefA:
undetectable		 1kqbC-5vefA:
21.34
1kqbD-5vefA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_D_BEZD523_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		4 / 6 GLU A 507
GLY A 511
SER A 443
THR A 404
 ACT  A 602 (-3.9A)
None
ACT  A 602 (-3.4A)
ACT  A 602 (-3.3A)
 0.89A 1kqbC-5vefA:
undetectable
1kqbD-5vefA:
undetectable		 1kqbC-5vefA:
21.34
1kqbD-5vefA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MOG_A_RBFA200_1
(DODECIN)		 5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		3 / 3 PHE A 324
TRP A 392
GLU A 390
 None
 0.90A 1mogA-5vefA:
undetectable		 1mogA-5vefA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		5 / 11 PHE A 548
VAL A 407
LEU A 403
LEU A 552
LEU A 501
 None
 1.30A 1mx1B-5vefA:
undetectable		 1mx1B-5vefA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		6 / 12 VAL A 335
ALA A 348
GLU A 366
VAL A 379
PHE A 397
GLY A 401
 M77  A 601 (-4.5A)
M77  A 601 ( 3.5A)
None
None
M77  A 601 (-4.1A)
M77  A 601 ( 4.8A)
 0.89A 1opjB-5vefA:
21.9		 1opjB-5vefA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CC8_A_RBFA1067_1
(VNG1446H)		 5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		3 / 3 PHE A 324
VAL A 349
TRP A 392
 None
 0.90A 2cc8A-5vefA:
undetectable		 2cc8A-5vefA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CCB_A_RBFA1067_1
(VNG1446H)		 5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		3 / 3 PHE A 324
VAL A 349
TRP A 392
 None
 0.90A 2ccbA-5vefA:
undetectable		 2ccbA-5vefA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_C_CHDC3_0
(LIVER
CARBOXYLESTERASE 1)		 5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		4 / 6 LEU A 535
LYS A 546
LEU A 549
PRO A 532
 None
 1.21A 2dqyC-5vefA:
undetectable		 2dqyC-5vefA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		7 / 11 GLY A 328
GLY A 330
VAL A 335
ALA A 348
MET A 395
LEU A 447
ASP A 458
 M77  A 601 (-3.4A)
M77  A 601 (-2.6A)
M77  A 601 (-4.5A)
M77  A 601 ( 3.5A)
M77  A 601 ( 2.9A)
M77  A 601 (-4.6A)
M77  A 601 ( 3.5A)
 0.64A 2evaA-5vefA:
25.7		 2evaA-5vefA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		7 / 12 GLY A 328
GLY A 330
VAL A 335
ALA A 348
MET A 395
LYS A 442
ASP A 458
 M77  A 601 (-3.4A)
M77  A 601 (-2.6A)
M77  A 601 (-4.5A)
M77  A 601 ( 3.5A)
M77  A 601 ( 2.9A)
None
M77  A 601 ( 3.5A)
 0.91A 2fumD-5vefA:
25.4		 2fumD-5vefA:
27.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		7 / 12 VAL A 335
ALA A 348
GLU A 366
VAL A 379
PHE A 397
GLY A 401
LEU A 447
 M77  A 601 (-4.5A)
M77  A 601 ( 3.5A)
None
None
M77  A 601 (-4.1A)
M77  A 601 ( 4.8A)
M77  A 601 (-4.6A)
 0.77A 2hyyC-5vefA:
22.8		 2hyyC-5vefA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VX9_A_RBFA1064_1
(DODECIN)		 5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		3 / 3 PHE A 324
VAL A 349
TRP A 392
 None
 0.88A 2vx9A-5vefA:
undetectable		 2vx9A-5vefA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		6 / 12 ILE A 327
VAL A 335
ALA A 348
GLY A 401
LEU A 447
ASP A 458
 M77  A 601 ( 4.8A)
M77  A 601 (-4.5A)
M77  A 601 ( 3.5A)
M77  A 601 ( 4.8A)
M77  A 601 (-4.6A)
M77  A 601 ( 3.5A)
 0.57A 2y7jA-5vefA:
30.2		 2y7jA-5vefA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		6 / 10 ILE A 327
VAL A 335
ALA A 348
GLY A 401
LEU A 447
ASP A 458
 M77  A 601 ( 4.8A)
M77  A 601 (-4.5A)
M77  A 601 ( 3.5A)
M77  A 601 ( 4.8A)
M77  A 601 (-4.6A)
M77  A 601 ( 3.5A)
 0.64A 2y7jB-5vefA:
30.4		 2y7jB-5vefA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		9 / 11 ILE A 327
ALA A 348
LYS A 350
VAL A 379
PHE A 397
GLY A 401
LEU A 447
SER A 457
ASP A 458
 M77  A 601 ( 4.8A)
M77  A 601 ( 3.5A)
M77  A 601 ( 4.7A)
None
M77  A 601 (-4.1A)
M77  A 601 ( 4.8A)
M77  A 601 (-4.6A)
M77  A 601 (-3.2A)
M77  A 601 ( 3.5A)
 0.87A 3miyA-5vefA:
24.1		 3miyA-5vefA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		7 / 9 ILE A 327
ALA A 348
LYS A 350
PHE A 397
GLY A 401
LEU A 447
SER A 457
 M77  A 601 ( 4.8A)
M77  A 601 ( 3.5A)
M77  A 601 ( 4.7A)
M77  A 601 (-4.1A)
M77  A 601 ( 4.8A)
M77  A 601 (-4.6A)
M77  A 601 (-3.2A)
 0.69A 3miyB-5vefA:
23.8		 3miyB-5vefA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		5 / 9 ILE A 327
ALA A 348
VAL A 379
PHE A 397
LEU A 447
 M77  A 601 ( 4.8A)
M77  A 601 ( 3.5A)
None
M77  A 601 (-4.1A)
M77  A 601 (-4.6A)
 0.56A 3ti1A-5vefA:
25.6		 3ti1A-5vefA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		7 / 12 VAL A 335
ALA A 348
GLU A 366
VAL A 379
PHE A 397
GLY A 401
LEU A 447
 M77  A 601 (-4.5A)
M77  A 601 ( 3.5A)
None
None
M77  A 601 (-4.1A)
M77  A 601 ( 4.8A)
M77  A 601 (-4.6A)
 0.80A 3ue4B-5vefA:
25.2		 3ue4B-5vefA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		4 / 5 ILE A 369
VAL A 379
LEU A 447
ASP A 458
 None
None
M77  A 601 (-4.6A)
M77  A 601 ( 3.5A)
 1.17A 3wzdA-5vefA:
22.3		 3wzdA-5vefA:
26.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		8 / 12 VAL A 335
ALA A 348
LYS A 350
GLU A 366
VAL A 379
PHE A 397
GLY A 401
LEU A 447
 M77  A 601 (-4.5A)
M77  A 601 ( 3.5A)
M77  A 601 ( 4.7A)
None
None
M77  A 601 (-4.1A)
M77  A 601 ( 4.8A)
M77  A 601 (-4.6A)
 0.70A 4ag8A-5vefA:
22.0		 4ag8A-5vefA:
26.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		5 / 11 ALA A 348
VAL A 379
PHE A 397
GLY A 401
LEU A 447
 M77  A 601 ( 3.5A)
None
M77  A 601 (-4.1A)
M77  A 601 ( 4.8A)
M77  A 601 (-4.6A)
 0.49A 4agdA-5vefA:
21.3		 4agdA-5vefA:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		7 / 12 VAL A 335
ALA A 348
LYS A 350
GLU A 366
PHE A 397
GLY A 401
HIS A 438
 M77  A 601 (-4.5A)
M77  A 601 ( 3.5A)
M77  A 601 ( 4.7A)
None
M77  A 601 (-4.1A)
M77  A 601 ( 4.8A)
None
 0.58A 4asdA-5vefA:
21.8		 4asdA-5vefA:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		5 / 12 VAL A 509
THR A 408
ILE A 581
VAL A 420
ILE A 446
 None
 1.21A 4eb6B-5vefA:
undetectable
4eb6C-5vefA:
undetectable		 4eb6B-5vefA:
22.58
4eb6C-5vefA:
20.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		6 / 10 ALA A 348
VAL A 379
MET A 395
PHE A 397
LEU A 398
GLY A 400
 M77  A 601 ( 3.5A)
None
M77  A 601 ( 2.9A)
M77  A 601 (-4.1A)
M77  A 601 (-4.4A)
None
 1.21A 4ks8A-5vefA:
44.6		 4ks8A-5vefA:
70.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		10 / 10 ILE A 327
ALA A 348
VAL A 379
MET A 395
PHE A 397
LEU A 398
GLY A 401
LEU A 447
SER A 457
ASP A 458
 M77  A 601 ( 4.8A)
M77  A 601 ( 3.5A)
None
M77  A 601 ( 2.9A)
M77  A 601 (-4.1A)
M77  A 601 (-4.4A)
M77  A 601 ( 4.8A)
M77  A 601 (-4.6A)
M77  A 601 (-3.2A)
M77  A 601 ( 3.5A)
 0.53A 4ks8A-5vefA:
44.6		 4ks8A-5vefA:
70.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		7 / 12 ILE A 327
GLY A 328
VAL A 335
ALA A 348
MET A 395
LEU A 398
LEU A 447
 M77  A 601 ( 4.8A)
M77  A 601 (-3.4A)
M77  A 601 (-4.5A)
M77  A 601 ( 3.5A)
M77  A 601 ( 2.9A)
M77  A 601 (-4.4A)
M77  A 601 (-4.6A)
 0.62A 4qmzA-5vefA:
37.4		 4qmzA-5vefA:
35.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		6 / 12 ILE A 327
GLY A 328
VAL A 335
LEU A 398
GLY A 400
LEU A 447
 M77  A 601 ( 4.8A)
M77  A 601 (-3.4A)
M77  A 601 (-4.5A)
M77  A 601 (-4.4A)
None
M77  A 601 (-4.6A)
 0.85A 4qmzA-5vefA:
37.4		 4qmzA-5vefA:
35.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		4 / 5 GLY A 460
SER A 331
GLU A 366
ASP A 440
 None
 1.02A 4xueA-5vefA:
undetectable		 4xueA-5vefA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		6 / 12 ILE A 327
ALA A 348
LYS A 350
GLY A 401
LEU A 447
SER A 457
 M77  A 601 ( 4.8A)
M77  A 601 ( 3.5A)
M77  A 601 ( 4.7A)
M77  A 601 ( 4.8A)
M77  A 601 (-4.6A)
M77  A 601 (-3.2A)
 0.73A 5i9yA-5vefA:
22.6		 5i9yA-5vefA:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JCN_B_ASCB502_0
(OS09G0567300 PROTEIN)		 5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		4 / 6 GLU A 495
PRO A 557
GLY A 493
ARG A 471
 None
 1.20A 5jcnB-5vefA:
undetectable		 5jcnB-5vefA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_B_ADNB401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		5 / 9 ILE A 327
GLY A 328
VAL A 335
ALA A 348
MET A 395
 M77  A 601 ( 4.8A)
M77  A 601 (-3.4A)
M77  A 601 (-4.5A)
M77  A 601 ( 3.5A)
M77  A 601 ( 2.9A)
 0.55A 5lw1B-5vefA:
23.9		 5lw1B-5vefA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		6 / 12 GLY A 330
VAL A 335
ALA A 348
LYS A 350
LEU A 447
SER A 457
 M77  A 601 (-2.6A)
M77  A 601 (-4.5A)
M77  A 601 ( 3.5A)
M77  A 601 ( 4.7A)
M77  A 601 (-4.6A)
M77  A 601 (-3.2A)
 0.93A 5p9iA-5vefA:
24.7		 5p9iA-5vefA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		6 / 12 ALA A 348
GLU A 366
VAL A 379
PHE A 397
GLY A 401
LEU A 447
 M77  A 601 ( 3.5A)
None
None
M77  A 601 (-4.1A)
M77  A 601 ( 4.8A)
M77  A 601 (-4.6A)
 0.60A 5te0A-5vefA:
25.4		 5te0A-5vefA:
28.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		4 / 4 GLY A 493
PRO A 494
VAL A 465
ARG A 471
 None
 1.15A 5uunA-5vefA:
undetectable
5uunB-5vefA:
undetectable		 5uunA-5vefA:
23.63
5uunB-5vefA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_C_HFGC1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		5 / 12 PRO A 479
THR A 478
TRP A 481
THR A 404
SER A 445
 None
None
None
ACT  A 602 (-3.3A)
None
 1.22A 5xiqC-5vefA:
undetectable		 5xiqC-5vefA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		7 / 12 GLY A 328
VAL A 335
ALA A 348
LYS A 350
MET A 395
LEU A 447
ASP A 458
 M77  A 601 (-3.4A)
M77  A 601 (-4.5A)
M77  A 601 ( 3.5A)
M77  A 601 ( 4.7A)
M77  A 601 ( 2.9A)
M77  A 601 (-4.6A)
M77  A 601 ( 3.5A)
 1.20A 5yu9B-5vefA:
22.7		 5yu9B-5vefA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		5 / 10 PHE A 548
SER A 544
ALA A 575
LEU A 572
PHE A 459
 None
 1.47A 5zjiA-5vefA:
undetectable
5zjiJ-5vefA:
undetectable		 5zjiA-5vefA:
15.00
5zjiJ-5vefA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens) 		4 / 6 VAL A 476
LEU A 308
MET A 395
ARG A 371
 SEP  A 474 ( 4.4A)
None
M77  A 601 ( 2.9A)
None
 0.99A 6brdB-5vefA:
1.2		 6brdB-5vefA:
13.59